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Article: Einführung einer umfassenden Leistungserfassung in der Psychiatrie. Erste Erfahrungen an der Klinik Hohe Mark

Bachner, Ulrike / Grabe, Martin / Haselhorst, Gerd

2012 Volume 81, Issue 6, Page(s) 23

Language	German
Document type	Article
ZDB-ID	2420760-3
ISSN	1867-9269 ; 0023-4508
Database	Current Contents Medicine

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Book ; Online: Sponsoring im internationalen Profi-Fußball

Bachner, Michael

2012

Abstract: ... von Automobilherstellern genutzt, um in einem positiven Umfeld bzw. auf der Plattform Fußball ihre Marke zu präsentieren ...

Abstract	Die FIFA Fussball Weltmeisterschaft 2006 in Deutschland wurde nach Angaben der FIFA weltweit in 214 Ländern übertragen. Insgesamt verfolgten dieses sportliche Großereignis über 26 Milliarden Zuschauer vor dem Fernseher. Diese unglaublich große Begeisterung und Faszination für den Fußball wird zunehmend von Automobilherstellern genutzt, um in einem positiven Umfeld bzw. auf der Plattform Fußball ihre Marke zu präsentieren. Sportsponsoring stellt dabei im Rahmen einer erlebnisorientierten Markenführung für einen Automobilhersteller ein sehr gutes Kommunikationsinstrument dar. Neben dem reinen fu
Keywords	Wirtschaft Marketing / Verkauf
Language	German
Size	Online-Ressource (105 p)
Publisher	Diplomica Verlag
Publishing place	Hamburg
Document type	Book ; Online
Note	Description based upon print version of record
ISBN	9783842884960 ; 3842884966
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article: Vinflunine in the treatment of bladder cancer.

Bachner, Mark / De Santis, Maria

Therapeutics and clinical risk management

2009 Volume 4, Issue 6, Page(s) 1243–1253

Abstract: Vinflunine (VFL) is a third-generation bifluorinated semi-synthetic vinca alkaloid obtained by superacidic chemistry from its parent compound, vinorelbine. As with the other vinca alkaloids, the main antineoplastic effects of VFL arise from its ... ...

Abstract	Vinflunine (VFL) is a third-generation bifluorinated semi-synthetic vinca alkaloid obtained by superacidic chemistry from its parent compound, vinorelbine. As with the other vinca alkaloids, the main antineoplastic effects of VFL arise from its interaction with tubulin, the major component of microtubules in mitotic spindles. In contrast to other vinca alkaloids, VFL shows some distinctive properties in terms of tubulin binding, possibly explaining its superior antitumor activity in vitro and in vivo compared with vinorelbine as well as its excellent safety profile. In transitional cell carcinoma (TCC), two single-agent phase II trials were performed testing VFL in platinum-pretreated patients, showing moderate response rates and promising disease control rates. Therefore, the first phase III trial in modern times for second-line TCC of the urothelium was designed in order to further investigate the activity of VFL. First results were presented at the 2008 ASCO conference. VFL appears to be a possible treatment option for patients with TCC progressing after first-line platinum-containing chemotherapy.
Language	English
Publishing date	2009-01-06
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2186560-7
ISSN	1178-203X ; 1176-6336
ISSN (online)	1178-203X
ISSN	1176-6336
DOI	10.2147/tcrm.s3384
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Second-line therapy in bladder cancer.

Bachner, Mark / De Santis, Maria

Current opinion in urology

2009 Volume 19, Issue 5, Page(s) 533–539

Abstract: Purpose of review: To review new developments in second-line treatment for transitional cell carcinoma of the urinary bladder focusing on advances and findings within the last year.: Recent findings: So far no standard therapy has been established ... ...

Abstract	Purpose of review: To review new developments in second-line treatment for transitional cell carcinoma of the urinary bladder focusing on advances and findings within the last year. Recent findings: So far no standard therapy has been established for pretreated patients with transitional cell carcinoma. Prognostic and predictive factors for response and outcome in pretreated patients have been studied retrospectively and will help to identify those who might benefit from intensive therapy and those who would rather improve their quality of life with best supportive care. Single-agent chemotherapy in this setting provided low response rates, short progression-free and overall survival. Vinflunine, a novel vinca-alkaloid, and best supportive care had a modest, but still significant benefit at a very moderate toxicity rate in a randomized phase III trial. As for second-line combination chemotherapy, response rates as well as potential toxicities are higher and the progression-free survival and overall survival benefits are still poorly understood. New chemotherapeutics and approaches like metronomic chemotherapy and novel agents are under investigation. Summary: With vinflunine there is reasonable hope for a new standard chemotherapy in second-line management of transitional cell carcinoma. However, due to the reported results with single agents and combination chemotherapy, treatment within clinical trials is still the best choice in patients progressing after first-line chemotherapy.
MeSH term(s)	Antineoplastic Agents/therapeutic use ; Carcinoma, Transitional Cell/diagnosis ; Carcinoma, Transitional Cell/drug therapy ; Drug Therapy, Combination ; Folic Acid Antagonists/therapeutic use ; Humans ; Neoplasm Recurrence, Local/drug therapy ; Salvage Therapy ; Urinary Bladder Neoplasms/diagnosis ; Urinary Bladder Neoplasms/drug therapy ; Vinblastine/analogs & derivatives ; Vinblastine/therapeutic use
Chemical Substances	Antineoplastic Agents ; Folic Acid Antagonists ; vinflunine (5BF646324K) ; Vinblastine (5V9KLZ54CY)
Language	English
Publishing date	2009-09
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1091792-5
ISSN	1473-6586 ; 0963-0643
ISSN (online)	1473-6586
ISSN	0963-0643
DOI	10.1097/MOU.0b013e32832eb473
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: New developments in first- and second-line chemotherapy for transitional cell, squamous cell and adenocarcinoma of the bladder.

De Santis, Maria / Bachner, Mark

Current opinion in urology

2007 Volume 17, Issue 5, Page(s) 363–368

Abstract: Purpose of review: To review the systemic treatment, patient selection and treatment outcome of transitional cell carcinoma of the urinary bladder, squamous cell carcinoma and adenocarcinoma, focusing on advances and findings within the last year.: ... ...

Abstract	Purpose of review: To review the systemic treatment, patient selection and treatment outcome of transitional cell carcinoma of the urinary bladder, squamous cell carcinoma and adenocarcinoma, focusing on advances and findings within the last year. Recent findings: Cisplatin-based chemotherapy is considered to be the standard treatment for transitional cell carcinoma. In recent updates of randomized trials, patients with favorable prognostic factors were shown to have a chance of long-term disease-free survival even after chemotherapy for metastatic disease. Patient selection for cisplatin, newer drugs or alternative combinations is crucial. New genetic markers like excision repair cross-complementing 1 expression were developed and tested for this purpose. Adequate evaluation of renal function plays an important role for treatment selection, especially in the elderly population. Newer chemotherapeutics like oxaliplatin, vinflunine and pemetrexed have been studied in the first- or second-line settings. Their efficacy is promising, but there is still a need for further testing. Only few data are available on the systemic treatment of squamous cell carcinoma and adenocarcinoma. Complete resection seems to be more important than chemotherapy in the rare cases of adenocarcinoma of the urinary tract. Summary: In locally advanced and metastatic disease patient- and tumor-related prognostic factors and predictive factors for response to treatment will guide treatment decisions in the future.
MeSH term(s)	Adenocarcinoma/drug therapy ; Adenocarcinoma/mortality ; Adenocarcinoma/pathology ; Age Factors ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Carcinoma, Squamous Cell/drug therapy ; Carcinoma, Squamous Cell/mortality ; Carcinoma, Squamous Cell/pathology ; Carcinoma, Transitional Cell/drug therapy ; Carcinoma, Transitional Cell/mortality ; Carcinoma, Transitional Cell/pathology ; Chemotherapy, Adjuvant ; Cisplatin/administration & dosage ; Humans ; Neoplasm Metastasis ; Patient Selection ; Treatment Outcome ; Urinary Bladder Neoplasms/drug therapy ; Urinary Bladder Neoplasms/mortality ; Urinary Bladder Neoplasms/pathology
Chemical Substances	Cisplatin (Q20Q21Q62J)
Language	English
Publishing date	2007-09
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1091792-5
ISSN	1473-6586 ; 0963-0643
ISSN (online)	1473-6586
ISSN	0963-0643
DOI	10.1097/MOU.0b013e3282c4b0cb
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Vinflunine in the treatment of bladder cancer

Mark Bachner / Maria De Santis

Therapeutics and Clinical Risk Management, Vol 2008, Iss Issue 6, Pp 1243-

2008 Volume 1253

Abstract: Mark Bachner, Maria De Santis3rd Medical Department – Center for Oncology and Hematology, Kaiser ...

Abstract	Mark Bachner, Maria De Santis3rd Medical Department – Center for Oncology and Hematology, Kaiser Franz Josef-Spital der Stadt Wien, and Ludwig Boltzmann-Institute for Applied Cancer Research Vienna (LBI-ACR VIEnna), Cluster Translational Oncology, Kaiser Franz Josef-Spital der Stadt Wien, and Applied Cancer Research – Institution for Translational Research Vienna (ACR-ITR VIEnna)/CEADDP, Vienna, AustriaAbstract: Vinflunine (VFL) is a third-generation bifluorinated semi-synthetic vinca alkaloid obtained by superacidic chemistry from its parent compound, vinorelbine. As with the other vinca alkaloids, the main antineoplastic effects of VFL arise from its interaction with tubulin, the major component of microtubules in mitotic spindles. In contrast to other vinca alkaloids, VFL shows some distinctive properties in terms of tubulin binding, possibly explaining its superior antitumor activity in vitro and in vivo compared with vinorelbine as well as its excellent safety profile. In transitional cell carcinoma (TCC), two single-agent phase II trials were performed testing VFL in platinum-pretreated patients, showing moderate response rates and promising disease control rates. Therefore, the first phase III trial in modern times for second-line TCC of the urothelium was designed in order to further investigate the activity of VFL. First results were presented at the 2008 ASCO conference. VFL appears to be a possible treatment option for patients with TCC progressing after first-line platinum-containing chemotherapy.Keywords: vinflunine, transitional cell carcinoma (TCC) of the bladder, bladder cancer, chemotherapy, second-line chemotherapy
Keywords	Pharmacy and materia medica ; RS1-441 ; Medicine ; R ; DOAJ:Pharmacy and materia medica ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	610
Language	English
Publishing date	2008-11-01T00:00:00Z
Publisher	Dove Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: The polycyclic Lausche Volcano (Lausitz Volcanic Field) and its message concerning landscape evolution in the Lausitz Mountains (northern Bohemian Massif, Central Europe)

Wenger, Erik / JÃ¶rg BÃ¼chner / Jan Mrlina / Olaf Tietz

Geomorphology. 2017,

2017

Abstract: ... environs. The remnant of an alluvial fan marking a Middle PaleoceneâLower Eocene palaeo-surface is ...

Abstract	The Tertiary Lausitz Volcanic Field covers a broad area encompassing parts of Eastern Saxony (Germany), Lower Silesia (Poland) and North Bohemia (Czech Republic). Volcanism was predominantly controlled by the volcano-tectonic evolution of the OhÅe Rift and culminated in the Lower Oligocene. This paper deals with the highest volcano of this area, the Lausche Hill (792.6m a.s.l.) situated in the Lausitz Mountains. We offer a reconstruction of the volcanic edifice and its eruptive history. Its complex genesis is reflected by six different eruption styles and an associated petrographic variety. Furthermore, the Lausche Volcano provides valuable information concerning the morphological evolution of its broader environs. The remnant of an alluvial fan marking a Middle PaleoceneâLower Eocene palaeo-surface is preserved at the base of the volcano. The deposition of this fan can be attributed to a period of erosion of its nearby source area, the Lausitz Block that has undergone intermittent uplift at the Lausitz Overthrust since the Upper Cretaceous. The Lausche Hill is one of at least six volcanoes in the Lausitz Mountains which show an eminent low level of erosion despite their Oligocene age and position on elevated terrain. These volcanoes are exposed in their superficial level which clearly contradicts their former interpretation as subvolcanoes. Among further indications, this implies that the final morphotectonic uplift of the Lausitz Mountains started in the upper Lower Pleistocene due to revived subsidence of the nearby Zittau Basin. The formation of the low mountain range was substantially controlled by the intersection of the Lausitz Overthrust and the OhÅe Rift.
Keywords	basins ; landscapes ; mountains ; subsidence ; volcanic activity ; volcanoes ; Central European region ; Czech Republic ; Germany ; Poland
Language	English
Size	p. .
Publishing place	Elsevier B.V.
Document type	Article
Note	Pre-press version
ZDB-ID	58028-4
ISSN	0169-555X
ISSN	0169-555X
DOI	10.1016/j.geomorph.2017.04.021
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Organisation, Administration und Durchfuhrung von klinischen Studien.

Bachner, Mark / Steininger, Tanja / Gneist, Margit

Onkologie

2008 Volume 31 Suppl 2, Page(s) 3–6

Abstract: This contribution deals with all important organizational and administrative aspects of clinical studies in German speaking countries. All trials are to be executed in accordance with the Good Clinical Practice (GCP) Guidelines. GCP applies to the ... ...

Title translation	Organization, administration, and performance of clinical studies.
Abstract	This contribution deals with all important organizational and administrative aspects of clinical studies in German speaking countries. All trials are to be executed in accordance with the Good Clinical Practice (GCP) Guidelines. GCP applies to the process of designing, conducting, recording, and reporting of clinical studies. Compliance with GCP facilitates the mutual acceptance of resulting clinical data by the respective regulatory authorities worldwide. Before initiating a clinical study the investigator has to obtain written and dated approval from the responsible ethics committee, the competent authorities, and the hospital administration. The investigator's study file contains all essential study documents. One of the most important tasks of an investigator is to properly inform the prospective subjects and to obtain their informed consent. All relevant treatment-related information has to be recorded in the patient files. These source data are transferred to case report forms. During monitoring visits, audits, and inspections, source data verification will be performed routinely. Any adverse events (AEs) must be documented according to the CTCAE, the Common Terminology Criteria for Adverse Events. All serious adverse events (SAEs) have to be reported to the sponsor immediately. At the end of the study a termination visit is performed, and all authorities are officially informed about the termination of the trial.
MeSH term(s)	Clinical Trials as Topic/methods ; Clinical Trials as Topic/standards ; Germany ; Guideline Adherence/organization & administration ; Informed Consent/standards ; Practice Guidelines as Topic ; Research/organization & administration ; Research Design
Language	German
Publishing date	2008
Publishing country	Switzerland
Document type	English Abstract ; Journal Article
ZDB-ID	549601-9
ISSN	1423-0240 ; 0378-584X
ISSN (online)	1423-0240
ISSN	0378-584X
DOI	10.1159/000113030
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Quality improvement in the modern clinical laboratory: the regulatory and accreditation perspective.

Bachner, P

Disease markers

1992 Volume 10, Issue 1, Page(s) 27–35

MeSH term(s)	Accreditation ; Humans ; Laboratories/standards ; Quality Control ; United States
Language	English
Publishing date	1992-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	604951-5
ISSN	1875-8630 ; 0278-0240
ISSN (online)	1875-8630
ISSN	0278-0240
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Article ; Online: Physical therapy students' willingness to report misconduct to protect the patient's interests.

Mansbach, Abraham / Bachner, Yaacov G / Melzer, Itzik

Journal of medical ethics

2010 Volume 36, Issue 12, Page(s) 802–805

Abstract: ... than externally. The pattern reveals a desire to correct the misconduct coupled with a marked decline ...

Abstract	This article presents a study on the ethical dilemma of whistleblowing in physical therapy, and suggests some lines for further research on this topic as well as ways for integrating it in the physical therapy curriculum. The study examines the self-reported willingness of physical therapy students to report misconduct, whether internally or externally, to protect the patient's interests. Internal disclosure entails reporting the wrongdoing to an authority within the organisation. External disclosure entails reporting the offence to an outside agency, such as the police, professional organisation, or press. The findings indicate that the students view the acts that are detrimental or cause injustice to the patient in a very serious light. In dilemma situations such as these, the students reported a willingness to act. The students also report considerably greater likelihood of whistleblowing internally than externally. The pattern reveals a desire to correct the misconduct coupled with a marked decline in the willingness to blow the whistle as this act moved from the workplace to an external authority.
MeSH term(s)	Adult ; Attitude of Health Personnel ; Female ; Humans ; Interpersonal Relations ; Male ; Patient Rights ; Physical Therapy Modalities/ethics ; Professional Misconduct ; Students, Medical/psychology ; Surveys and Questionnaires ; Whistleblowing/ethics ; Workplace ; Young Adult
Language	English
Publishing date	2010-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	194927-5
ISSN	1473-4257 ; 0306-6800
ISSN (online)	1473-4257
ISSN	0306-6800
DOI	10.1136/jme.2010.036046
Database	MEDical Literature Analysis and Retrieval System OnLINE

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