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  1. Book ; Online ; Thesis: Evaluation der Ernährungstherapie in einer geriatrischen Klinik

    Noreik, Michaela / Schulz, Ralf-Joachim / Stock, Stephanie

    Analyse von Effekt, Kosten und Nutzen der Ernährungstherapie in einer Jahresbilanz

    2012  

    Institution Klinik für Geriatrie
    Author's details vorgelegt von Michaela Noreik ; 1. Berichterstatterin/Berichterstatter: Universitätsprofessor Dr. med. R.-J. Schulz, 2. Berichterstatterin/Berichterstatter: Frau Privatdozentin Dr. med. S.A.K. Stock ; aus der Geriatrischen Klinik des St. Marien-Hospitals Akademisches Lehrkrankenhaus für die Universität zu Köln
    Subject code 610
    Language German
    Size 125 Bl. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Köln, Univ., Diss., 2012
    HBZ-ID HT017494996
    DOI 10.4126/38m-004902061
    Database Repository for Life Sciences

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  2. Book ; Thesis: Evaluation der Ernährungstherapie in einer geriatrischen Klinik

    Noreik, Michaela / Schulz, Ralf-Joachim / Stock, Stephanie

    Analyse von Effekt, Kosten und Nutzen der Ernährungstherapie in einer Jahresbilanz

    2012  

    Institution Klinik für Geriatrie
    Author's details vorgelegt von Michaela Noreik ; 1. Berichterstatterin/Berichterstatter: Universitätsprofessor Dr. med. R.-J. Schulz, 2. Berichterstatterin/Berichterstatter: Frau Privatdozentin Dr. med. S.A.K. Stock ; aus der Geriatrischen Klinik des St. Marien-Hospitals Akademisches Lehrkrankenhaus für die Universität zu Köln
    Subject code 610
    Language German
    Size 125 Bl. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Köln, Univ., Diss., 2012
    HBZ-ID HT017500632
    Database Catalogue ZB MED Medicine, Health

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  3. Article: Survey of disinfection of gloved hands in Germany in 2016 and 2022: Change of attitude but persistent problems with glove use.

    Schulz-Stübner, Sebastian / Nopper, Katharina

    Journal of infection prevention

    2023  Volume 24, Issue 6, Page(s) 278–280

    Language English
    Publishing date 2023-09-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2595000-9
    ISSN 1757-1782 ; 1757-1774
    ISSN (online) 1757-1782
    ISSN 1757-1774
    DOI 10.1177/17571774231203389
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Tinnitus Prevalence in the Adult Population-Results from the Gutenberg Health Study.

    Hackenberg, Berit / O'Brien, Karoline / Döge, Julia / Lackner, Karl J / Beutel, Manfred E / Münzel, Thomas / Pfeiffer, Norbert / Schulz, Andreas / Schmidtmann, Irene / Wild, Philipp S / Matthias, Christoph / Bahr-Hamm, Katharina

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 3

    Abstract: Background and ... ...

    Abstract Background and Objectives
    MeSH term(s) Male ; Adult ; Humans ; Female ; Aged ; Tinnitus/epidemiology ; Tinnitus/etiology ; Cohort Studies ; Prevalence ; Hearing Loss/epidemiology ; Hearing Loss/complications ; Risk Factors ; Deafness
    Language English
    Publishing date 2023-03-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59030620
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Viral Evasion Strategies in Type I IFN Signaling - A Summary of Recent Developments.

    Schulz, Katharina S / Mossman, Karen L

    Frontiers in immunology

    2016  Volume 7, Page(s) 498

    Abstract: The immune system protects the organism against infections and the damage associated with them. The first line of defense against pathogens is the innate immune response. In the case of a viral infection, it induces the interferon (IFN) signaling cascade ...

    Abstract The immune system protects the organism against infections and the damage associated with them. The first line of defense against pathogens is the innate immune response. In the case of a viral infection, it induces the interferon (IFN) signaling cascade and eventually the expression of type I IFN, which then causes an antiviral state in the cells. However, many viruses have developed strategies to counteract this mechanism and prevent the production of IFN. In order to modulate or inhibit the IFN signaling cascade in their favor, viruses have found ways to interfere at every single step of the cascade, for example, by inducing protein degradation or cleavage, or by mediate protein polyubiquitination. In this article, we will review examples of viruses that modulate the IFN response and describe the mechanisms they use.
    Keywords covid19
    Language English
    Publishing date 2016
    Publishing country Switzerland
    Document type Review ; Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2016.00498
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Cognitive and neuropsychiatric trajectories up to one year after mild to severe COVID-19.

    Costa, Ana S / Balloff, Carolin / Bungenberg, Julia / Tauber, Simone C / Telke, Ann-Kathrin / Bandlow, Carolina / Groiss, Stefan J / Hartmann, Christian J / Elben, Saskia / Penner, Iris-Katharina / Schulz, Jörg B / Meuth, Sven G / Schnitzler, Alfons / Reetz, Kathrin / Albrecht, Philipp

    Psychiatry research

    2023  Volume 327, Page(s) 115375

    MeSH term(s) Humans ; COVID-19/psychology ; Cognitive Dysfunction/etiology ; Cognitive Dysfunction/psychology ; Alzheimer Disease/psychology ; Cognition
    Language English
    Publishing date 2023-07-26
    Publishing country Ireland
    Document type Letter
    ZDB-ID 445361-x
    ISSN 1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
    ISSN (online) 1872-7123 ; 1872-7506
    ISSN 0925-4927 ; 0165-1781
    DOI 10.1016/j.psychres.2023.115375
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Conference proceedings: Das Auftreten von Tinnitus und Angststörungen in der deutschen Bevölkerung

    Hackenberg, Berit / O’Brien, Karoline / Döge, Julia / Lackner, Karl / Beutel, Manfred E. / Münzel, Thomas / Wild, Philipp S. / Pfeiffer, Norbert / Schulz, Andreas / Matthias, Christoph / Bahr-Hamm, Katharina

    2023  , Page(s) 12

    Event/congress Jahrestagung der Vereinigung Westdeutscher Hals-Nasen-Ohren-Ärzte; Wuppertal; Vereinigung Westdeutscher HNO-Ärzte; 2023
    Keywords Medizin, Gesundheit
    Publishing date 2023-03-09
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/23wdhno12
    Database German Medical Science

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  8. Article ; Online: Paradigmatic Approach to Support Personalized Counseling With Digital Health (iKNOW).

    Speiser, Dorothee / Heibges, Maren / Besch, Laura / Hilger, Caren / Keinert, Marie / Klein, Katharina / Rauwolf, Gudrun / Schmid, Christine / Schulz-Niethammer, Sven / Stegen, Steffi / Westfal, Viola / Witzel, Isabell / Zang, Benedikt / Kendel, Friederike / Feufel, Markus A

    JMIR formative research

    2023  Volume 7, Page(s) e41179

    Abstract: ... should respect the counselee's data privacy rights (eg, through strict pseudonymization and opt-in consent); and ...

    Abstract iKNOW is the first evidence-based digital tool to support personalized counseling for women in Germany with a hereditary cancer risk. The counseling tool is designed for carriers of pathogenic gBRCA (germline breast cancer gene) variants that increase the lifetime risk of breast and ovarian cancer. Carriers of pathogenic variants are confronted with complex, individualized risk information, and physicians must be able to convey this information in a comprehensible way to enable preference-sensitive health decisions. In this paper, we elaborate on the clinical, regulatory, and practical premises of personalized counseling in Germany. By operationalizing these premises, we formulate 5 design principles that, we suggest, are specific enough to develop a digital tool (eg, iKNOW), yet wide-ranging enough to inform the development of counseling tools for personalized medicine more generally: (1) digital counseling tools should implement the current standard of care (eg, based on guidelines); (2) digital counseling tools should help to both standardize and personalize the counseling process (eg, by enabling the preference-sensitive selection of counseling contents from a common information base); (3) digital counseling tools should make complex information easy to access both cognitively (eg, by using evidenced-based risk communication formats) and technically (eg, by means of responsive design for various devices); (4) digital counseling tools should respect the counselee's data privacy rights (eg, through strict pseudonymization and opt-in consent); and (5) digital counseling tools should be systematically and iteratively evaluated with the users in mind (eg, using formative prototype testing to ensure a user-centric design and a summative multicenter, randomized controlled trial). On the basis of these paradigmatic design principles, we hope that iKNOW can serve as a blueprint for the development of more digital innovations to support personalized counseling approaches in cancer medicine.
    Language English
    Publishing date 2023-04-21
    Publishing country Canada
    Document type Journal Article
    ISSN 2561-326X
    ISSN (online) 2561-326X
    DOI 10.2196/41179
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: ATP citrate lyase (ACLY)-dependent immunometabolism in mucosal T cells drives experimental colitis in vivo.

    Schulz-Kuhnt, Anja / Rühle, Katharina / Javidmehr, Asal / Döbrönti, Michael / Biwank, Jana / Knittel, Selina / Neidlinger, Peter / Leupold, Jannik / Liu, Li-Juan / Dedden, Mark / Taudte, Regina Verena / Gessner, Arne / Fromm, Martin F / Mielenz, Dirk / Kreiss, Lucas / Waldner, Maximilian J / Schürmann, Sebastian / Friedrich, Oliver / Dietel, Barbara /
    López-Posadas, Rocío / Plattner, Christina / Zundler, Sebastian / Becker, Christoph / Atreya, Raja / Neurath, Markus F / Atreya, Imke

    Gut

    2024  Volume 73, Issue 4, Page(s) 601–612

    Abstract: Objective: Mucosal T cells play a major role in inflammatory bowel disease (IBD). However, their immunometabolism during intestinal inflammation is poorly understood. Due to its impact on cellular metabolism and proinflammatory immune cell function, we ... ...

    Abstract Objective: Mucosal T cells play a major role in inflammatory bowel disease (IBD). However, their immunometabolism during intestinal inflammation is poorly understood. Due to its impact on cellular metabolism and proinflammatory immune cell function, we here focus on the enzyme ATP citrate lyase (ACLY) in mucosal T cell immunometabolism and its relevance for IBD.
    Design: ACLY expression and its immunometabolic impact on colitogenic T cell function were analysed in mucosal T cells from patients with IBD and in two experimental colitis models.
    Results: ACLY was markedly expressed in colon tissue under steady-state conditions but was significantly downregulated in lamina propria mononuclear cells in experimental dextran sodium sulfate-induced colitis and in CD4
    Conclusion: ACLY controls mucosal T cell immunometabolism and experimental colitis. Therapeutic modulation of ACLY expression in T cells emerges as a novel strategy to promote the resolution of intestinal inflammation.
    MeSH term(s) Humans ; Animals ; Intraepithelial Lymphocytes/metabolism ; ATP Citrate (pro-S)-Lyase/metabolism ; CD8-Positive T-Lymphocytes/metabolism ; Colitis/metabolism ; Inflammatory Bowel Diseases ; Inflammation/metabolism ; Butyrates ; Intestinal Mucosa/metabolism ; Dextran Sulfate ; Disease Models, Animal
    Chemical Substances ATP Citrate (pro-S)-Lyase (EC 2.3.3.8) ; Butyrates ; Dextran Sulfate (9042-14-2)
    Language English
    Publishing date 2024-03-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2023-330543
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Tinnitus and Its Relation to Depression, Anxiety, and Stress-A Population-Based Cohort Study.

    Hackenberg, Berit / Döge, Julia / O'Brien, Karoline / Bohnert, Andrea / Lackner, Karl J / Beutel, Manfred E / Michal, Matthias / Münzel, Thomas / Wild, Philipp S / Pfeiffer, Norbert / Schulz, Andreas / Schmidtmann, Irene / Matthias, Christoph / Bahr, Katharina

    Journal of clinical medicine

    2023  Volume 12, Issue 3

    Abstract: Tinnitus is a common symptom reported in otolaryngologic practice. Although the pathophysiology of tinnitus has not been fully understood, clinical studies suggest that psychological symptoms of depression, anxiety, and somatization are increased in ... ...

    Abstract Tinnitus is a common symptom reported in otolaryngologic practice. Although the pathophysiology of tinnitus has not been fully understood, clinical studies suggest that psychological symptoms of depression, anxiety, and somatization are increased in tinnitus patients. However, patients seeking medical treatment for tinnitus may be especially vulnerable. Population-based studies reporting on the association between tinnitus and psychological distress are still lacking. The aim of this study was to investigate the correlation of tinnitus with depression, anxiety, or somatization in a large population-based cohort. The Gutenberg Health Study is a population-based cohort study. Participants were asked about the occurrence of tinnitus (yes/no) and how much they were bothered by it. In addition, they completed the PHQ-9, GAD-7, and SSS-8 questionnaires to assess depressive symptoms, anxiety, and somatic symptom disorders. A total of 8539 participants were included in the study cohort. Tinnitus prevalence was 28.0% (2387). The prevalence of depression/anxiety/somatic symptom disorders was significantly higher among participants with tinnitus than among participants without tinnitus (7.9%/5.4%/40.4% participants with tinnitus vs. 4.6%/3.3%/26.9% participants without tinnitus,
    Language English
    Publishing date 2023-02-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12031169
    Database MEDical Literature Analysis and Retrieval System OnLINE

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