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  1. Article ; Online: Bidirectional Evolution of SARS-CoV-2 Virus in Immunocompromised Hosts.

    Chew, Charmaine W Y / Young, Barnaby E / Tambyah, Paul A / Vasoo, Shawn / Chan, Conrad E Z

    Influenza and other respiratory viruses

    2024  Volume 18, Issue 3, Page(s) e13266

    MeSH term(s) Humans ; SARS-CoV-2/genetics ; COVID-19 ; Immunocompromised Host
    Language English
    Publishing date 2024-03-11
    Publishing country England
    Document type Letter
    ZDB-ID 2274538-5
    ISSN 1750-2659 ; 1750-2640
    ISSN (online) 1750-2659
    ISSN 1750-2640
    DOI 10.1111/irv.13266
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  2. Article ; Online: Efficacy and Safety of Ensovibep for Adults Hospitalized With COVID-19.

    Mylonakis, Eleftherios / Barkauskas, Christina / Poulakou, Garyfallia / Young, Barnaby E

    Annals of internal medicine

    2023  Volume 176, Issue 2, Page(s) eL220456

    MeSH term(s) Adult ; Humans ; COVID-19 ; Recombinant Fusion Proteins ; SARS-CoV-2 ; Hospitalization
    Chemical Substances ensovibep (PV6AA88RDU) ; Recombinant Fusion Proteins
    Language English
    Publishing date 2023-02-20
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/L22-0456
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  3. Article: Clinical Predictors for Abnormal ALT in Patients Infected with COVID-19-A Retrospective Single Centre Study.

    Chew, Wei Da / Kuang, Jonathan / Lin, Huiyu / Ang, Li Wei / Yang, Wei Lyn / Lye, David C / Young, Barnaby E

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 3

    Abstract: Objective: Abnormal liver tests have been associated with worse clinical outcomes in patients infected with COVID-19. This retrospective observational study from Singapore aims to elucidate simple clinical predictors of abnormal alanine aminotransferase ...

    Abstract Objective: Abnormal liver tests have been associated with worse clinical outcomes in patients infected with COVID-19. This retrospective observational study from Singapore aims to elucidate simple clinical predictors of abnormal alanine aminotransferase (ALT) in COVID-19 infections.
    Design: 717 patients hospitalised with COVID-19 at the National Centre for Infectious Diseases (NCID), Singapore, from 23 January-15 April 2020 were screened, of which 163 patients with baseline normal alanine transferase (ALT) and at least two subsequent ALTs performed were included in the final analysis. Information on baseline demographics, clinical characteristics and biochemical laboratory tests were collected.
    Results: 30.7% of patients developed abnormal ALT. They were more likely to be older (60 vs. 55,
    Conclusions: Liver injury is associated with poor clinical outcomes in patients with COVID-19. R-factor ≥1 on admission and hypoxia are independent simple clinical predictors for developing abnormal ALT in COVID-19.
    Language English
    Publishing date 2023-03-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12030473
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  4. Article ; Online: Neutralization escape of emerging subvariants XBB.1.5/1.9.1 and XBB.2.3 from current therapeutic monoclonal antibodies.

    Chye, De Hoe / Chew, Charmaine W Y / Yeo, He Ping / Tambyah, Paul A / Young, Barnaby E / Tan, Gladys G Y / Tan, Boon Huan / Vasoo, Shawn / Chan, Conrad E Z

    Journal of medical virology

    2023  Volume 95, Issue 9, Page(s) e29074

    Language English
    Publishing date 2023-09-04
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.29074
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  5. Article ; Online: Clinical Predictors for Abnormal ALT in Patients Infected with COVID-19—A Retrospective Single Centre Study

    Wei Da Chew / Jonathan Kuang / Huiyu Lin / Li Wei Ang / Wei Lyn Yang / David C. Lye / Barnaby E. Young

    Pathogens, Vol 12, Iss 473, p

    2023  Volume 473

    Abstract: Objective: Abnormal liver tests have been associated with worse clinical outcomes in patients infected with COVID-19. This retrospective observational study from Singapore aims to elucidate simple clinical predictors of abnormal alanine aminotransferase ( ...

    Abstract Objective: Abnormal liver tests have been associated with worse clinical outcomes in patients infected with COVID-19. This retrospective observational study from Singapore aims to elucidate simple clinical predictors of abnormal alanine aminotransferase (ALT) in COVID-19 infections. Design: 717 patients hospitalised with COVID-19 at the National Centre for Infectious Diseases (NCID), Singapore, from 23 January–15 April 2020 were screened, of which 163 patients with baseline normal alanine transferase (ALT) and at least two subsequent ALTs performed were included in the final analysis. Information on baseline demographics, clinical characteristics and biochemical laboratory tests were collected. Results: 30.7% of patients developed abnormal ALT. They were more likely to be older (60 vs. 55, p = 0.022) and have comorbidities of hyperlipidaemia and hypertension. The multivariate logistic regression showed that R-factor ≥1 on admission (adjusted odds ratio (aOR) 3.13, 95% Confidence Interval (CI) 1.41–6.95) and hypoxia (aOR 3.54, 95% CI 1.29–9.69) were independent risk factors for developing abnormal ALT. The patients who developed abnormal ALT also ran a more severe course of illness with a greater proportion needing supplementary oxygen (58% vs. 18.6%, p < 0.0005), admission to the Intensive Care Unit (ICU)/High Dependency Unit (HDU) (32% vs. 11.5%, p = 0.003) and intubation (20% vs. 2.7%, p < 0.0005). There was no difference in death rate between the two groups. Conclusions: Liver injury is associated with poor clinical outcomes in patients with COVID-19. R-factor ≥1 on admission and hypoxia are independent simple clinical predictors for developing abnormal ALT in COVID-19.
    Keywords COVID-19 ; ALT ; R-factor ; hypoxia ; liver test ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: What's new in critical illness and injury science? Preventing surgical infections requires the right antibiotic for the right duration.

    Young, Barnaby E

    International journal of critical illness and injury science

    2012  Volume 2, Issue 2, Page(s) 55–56

    Language English
    Publishing date 2012-07-10
    Publishing country India
    Document type Journal Article
    ZDB-ID 2638865-0
    ISSN 2231-5004 ; 2229-5151
    ISSN (online) 2231-5004
    ISSN 2229-5151
    DOI 10.4103/2229-5151.97267
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  7. Article ; Online: Influenza on cruise ships.

    Young, Barnaby E / Wilder-Smith, Annelies

    Journal of travel medicine

    2018  Volume 25, Issue 1

    MeSH term(s) Alaska ; Disease Outbreaks ; Humans ; Influenza, Human/epidemiology ; Pilot Projects ; Ships ; Travel
    Language English
    Publishing date 2018-12-11
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1212504-0
    ISSN 1708-8305 ; 1195-1982
    ISSN (online) 1708-8305
    ISSN 1195-1982
    DOI 10.1093/jtm/tay146
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  8. Article ; Online: Comparative neutralisation profile of SARS-CoV-2 omicron subvariants BA.2.75 and BA.5.

    Tan, Chee-Wah / Lim, Beng-Lee / Young, Barnaby E / Yeoh, Aileen Ying-Yan / Yung, Chee-Fu / Yap, Wee-Chee / Althaus, Thomas / Chia, Wan-Ni / Zhu, Feng / Lye, David Chien / Wang, Lin-Fa

    The Lancet. Microbe

    2022  Volume 3, Issue 12, Page(s) e898

    MeSH term(s) Humans ; SARS-CoV-2 ; COVID-19
    Language English
    Publishing date 2022-08-10
    Publishing country England
    Document type Letter
    ISSN 2666-5247
    ISSN (online) 2666-5247
    DOI 10.1016/S2666-5247(22)00220-8
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  9. Article ; Online: Reply.

    Jun Seah, Ivan Yu / Anderson, Danielle E / Wang, Linfa / Young, Barnaby Edward / Lye, David Chien / Agrawal, Rupesh

    Ophthalmology

    2020  Volume 127, Issue 11, Page(s) e104–e105

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Virus Shedding
    Keywords covid19
    Language English
    Publishing date 2020-05-25
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 392083-5
    ISSN 1549-4713 ; 0161-6420
    ISSN (online) 1549-4713
    ISSN 0161-6420
    DOI 10.1016/j.ophtha.2020.05.041
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  10. Article ; Online: Statin use is associated with lower disease severity in COVID-19 infection.

    Tan, Wilnard Y T / Young, Barnaby E / Lye, David Chien / Chew, Daniel E K / Dalan, Rinkoo

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 17458

    Abstract: We aim to study the association of hyperlipidemia and statin use with COVID-19 severity. We analysed a retrospective cohort of 717 patients admitted to a tertiary centre in Singapore for COVID-19 infection. Clinical outcomes of interest were oxygen ... ...

    Abstract We aim to study the association of hyperlipidemia and statin use with COVID-19 severity. We analysed a retrospective cohort of 717 patients admitted to a tertiary centre in Singapore for COVID-19 infection. Clinical outcomes of interest were oxygen saturation ≤ 94% requiring supplemental oxygen, intensive-care unit (ICU) admission, invasive mechanical-ventilation and death. Patients on long term dyslipidaemia medications (statins, fibrates or ezetimibe) were considered to have dyslipidaemia. Logistic regression models were used to study the association between dyslipidaemia and clinical outcomes adjusted for age, gender and ethnicity. Statin treatment effect was determined, in a nested case-control design, through logistic treatment models with 1:3 propensity matching for age, gender and ethnicity. All statistical tests were two-sided, and statistical significance was taken as p < 0.05. One hundred fifty-six (21.8%) patients had dyslipidaemia and 97% of these were on statins. Logistic treatment models showed a lower chance of ICU admission for statin users when compared to non-statin users (ATET: Coeff (risk difference): - 0.12 (- 0.23, - 0.01); p = 0.028). There were no other significant differences in other outcomes. Statin use was independently associated with lower ICU admission. This supports current practice to continue prescription of statins in COVID-19 patients.
    MeSH term(s) Aged ; Betacoronavirus/isolation & purification ; COVID-19 ; Case-Control Studies ; Coronavirus Infections/complications ; Coronavirus Infections/pathology ; Coronavirus Infections/virology ; Dyslipidemias/complications ; Dyslipidemias/drug therapy ; Dyslipidemias/pathology ; Female ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Immunity, Innate ; Intensive Care Units ; Leukocyte Count ; Logistic Models ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/pathology ; Pneumonia, Viral/virology ; Retrospective Studies ; SARS-CoV-2 ; Severity of Illness Index
    Chemical Substances Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Keywords covid19
    Language English
    Publishing date 2020-10-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-74492-0
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