Article ; Online: Co-administration of an effector antibody enhances the half-life and therapeutic potential of RNA-encoded nanobodies.
2023 Volume 13, Issue 1, Page(s) 14632
Abstract: The incidence of Clostridioides difficile infection (CDI) and associated mortality have increased rapidly worldwide in recent years. Therefore, it is critical to develop new therapies for CDI. Here we report on the development of mRNA-LNPs encoding ... ...
Abstract | The incidence of Clostridioides difficile infection (CDI) and associated mortality have increased rapidly worldwide in recent years. Therefore, it is critical to develop new therapies for CDI. Here we report on the development of mRNA-LNPs encoding camelid-derived V |
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MeSH term(s) | Swine ; Animals ; Mice ; Single-Domain Antibodies ; RNA ; Clostridioides difficile ; Half-Life ; Antibodies ; RNA, Messenger |
Chemical Substances | Single-Domain Antibodies ; RNA (63231-63-0) ; Antibodies ; RNA, Messenger |
Language | English |
Publishing date | 2023-09-05 |
Publishing country | England |
Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural |
ZDB-ID | 2615211-3 |
ISSN | 2045-2322 ; 2045-2322 |
ISSN (online) | 2045-2322 |
ISSN | 2045-2322 |
DOI | 10.1038/s41598-023-41092-7 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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