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  1. Article: Impact of Megha-Tropiques SAPHIR radiances in T574L64 global data assimilation and forecasting system at NCMRWF

    Singh, Sanjeev Kumar / V. S. Prasad

    International journal of remote sensing. 2017 Aug. 18, v. 38, no. 16

    2017  

    Abstract: The Sounder for Probing Vertical Profiles of Humidity (SAPHIR) is a sounding instrument of Megha ...

    Abstract The Sounder for Probing Vertical Profiles of Humidity (SAPHIR) is a sounding instrument of Megha-Tropiques (Indo-French joint satellite); launched by the Indian Space Research Organization on 12 October 2011 with six channels near the absorption band of water vapour at 183 GHz. In the framework of this work, the assimilation scheme has been first modified to enable the SAPHIR radiance observations being used as additional observation type, and second, a methodology has been prepared to remove the radiance pixels significantly affected by clouds. The impact of SAPHIR radiances on analysis as well as forecasts of the National Centre for Medium Range Weather Forecasting-Global Forecast System (NGFS) at T574L64 resolution has been investigated through data assimilation. Measurements from SAPHIR are incorporated into the Gridpoint Statistical Interpolation three-dimensional variational assimilation system to provide the improved initial conditions. To find out the impact, analysis/forecast cycling experiments with and without SAPHIR radiances are performed during the period 10–29 November 2013. The impact of the improvement in term of root mean square error has been clearly evaluated for five parameters, namely, relative humidity, temperature, wind, geopotential height, and specific humidity. It is demonstrated that the assimilation of SAPHIR observations results in a considerable improvement for the five parameters over the global region. During the study period, two tropical cyclones (HELEN, 19–22 November and LEHAR, 23–28 November) were formed over the North Indian Ocean. Impact on specific humidity and track forecast errors of tropical cyclone are also examined. Overall, initial results show the usefulness of SAPHIR radiances in the NGFS.
    Keywords absorption ; hurricanes ; relative humidity ; remote sensing ; satellites ; temperature ; water vapor ; wind ; Indian Ocean
    Language English
    Dates of publication 2017-0818
    Size p. 4587-4610.
    Publishing place Taylor & Francis
    Document type Article
    ZDB-ID 1497529-4
    ISSN 1366-5901 ; 0143-1161
    ISSN (online) 1366-5901
    ISSN 0143-1161
    DOI 10.1080/01431161.2017.1323279
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: In Reply: Should I start an SGLT-2 inhibitor in my patient with heart failure and chronic kidney disease?

    Prasad, Pooja / Prasad, Megha

    Cleveland Clinic journal of medicine

    2024  Volume 91, Issue 2, Page(s) 82–83

    MeSH term(s) Humans ; Sodium-Glucose Transporter 2 Inhibitors/adverse effects ; Heart Failure/drug therapy ; Hypoglycemic Agents/pharmacology ; Renal Insufficiency, Chronic/complications
    Chemical Substances Sodium-Glucose Transporter 2 Inhibitors ; Hypoglycemic Agents
    Language English
    Publishing date 2024-02-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639116-3
    ISSN 1939-2869 ; 0891-1150
    ISSN (online) 1939-2869
    ISSN 0891-1150
    DOI 10.3949/ccjm.91c.02002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: On the Frontlines of the Coronavirus Disease 2019 (COVID-19) Crisis-The Many Faces of Leadership.

    Prasad, Megha

    JAMA cardiology

    2020  Volume 5, Issue 9, Page(s) 983–984

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/therapy ; Delivery of Health Care/organization & administration ; Humans ; Leadership ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; Professional Role ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-08-03
    Publishing country United States
    Document type Journal Article
    ISSN 2380-6591
    ISSN (online) 2380-6591
    DOI 10.1001/jamacardio.2020.2240
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The Know-how of Polymeric Nanocarrier Based Vaginal Drug Delivery System: Pitfalls, Challenges and Trends.

    Kanojiya, Pranita / Wadetwar, Rita / Karemore, Megha / Prasad, Satyendra

    Pharmaceutical nanotechnology

    2024  

    Abstract: Objective: Gynecological health is a global concern, and thus, the formulator researcher strives to improve the quality of life through innovative feminine pharmaceutical formulations. Vaginal delivery appears to be one of the vital strategies for local ...

    Abstract Objective: Gynecological health is a global concern, and thus, the formulator researcher strives to improve the quality of life through innovative feminine pharmaceutical formulations. Vaginal delivery appears to be one of the vital strategies for local and systemic action of the therapeutically active agent. The rich vascular network, mucosal permeability, bypass of hepatic first-pass effect, and low enzymatic activity are the exclusive advantages of the vaginal route. But certain hindrances truncate the vaginal route, such as physiological factors including lower pH, self-cleansing mucus with constant secretion, and varying thickness of mucus layer due to menstrual cycle and microbiota. Significance of Review: This present review envisages the advances in the polymeric nanocarriers in the delivery to the vaginal route. Polymeric (mucoadhesive and PEGylated, etc.) nanocarriers have been recently utilized for drug delivery purposes. The modernized analysis of the updated advancements in the polymeric nanocarrier-based vaginal drug delivery system with the budding development is compiled in the present review.
    Result: The literature search reveals that the novel polymeric nanocarrier design strategies currently being proposed to perk up the delivery of customary drugs through the vaginal route prove effective.
    Conclusion: Polymeric nanocarrier for vaginal delivery has provided better therapeutic efficacy due to higher drug residence, improved permeation, and sustained release of the active therapeutic agent. The polymeric nanocarriers can deliver different proteins, peptides, nuclear materials, hormones, etc., vaginally that are difficult for administration.
    Language English
    Publishing date 2024-01-25
    Publishing country United Arab Emirates
    Document type Journal Article
    ISSN 2211-7393
    ISSN (online) 2211-7393
    DOI 10.2174/0122117385283801231212114538
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: On the Frontlines of the Coronavirus Disease 2019 (COVID-19) Crisis—The Many Faces of Leadership

    Prasad, Megha

    JAMA Cardiology

    2020  Volume 5, Issue 9, Page(s) 983

    Keywords covid19
    Language English
    Publisher American Medical Association (AMA)
    Publishing country us
    Document type Article ; Online
    ISSN 2380-6583
    DOI 10.1001/jamacardio.2020.2240
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Should I start an SGLT-2 inhibitor in my patient with heart failure and chronic kidney disease?

    Sekerak, Richard / Lerner, Johanna Ben-Ami / Prasad, Pooja / Prasad, Megha

    Cleveland Clinic journal of medicine

    2023  Volume 90, Issue 10, Page(s) 607–609

    MeSH term(s) Humans ; Sodium-Glucose Transporter 2 Inhibitors/adverse effects ; Heart Failure/drug therapy ; Hypoglycemic Agents/pharmacology ; Renal Insufficiency, Chronic/complications ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy
    Chemical Substances Sodium-Glucose Transporter 2 Inhibitors ; Hypoglycemic Agents
    Language English
    Publishing date 2023-10-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639116-3
    ISSN 1939-2869 ; 0891-1150
    ISSN (online) 1939-2869
    ISSN 0891-1150
    DOI 10.3949/ccjm.90a.23004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Commentary: Multifocal versus modified monovision contact lens correction for presbyopia - A synopsis.

    Bhayana, Amber A / Gautam, Megha / Prasad, Laxmi / Sharma, Bhavana

    Indian journal of ophthalmology

    2023  Volume 71, Issue 5, Page(s) 1842–1843

    MeSH term(s) Humans ; Presbyopia/surgery ; Vision, Monocular ; Contact Lenses ; Visual Acuity
    Language English
    Publishing date 2023-05-18
    Publishing country India
    Document type Journal Article ; Comment
    ZDB-ID 187392-1
    ISSN 1998-3689 ; 0301-4738
    ISSN (online) 1998-3689
    ISSN 0301-4738
    DOI 10.4103/IJO.IJO_900_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Are All Total Occlusions Created Equal?: Striving for Complete Revascularization While Differentiating Apples From Oranges.

    Moses, Jeffrey W / Prasad, Megha

    Journal of the American College of Cardiology

    2021  Volume 77, Issue 5, Page(s) 541–543

    MeSH term(s) Citrus sinensis ; Coronary Occlusion ; Humans ; Malus ; Percutaneous Coronary Intervention
    Language English
    Publishing date 2021-02-03
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2020.12.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: In vivo models to study neurogenesis and associated neurodevelopmental disorders-Microcephaly and autism spectrum disorder.

    Prasad, Tuhina / Iyer, Sharada / Chatterjee, Sayoni / Kumar, Megha

    WIREs mechanisms of disease

    2023  Volume 15, Issue 4, Page(s) e1603

    Abstract: The genesis and functioning of the central nervous system are one of the most intricate and intriguing aspects of embryogenesis. The big lacuna in the field of human CNS development is the lack of accessibility of the human brain for direct observation ... ...

    Abstract The genesis and functioning of the central nervous system are one of the most intricate and intriguing aspects of embryogenesis. The big lacuna in the field of human CNS development is the lack of accessibility of the human brain for direct observation during embryonic and fetal development. Thus, it is imperative to establish alternative animal models to gain deep mechanistic insights into neurodevelopment, establishment of neural circuitry, and its function. Neurodevelopmental events such as neural specification, differentiation, and generation of neuronal and non-neuronal cell types have been comprehensively studied using a variety of animal models and in vitro model systems derived from human cells. The experimentations on animal models have revealed novel, mechanistic insights into neurogenesis, formation of neural networks, and function. The models, thus serve as indispensable tools to understand the molecular basis of neurodevelopmental disorders (NDDs) arising from aberrations during embryonic development. Here, we review the spectrum of in vivo models such as fruitfly, zebrafish, frog, mice, and nonhuman primates to study neurogenesis and NDDs like microcephaly and Autism Spectrum Disorder. We also discuss nonconventional models such as ascidians and the recent technological advances in the field to study neurogenesis, disease mechanisms, and pathophysiology of human NDDs. This article is categorized under: Cancer > Stem Cells and Development Congenital Diseases > Stem Cells and Development Neurological Diseases > Stem Cells and Development Congenital Diseases > Genetics/Genomics/Epigenetics.
    MeSH term(s) Humans ; Animals ; Mice ; Autism Spectrum Disorder ; Microcephaly ; Zebrafish ; Neurogenesis/physiology ; Neurodevelopmental Disorders
    Language English
    Publishing date 2023-02-08
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ISSN 2692-9368
    ISSN (online) 2692-9368
    DOI 10.1002/wsbm.1603
    Database MEDical Literature Analysis and Retrieval System OnLINE

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