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Article ; Online: The absence of seroconversion after exposition to hepatitis C virus is not related to KIR-HLA genotype combinations (GEHEP-012 study).

Martín-Sierra, Carmen / Bravo, María José / Sáez, María Eugenia / De Rojas, Itziar / Santos, Marta / Martín-Carmona, Jesica / Corma-Gómez, Anaïs / González-Serna, Alejandro / Royo, José Luis / Pineda, Juan A / Rivero, Antonio / Rivero-Juárez, Antonio / Macías, Juan / Real, Luis Miguel

Antiviral research

2024 Volume 222, Page(s) 105795

Abstract: Background & aims: It has been reported that specific killer-cell immunoglobulin-like receptors (KIRs) and HLA genotype combinations, such as KIR2DS4/HLA-C1 with presence of KIRDL2 or KIRDL3, homozygous KIRDL3/HLA-C1 and KIR3DL1/≥2HLA-Bw4, are strongly ... ...

Abstract	Background & aims: It has been reported that specific killer-cell immunoglobulin-like receptors (KIRs) and HLA genotype combinations, such as KIR2DS4/HLA-C1 with presence of KIRDL2 or KIRDL3, homozygous KIRDL3/HLA-C1 and KIR3DL1/≥2HLA-Bw4, are strongly associated with the lack of active infection and seroconversion after exposition to hepatitis C virus (HCV). Objective: To determine whether these KIR-HLA combinations are relevant factors involved in that phenotype. Patients and methods: In this retrospective case-control study, genotype data from a genome-wide association study previously performed on low susceptibility to HCV-infection carried out on 27 high-risk HCV-seronegative (HRSN) individuals and 743 chronically infected (CI) subjects were used. HLA alleles were imputed using R package HIBAG v1.2223 and KIR genotypes were imputed using the online resource KIRIMP v1.2.0. Results:* It was possible to successfully impute at least one KIR-HLA genotype combination previously associated with the lack of infection and seroconversion after exposition to HCV in a total of 23 (85.2%) HRSN individuals and in 650 (87.5%) CI subjects. No KIR-HLA genotype combination analyzed was related to the HRSN condition. Conclusions: Our results suggest that those KIR-HLA genotype combinations are not relevant factors involved in the lack of infection and seroconversion after exposition to HCV. More studies will be needed to completely understand this phenotype.
MeSH term(s)	Humans ; Hepacivirus/genetics ; Case-Control Studies ; Retrospective Studies ; Genome-Wide Association Study ; Seroconversion ; Genotype ; Hepatitis C ; Receptors, KIR/genetics
Chemical Substances	Receptors, KIR
Language	English
Publishing date	2024-01-03
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	306628-9
ISSN	1872-9096 ; 0166-3542
ISSN (online)	1872-9096
ISSN	0166-3542
DOI	10.1016/j.antiviral.2024.105795
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Article ; Online: Real-life experience in two cases of secondary prophylaxis with letermovir for CMV infection in solid organ transplantation.

Pérez, Ana-Belén / Santos Bravo, Marta / Vidal-Verdú, Elisa / Páez-Vega, Aurora / Vaquero-Barrios, José-Manuel / Montero, José-Luis / Marcos, María-Ángeles / Torre-Cisneros, Julián

Microbiology spectrum

2023 Volume 11, Issue 6, Page(s) e0163023

Abstract: Importance: This observation provides comprehensive data on the clinical correlates of both cytomegalovirus (CMV) genotypic follow-up and clinical monitoring and outcomes for two different solid organ transplantation recipients that received letermovir ... ...

Abstract	Importance: This observation provides comprehensive data on the clinical correlates of both cytomegalovirus (CMV) genotypic follow-up and clinical monitoring and outcomes for two different solid organ transplantation recipients that received letermovir as secondary prophylaxis. Our study emphasizes that monitoring of CMV disease in the patient and early genotypic detection of resistance mutations are essential when using new antiviral drugs for off-label indication in patients experiencing CMV relapses or not responding to standard antiviral therapy. These cases and the bibliography reviewed can be helpful for other researchers and clinicians working in the field to optimize the use of new treatments for transplant recipients since drug-resistant CMV infection is an important emerging problem even with new developments in antiviral treatment.
MeSH term(s)	Humans ; Antiviral Agents/therapeutic use ; Cytomegalovirus Infections/drug therapy ; Cytomegalovirus Infections/prevention & control ; Cytomegalovirus/genetics ; Transplant Recipients ; Organ Transplantation/adverse effects
Chemical Substances	Antiviral Agents ; letermovir (1H09Y5WO1F)
Language	English
Publishing date	2023-10-30
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.01630-23
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Article ; Online: Assessment of UL56 Mutations before Letermovir Therapy in Refractory Cytomegalovirus Transplant Recipients.

Santos Bravo, Marta / Tilloy, Valentin / Plault, Nicolas / Palomino, Sonsoles Sánchez / Mosquera, María Mar / Navarro Gabriel, Mireia / Fernández Avilés, Francesc / Suárez Lledó, María / Rovira, Montserrat / Moreno, Asunción / Linares, Laura / Bodro, Marta / Hantz, Sébastien / Alain, Sophie / Marcos, María Ángeles

Microbiology spectrum

2022 Volume 10, Issue 2, Page(s) e0019122

Abstract: ... De ... ...

Abstract	De novo
MeSH term(s)	Acetates ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Cytomegalovirus/genetics ; Cytomegalovirus Infections/drug therapy ; Drug Resistance, Viral/genetics ; Humans ; Mutation ; Quinazolines ; Recurrence ; Transplant Recipients
Chemical Substances	Acetates ; Antiviral Agents ; Quinazolines ; letermovir (1H09Y5WO1F)
Language	English
Publishing date	2022-03-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.00191-22
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Article: Acute infectious diarrhoea and empirical antibiotic therapy sensitivity. Single-centre review.

Montero Moretón, Ángela Martina / Cabezudo Molleda, Luis / García Castro, María Antonia / García Bravo, Moisés / Tinajas Puertas, Almudena / Santos Santamarta, Fernando / Cimavilla Román, Marta / Fernández Fernández, Seila / Maestro Antolín, Sergio / Pérez Millán, Antonio Germán

Gastroenterologia y hepatologia

2021 Volume 45 Suppl 1, Page(s) 117–118

MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Diarrhea/drug therapy ; Diarrhea/etiology ; Dysentery ; Humans
Chemical Substances	Anti-Bacterial Agents
Language	Spanish
Publishing date	2021-06-09
Publishing country	Spain
Document type	Case Reports ; Journal Article
ZDB-ID	632502-6
ISSN	0210-5705
ISSN	0210-5705
DOI	10.1016/j.gastrohep.2021.05.003
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Article ; Online: Prolonged viral replication in patients with hematologic malignancies hospitalized with COVID-19.

Haematologica

2022 Volume 107, Issue 7, Page(s) 1731–1735

MeSH term(s)	COVID-19 ; Hematologic Neoplasms/complications ; Hematologic Neoplasms/pathology ; Hospitalization ; Humans ; SARS-CoV-2 ; Virus Replication
Language	English
Publishing date	2022-07-01
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2333-4
ISSN	1592-8721 ; 0017-6567 ; 0390-6078
ISSN (online)	1592-8721
ISSN	0017-6567 ; 0390-6078
DOI	10.3324/haematol.2021.280407
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Article: Cutaneous Allodynia in Migraine: A Narrative Review.

Mínguez-Olaondo, Ane / Quintas, Sonia / Morollón Sánchez-Mateos, Noemí / López-Bravo, Alba / Vila-Pueyo, Marta / Grozeva, Vesselina / Belvís, Robert / Santos-Lasaosa, Sonia / Irimia, Pablo

Frontiers in neurology

2022 Volume 12, Page(s) 831035

Abstract: Objective: In the present work, we conduct a narrative review of the most relevant literature on cutaneous allodynia (CA) in migraine.: Background: CA is regarded as the perception of pain in response to non-noxious skin stimulation. The number of ... ...

Abstract	Objective: In the present work, we conduct a narrative review of the most relevant literature on cutaneous allodynia (CA) in migraine. Background: CA is regarded as the perception of pain in response to non-noxious skin stimulation. The number of research studies relating to CA and migraine has increased strikingly over the last few decades. Therefore, the clinician treating migraine patients must recognize this common symptom and have up-to-date knowledge of its importance from the pathophysiological, diagnostic, prognostic and therapeutic point of view. Methods: We performed a comprehensive narrative review to analyze existing literature regarding CA in migraine, with a special focus on epidemiology, pathophysiology, assessment methods, risk for chronification, diagnosis and management. PubMed and the Cochrane databases were used for the literature search. Results: The prevalence of CA in patients with migraine is approximately 60%. The mechanisms underlying CA in migraine are not completely clarified but include a sensitization phenomenon at different levels of the trigemino-talamo-cortical nociceptive pathway and dysfunction of brainstem and cortical areas that modulate thalamocortical inputs. The gold standard for the assessment of CA is quantitative sensory testing (QST), but the validated Allodynia 12-item questionnaire is preferred in clinical setting. The presence of CA is associated with an increased risk of migraine chronification and has therapeutic implications. Conclusions: CA is a marker of central sensitization in patients with migraine that has been associated with an increased risk of chronification and may influence therapeutic decisions.
Language	English
Publishing date	2022-01-21
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2021.831035
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Article ; Online: Eco-friendly fabricated multibioactive Ca(II)-antibiotic coordination framework coating on zinc towards improved bone tissue regeneration.

Mota, Juliana / Bravo, Catarina / Santos, Catarina / Alves, Paula C / Rijo, Patrícia / Antunes, Alexandra M / Grenho, Liliana / Helena Fernandes, M / Alves, Marta M / André, Vânia

Colloids and surfaces. B, Biointerfaces

2022 Volume 221, Page(s) 113008

Abstract: Zinc is a biodegradable candidate material for bone regeneration; however, concomitant implant-related infection and rejection require new solutions to raise the biomedical potential of zinc. Functionalization towards localized drug administration with ... ...

Abstract	Zinc is a biodegradable candidate material for bone regeneration; however, concomitant implant-related infection and rejection require new solutions to raise the biomedical potential of zinc. Functionalization towards localized drug administration with bioactive frameworks can be a solution. It is herein reported for the first time an eco-friendly approach for coating zinc with multibioactive antibiotic coordination frameworks (ACF). ACF1, a new 1D framework with deprotonated nalidixic and salicylic acids, obtained by mechanochemistry, results from the coordination of Ca(II) centers to the organic acids anions. To maximize ACF1 loading and cells' adhesion, the surface area was increased by creating a porous 3D Zn layer. A coverage of ∼70% of the surface with ACF1, achieved by electrophoretic deposition in an aqueous solution, preserved the desired Zn degradation as \|Z\| in the order of 10
MeSH term(s)	Zinc/pharmacology ; Zinc/chemistry ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Coated Materials, Biocompatible/pharmacology ; Coated Materials, Biocompatible/chemistry ; Bone Regeneration ; Bone and Bones ; Escherichia coli ; Organic Chemicals
Chemical Substances	Zinc (J41CSQ7QDS) ; Anti-Bacterial Agents ; Coated Materials, Biocompatible ; Organic Chemicals
Language	English
Publishing date	2022-11-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1500523-9
ISSN	1873-4367 ; 0927-7765
ISSN (online)	1873-4367
ISSN	0927-7765
DOI	10.1016/j.colsurfb.2022.113008
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Article: Lack of Usefulness of Donor-Derived Cell-Free DNA as a Biomarker for Cardiac Allograft Vasculopathy: A Prospective Study.

Jiménez-Blanco Bravo, Marta / Pérez-Gómez, Laura / Hernández-Pérez, Francisco J / Arellano-Serrano, Carlos / Torres-Sanabria, Mario / Gómez-Bueno, Manuel / Oteo-Domínguez, Juan F / Mingo-Santos, Susana / Segovia-Cubero, Javier

Frontiers in cardiovascular medicine

2022 Volume 9, Page(s) 856600

Abstract: Background: Cardiac allograft vasculopathy (CAV) remains a major cause of morbidity and mortality among long-term heart transplant recipients. There is an unmet need for a non-invasive biomarker of CAV that could obviate the need to perform surveillance ...

Abstract	Background: Cardiac allograft vasculopathy (CAV) remains a major cause of morbidity and mortality among long-term heart transplant recipients. There is an unmet need for a non-invasive biomarker of CAV that could obviate the need to perform surveillance coronary angiograms in these patients. Our aim was to evaluate the performance of Donor-derived Cell Free DNA (dd-cfDNA) as a biomarker of CAV. Methods: We prospectively measured dd-cfDNA levels in all patients undergoing routine coronary angiography >1 year after heart transplant at a single center. Endpoints included the association between dd-cfDNA levels and the presence CAV, according to several prespecified criteria. Results: We included 94 heart transplant recipients, a median of 10.9 years after transplant. Coronary angiogram revealed CAV Conclusion: In this study, dd-cfDNA did not perform as a useful biomarker to avoid surveillance coronary angiograms for CAV diagnosis. Clinical trial notation: Potential Role of Donor-derived Cell Free DNA as a Biomarker in Cardiac Allograft Vasculopathy, NCT04791852.
Language	English
Publishing date	2022-04-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2022.856600
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Article ; Online: Severe Acute Respiratory Syndrome Coronavirus 2 Normalized Viral Loads and Subgenomic RNA Detection as Tools for Improving Clinical Decision Making and Work Reincorporation.

Santos Bravo, Marta / Nicolás, David / Berengua, Carla / Fernandez, Mariana / Hurtado, Juan Carlos / Tortajada, Marta / Barroso, Sonia / Vilella, Anna / Mosquera, Maria Mar / Vila, Jordi / Marcos, María Angeles

The Journal of infectious diseases

2021 Volume 224, Issue 8, Page(s) 1325–1332

Abstract: Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reverse-transcription polymerase chain reaction (RT-PCR) provides a highly variable cycle threshold (Ct) value that cannot distinguish viral infectivity. Subgenomic ribonucleic ... ...

Abstract	Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reverse-transcription polymerase chain reaction (RT-PCR) provides a highly variable cycle threshold (Ct) value that cannot distinguish viral infectivity. Subgenomic ribonucleic acid (sgRNA) has been used to monitor active replication. Given the importance of long RT-PCR positivity and the need for work reincorporation and discontinuing isolation, we studied the functionality of normalized viral loads (NVLs) for patient monitoring and sgRNA for viral infectivity detection. Methods: The NVLs measured through the Nucleocapsid and RNA-dependent-RNA-polymerase genes and sgRNA RT-PCRs were performed in 2 consecutive swabs from 84 healthcare workers. Results: The NVLs provided similar and accurate quantities of both genes of SARS-CoV-2 at 2 different timepoints of infection, overcoming Ct-value and swab collection variability. Among SARS-CoV-2-positive samples, 51.19% were sgRNA-positive in the 1st RT-PCR and 5.95% in the 2nd RT-PCR. All sgRNA-positive samples had >4 log10 RNA copies/1000 cells, whereas samples with ≤1 log10 NVLs were sgRNA-negative. Although NVLs were positive until 29 days after symptom onset, 84.1% of sgRNA-positive samples were from the first 7 days, which correlated with viral culture viability. Multivariate analyses showed that sgRNA, NVLs, and days of symptoms were significantly associated (P < .001). Conclusions: The NVLs and sgRNA are 2 rapid accessible techniques that could be easily implemented in routine hospital practice providing a useful proxy for viral infectivity and coronavirus disease 2019 patient follow-up.
MeSH term(s)	Adult ; Aftercare/standards ; COVID-19/diagnosis ; COVID-19/therapy ; COVID-19/transmission ; COVID-19/virology ; COVID-19 Nucleic Acid Testing/statistics & numerical data ; Clinical Decision-Making/methods ; Epidemiological Monitoring ; Female ; Health Personnel/statistics & numerical data ; Humans ; Male ; Middle Aged ; Nasopharynx/pathology ; Nasopharynx/virology ; RNA, Viral/isolation & purification ; SARS-CoV-2/genetics ; SARS-CoV-2/isolation & purification ; SARS-CoV-2/pathogenicity ; Viral Load/standards
Chemical Substances	RNA, Viral
Language	English
Publishing date	2021-07-28
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	3019-3
ISSN	1537-6613 ; 0022-1899
ISSN (online)	1537-6613
ISSN	0022-1899
DOI	10.1093/infdis/jiab394
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Uh II Zs.50: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: SARS-CoV-2-Mediated Lung Edema and Replication Are Diminished by Cystic Fibrosis Transmembrane Conductance Regulator Modulators.

Honrubia, Jose M / Gutierrez-Álvarez, Javier / Sanz-Bravo, Alejandro / González-Miranda, Ezequiel / Muñoz-Santos, Diego / Castaño-Rodriguez, Carlos / Wang, Li / Villarejo-Torres, Marta / Ripoll-Gómez, Jorge / Esteban, Ana / Fernandez-Delgado, Raul / Sánchez-Cordón, Pedro José / Oliveros, Juan Carlos / Perlman, Stanley / McCray, Paul B / Sola, Isabel / Enjuanes, Luis

mBio

2023 Volume 14, Issue 1, Page(s) e0313622

Abstract: Coronaviruses (CoVs) of genera α, β, γ, and δ encode proteins that have a PDZ-binding motif (PBM) consisting of the last four residues of the envelope (E) protein (PBM core). PBMs may bind over 400 cellular proteins containing PDZ domains (an acronym ... ...

Abstract	Coronaviruses (CoVs) of genera α, β, γ, and δ encode proteins that have a PDZ-binding motif (PBM) consisting of the last four residues of the envelope (E) protein (PBM core). PBMs may bind over 400 cellular proteins containing PDZ domains (an acronym formed by the combination of the first letter of the names of the three first proteins where this domain was identified), making them relevant for the control of cell function. Three highly pathogenic human CoVs have been identified to date: severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), and SARS-CoV-2. The PBMs of the three CoVs were virulence factors. SARS-CoV mutants in which the E protein PBM core was replaced by the E protein PBM core from virulent or attenuated CoVs were constructed. These mutants showed a gradient of virulence, depending on whether the alternative PBM core introduced was derived from a virulent or an attenuated CoV. Gene expression patterns in the lungs of mice infected with SARS-CoVs encoding each of the different PBMs were analyzed by RNA sequencing of infected lung tissues. E protein PBM of SARS-CoV and SARS-CoV-2 dysregulated gene expression related to ion transport and cell homeostasis. Decreased expression of cystic fibrosis transmembrane conductance regulator (CFTR) mRNA, essential for alveolar edema resolution, was shown. Reduced CFTR mRNA levels were associated with edema accumulation in the alveoli of mice infected with SARS-CoV and SARS-CoV-2. Compounds that increased CFTR expression and activity, significantly reduced SARS-CoV-2 growth in cultured cells and protected against mouse infection, suggesting that E protein virulence is mediated by a decreased CFTR expression.
MeSH term(s)	Animals ; Mice ; Humans ; SARS-CoV-2/genetics ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Severe acute respiratory syndrome-related coronavirus/genetics ; COVID-19 ; Virulence Factors/genetics ; Virulence Factors/metabolism ; Middle East Respiratory Syndrome Coronavirus/genetics ; Lung/metabolism ; RNA, Messenger
Chemical Substances	Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6) ; Virulence Factors ; RNA, Messenger
Language	English
Publishing date	2023-01-10
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2557172-2
ISSN	2150-7511 ; 2161-2129
ISSN (online)	2150-7511
ISSN	2161-2129
DOI	10.1128/mbio.03136-22
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