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  1. AU=Moorman Jonathan P
  2. AU="Tallaksen, Helene Bandsholm Leere"
  3. AU=Kramer Barnett S
  4. AU="Wurm, Johannes"
  5. AU="Chahboune, Halima"
  6. AU="Louache, Fawzia"
  7. AU="Ghanim, Husam"
  8. AU="Cassetta, Alberto"
  9. AU="Guan, Xiao-Li"
  10. AU="de Neve-Enthoven, N G M"
  11. AU="Konjeti R. Sekhar"
  12. AU="Dufresne, Eric M"
  13. AU="Pérez-Monje, Dan A"
  14. AU="Gazzola, Stefania"
  15. AU="Gruner, William"
  16. AU="Didichenko, Svetlana A"
  17. AU="Milone F."
  18. AU="Bianski, Brandon"
  19. AU="Swan, Aili"
  20. AU="Cao, Mengli"
  21. AU="Rayya, W."
  22. AU="Bleher, Jana"
  23. AU="Fong, Fuk-Kei"
  24. AU="Bouvier, Nicolas"
  25. AU="Mims, Catherine"
  26. AU="Abbasi, Ardeshir"
  27. AU="Gailey, Samantha" AU="Gailey, Samantha"
  28. AU="Yano, Shuya"
  29. AU="Balaur, Eugeniu"
  30. AU="Ağaçfidan, Ali"
  31. AU="Perkins, James A."
  32. AU="Arkoun, Brahim"

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Treffer 1 - 10 von insgesamt 160

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  1. Artikel ; Online: PKIB, a Novel Target for Cancer Therapy.

    Musket, Anna / Moorman, Jonathan P / Zhang, Jinyu / Jiang, Yong

    International journal of molecular sciences

    2024  Band 25, Heft 9

    Abstract: The serine-threonine kinase protein kinase A (PKA) is a cyclic AMP (cAMP)-dependent intracellular protein with multiple roles in cellular biology including metabolic and transcription regulation functions. The cAMP-dependent protein kinase inhibitor β ( ... ...

    Abstract The serine-threonine kinase protein kinase A (PKA) is a cyclic AMP (cAMP)-dependent intracellular protein with multiple roles in cellular biology including metabolic and transcription regulation functions. The cAMP-dependent protein kinase inhibitor β (PKIB) is one of three known endogenous protein kinase inhibitors of PKA. The role of PKIB is not yet fully understood. Hormonal signaling is correlated with increased PKIB expression through genetic regulation, and increasing PKIB expression is associated with decreased cancer patient prognosis. Additionally, PKIB impacts cancer cell behavior through two mechanisms; the first is the nuclear modulation of transcriptional activation and the second is the regulation of oncogenic AKT signaling. The limited research into PKIB indicates the oncogenic potential of PKIB in various cancers. However, some studies suggest a role of PKIB in non-cancerous disease states. This review aims to summarize the current literature and background of PKIB regarding cancer and related issues. In particular, we will focus on cancer development and therapeutic possibilities, which are of paramount interest in PKIB oncology research.
    Mesh-Begriff(e) Animals ; Humans ; Antineoplastic Agents/therapeutic use ; Antineoplastic Agents/pharmacology ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Gene Expression Regulation, Neoplastic/drug effects ; Molecular Targeted Therapy/methods ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Neoplasms/genetics ; Protein Kinase Inhibitors/metabolism ; Signal Transduction/drug effects ; Intracellular Signaling Peptides and Proteins/metabolism
    Chemische Substanzen Antineoplastic Agents ; Cyclic AMP-Dependent Protein Kinases (EC 2.7.11.11) ; Protein Kinase Inhibitors ; PKIB protein, human ; Intracellular Signaling Peptides and Proteins
    Sprache Englisch
    Erscheinungsdatum 2024-04-25
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25094664
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Response to Moore and Colleagues.

    Loudon, Andrew M / Rushing, Amy P / Hue, Jonathan J / Moorman, Matthew L

    The journal of trauma and acute care surgery

    2023  Band 95, Heft 3, Seite(n) e21–e22

    Sprache Englisch
    Erscheinungsdatum 2023-04-30
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 2651070-4
    ISSN 2163-0763 ; 2163-0755
    ISSN (online) 2163-0763
    ISSN 2163-0755
    DOI 10.1097/TA.0000000000003986
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  3. Buch: Gantz's manual of clinical problems in infectious disease

    Myers, James W. / Moorman, Jonathan P. / Salgado, Cassandra D. / Gantz, Nelson Murray

    2013  

    Titelvarianten Manual of clinical problems in infectious disease
    Verfasserangabe James W. Myers ; Jonathan P. Moorman ; Cassandra D. Salgado
    Schlagwörter Communicable Diseases
    Sprache Englisch
    Umfang XV, 639 S. : Ill., graph. Darst.
    Ausgabenhinweis 6. ed.
    Verlag Wolters Kluwer Lippincott Williams & Wilkins
    Erscheinungsort Philadelphia u.a.
    Erscheinungsland Vereinigte Staaten
    Dokumenttyp Buch
    Anmerkung Includes bibliographical references and index
    Begleitmaterial Zugang zu zusätzlichem Internetmaterial über Code
    HBZ-ID HT017504361
    ISBN 978-1-4511-1697-7 ; 1-4511-1697-7
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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    2012 A 4841 bestellbar zur Ausleihe Magazin
    Zugang zu zusätzlichem Internetmaterial über Code aus lizenzrechtlichen Gründen nicht verfügbar

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  4. Artikel ; Online: The application of radionuclide therapy for breast cancer

    Anna Musket / Sandra Davern / Brianna M. Elam / Philip R. Musich / Jonathan P. Moorman / Yong Jiang

    Frontiers in Nuclear Medicine, Vol

    2024  Band 3

    Abstract: Radionuclide-mediated diagnosis and therapy have emerged as effective and low-risk approaches to treating breast cancer. Compared to traditional anatomic imaging techniques, diagnostic radionuclide-based molecular imaging systems exhibit much greater ... ...

    Abstract Radionuclide-mediated diagnosis and therapy have emerged as effective and low-risk approaches to treating breast cancer. Compared to traditional anatomic imaging techniques, diagnostic radionuclide-based molecular imaging systems exhibit much greater sensitivity and ability to precisely illustrate the biodistribution and metabolic processes from a functional perspective in breast cancer; this transitions diagnosis from an invasive visualization to a noninvasive visualization, potentially ensuring earlier diagnosis and on-time treatment. Radionuclide therapy is a newly developed modality for the treatment of breast cancer in which radionuclides are delivered to tumors and/or tumor-associated targets either directly or using delivery vehicles. Radionuclide therapy has been proven to be eminently effective and to exhibit low toxicity in eliminating both primary tumors and metastases, and even undetected tumors. In addition, the specific interaction between the surface modules of the delivery vehicles and the targets on the surface of tumor cells enables radionuclide targeting therapy, and this represents an exceptional potential for this treatment in breast cancer. This article reviews the development of radionuclide molecular imaging techniques that are currently employed for early breast cancer diagnosis and both the progress and challenges of radionuclide therapy employed in breast cancer treatment.
    Schlagwörter radionuclide ; early diagnosis ; breast cancer ; tumor ; therapy ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Thema/Rubrik (Code) 610 ; 616
    Sprache Englisch
    Erscheinungsdatum 2024-01-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Trained Immunity: An Overview and the Impact on COVID-19.

    Brueggeman, Justin M / Zhao, Juan / Schank, Madison / Yao, Zhi Q / Moorman, Jonathan P

    Frontiers in immunology

    2022  Band 13, Seite(n) 837524

    Abstract: Effectively treating infectious diseases often requires a multi-step approach to target different components involved in disease pathogenesis. Similarly, the COVID-19 pandemic has become a global health crisis that requires a comprehensive understanding ... ...

    Abstract Effectively treating infectious diseases often requires a multi-step approach to target different components involved in disease pathogenesis. Similarly, the COVID-19 pandemic has become a global health crisis that requires a comprehensive understanding of Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) infection to develop effective therapeutics. One potential strategy to instill greater immune protection against COVID-19 is boosting the innate immune system. This boosting, termed trained immunity, employs immune system modulators to train innate immune cells to produce an enhanced, non-specific immune response upon reactivation following exposure to pathogens, a process that has been studied in the context of
    Mesh-Begriff(e) COVID-19/immunology ; Humans ; Immunity, Innate/immunology ; Killer Cells, Natural/immunology ; Monocytes/immunology ; SARS-CoV-2/immunology
    Sprache Englisch
    Erscheinungsdatum 2022-02-17
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.837524
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: The Impact of HIV- and ART-Induced Mitochondrial Dysfunction in Cellular Senescence and Aging.

    Schank, Madison / Zhao, Juan / Moorman, Jonathan P / Yao, Zhi Q

    Cells

    2021  Band 10, Heft 1

    Abstract: According to the WHO, 38 million individuals were living with human immunodeficiency virus (HIV), 25.4 million of which were using antiretroviral therapy (ART) at the end of 2019. Despite ART-mediated suppression of viral replication, ART is not a cure ... ...

    Abstract According to the WHO, 38 million individuals were living with human immunodeficiency virus (HIV), 25.4 million of which were using antiretroviral therapy (ART) at the end of 2019. Despite ART-mediated suppression of viral replication, ART is not a cure and is associated with viral persistence, residual inflammation, and metabolic disturbances. Indeed, due to the presence of viral reservoirs, lifelong ART therapy is required to control viremia and prevent disease progression into acquired immune deficiency syndrome (AIDS). Successful ART treatment allows people living with HIV (PLHIV) to achieve a similar life expectancy to uninfected individuals. However, recent studies have illustrated the presence of increased comorbidities, such as accelerated, premature immune aging, in ART-controlled PLHIV compared to uninfected individuals. Studies suggest that both HIV-infection and ART-treatment lead to mitochondrial dysfunction, ultimately resulting in cellular exhaustion, senescence, and apoptosis. Since mitochondria are essential cellular organelles for energy homeostasis and cellular metabolism, their compromise leads to decreased oxidative phosphorylation (OXPHOS), ATP synthesis, gluconeogenesis, and beta-oxidation, abnormal cell homeostasis, increased oxidative stress, depolarization of the mitochondrial membrane potential, and upregulation of mitochondrial DNA mutations and cellular apoptosis. The progressive mitochondrial damage induced by HIV-infection and ART-treatment likely contributes to accelerated aging, senescence, and cellular dysfunction in PLHIV. This review discusses the connections between mitochondrial compromise and cellular dysfunction associated with HIV- and ART-induced toxicities, providing new insights into how HIV and current ART directly impact mitochondrial functions and contribute to cellular senescence and aging in PLHIV. Identifying this nexus and potential mechanisms may be beneficial in developing improved therapeutics for treating PLHIV.
    Mesh-Begriff(e) Acquired Immunodeficiency Syndrome/genetics ; Acquired Immunodeficiency Syndrome/metabolism ; Acquired Immunodeficiency Syndrome/pathology ; Aging/genetics ; Aging/metabolism ; Aging/pathology ; Apoptosis ; Cellular Senescence ; HIV-1/genetics ; HIV-1/metabolism ; Humans ; Mitochondria/genetics ; Mitochondria/metabolism ; Mitochondria/pathology ; Oxidative Phosphorylation
    Sprache Englisch
    Erscheinungsdatum 2021-01-16
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10010174
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  7. Artikel ; Online: The master antioxidant defense is activated during EBV latent infection.

    Wang, Ling / Howell, Mary E A / Hensley, Culton R / Ning, Katharine / Moorman, Jonathan P / Yao, Zhi Q / Ning, Shunbin

    Journal of virology

    2023  Band 97, Heft 11, Seite(n) e0095323

    Abstract: Importance: To our knowledge, this is the first report delineating the activation of the master antioxidant defense during EBV latency. We show that EBV-triggered reactive oxygen species production activates the Keap1-NRF2 pathway in EBV-transformed ... ...

    Abstract Importance: To our knowledge, this is the first report delineating the activation of the master antioxidant defense during EBV latency. We show that EBV-triggered reactive oxygen species production activates the Keap1-NRF2 pathway in EBV-transformed cells, and LMP1 plays a major role in this event, and the stress-related kinase TBK1 is required for NRF2 activation. Moreover, we show that the Keap1-NRF2 pathway is important for cell proliferation and EBV latency maintenance. Our findings disclose how EBV controls the balance between oxidative stress and antioxidant defense, which greatly improve our understanding of EBV latency and pathogenesis and may be leveraged to opportunities toward the improvement of therapeutic outcomes in EBV-associated diseases.
    Mesh-Begriff(e) Humans ; Antioxidants/metabolism ; Epstein-Barr Virus Infections/metabolism ; Epstein-Barr Virus Infections/virology ; Herpesvirus 4, Human/pathogenicity ; Herpesvirus 4, Human/physiology ; Kelch-Like ECH-Associated Protein 1/metabolism ; Latent Infection/metabolism ; Latent Infection/virology ; NF-E2-Related Factor 2/metabolism ; Oxidative Stress ; Reactive Oxygen Species/metabolism ; Cell Proliferation ; Virus Latency
    Chemische Substanzen Antioxidants ; Kelch-Like ECH-Associated Protein 1 ; NF-E2-Related Factor 2 ; Reactive Oxygen Species ; KEAP1 protein, human ; NFE2L2 protein, human ; TBK1 protein, human (EC 2.7.11.1) ; EBV-associated membrane antigen, Epstein-Barr virus
    Sprache Englisch
    Erscheinungsdatum 2023-10-25
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/jvi.00953-23
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 609: Hefte anzeigen Standort:
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  8. Artikel ; Online: The Impact of HIV- and ART-Induced Mitochondrial Dysfunction in Cellular Senescence and Aging

    Madison Schank / Juan Zhao / Jonathan P. Moorman / Zhi Q. Yao

    Cells, Vol 10, Iss 174, p

    2021  Band 174

    Abstract: According to the WHO, 38 million individuals were living with human immunodeficiency virus (HIV), 25.4 million of which were using antiretroviral therapy (ART) at the end of 2019. Despite ART-mediated suppression of viral replication, ART is not a cure ... ...

    Abstract According to the WHO, 38 million individuals were living with human immunodeficiency virus (HIV), 25.4 million of which were using antiretroviral therapy (ART) at the end of 2019. Despite ART-mediated suppression of viral replication, ART is not a cure and is associated with viral persistence, residual inflammation, and metabolic disturbances. Indeed, due to the presence of viral reservoirs, lifelong ART therapy is required to control viremia and prevent disease progression into acquired immune deficiency syndrome (AIDS). Successful ART treatment allows people living with HIV (PLHIV) to achieve a similar life expectancy to uninfected individuals. However, recent studies have illustrated the presence of increased comorbidities, such as accelerated, premature immune aging, in ART-controlled PLHIV compared to uninfected individuals. Studies suggest that both HIV-infection and ART-treatment lead to mitochondrial dysfunction, ultimately resulting in cellular exhaustion, senescence, and apoptosis. Since mitochondria are essential cellular organelles for energy homeostasis and cellular metabolism, their compromise leads to decreased oxidative phosphorylation (OXPHOS), ATP synthesis, gluconeogenesis, and beta-oxidation, abnormal cell homeostasis, increased oxidative stress, depolarization of the mitochondrial membrane potential, and upregulation of mitochondrial DNA mutations and cellular apoptosis. The progressive mitochondrial damage induced by HIV-infection and ART-treatment likely contributes to accelerated aging, senescence, and cellular dysfunction in PLHIV. This review discusses the connections between mitochondrial compromise and cellular dysfunction associated with HIV- and ART-induced toxicities, providing new insights into how HIV and current ART directly impact mitochondrial functions and contribute to cellular senescence and aging in PLHIV. Identifying this nexus and potential mechanisms may be beneficial in developing improved therapeutics for treating PLHIV.
    Schlagwörter HIV ; ART ; mitochondria ; mtDNA ; ROS ; cellular dysfunction ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 700
    Sprache Englisch
    Erscheinungsdatum 2021-01-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: HIV-1 Latency and Viral Reservoirs: Existing Reversal Approaches and Potential Technologies, Targets, and Pathways Involved in HIV Latency Studies.

    Khanal, Sushant / Schank, Madison / El Gazzar, Mohamed / Moorman, Jonathan P / Yao, Zhi Q

    Cells

    2021  Band 10, Heft 2

    Abstract: Eradication of latent human immunodeficiency virus (HIV) infection is a global health challenge. Reactivation of HIV latency and killing of virus-infected cells, the so-called "kick and kill" or "shock and kill" approaches, are a popular strategy for HIV ...

    Abstract Eradication of latent human immunodeficiency virus (HIV) infection is a global health challenge. Reactivation of HIV latency and killing of virus-infected cells, the so-called "kick and kill" or "shock and kill" approaches, are a popular strategy for HIV cure. While antiretroviral therapy (ART) halts HIV replication by targeting multiple steps in the HIV life cycle, including viral entry, integration, replication, and production, it cannot get rid of the occult provirus incorporated into the host-cell genome. These latent proviruses are replication-competent and can rebound in cases of ART interruption or cessation. In general, a very small population of cells harbor provirus, serve as reservoirs in ART-controlled HIV subjects, and are capable of expressing little to no HIV RNA or proteins. Beyond the canonical resting memory CD4
    Mesh-Begriff(e) Animals ; Apoptosis ; Disease Reservoirs/virology ; HIV Infections/virology ; HIV-1/physiology ; Humans ; Models, Biological ; Virus Latency/physiology
    Sprache Englisch
    Erscheinungsdatum 2021-02-23
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10020475
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  10. Artikel ; Online: When is enough enough? Odds of survival by unit transfused.

    Loudon, Andrew M / Rushing, Amy P / Hue, Jonathan J / Ziemak, Alison / Sarode, Anuja L / Moorman, Matthew L

    The journal of trauma and acute care surgery

    2022  Band 94, Heft 2, Seite(n) 205–211

    Abstract: ... increased with unit transfused (16% transfused vs. 36% massive transfusion, p = 0.003; 36% massive ... transfusion vs. 67% ultramassive transfusion, p = 0.006).: Conclusion: Mortality increases with each unit ...

    Abstract Background: Balanced transfusion is lifesaving for hemorrhagic shock. The American Red Cross critical blood shortage in 2022 threatened the immediate availability of blood. To eliminate waste, we reviewed the utility of transfusions per unit to define expected mortality at various levels of balanced transfusion.
    Methods: A retrospective study of 296 patients receiving massive transfusion on presentation at a level 1 trauma center was performed from January 2018 to December 2021. Units of packed red blood cells (PRBCs), fresh frozen plasma (FFP), and platelets received in the first 4 hours were recorded. Patients were excluded if they died in the emergency department, died on arrival, received <2 U PRBCs or FFP, or received PRBC/FFP >2:1. Primary outcomes were mortality and odds of survival to discharge. Subgroups were defined as transfused if receiving 2 to 9 U PRBCs, massive transfusion for 10 to 19 U PRBCs, and ultramassive transfusion for ≥20 U PRBCs.
    Results: A total of 207 patients were included (median age, 32 years; median Injury Severity Score, 25; 67% with penetrating mechanism). Mortality was 29% (61 of 207 patients). Odds of survival is equal to odds of mortality at 11 U PRBCs (odds ratio [OR], 0.95; 95% confidence interval [CI], 0.50-1.79). Beyond 16 U PRBCs, odds of mortality exceed survival (OR, 0.36; 95% CI, 0.16-0.82). Survival approaches zero >36 U PRBCs (OR, 0.09; 95% CI, 0.00-0.56). Subgroup mortality rates increased with unit transfused (16% transfused vs. 36% massive transfusion, p = 0.003; 36% massive transfusion vs. 67% ultramassive transfusion, p = 0.006).
    Conclusion: Mortality increases with each unit balanced transfusion. Surgeons should view efforts heroic beyond 16 U PRBCs/4 hours and near futile beyond 36 U PRBCs/4 hours. While extreme outliers can survive, consider cessation of resuscitation beyond 36 U PRBCs. This is especially true if hemostasis has not been achieved or blood supplies are limited.
    Level of evidence: Prognostic and Epidemiologic; Level IV.
    Mesh-Begriff(e) Humans ; Adult ; Blood Component Transfusion ; Erythrocyte Transfusion ; Retrospective Studies ; Blood Transfusion ; Shock, Hemorrhagic/therapy ; Resuscitation ; Wounds and Injuries/therapy
    Sprache Englisch
    Erscheinungsdatum 2022-11-10
    Erscheinungsland United States
    Dokumenttyp Review ; Journal Article
    ZDB-ID 2651070-4
    ISSN 2163-0763 ; 2163-0755
    ISSN (online) 2163-0763
    ISSN 2163-0755
    DOI 10.1097/TA.0000000000003835
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

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