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  1. Article ; Online: Endomyocardial biopsy in fulminant myocarditis: need for early and accurate diagnosis to improve the outcome.

    Schultheiss, Heinz-Peter / Escher, Felicitas

    European heart journal

    2023  Volume 44, Issue 48, Page(s) 5125–5127

    MeSH term(s) Humans ; Myocarditis/diagnosis ; Myocarditis/pathology ; Heart ; Myocardium/pathology ; Biopsy
    Language English
    Publishing date 2023-11-08
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehad489
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1563: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 640: Show issues

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  2. Book: Inflammatory cardiomyopathy (DCMi)

    Schultheiss, Heinz-Peter / Noutsias, Michel

    pathogenesis and therapy

    (Progress in inflammatory research)

    2010  

    Author's details Heinz-Peter Schultheiss ; Michel Noutsias, ed
    Series title Progress in inflammatory research
    Language English
    Size XII, 294 S. : Ill., graph. Darst.
    Publisher Birkhäuser
    Publishing place Basel
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT016445417
    ISBN 978-3-7643-8351-0 ; 3-7643-8351-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2010 A 3767 order for loan Magazin

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  3. Book ; Conference proceedings: Handbuch Kardiologie 2010

    Schultheiss, Heinz-Peter

    2010  

    Title variant Cardio-Up-date 2010 ; Cardio-Update 2010
    Institution Med-Update GmbH
    Event/congress Kardiologie-Update-Seminar (5, 2010, Wiesbaden)
    Author's details [5. Kardiologie-Update-Seminar. Wiss. Leiter: Helmut Drexler ; Heinz-Peter Schultheiß. Veranst.: med update GmbH, Wiesbaden]. Hrsg. Heinz-Peter Schultheiß
    Keywords Herzkrankheit
    Subject Herzerkrankung ; Herzkrankheiten
    Language German
    Size 380 S. in getr. Zählung : Ill., graph. Darst., 32 cm
    Publisher Springer-Medizin-Verl
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Conference proceedings
    Note Literaturangaben
    HBZ-ID HT016334595
    ISBN 978-3-642-04715-2 ; 3-642-04715-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2010 C 28 order to use in reading room Magazin

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  4. Book ; Conference proceedings: Chronic viral and inflammatory cardiomyopathy

    Schultheiss, Heinz-Peter

    (Ernst Schering Research Foundation workshop ; 55)

    2006  

    Event/congress Workshop on Chronic Viral and Inflammatory Cardiomyopathy (2004, Berlin)
    Author's details H.-P. Schultheis ... eds
    Series title Ernst Schering Research Foundation workshop ; 55
    Collection
    Keywords Herzmuskelkrankheit ; Virusinfektion ; Chronische Krankheit
    Subject Krankheit ; Chronisches Leiden ; Chronische Krankheiten ; Virale Infektion ; Herzmyopathie ; Kardiomyopathie ; Myokardiopathie ; Myokardopathie ; Cardiomyopathie ; Myocardiopathie ; Myokarderkrankung
    Language English
    Size XVIII, 361 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book ; Conference proceedings
    HBZ-ID HT014571973
    ISBN 3-540-23971-5 ; 978-3-540-23971-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2005 A 5301 order for loan Magazin

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  5. Book ; Conference proceedings: New aspects in inflammatory cardiomyopathy

    Schultheiss, Heinz-Peter

    diagnosis and treatment ; proceedings of an international symposium, held January 18 - 20, 2002, in Berlin, Germany

    (European heart journal : Supplements ; 4I)

    2002  

    Author's details ed. by H.-P. Schultheiss
    Series title European heart journal : Supplements ; 4I
    European heart journal
    European heart journal ; Supplements
    Collection European heart journal
    European heart journal ; Supplements
    Language English
    Size I87 S. : Ill., graph. Darst.
    Publisher Saunders
    Publishing place London u.a.
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT013538800
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 1563 -Suppl.4I- not available for loan Zeitschriften-Lesesaal

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  6. Article ; Online: Advancing Precision Medicine in Myocarditis

    Christian Baumeier / Dominik Harms / Ganna Aleshcheva / Ulrich Gross / Felicitas Escher / Heinz-Peter Schultheiss

    Journal of Clinical Medicine, Vol 12, Iss 5050, p

    Current Status and Future Perspectives in Endomyocardial Biopsy-Based Diagnostics and Therapeutic Approaches

    2023  Volume 5050

    Abstract: The diagnosis and specific and causal treatment of myocarditis and inflammatory cardiomyopathy remain a major clinical challenge. Despite the rapid development of new imaging techniques, endomyocardial biopsies remain the gold standard for accurate ... ...

    Abstract The diagnosis and specific and causal treatment of myocarditis and inflammatory cardiomyopathy remain a major clinical challenge. Despite the rapid development of new imaging techniques, endomyocardial biopsies remain the gold standard for accurate diagnosis of inflammatory myocardial disease. With the introduction and continued development of immunohistochemical inflammation diagnostics in combination with viral nucleic acid testing, myocarditis diagnostics have improved significantly since their introduction. Together with new technologies such as miRNA and gene expression profiling, quantification of specific immune cell markers, and determination of viral activity, diagnostic accuracy and patient prognosis will continue to improve in the future. In this review, we summarize the current knowledge on the pathogenesis and diagnosis of myocarditis and inflammatory cardiomyopathies and highlight future perspectives for more in-depth and specialized biopsy diagnostics and precision, personalized medicine approaches.
    Keywords endomyocardial biopsy ; myocarditis ; viral myocarditis ; inflammatory cardiomyopathy ; precision medicine ; antiviral therapy ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Article: Advancing Precision Medicine in Myocarditis: Current Status and Future Perspectives in Endomyocardial Biopsy-Based Diagnostics and Therapeutic Approaches.

    Baumeier, Christian / Harms, Dominik / Aleshcheva, Ganna / Gross, Ulrich / Escher, Felicitas / Schultheiss, Heinz-Peter

    Journal of clinical medicine

    2023  Volume 12, Issue 15

    Abstract: The diagnosis and specific and causal treatment of myocarditis and inflammatory cardiomyopathy remain a major clinical challenge. Despite the rapid development of new imaging techniques, endomyocardial biopsies remain the gold standard for accurate ... ...

    Abstract The diagnosis and specific and causal treatment of myocarditis and inflammatory cardiomyopathy remain a major clinical challenge. Despite the rapid development of new imaging techniques, endomyocardial biopsies remain the gold standard for accurate diagnosis of inflammatory myocardial disease. With the introduction and continued development of immunohistochemical inflammation diagnostics in combination with viral nucleic acid testing, myocarditis diagnostics have improved significantly since their introduction. Together with new technologies such as miRNA and gene expression profiling, quantification of specific immune cell markers, and determination of viral activity, diagnostic accuracy and patient prognosis will continue to improve in the future. In this review, we summarize the current knowledge on the pathogenesis and diagnosis of myocarditis and inflammatory cardiomyopathies and highlight future perspectives for more in-depth and specialized biopsy diagnostics and precision, personalized medicine approaches.
    Language English
    Publishing date 2023-07-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12155050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: MicroRNAs as novel biomarkers and potential therapeutic options for inflammatory cardiomyopathy.

    Aleshcheva, Ganna / Baumeier, Christian / Harms, Dominik / Bock, C-Thomas / Escher, Felicitas / Schultheiss, Heinz-Peter

    ESC heart failure

    2023  Volume 10, Issue 6, Page(s) 3410–3418

    Abstract: Aims: Inflammation of the heart is a complex biological and pathophysiological response of the immune system to a variety of injuries leading to tissue damage and heart failure. MicroRNAs (miRNAs) emerge as pivotal players in the development of numerous ...

    Abstract Aims: Inflammation of the heart is a complex biological and pathophysiological response of the immune system to a variety of injuries leading to tissue damage and heart failure. MicroRNAs (miRNAs) emerge as pivotal players in the development of numerous diseases, suggesting their potential utility as biomarkers for inflammation and as viable candidates for therapeutic interventions. The primary aim of this investigation was to pinpoint and assess particular miRNAs in individuals afflicted by virus-negative inflammatory dilated cardiomyopathy (DCMi).
    Methods and results: The study involved the analysis of 152 serum samples sourced from patients diagnosed with unexplained heart failure through endomyocardial biopsy. Among these samples, 38 belonged to DCMi patients, 24 to DCM patients, 44 to patients displaying inflammation alongside diverse viral infections, and 46 to patients solely affected by viral infections without concurrent inflammation. Additionally, serum samples from 10 healthy donors were included. The expression levels of 754 distinct miRNAs were evaluated using TaqMan OpenArray. MiR-1, miR-23, miR-142-5p, miR-155, miR-193, and miR-195 exhibited exclusive down-regulation solely in DCMi patients (P < 0.005). These miRNAs enabled effective differentiation between individuals with inflammation unlinked to viruses (DCMi) and all other participant groups (P < 0.005), boasting a specificity surpassing 86%.
    Conclusions: The identification of specific miRNAs offers a novel diagnostic perspective for recognizing intramyocardial inflammation within virus-negative DCMi patients. Furthermore, these miRNAs hold promise as potential candidates for tailored therapeutic strategies in the context of virus-negative DCMi.
    MeSH term(s) Humans ; MicroRNAs ; Myocarditis/diagnosis ; Myocarditis/therapy ; Inflammation ; Cardiomyopathy, Dilated/diagnosis ; Cardiomyopathy, Dilated/genetics ; Cardiomyopathy, Dilated/therapy ; Biomarkers ; Heart Failure/diagnosis ; Heart Failure/therapy ; Virus Diseases
    Chemical Substances MicroRNAs ; Biomarkers
    Language English
    Publishing date 2023-09-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2814355-3
    ISSN 2055-5822 ; 2055-5822
    ISSN (online) 2055-5822
    ISSN 2055-5822
    DOI 10.1002/ehf2.14523
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Conference proceedings: The role of immune mechanisms in cardiovascular disease

    Schultheiss, Heinz-Peter

    with contributions by numerous experts ; [proceedings of the International Symposium on "The Role of Immune Mechanisms in Cardiovascular Disease", held in Berlin 1995] ; with 24 tab

    1997  

    Event/congress International Symposium on the Role of Immune Mechanisms in Cardiovascular Disease (1995, Berlin)
    Author's details H.-P. Schultheiss ... (ed.)
    Keywords Heart Diseases / immunology / congresses ; Kardiovaskuläre Krankheit ; Immunsystem
    Subject Körpereigene Abwehr ; Körpereigene Abwehrkräfte ; Körpereigenes Abwehrsystem ; Abwehrkräfte ; Herz-Kreislauf-Krankheit ; Herz-Kreislauf-Erkrankung ; Kardiovaskuläres System ; Cardiovasculäre Krankheit ; Kardiovaskuläre Krankheiten
    Language English
    Size XIX, 317 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book ; Conference proceedings
    HBZ-ID HT007344018
    ISBN 3-540-61358-7 ; 978-3-540-61358-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1997 A 2760 order for loan Magazin

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  10. Article: Interferon-β Suppresses Transcriptionally Active Parvovirus B19 Infection in Viral Cardiomyopathy: A Subgroup Analysis of the BICC-Trial

    Schultheiss, Heinz-Peter / Bock, Claus-Thomas / Aleshcheva, Ganna / Baumeier, Christian / Poller, Wolfgang / Escher, Felicitas

    Viruses. 2022 Feb. 21, v. 14, no. 2

    2022  

    Abstract: Human parvovirus B19 (B19V) is the predominant virus currently detected in endomyocardial biopsies (EMBs). Recent findings indicate that, specifically, transcriptionally active B19V with detectable viral RNA is of prognostic relevance in inflammatory ... ...

    Abstract Human parvovirus B19 (B19V) is the predominant virus currently detected in endomyocardial biopsies (EMBs). Recent findings indicate that, specifically, transcriptionally active B19V with detectable viral RNA is of prognostic relevance in inflammatory viral cardiomyopathy. We aimed to evaluate B19V replicative status (viral RNA) and beneficial effects in a sub-collective of the prospective randomized placebo-controlled phase II multi-center BICC-Trial (Betaferon In Chronic Viral Cardiomyopathy) after interferon beta-1b (IFN-β) treatment. EMBs of n = 64 patients with B19V mono-infected tissue were retrospectively analyzed. Viral RNA could be detected in n = 18/64 (28.1%) of B19V DNA positive samples (mean age 51.7 years, 12 male), of whom n = 13 had been treated with IFN-ß. Five patients had received placebo. PCR analysis confirmed in follow-up that EMBs significantly reduced viral RNA loads in n = 11/13 (84.6%) of IFN-ß treated patients (p = 0.001), independently from the IFN-ß dose, in contrast to the placebo group, where viral RNA load was not affected or even increased. Consequently, a significant improvement of left ventricular ejection fraction (LVEF) after treatment with IFN-ß was observed (LVEF mean baseline 51.6 ± 14.1% vs. follow-up 61.0 ± 17.5%, p = 0.03). In contrast, in the placebo group, worsening of LVEF was evaluated in n = 4/5 (80.0%) of patients. We could show for the first-time the beneficial effects from treatment with IFN-ß, suppressing B19V viral RNA and improving the hemodynamic course. Our results need further verification in a larger prospective randomized controlled trial.
    Keywords DNA ; Primate erythroparvovirus 1 ; Protoparvovirus ; RNA ; cardiomyopathy ; hemodynamics ; males ; placebos ; polymerase chain reaction ; randomized clinical trials ; transcription (genetics) ; viruses
    Language English
    Dates of publication 2022-0221
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2516098-9
    ISSN 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14020444
    Database NAL-Catalogue (AGRICOLA)

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