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Article ; Online: Rbp4-Gal4, a germline driver that activates in meiosis, reveals functions for VCP in spermatid development.

Butsch, Tyler J / Johnson, Alyssa E / Bohnert, K Adam

Fly

2023 Volume 17, Issue 1, Page(s) 2234795

Abstract: Valosin-containing protein (VCP) is a versatile and ubiquitously expressed AAA+ ATPase that regulates multiple stages ... ...

Abstract	Valosin-containing protein (VCP) is a versatile and ubiquitously expressed AAA+ ATPase that regulates multiple stages of
MeSH term(s)	Male ; Animals ; Spermatids/physiology ; Valosin Containing Protein/genetics ; Spermatogenesis/genetics ; Meiosis ; Drosophila/genetics ; Chromatin
Chemical Substances	Valosin Containing Protein (EC 3.6.4.6) ; Chromatin
Language	English
Publishing date	2023-07-06
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	1933-6942
ISSN (online)	1933-6942
DOI	10.1080/19336934.2023.2234795
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Article ; Online: Predicting Redox Conditions in Groundwater at a National Scale Using Random Forest Classification.

Tesoriero, Anthony J / Wherry, Susan A / Dupuy, Danielle I / Johnson, Tyler D

Environmental science & technology

2024 Volume 58, Issue 11, Page(s) 5079–5092

Abstract: Redox conditions in groundwater may markedly affect the fate and transport of nutrients, volatile organic compounds, and trace metals, with significant implications for human health. While many local assessments of redox conditions have been made, the ... ...

Abstract	Redox conditions in groundwater may markedly affect the fate and transport of nutrients, volatile organic compounds, and trace metals, with significant implications for human health. While many local assessments of redox conditions have been made, the spatial variability of redox reaction rates makes the determination of redox conditions at regional or national scales problematic. In this study, redox conditions in groundwater were predicted for the contiguous United States using random forest classification by relating measured water quality data from over 30,000 wells to natural and anthropogenic factors. The model correctly predicted the oxic/suboxic classification for 78 and 79% of the samples in the out-of-bag and hold-out data sets, respectively. Variables describing geology, hydrology, soil properties, and hydrologic position were among the most important factors affecting the likelihood of oxic conditions in groundwater. Important model variables tended to relate to aquifer recharge, groundwater travel time, or prevalence of electron donors, which are key drivers of redox conditions in groundwater. Partial dependence plots suggested that the likelihood of oxic conditions in groundwater decreased sharply as streams were approached and gradually as the depth below the water table increased. The probability of oxic groundwater increased as base flow index values increased, likely due to the prevalence of well-drained soils and geologic materials in high base flow index areas. The likelihood of oxic conditions increased as topographic wetness index (TWI) values decreased. High topographic wetness index values occur in areas with a propensity for standing water and overland flow, conditions that limit the delivery of dissolved oxygen to groundwater by recharge; higher TWI values also tend to occur in discharge areas, which may contain groundwater with long travel times. A second model was developed to predict the probability of elevated manganese (Mn) concentrations in groundwater (i.e., ≥50 μg/L). The Mn model relied on many of the same variables as the oxic/suboxic model and may be used to identify areas where Mn-reducing conditions occur and where there is an increased risk to domestic water supplies due to high Mn concentrations. Model predictions of redox conditions in groundwater produced in this study may help identify regions of the country with elevated groundwater vulnerability and stream vulnerability to groundwater-derived contaminants.
MeSH term(s)	Humans ; Random Forest ; Environmental Monitoring ; Groundwater ; Water Supply ; Soil ; Manganese ; Oxidation-Reduction ; Water Pollutants, Chemical/analysis
Chemical Substances	Soil ; Manganese (42Z2K6ZL8P) ; Water Pollutants, Chemical
Language	English
Publishing date	2024-03-07
Publishing country	United States
Document type	Journal Article
ISSN	1520-5851
ISSN (online)	1520-5851
DOI	10.1021/acs.est.3c07576
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Article ; Online: Minimally Invasive Approaches to Haglund's Deformity and Insertional Achilles Tendinopathy: A Contemporary Review.

Hall, SarahRose / Kaplan, Jonathan R M / Schipper, Oliver N / Vulcano, Ettore / Johnson, A Holly / Jackson, J Benjamin / Aiyer, Amiethab A / Gonzalez, Tyler A

Foot & ankle international

2024 , Page(s) 10711007241237529

Language	English
Publishing date	2024-04-22
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1183283-6
ISSN	1944-7876 ; 1071-1007
ISSN (online)	1944-7876
ISSN	1071-1007
DOI	10.1177/10711007241237529
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Zs.A 1600: Show issues

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Article ; Online: Pediatric Traumatic Lumbar Hernias and Associated Injuries: A Case Series.

Leiva, Tyler / Golubkova, Alena / Snyder, Katherine / Johnson, Jeremy / Hunter, Catherine J

Pediatric emergency care

2024 Volume 40, Issue 2, Page(s) 103–107

Abstract: Objective: Traumatic lumbar hernias are a rare entity mostly seen with high-impact, blunt abdominal trauma. This injury occurs when there is disruption of the posterior musculature along with bony structures, allowing for herniation of abdominal ... ...

Abstract	Objective: Traumatic lumbar hernias are a rare entity mostly seen with high-impact, blunt abdominal trauma. This injury occurs when there is disruption of the posterior musculature along with bony structures, allowing for herniation of abdominal contents. There are minimal cases of this entity reported in adults, but even fewer in the pediatric population. Methods: We describe 3 cases of traumatic lumbar hernia at our institution as well as provide a review of the literature to elucidate the most common mechanisms, severity of injury, and associated injuries. Results: Traumatic lumbar hernia is most commonly seen in restrained passengers involved in motor vehicle collisions. A majority of cases are diagnosed using computed tomography imaging and less frequently during primary surgical exploration. The most common associated injuries were mesenteric and bowel injuries, followed by spinal and chest trauma. Traumatic lumbar hernia often leads to prolonged hospital stays and increased need for posthospital rehabilitation because of associated traumatic comorbidities. Conclusions: Traumatic lumbar hernia is a rare entity in children, and early suspicion and identification of associated injuries is necessary in the management of these patients.
MeSH term(s)	Adult ; Humans ; Child ; Hernia, Ventral/etiology ; Wounds, Nonpenetrating/diagnosis ; Abdominal Injuries/complications ; Abdominal Injuries/diagnostic imaging ; Tomography, X-Ray Computed/adverse effects ; Accidents, Traffic
Language	English
Publishing date	2024-01-31
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	632588-9
ISSN	1535-1815 ; 0749-5161
ISSN (online)	1535-1815
ISSN	0749-5161
DOI	10.1097/PEC.0000000000003116
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Article ; Online: VCP promotes tTAF-target gene expression and spermatocyte differentiation by downregulating mono-ubiquitylated H2A.

Butsch, Tyler J / Dubuisson, Olga / Johnson, Alyssa E / Bohnert, K Adam

Development (Cambridge, England)

2023 Volume 150, Issue 14

Abstract: Valosin-containing protein (VCP) binds and extracts ubiquitylated cargo to regulate protein homeostasis. VCP has been studied primarily in aging and disease contexts, but it also affects germline development. However, the precise molecular functions of ... ...

Abstract	Valosin-containing protein (VCP) binds and extracts ubiquitylated cargo to regulate protein homeostasis. VCP has been studied primarily in aging and disease contexts, but it also affects germline development. However, the precise molecular functions of VCP in the germline, particularly in males, are poorly understood. Using the Drosophila male germline as a model system, we find that VCP translocates from the cytosol to the nucleus as germ cells transition into the meiotic spermatocyte stage. Importantly, nuclear translocation of VCP appears to be one crucial event stimulated by testis-specific TBP-associated factors (tTAFs) to drive spermatocyte differentiation. VCP promotes the expression of several tTAF-target genes, and VCP knockdown, like tTAF loss of function, causes cells to arrest in early meiotic stages. At a molecular level, VCP activity supports spermatocyte gene expression by downregulating a repressive histone modification, mono-ubiquitylated H2A (H2Aub), during meiosis. Remarkably, experimentally blocking H2Aub in VCP-RNAi testes is sufficient to overcome the meiotic-arrest phenotype and to promote development through the spermatocyte stage. Collectively, our data highlight VCP as a downstream effector of tTAFs that downregulates H2Aub to facilitate meiotic progression.
MeSH term(s)	Animals ; Male ; Spermatocytes/metabolism ; Valosin Containing Protein/genetics ; Valosin Containing Protein/metabolism ; Cell Differentiation/genetics ; Drosophila/genetics ; Drosophila/metabolism ; Testis/metabolism ; Gene Expression ; Spermatogenesis/genetics ; Meiosis/genetics
Chemical Substances	Valosin Containing Protein (EC 3.6.4.6)
Language	English
Publishing date	2023-07-19
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	90607-4
ISSN	1477-9129 ; 0950-1991
ISSN (online)	1477-9129
ISSN	0950-1991
DOI	10.1242/dev.201557
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Ub I Zs.183: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 91: Show issues

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Article ; Online: Transmembrane peptide effects on bacterial membrane integrity and organization.

Mitchell, Chloe J / Johnson, Tyler S / Deber, Charles M

Biophysical journal

2022 Volume 121, Issue 17, Page(s) 3253–3262

Abstract: As the bacterial multidrug resistance crisis continues, membrane-active antimicrobial peptides are being explored as an alternate treatment to conventional antibiotics. In contrast to antimicrobial peptides, which function by a nonspecific membrane ... ...

Abstract	As the bacterial multidrug resistance crisis continues, membrane-active antimicrobial peptides are being explored as an alternate treatment to conventional antibiotics. In contrast to antimicrobial peptides, which function by a nonspecific membrane disruption mechanism, here we describe a series of transmembrane (TM) peptides that are designed to act as drug efflux inhibitors by aligning with and out-competing a conserved TM4-TM4 homodimerization motif within bacterial small multidrug resistance proteins. The peptides contain two terminal tags: a C-terminal lysine tag to direct the peptides toward the negatively charged bacterial membrane, and an uncharged N-terminal sarcosine (N-methyl-glycine) tag to promote membrane insertion. While effective at inhibiting efflux activity, ostensibly through their designed mechanism of action, the impact of the peptides on the bacterial inner membrane remains undetermined. To evaluate the extant peptide-membrane interactions, we performed a series of biophysical measurements. Circular dichroism spectroscopy and Trp fluorescence showed that the peptides insert into the membrane generally in helical form. Interestingly, differential scanning calorimetry of the peptides added to bacterial-like membranes (POPE:POPG 3:1) revealed the peptides' ability to demix the POPE and POPG lipids, creating two pools, one of which is likely a peptide-POPG conglomerate, and the other a POPE-rich component where the native POPG content has been depleted. However, dye leakage assays confirmed that these events occur without causing significant membrane disruption both in vitro and in vivo, indicating that the peptides can target the small multidrug resistance TM4-TM4 motif without nonspecific membrane disruption. In related studies, DiOC
MeSH term(s)	Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Bacteria ; Cell Membrane/chemistry ; Circular Dichroism ; Hydrophobic and Hydrophilic Interactions ; Peptides/chemistry ; Peptides/pharmacology
Chemical Substances	Anti-Bacterial Agents ; Peptides
Language	English
Publishing date	2022-08-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218078-9
ISSN	1542-0086 ; 0006-3495
ISSN (online)	1542-0086
ISSN	0006-3495
DOI	10.1016/j.bpj.2022.07.026
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Zs.A 235: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 2: Show issues

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Article ; Online: Equity and Artificial Intelligence in Surgical Care.

Johnson-Mann, Crystal N / Loftus, Tyler J / Bihorac, Azra

JAMA surgery

2021 Volume 156, Issue 6, Page(s) 509–510

MeSH term(s)	Artificial Intelligence ; Bias, Implicit ; Clinical Decision-Making ; Healthcare Disparities ; Humans ; Patient Selection ; Surgical Procedures, Operative
Language	English
Publishing date	2021-02-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2701841-6
ISSN	2168-6262 ; 2168-6254
ISSN (online)	2168-6262
ISSN	2168-6254
DOI	10.1001/jamasurg.2020.7208
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Article ; Online: Male lake char release taurocholic acid as part of a mating pheromone.

Buchinger, Tyler J / Li, Ke / Bussy, Ugo / Huerta, Belinda / Tamrakar, Sonam / Johnson, Nicholas S / Li, Weiming

The Journal of experimental biology

2024 Volume 227, Issue 2

Abstract: The evolutionary origins of sexual preferences for chemical signals remain poorly understood, due, in part, to scant information on the molecules involved. In the current study, we identified a male pheromone in lake char (Salvelinus namaycush) to ... ...

Abstract	The evolutionary origins of sexual preferences for chemical signals remain poorly understood, due, in part, to scant information on the molecules involved. In the current study, we identified a male pheromone in lake char (Salvelinus namaycush) to evaluate the hypothesis that it exploits a non-sexual preference for juvenile odour. In anadromous char species, the odour of stream-resident juveniles guides migratory adults into spawning streams. Lake char are also attracted to juvenile odour but have lost the anadromous phenotype and spawn on nearshore reefs, where juvenile odour does not persist long enough to act as a cue for spawning site selection by adults. Previous behavioural data raised the possibility that males release a pheromone that includes components of juvenile odour. Using metabolomics, we found that the most abundant molecule released by males was also released by juveniles but not females. Tandem mass spectrometry and nuclear magnetic resonance were used to identify the molecule as taurocholic acid (TCA), which was previously implicated as a component of juvenile odour. Additional chemical analyses revealed that males release TCA at high rates via their urine during the spawning season. Finally, picomolar concentrations of TCA attracted pre-spawning and spawning females but not males. Taken together, our results indicate that male lake char release TCA as a mating pheromone and support the hypothesis that the pheromone is a partial match of juvenile odour.
MeSH term(s)	Animals ; Female ; Male ; Pheromones ; Reproduction ; Taurocholic Acid ; Trout
Chemical Substances	Pheromones ; Taurocholic Acid (5E090O0G3Z)
Language	English
Publishing date	2024-01-25
Publishing country	England
Document type	Journal Article
ZDB-ID	218085-6
ISSN	1477-9145 ; 0022-0949
ISSN (online)	1477-9145
ISSN	0022-0949
DOI	10.1242/jeb.246801
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Article ; Online: Acute moderate normobaric hypoxia does not modify circulating thyroid hormone concentrations induced by one hour of head out cold-water immersion.

Keeler, Jason M / Greenshields, Joel T / Goss, Curtis S / Baker, Tyler B / Chapman, Robert F / Johnson, Blair D / Schlader, Zachary J

Journal of applied physiology (Bethesda, Md. : 1985)

2024

Abstract: This study tested the hypothesis that acute moderate normobaric hypoxia augments circulating thyroid hormone concentrations during and following one hour of cold head out water immersion (HOWI), compared to when cold HOWI is completed during normobaric ... ...

Abstract	This study tested the hypothesis that acute moderate normobaric hypoxia augments circulating thyroid hormone concentrations during and following one hour of cold head out water immersion (HOWI), compared to when cold HOWI is completed during normobaric normoxia. In a randomized crossover single blind design, 12 healthy adults (27 ± 2 y, 2 women) completed one hour of cold (22.0±0.1⁰C) HOWI breathing either normobaric normoxia (FiO
Language	English
Publishing date	2024-04-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	219139-8
ISSN	1522-1601 ; 0021-8987 ; 0161-7567 ; 8750-7587
ISSN (online)	1522-1601
ISSN	0021-8987 ; 0161-7567 ; 8750-7587
DOI	10.1152/japplphysiol.00061.2024
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Article ; Online: A meiotic switch in lysosome activity supports spermatocyte development in young flies but collapses with age.

Butsch, Tyler J / Dubuisson, Olga / Johnson, Alyssa E / Bohnert, K Adam

iScience

2022 Volume 25, Issue 6, Page(s) 104382

Abstract: Gamete development ultimately influences animal fertility. Identifying mechanisms that direct gametogenesis, and how they deteriorate with age, may inform ways to combat infertility. Recently, we found that lysosomes acidify during oocyte maturation ... ...

Abstract	Gamete development ultimately influences animal fertility. Identifying mechanisms that direct gametogenesis, and how they deteriorate with age, may inform ways to combat infertility. Recently, we found that lysosomes acidify during oocyte maturation in
Language	English
Publishing date	2022-05-10
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2022.104382
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