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  1. Book ; Online ; E-Book: Bats and viruses

    Corrales-Aguilar, Eugenia / Schwemmle, Martin

    current research and future trends

    2020  

    Author's details edited by Eugenia Corrales-Aguilar and Martin Schwemmle
    Keywords Bats as carriers of disease ; Electronic books
    Language English
    Size 1 Online-Ressource (iv, 224 Seiten), Illustrationen, Diagramme
    Publisher Caister Academic Press
    Publishing place Norfolk
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020905850
    ISBN 978-1-912530-15-1 ; 9781912530144 ; 1-912530-15-5 ; 1912530147
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Advocating a watch-and-prepare approach with avian influenza.

    Ciminski, Kevin / Chase, Geoffrey / Schwemmle, Martin / Beer, Martin

    Nature microbiology

    2023  Volume 8, Issue 9, Page(s) 1603–1605

    MeSH term(s) Animals ; Influenza in Birds/prevention & control
    Language English
    Publishing date 2023-08-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2058-5276
    ISSN (online) 2058-5276
    DOI 10.1038/s41564-023-01457-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Anti-influenza A virus restriction factors that shape the human species barrier and virus evolution.

    Petric, Philipp Peter / Schwemmle, Martin / Graf, Laura

    PLoS pathogens

    2023  Volume 19, Issue 7, Page(s) e1011450

    MeSH term(s) Humans ; Influenza, Human ; Host-Pathogen Interactions ; Evolution, Molecular
    Language English
    Publishing date 2023-07-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7374
    ISSN (online) 1553-7374
    ISSN 1553-7374
    DOI 10.1371/journal.ppat.1011450
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Bat-Borne Influenza A Viruses: An Awakening.

    Ciminski, Kevin / Schwemmle, Martin

    Cold Spring Harbor perspectives in medicine

    2021  Volume 11, Issue 2

    Abstract: Influenza A viruses (IAVs) originating from aquatic waterfowl recurrently cross interspecies barriers, which is greatly facilitated by utilizing cell surface-exposed monosaccharide sialic acids located on vertebrate cells as a universal host cell ... ...

    Abstract Influenza A viruses (IAVs) originating from aquatic waterfowl recurrently cross interspecies barriers, which is greatly facilitated by utilizing cell surface-exposed monosaccharide sialic acids located on vertebrate cells as a universal host cell receptor. These glycan structures are first bound by the viral hemagglutinin (HA) for cell entry and then cleaved by the viral neuraminidase (NA) for particle release. In contrast, viruses of the recently identified bat-borne IAV subtypes H17N10 and H18N11 encode HA and NA homologs unable to interact with sialic acid residues despite a high degree of structural homology with their conventional counterparts. However, the most recent findings show that bat IAV HAs make use of the major histocompatibility complex class II proteins of different vertebrate species to gain entry into host cells, potentially permitting a broader host tropism. This review recapitulates current progress in the field of bat IAV research including the first assessment of the spillover potential of these bat viruses into other mammals.
    MeSH term(s) Animals ; Chiroptera/virology ; Humans ; Influenza A virus/metabolism ; Viral Tropism ; Viral Zoonoses ; Virus Replication
    Language English
    Publishing date 2021-02-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 2157-1422
    ISSN (online) 2157-1422
    DOI 10.1101/cshperspect.a038612
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Advocating a watch-and-prepare approach with avian influenza

    Ciminski, Kevin / Chase, Geoffrey / Schwemmle, Martin / Beer, Martin

    2023  

    Abstract: The global outbreak of H5N1 highly pathogenic avian influenza virus and its high toll on animal populations raise concerns about spillover into humans, but human host barriers need to be considered when estimating transmission potential. ...

    Abstract The global outbreak of H5N1 highly pathogenic avian influenza virus and its high toll on animal populations raise concerns about spillover into humans, but human host barriers need to be considered when estimating transmission potential.
    Keywords Text ; ddc:630
    Language English
    Publishing date 2023-08-28
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Anti-influenza A virus restriction factors that shape the human species barrier and virus evolution.

    Philipp Peter Petric / Martin Schwemmle / Laura Graf

    PLoS Pathogens, Vol 19, Iss 7, p e

    2023  Volume 1011450

    Keywords Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Reverse Genetics of Bat Influenza A Viruses.

    Kessler, Susanne / García-Sastre, Adolfo / Schwemmle, Martin / Ciminski, Kevin

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2733, Page(s) 75–86

    Abstract: New World fruit bats were recently found to harbor two distinct and previously unknown influenza A viruses (IAVs) of the subtypes H17N10 and H18N11. Although viral genome sequences were detected in the liver, intestine, lung, and kidney of infected bats ... ...

    Abstract New World fruit bats were recently found to harbor two distinct and previously unknown influenza A viruses (IAVs) of the subtypes H17N10 and H18N11. Although viral genome sequences were detected in the liver, intestine, lung, and kidney of infected bats and the complete genome sequences have been isolated from their rectal swab samples, all attempts to isolate an infectious virus from bats in nature have failed. The lack of an infectious bat IAV isolate was overcome by reverse genetic approaches that led to the generation of an infectious virus in vitro. Using such synthetic bat IAVs enabled the identification of their unconventional cell entry via major histocompatibility complex II (MCH-II) molecules and their ability to replicate in mice, ferrets, and bats. Importantly, we also showed that these synthetic recombinant bat IAVs are not able to reassort with conventional IAVs, preventing the acquisition of enhanced transmission properties in non-bat species by reassortment with conventional IAVs. As authentic viruses are key for understanding the molecular biology of bat IAVs, in this chapter, we describe our recently established reverse genetics protocol for generating H17N10 and H18N11 in vitro. This step-by-step protocol starts with cloning of cDNA copies of the viral RNA segments into reverse genetics plasmids, followed by the generation of a highly concentrated stock and finally a method to determine viral titers.
    MeSH term(s) Animals ; Mice ; Influenza A virus/genetics ; Chiroptera ; Orthomyxoviridae Infections ; Reverse Genetics ; Ferrets/genetics
    Language English
    Publishing date 2023-12-08
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3533-9_5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Different but Not Unique: Deciphering the Immunity of the Jamaican Fruit Bat by Studying Its Viriome.

    David, Quinnlan / Schountz, Tony / Schwemmle, Martin / Ciminski, Kevin

    Viruses

    2022  Volume 14, Issue 2

    Abstract: A specialized and fine-tuned immune response of bats upon infection with viruses is believed to provide the basis for a "friendly" coexistence with these pathogens, which are often lethal for humans and other mammals. First insights into the immunity of ... ...

    Abstract A specialized and fine-tuned immune response of bats upon infection with viruses is believed to provide the basis for a "friendly" coexistence with these pathogens, which are often lethal for humans and other mammals. First insights into the immunity of bats suggest that bats have evolved to possess their own strategies to cope with viral infections. Yet, the molecular details for this innocuous coexistence remain poorly described and bat infection models are the key to unveiling these secrets. In Jamaican fruit bats
    MeSH term(s) Adaptive Immunity ; Animals ; Arenaviridae Infections/immunology ; Arenaviridae Infections/veterinary ; Arenaviridae Infections/virology ; Arenaviruses, New World/isolation & purification ; Chiroptera/immunology ; Chiroptera/virology ; Immunity, Innate ; Influenza A virus/isolation & purification ; Orthomyxoviridae Infections/immunology ; Orthomyxoviridae Infections/veterinary ; Rabies/immunology ; Rabies/veterinary ; Rabies/virology ; Rabies virus/isolation & purification ; Virome ; Virus Diseases/immunology ; Virus Diseases/veterinary
    Language English
    Publishing date 2022-01-25
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14020238
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Bats reveal the true power of influenza A virus adaptability.

    Ciminski, Kevin / Pfaff, Florian / Beer, Martin / Schwemmle, Martin

    PLoS pathogens

    2020  Volume 16, Issue 4, Page(s) e1008384

    MeSH term(s) Adaptation, Biological ; Animals ; Chiroptera/virology ; Disease Reservoirs/virology ; Evolution, Molecular ; Humans ; Influenza A virus/pathogenicity ; Influenza, Human/epidemiology ; Influenza, Human/virology ; Orthomyxoviridae Infections/epidemiology ; Orthomyxoviridae Infections/veterinary ; Orthomyxoviridae Infections/virology ; Selection, Genetic ; Viral Proteins/metabolism
    Chemical Substances Viral Proteins
    Keywords covid19
    Language English
    Publishing date 2020-04-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7366
    ISSN (online) 1553-7374
    ISSN 1553-7366
    DOI 10.1371/journal.ppat.1008384
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Functionality of IAV packaging signals depends on site-specific charges within the viral nucleoprotein.

    Ciminski, Kevin / Flore, Viktoria / Jakob, Celia / Mues, Helen / Smedegaard Frederiksen, Anne / Schwemmle, Martin / Bolte, Hardin / Giese, Sebastian

    Journal of virology

    2024  Volume 98, Issue 4, Page(s) e0197223

    Abstract: The coordinated packaging of the segmented genome of the influenza A virus (IAV) into virions is an essential step of the viral life cycle. This process is controlled by the interaction of packaging signals present in all eight viral RNA (vRNA) segments ... ...

    Abstract The coordinated packaging of the segmented genome of the influenza A virus (IAV) into virions is an essential step of the viral life cycle. This process is controlled by the interaction of packaging signals present in all eight viral RNA (vRNA) segments and the viral nucleoprotein (NP), which binds vRNA via a positively charged binding groove. However, mechanistic models of how the packaging signals and NP work together to coordinate genome packaging are missing. Here, we studied genome packaging in influenza A/SC35M virus mutants that carry mutated packaging signals as well as specific amino acid substitutions at the highly conserved lysine (K) residues 184 and 229 in the RNA-binding groove of NP. Because these lysines are acetylated and thus neutrally charged in infected host cells, we replaced them with glutamine to mimic the acetylated, neutrally charged state or arginine to mimic the non-acetylated, positively charged state. Our analysis shows that the coordinated packaging of eight vRNAs is influenced by (i) the charge state of the replacing amino acid and (ii) its location within the RNA-binding groove. Accordingly, we propose that lysine acetylation induces different charge states within the RNA-binding groove of NP, thereby supporting the activity of specific packaging signals during coordinated genome packaging.
    Importance: Influenza A viruses (IAVs) have a segmented viral RNA (vRNA) genome encapsidated by multiple copies of the viral nucleoprotein (NP) and organized into eight distinct viral ribonucleoprotein complexes. Although genome segmentation contributes significantly to viral evolution and adaptation, it requires a highly sophisticated genome-packaging mechanism. How eight distinct genome complexes are incorporated into the virion is poorly understood, but previous research suggests an essential role for both vRNA packaging signals and highly conserved NP amino acids. By demonstrating that the packaging process is controlled by charge-dependent interactions of highly conserved lysine residues in NP and vRNA packaging signals, our study provides new insights into the sophisticated packaging mechanism of IAVs.
    MeSH term(s) Influenza A virus/genetics ; Influenza A virus/metabolism ; Nucleoproteins/genetics ; Nucleoproteins/metabolism ; Lysine/genetics ; Virus Assembly/genetics ; Genome, Viral ; Amino Acids/genetics ; Nucleocapsid Proteins/genetics ; RNA, Viral/metabolism
    Chemical Substances Nucleoproteins ; Lysine (K3Z4F929H6) ; Amino Acids ; Nucleocapsid Proteins ; RNA, Viral
    Language English
    Publishing date 2024-03-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/jvi.01972-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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