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  1. Book: AIDS

    Fan, Hung / Conner, Ross F. / Villarreal, Luis P.

    science and society

    2013  

    Author's details Hung Y. Fan ; Ross F. Conner ; Luis P. Villarreal
    Keywords HIV Infections ; Acquired Immunodeficiency Syndrome
    Language English
    Size XV, 242 S. : Ill., graph. Darst.
    Edition 7. ed.
    Publisher Jones and Bartlett
    Publishing place Burlington, Mass
    Publishing country United States
    Document type Book
    Accompanying material Zugang zur Internetausgabe über Code
    HBZ-ID HT017595648
    ISBN 978-1-4496-8332-0 ; 1-4496-8332-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2013 A 2603 available for loan (reading room) Lesesaal EG
    Zugang zur Internetausgabe über Code aus lizenzrechtlichen Gründen nicht verfügbar

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  2. Article ; Online: Social Networking of Quasi-Species Consortia drive Virolution via Persistence.

    Villarreal, Luis P / Witzany, Guenther

    AIMS microbiology

    2021  Volume 7, Issue 2, Page(s) 138–162

    Abstract: The emergence of cooperative quasi-species consortia (QS-C) thinking from the more accepted quasispecies equations of Manfred Eigen, provides a conceptual foundation from which concerted action of RNA agents can now be understood. As group membership ... ...

    Abstract The emergence of cooperative quasi-species consortia (QS-C) thinking from the more accepted quasispecies equations of Manfred Eigen, provides a conceptual foundation from which concerted action of RNA agents can now be understood. As group membership becomes a basic criteria for the emergence of living systems, we also start to understand why the history and context of social RNA networks become crucial for survival and function. History and context of social RNA networks also lead to the emergence of a natural genetic code. Indeed, this QS-C thinking can also provide us with a transition point between the chemical world of RNA replicators and the living world of RNA agents that actively differentiate self from non-self and generate group identity with membership roles. Importantly the social force of a consortia to solve complex, multilevel problems also depend on using opposing and minority functions. The consortial action of social networks of RNA stem-loops subsequently lead to the evolution of cellular organisms representing a tree of life.
    Language English
    Publishing date 2021-04-30
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2471-1888
    ISSN (online) 2471-1888
    DOI 10.3934/microbiol.2021010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Viruses and the placenta: the essential virus first view.

    Villarreal, Luis P

    APMIS : acta pathologica, microbiologica, et immunologica Scandinavica

    2016  Volume 124, Issue 1-2, Page(s) 20–30

    Abstract: A virus first perspective is presented as an alternative hypothesis to explain the role of various endogenized retroviruses in the origin of the mammalian placenta. It is argued that virus-host persistence is a key determinant of host survival and the ... ...

    Abstract A virus first perspective is presented as an alternative hypothesis to explain the role of various endogenized retroviruses in the origin of the mammalian placenta. It is argued that virus-host persistence is a key determinant of host survival and the various ERVs involved have directly affected virus-host persistence.
    MeSH term(s) Animals ; Endogenous Retroviruses/genetics ; Endogenous Retroviruses/physiology ; Evolution, Molecular ; Female ; Gammaretrovirus/genetics ; Gammaretrovirus/pathogenicity ; Gammaretrovirus/physiology ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Placenta/physiology ; Placenta/virology ; Pregnancy
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2016-01
    Publishing country Denmark
    Document type Journal Article ; Review
    ZDB-ID 93340-5
    ISSN 1600-0463 ; 0903-4641
    ISSN (online) 1600-0463
    ISSN 0903-4641
    DOI 10.1111/apm.12485
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.73: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Persistent virus and addiction modules: an engine of symbiosis.

    Villarreal, Luis P

    Current opinion in microbiology

    2016  Volume 31, Page(s) 70–79

    Abstract: The giant DNA viruses are highly prevalent and have a particular affinity for the lytic infection of unicellular eukaryotic host. The giant viruses can also be infected by inhibitory virophage which can provide lysis protection to their host. The ... ...

    Abstract The giant DNA viruses are highly prevalent and have a particular affinity for the lytic infection of unicellular eukaryotic host. The giant viruses can also be infected by inhibitory virophage which can provide lysis protection to their host. The combined protective and destructive action of such viruses can define a general model (PD) of virus-mediated host survival. Here, I present a general model for role such viruses play in the evolution of host symbiosis. By considering how virus mixtures can participate in addiction modules, I provide a functional explanation for persistence of virus derived genetic 'junk' in their host genomic habitats.
    Language English
    Publishing date 2016-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1418474-6
    ISSN 1879-0364 ; 1369-5274
    ISSN (online) 1879-0364
    ISSN 1369-5274
    DOI 10.1016/j.mib.2016.03.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5514: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 51: Show issues

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  5. Book: AIDS

    Fan, Hung / Conner, Ross F. / Villarreal, Luis P.

    science and society

    2007  

    Author's details Hung Y. Fan ; Ross F. Conner ; Luis P. Villarreal
    Keywords Acquired Immunodeficiency Syndrome
    Language English
    Size XV, 249 S. : Ill., graph. Darst.
    Edition 5. ed.
    Publisher Jones and Bartlett
    Publishing place Boston u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT015249389
    ISBN 0-7637-4263-5 ; 978-0-7637-4263-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2007 A 4554 order for loan Magazin

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  6. Article: Editorial: Genome Invading RNA Networks.

    Villarreal, Luis P / Witzany, Guenther

    Frontiers in microbiology

    2018  Volume 9, Page(s) 581

    Language English
    Publishing date 2018-03-27
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2018.00581
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: That is life: communicating RNA networks from viruses and cells in continuous interaction.

    Villarreal, Luis P / Witzany, Guenther

    Annals of the New York Academy of Sciences

    2019  Volume 1447, Issue 1, Page(s) 5–20

    Abstract: All the conserved detailed results of evolution stored in DNA must be read, transcribed, and translated via an RNA-mediated process. This is required for the development and growth of each individual cell. Thus, all known living organisms fundamentally ... ...

    Abstract All the conserved detailed results of evolution stored in DNA must be read, transcribed, and translated via an RNA-mediated process. This is required for the development and growth of each individual cell. Thus, all known living organisms fundamentally depend on these RNA-mediated processes. In most cases, they are interconnected with other RNAs and their associated protein complexes and function in a strictly coordinated hierarchy of temporal and spatial steps (i.e., an RNA network). Clearly, all cellular life as we know it could not function without these key agents of DNA replication, namely rRNA, tRNA, and mRNA. Thus, any definition of life that lacks RNA functions and their networks misses an essential requirement for RNA agents that inherently regulate and coordinate (communicate to) cells, tissues, organs, and organisms. The precellular evolution of RNAs occurred at the core of the emergence of cellular life and the question remained of how both precellular and cellular levels are interconnected historically and functionally. RNA networks and RNA communication can interconnect these levels. With the reemergence of virology in evolution, it became clear that communicating viruses and subviral infectious genetic parasites are bridging these two levels by invading, integrating, coadapting, exapting, and recombining constituent parts in host genomes for cellular requirements in gene regulation and coordination aims. Therefore, a 21st century understanding of life is of an inherently social process based on communicating RNA networks, in which viruses and cells continuously interact.
    MeSH term(s) Animals ; Cell Communication/physiology ; Gene Regulatory Networks/physiology ; Humans ; RNA, Viral/genetics ; RNA, Viral/metabolism ; Virus Replication/physiology ; Viruses/genetics ; Viruses/metabolism
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2019-03-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 211003-9
    ISSN 1749-6632 ; 0077-8923
    ISSN (online) 1749-6632
    ISSN 0077-8923
    DOI 10.1111/nyas.14040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Se 110: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Force for ancient and recent life: viral and stem-loop RNA consortia promote life.

    Villarreal, Luis P

    Annals of the New York Academy of Sciences

    2015  Volume 1341, Page(s) 25–34

    Abstract: Lytic viruses were thought to kill the most numerous host (i.e., kill the winner). But persisting viruses/defectives can also protect against viruses, especially in a ubiquitous virosphere. In 1991, Yarmolinsky et al. discovered the addiction modules of ... ...

    Abstract Lytic viruses were thought to kill the most numerous host (i.e., kill the winner). But persisting viruses/defectives can also protect against viruses, especially in a ubiquitous virosphere. In 1991, Yarmolinsky et al. discovered the addiction modules of P1 phage, in which opposing toxic and protective functions stabilize persistence. Subsequently, I proposed that lytic and persisting cryptic virus also provide addiction modules that promote group identity. In eukaryotes (and the RNA world), a distinct RNA virus-host relationship exists. Retrovirurses/retroposons are major contributors to eukaryotic genomes. Eukaryotic complexity appears to be mostly mediated by regulatory complexity involving noncoding retroposon-derived RNA. RNA viruses evolve via quasispecies, which contain cooperating, minority, and even opposing RNA types. Quasispecies can also demonstrate group preclusion (e.g., hepatitis C). Stem-loop RNA domains are found in long terminal repeats (and viral RNA) and mediate viral regulation/identity. Thus, stem-loop RNAs may be ancestral regulators. I consider the RNA (ribozyme) world scenario from the perspective of addiction modules and cooperating quasispecies (i.e., subfunctional agents that establish group identity). Such an RNA collective resembles a "gang" but requires the simultaneous emergence of endonuclease, ligase, cooperative catalysis, group identity, and history markers (RNA). I call such a collective a gangen (pathway to gang) needed for life to emerge.
    MeSH term(s) Eukaryota/genetics ; Eukaryota/virology ; Evolution, Molecular ; Host-Pathogen Interactions/genetics ; Humans ; Models, Genetic ; Nucleic Acid Conformation ; Origin of Life ; RNA/chemistry ; RNA/genetics ; RNA/metabolism ; RNA Viruses/genetics ; RNA Viruses/physiology ; RNA, Catalytic/genetics ; RNA, Catalytic/metabolism
    Chemical Substances RNA, Catalytic ; RNA (63231-63-0)
    Language English
    Publishing date 2015-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 211003-9
    ISSN 1749-6632 ; 0077-8923
    ISSN (online) 1749-6632
    ISSN 0077-8923
    DOI 10.1111/nyas.12565
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Se 110: Show issues Location:
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  9. Book ; Conference proceedings: Common mechanisms of transformation by small DNA tumor viruses

    Villarreal, Luis P.

    [based on the ICN-UCI Conference on Virology 1989, Newport Beach, Ca.]

    (ICN-UCI conferences in virology)

    1989  

    Event/congress Conference on Virology (1989, NewportBeachCalif.)
    Author's details ed. by Luis P. Villarreal
    Series title ICN-UCI conferences in virology
    Keywords Cell Transformation, Neoplastic / congresses ; DNA Tumor Viruses / congresses ; Gene Expression Regulation / congresses ; DNS-Tamorviren ; Maligne Transformation
    Subject Zelltransformation ; Neoplastische Transformation ; Onkogene Transformation
    Size XI, 259 S. : Ill., graph. Darst.
    Publisher American Society for Microbiology
    Publishing place Washington, DC
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT003878623
    ISBN 1-55581-013-6 ; 978-1-55581-013-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1991 A 4534 order for loan Magazin

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  10. Article: Persistent virus and addiction modules: an engine of symbiosis

    Villarreal, Luis P

    Current opinion in microbiology. 2016 June, v. 31

    2016  

    Abstract: The giant DNA viruses are highly prevalent and have a particular affinity for the lytic infection of unicellular eukaryotic host. The giant viruses can also be infected by inhibitory virophage which can provide lysis protection to their host. The ... ...

    Abstract The giant DNA viruses are highly prevalent and have a particular affinity for the lytic infection of unicellular eukaryotic host. The giant viruses can also be infected by inhibitory virophage which can provide lysis protection to their host. The combined protective and destructive action of such viruses can define a general model (PD) of virus-mediated host survival. Here, I present a general model for role such viruses play in the evolution of host symbiosis. By considering how virus mixtures can participate in addiction modules, I provide a functional explanation for persistence of virus derived genetic ‘junk’ in their host genomic habitats.
    Keywords DNA viruses ; habitats ; models ; symbiosis ; viruses
    Language English
    Dates of publication 2016-06
    Size p. 70-79.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 1418474-6
    ISSN 1879-0364 ; 1369-5274
    ISSN (online) 1879-0364
    ISSN 1369-5274
    DOI 10.1016/j.mib.2016.03.005
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

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    Zs.MG 51: Show issues

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