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  1. Article: The Potential of Plants to Absorb Xenobiotics.

    Capozzi, Fiore / Spagnuolo, Valeria

    Plants (Basel, Switzerland)

    2024  Volume 13, Issue 7

    Abstract: Environmental pollution is a pressing problem that endangers our biosphere [ ... ]. ...

    Abstract Environmental pollution is a pressing problem that endangers our biosphere [...].
    Language English
    Publishing date 2024-03-22
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants13070922
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Marginal Leakage of Class V Composite Restorations Assessed Using Microcomputed Tomography and Scanning Electron Microscope.

    Rengo, C / Goracci, C / Ametrano, G / Chieffi, N / Spagnuolo, G / Rengo, S / Ferrari, M

    Operative dentistry

    2015  Volume 40, Issue 4, Page(s) 440–448

    Abstract: Objective: The aim of the study was to compare in Class V composite restorations marginal leakage ... observations.: Methods: Class V cavities were prepared on 10 human molars and restored using Optibond FL ...

    Abstract Objective: The aim of the study was to compare in Class V composite restorations marginal leakage measurements obtained with microcomputed tomography (micro-CT) and scanning electron microscopy (SEM) observations.
    Methods: Class V cavities were prepared on 10 human molars and restored using Optibond FL (Kerr, Orange, CA, USA) and Premise Flowable (Kerr). Sealing ability was evaluated by assessing silver-nitrate penetration depth along enamel and dentin margins. Leakage was quantified using a scoring system. Micro-CT analysis provided 502 cross-sectional images for each tooth. Microleakage evaluation was performed first on three cross-sections corresponding to the sections examined by SEM, then on all 502 of the obtained micro-CT images. SEM observations were performed first at 20× magnification, then, if showing a zero score, at 80× magnification. Enamel and dentin microleakage scores assigned to corresponding sections through micro-CT and SEM (20×) were compared (Wilcoxon signed-rank test, α=0.05).
    Results: No statistically significant difference in leakage scores emerged between micro-CT and 20×-magnification SEM. Eight tooth sections that were given a zero score under SEM at 20× magnification showed to be infiltrated at the higher magnification (80×). For five teeth a higher score was assigned following scanning of 502 cross-sections than based on the observation of three sections.
    Conclusions: Micro-CT presents as a valid, nondestructive in vitro method to quantitatively evaluate marginal leakage of adhesive restorations.
    MeSH term(s) Composite Resins ; Dental Caries/therapy ; Dental Cavity Preparation ; Dental Enamel ; Dental Leakage/diagnostic imaging ; Dental Marginal Adaptation ; Dental Restoration, Permanent ; Dentin ; Humans ; Microscopy, Electron, Scanning ; Molar/anatomy & histology ; Molar/diagnostic imaging ; Resin Cements ; X-Ray Microtomography
    Chemical Substances Composite Resins ; OptiBond FL ; Resin Cements
    Language English
    Publishing date 2015-01-20
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 752995-8
    ISSN 1559-2863 ; 0361-7734
    ISSN (online) 1559-2863
    ISSN 0361-7734
    DOI 10.2341/14-022-L
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1963: Show issues Location:
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  3. Article ; Online: Problematizing “ethical eating”: the role of policy in an ethical food system

    Spagnuolo, Daniela

    Food, Culture & Society. 2022 Oct. 20, v. 25, no. 5 p.934-952

    2022  

    Abstract: The concept of “ethical eating” has become prominent within public discourse. It refers to a form of ethical consumption whereby consumers can feel that they have directly impacted the food system through their food choices. However, the terms and ... ...

    Abstract The concept of “ethical eating” has become prominent within public discourse. It refers to a form of ethical consumption whereby consumers can feel that they have directly impacted the food system through their food choices. However, the terms and practices often used to define “ethical eating” are incomplete and exclude other ethical issues within the food system that are more complex and have less clear solutions than those offered through ethical consumption. Through a content analysis of 100 newspaper and magazine articles discussing the practice of “ethical eating,” as well as a review of literature on this topic, this article argues that issues within the food system cannot be solved through ethical consumption alone. Instead, there must be an increased role for public policy to address ethical concerns within the food system. Through examining organic, meat-avoidant, fair trade, and local diets as the most frequently mentioned terms associated with “ethical eating,” three case studies are presented highlighting the tensions associated with access to eating ethically, Indigenous food sovereignty, and production of ethical food. This paper argues that addressing these ethical issues requires public policy to tackle the root causes and ensure all are served within the food system.
    Keywords ethics ; food sovereignty ; public policy ; Ethical eating ; organic ; food insecurity ; plant-based ; Indigenous ; fair trade ; local food
    Language English
    Dates of publication 2022-1020
    Size p. 934-952.
    Publishing place Routledge
    Document type Article ; Online
    ZDB-ID 2240542-2
    ISSN 1751-7443 ; 1552-8014
    ISSN (online) 1751-7443
    ISSN 1552-8014
    DOI 10.1080/15528014.2021.1939960
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  4. Article: Phytomonitoring and Phytoremediation of Environmental Pollutants.

    Sorrentino, Maria Cristina / Giordano, Simonetta / Spagnuolo, Valeria

    Plants (Basel, Switzerland)

    2024  Volume 13, Issue 3

    Abstract: Since 1973, with the activation of the Environmental Action Program (EAP), the European Union has produced a substantial body of legislative packages aimed at improving the environmental quality; as a result, air, water, and soil pollution have ... ...

    Abstract Since 1973, with the activation of the Environmental Action Program (EAP), the European Union has produced a substantial body of legislative packages aimed at improving the environmental quality; as a result, air, water, and soil pollution have significantly been reduced, as stated by the European Commission in the EAP 2020 [...].
    Language English
    Publishing date 2024-01-26
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants13030366
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  5. Article: Bioactive Compounds from Curcuma amada and Their Effect on Acute Myeloid Leukemia.

    Chandran, Ajila / Jayasankar, Varsha / Spagnuolo, Paul / Subramanian, Jayasankar

    Critical reviews in oncogenesis

    2023  Volume 27, Issue 3, Page(s) 23–31

    Abstract: Acute myeloid leukemia (AML) is an aggressive blood cancer with limited chemotherapy options and negative patient outcomes. Investigations with bioactive compounds from dietary sources against cancer have increased in the recent years, which highlight ... ...

    Abstract Acute myeloid leukemia (AML) is an aggressive blood cancer with limited chemotherapy options and negative patient outcomes. Investigations with bioactive compounds from dietary sources against cancer have increased in the recent years, which highlight the need for novel therapeutic approaches and new anti-leukemic agents possessing higher efficacy and selectivity for AML cells and fewer negative side effects. Bioactive compounds demonstrated the ability to induce cell cycle blockage and apoptosis or autophagy in cancer cells, as well as inhibition of proliferation/migration and tumor progression, etc. Bioactive compounds isolated from dietary sources such as mango ginger show promise for AML treatment. Curcuma amada roots have been used in traditional medicine and showed antioxidant, antimicrobial and anticancer properties. Bioactive molecules isolated from C. amada showed effects on the mitochondrial metabolism and reduced the viability of multiple leukemic cell lines.
    MeSH term(s) Humans ; Curcuma ; Leukemia, Myeloid, Acute/drug therapy ; Apoptosis
    Language English
    Publishing date 2023-05-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1036388-9
    ISSN 0893-9675
    ISSN 0893-9675
    DOI 10.1615/CritRevOncog.2023047542
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2587: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Efficacy and Safety Profile of Fostemsavir for the Treatment of People with Human Immunodeficiency Virus-1 (HIV-1): Current Evidence and Place in Therapy.

    Muccini, Camilla / Canetti, Diana / Castagna, Antonella / Spagnuolo, Vincenzo

    Drug design, development and therapy

    2022  Volume 16, Page(s) 297–304

    Abstract: Heavily-treatment-experienced people living with human immunodeficiency virus (HTE-PLWH) represent a population with limited therapeutic options and at high-risk of clinical progression, morbidity, and mortality. The development of new drugs and new drug ...

    Abstract Heavily-treatment-experienced people living with human immunodeficiency virus (HTE-PLWH) represent a population with limited therapeutic options and at high-risk of clinical progression, morbidity, and mortality. The development of new drugs and new drug classes for the treatment of HIV-1 infection in HTE-PLWH is critical to successfully suppress HIV-1 replication, restore the immune system, and improve quality of life. Fostemsavir is the first attachment inhibitor approved by Food and Drug Administration and European Medicines Agency for the treatment of HIV-1 infection. It is approved in combination with other antiretrovirals, for HTE-PLWH with multi-drug resistant HIV-1 after failing their current antiretroviral regimen due to resistance, intolerance, or safety considerations. In this review, we present and discuss the mechanism of action, the pharmacodynamic and pharmacokinetic properties, and the efficacy and safety of fostemsavir as an antiretroviral agent for the treatment of HIV-1 infection.
    MeSH term(s) Anti-HIV Agents/therapeutic use ; HIV Infections/drug therapy ; HIV-1/drug effects ; Humans ; Organophosphates/therapeutic use ; Piperazines/therapeutic use
    Chemical Substances Anti-HIV Agents ; Organophosphates ; Piperazines ; fostemsavir (97IQ273H4L)
    Language English
    Publishing date 2022-01-25
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2451346-5
    ISSN 1177-8881 ; 1177-8881
    ISSN (online) 1177-8881
    ISSN 1177-8881
    DOI 10.2147/DDDT.S273660
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: An evaluation of cabotegravir for HIV treatment and prevention.

    Canetti, Diana / Spagnuolo, Vincenzo

    Expert opinion on pharmacotherapy

    2020  Volume 22, Issue 4, Page(s) 403–414

    Abstract: ... ...

    Abstract Introduction
    MeSH term(s) Anti-HIV Agents/administration & dosage ; Drug Interactions ; HIV Infections/drug therapy ; Humans ; Pre-Exposure Prophylaxis ; Pyridones/administration & dosage ; Rilpivirine/administration & dosage
    Chemical Substances Anti-HIV Agents ; Pyridones ; Rilpivirine (FI96A8X663) ; cabotegravir (HMH0132Z1Q)
    Language English
    Publishing date 2020-11-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2001535-5
    ISSN 1744-7666 ; 1465-6566
    ISSN (online) 1744-7666
    ISSN 1465-6566
    DOI 10.1080/14656566.2020.1843635
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5130: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  8. Article ; Online: Interactions Between Nutraceutical Supplements and Standard Acute Myeloid Leukemia Chemotherapeutics.

    Spagnuolo, Paul

    Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    2015  Volume 18, Issue 4, Page(s) 339–343

    Abstract: ... KG1a and U937) using the MTS viability assay. Lead compounds were validated using with the Annexin V ...

    Abstract Purpose: Concomitant use of nutraceuticals with chemotherapy is very common. Cancer patients self-medicate to relieve the side effects associated with chemotherapy, improve disease outcome and to regain control of their medical care. However, there is limited empirical evidence on potential drug-nutraceutical interactions and their resulting effect on chemotherapy efficacy.
    Method: To investigate drug-nutraceutical interactions we created and screened a library of commonly used nutraceuticals for their modulatory effects on the activity of cytarabine and daunorubicin, two primary chemotherapeutics used to treat acute myeloid leukemia (AML). Combination screening was performed in 3 AML cell lines (OCI-AML2, KG1a and U937) using the MTS viability assay. Lead compounds were validated using with the Annexin V/ Propidium iodide assay and CalcuSyn drug combination software.
    Results: We identified zinc as a nutraceutical that enhanced AML chemotherapy efficacy with combination index (CI) values of 0.649, 0.632 and 0.615 at EC 25, 50 and 75, respectively; CI values <0.9, >1.1 or between 0.9-1.1 denote statistical synergy, antagonism or additivity, respectively. In contrast, we show that echinacea hindered AML chemotherapy efficacy by significantly reducing the ability of cytarabine to induce cell death.
    Conclusion: Given the positive and negative effects of nutraceuticals, patients undergoing chemotherapy must consult with their oncologist before consuming over-the-counter supplements. This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page.
    MeSH term(s) Antineoplastic Agents/pharmacology ; Cell Death/drug effects ; Cell Line, Tumor ; Cytarabine/pharmacology ; Daunorubicin/pharmacology ; Dietary Supplements ; Drug Interactions ; Humans ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/pathology ; U937 Cells
    Chemical Substances Antineoplastic Agents ; Cytarabine (04079A1RDZ) ; Daunorubicin (ZS7284E0ZP)
    Language English
    Publishing date 2015-11-27
    Publishing country Canada
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1482-1826
    ISSN (online) 1482-1826
    DOI 10.18433/j3m30k
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Assessment and Remediation of Soils Contaminated by Potentially Toxic Elements (PTE)

    Spagnuolo, Matteo / Adamo, Paola / Garau, Giovanni

    Soil systems. 2022 June 15, v. 6, no. 2

    2022  

    Abstract: Potentially toxic elements (PTE) can cause significant damage to the environment and human health in the functions of mobility and bioavailability [ ... ] ...

    Abstract Potentially toxic elements (PTE) can cause significant damage to the environment and human health in the functions of mobility and bioavailability [...]
    Keywords bioavailability ; environmental degradation ; human health ; remediation ; toxicity
    Language English
    Dates of publication 2022-0615
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ISSN 2571-8789
    DOI 10.3390/soilsystems6020055
    Database NAL-Catalogue (AGRICOLA)

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  10. Article: Decoding family‐level features for modern and fossil leaves from computer‐vision heat maps

    Spagnuolo, Edward J. / Wilf, Peter / Serre, Thomas

    American journal of botany. 2022 May, v. 109, no. 5

    2022  

    Abstract: PREMISE: Angiosperm leaves present a classic identification problem due to their morphological complexity. Computer‐vision algorithms can identify diagnostic regions in images, and heat map outputs illustrate those regions for identification, providing ... ...

    Abstract PREMISE: Angiosperm leaves present a classic identification problem due to their morphological complexity. Computer‐vision algorithms can identify diagnostic regions in images, and heat map outputs illustrate those regions for identification, providing novel insights through visual feedback. We investigate the potential of analyzing leaf heat maps to reveal novel, human‐friendly botanical information with applications for extant‐ and fossil‐leaf identification. METHODS: We developed a manual scoring system for hotspot locations on published computer‐vision heat maps of cleared leaves that showed diagnostic regions for family identification. Heat maps of 3114 cleared leaves of 930 genera in 14 angiosperm families were analyzed. The top‐5 and top‐1 hotspot regions of highest diagnostic value were scored for 21 leaf locations. The resulting data were viewed using box plots and analyzed using cluster and principal component analyses. We manually identified similar features in fossil leaves to informally demonstrate potential fossil applications. RESULTS: The method successfully mapped machine strategy using standard botanical language, and distinctive patterns emerged for each family. Hotspots were concentrated on secondary veins (Salicaceae, Myrtaceae, Anacardiaceae), tooth apices (Betulaceae, Rosaceae), and on the little‐studied margins of untoothed leaves (Rubiaceae, Annonaceae, Ericaceae). Similar features drove the results from multivariate analyses. The results echo many traditional observations, while also showing that most diagnostic leaf features remain undescribed. CONCLUSIONS: Machine‐derived heat maps that initially appear to be dominated by noise can be translated into human‐interpretable knowledge, highlighting paths forward for botanists and paleobotanists to discover new diagnostic botanical characters.
    Keywords Anacardiaceae ; Annonaceae ; Betulaceae ; Ericaceae ; Myrtaceae ; Rosaceae ; Rubiaceae ; Salicaceae ; disease diagnosis ; heat ; leaves
    Language English
    Dates of publication 2022-05
    Size p. 768-788.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 2935-x
    ISSN 1537-2197 ; 0002-9122
    ISSN (online) 1537-2197
    ISSN 0002-9122
    DOI 10.1002/ajb2.1842
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    In stock of ZB MED Bonn / Germany

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