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Book: Textbook of Plastic, Reconstructive, and Aesthetic Surgery, Vol 6

Agrawal, Karoon / Singh, Kuldeep / Kumar, Lokesh / Garg, Anil / Kalra, Rakesh / Ramachandran, K.

Aesthetic Surgery

2021

Keywords	body contouring ; genital ; hair restoration ; liposuction ; regenerative medicine ; rejuvenation techniques
Language	English
Size	848 p.
Edition	1
Publisher	Thieme Publishers Delhi
Document type	Book
Note	PDA Manuell_13
Format	225 x 291 x 42
ISBN	9788194857075 ; 8194857074
Database	PDA

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Article ; Online: Allosteric Modulation of Adenosine A

Korkutata, Mustafa / Agrawal, Lokesh / Lazarus, Michael

International journal of molecular sciences

2022 Volume 23, Issue 4

Abstract: The therapeutic potential of targeting adenosine ... ...

Abstract	The therapeutic potential of targeting adenosine A
MeSH term(s)	Adenosine A2 Receptor Agonists/pharmacology ; Adenosine A2 Receptor Antagonists/pharmacology ; Allosteric Regulation/physiology ; Animals ; Humans ; Ligands ; Receptor, Adenosine A2A/metabolism
Chemical Substances	Adenosine A2 Receptor Agonists ; Adenosine A2 Receptor Antagonists ; Ligands ; Receptor, Adenosine A2A
Language	English
Publishing date	2022-02-14
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23042101
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Article ; Online: Gamma delta T cells in acute myeloid leukemia: biology and emerging therapeutic strategies.

Rao, Adishwar / Agrawal, Akriti / Borthakur, Gautam / Battula, Venkata Lokesh / Maiti, Abhishek

Journal for immunotherapy of cancer

2024 Volume 12, Issue 2

Abstract: γδ T cells play an important role in disease control in acute myeloid leukemia (AML) and have become an emerging area of therapeutic interest. These cells represent a minor population of T lymphocytes with intrinsic abilities to recognize antigens in a ... ...

Abstract	γδ T cells play an important role in disease control in acute myeloid leukemia (AML) and have become an emerging area of therapeutic interest. These cells represent a minor population of T lymphocytes with intrinsic abilities to recognize antigens in a major histocompatibility complex-independent manner and functionally straddle the innate and adaptive immunity interface. AML shows high expression of phosphoantigens and UL-16 binding proteins that activate the Vδ2 and Vδ1 subtypes of γδ T cells, respectively, leading to γδ T cell-mediated cytotoxicity. Insights from murine models and clinical data in humans show improved overall survival, leukemia-free survival, reduced risk of relapse, enhanced graft-versus-leukemia effect, and decreased graft-versus-host disease in patients with AML who have higher reconstitution of γδ T cells following allogeneic hematopoietic stem cell transplantation. Clinical trials leveraging γδ T cell biology have used unmodified and modified allogeneic cells as well as bispecific engagers and monoclonal antibodies. In this review, we discuss γδ T cells' biology, roles in cancer and AML, and mechanisms of immune escape and antileukemia effect; we also discuss recent clinical advances related to γδ T cells in the field of AML therapeutics.
MeSH term(s)	Humans ; Animals ; Mice ; Intraepithelial Lymphocytes/metabolism ; Receptors, Antigen, T-Cell, gamma-delta/metabolism ; Leukemia, Myeloid, Acute/therapy ; Graft vs Host Disease ; Biology
Chemical Substances	Receptors, Antigen, T-Cell, gamma-delta
Language	English
Publishing date	2024-02-27
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2719863-7
ISSN	2051-1426 ; 2051-1426
ISSN (online)	2051-1426
ISSN	2051-1426
DOI	10.1136/jitc-2023-007981
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Article ; Online: Allosteric Modulation of Adenosine A 2A Receptors as a New Therapeutic Avenue

Mustafa Korkutata / Lokesh Agrawal / Michael Lazarus

International Journal of Molecular Sciences, Vol 23, Iss 2101, p

2022 Volume 2101

Abstract: The therapeutic potential of targeting adenosine A 2A receptors (A 2A Rs) is immense due to their broad expression in the body and central nervous system. The role of A 2A Rs in cardiovascular function, inflammation, sleep/wake behaviors, cognition, and ... ...

Abstract	The therapeutic potential of targeting adenosine A 2A receptors (A 2A Rs) is immense due to their broad expression in the body and central nervous system. The role of A 2A Rs in cardiovascular function, inflammation, sleep/wake behaviors, cognition, and other primary nervous system functions has been extensively studied. Numerous A 2A R agonist and antagonist molecules are reported, many of which are currently in clinical trials or have already been approved for treatment. Allosteric modulators can selectively elicit a physiologic response only where and when the orthosteric ligand is released, which reduces the risk of an adverse effect resulting from A 2A R activation. Thus, these allosteric modulators have a potential therapeutic advantage over classical agonist and antagonist molecules. This review focuses on the recent developments regarding allosteric A 2A R modulation, which is a promising area for future pharmaceutical research because the list of existing allosteric A 2A R modulators and their physiologic effects is still short.
Keywords	adenosine A 2A receptors ; allosteric modulator ; insomnia ; slow-wave sleep ; inflammation ; cardiovascular function ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	290
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Corrigendum to 'Role of serotonin 4 receptor in the growth of hippocampal neurons during the embryonic development in mice'.

Agrawal, Lokesh / Vimal, Sunil Kumar / Shiga, Takashi

Neuropharmacology

2020 Volume 165, Page(s) 107916

Language	English
Publishing date	2020-01-10
Publishing country	England
Document type	Published Erratum
ZDB-ID	218272-5
ISSN	1873-7064 ; 0028-3908
ISSN (online)	1873-7064
ISSN	0028-3908
DOI	10.1016/j.neuropharm.2019.107916
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Article ; Online: Hospital corneal retrieval program: A long way to go.

Jain, Anu / Sen, Snigdha / Upadhyay, Prerna / Dwivedi, Nishi / Singh, Lokesh K / Agrawal, Renu / Kumar, Sarvesh

Indian journal of ophthalmology

2024

Abstract: Purpose: The Hospital Corneal Retrieval Program (HCRP) aims to counsel and encourage the family of a critically ill or deceased person in the hospital for eye donation. Adequately sensitized health-care workers (HCWs) may play a pivotal role in boosting ...

Abstract	Purpose: The Hospital Corneal Retrieval Program (HCRP) aims to counsel and encourage the family of a critically ill or deceased person in the hospital for eye donation. Adequately sensitized health-care workers (HCWs) may play a pivotal role in boosting HCRP. Study design: Multicentric, cross-sectional, descriptive study. Methods: Study participants included all HCWs of three medical colleges, including one with eye bank and corneal transplant services. A pretested, structured questionnaire was used to record the awareness, knowledge, and attitude about eye donation among HCWs. The expected outcome was to seek differences in awareness, if any, among medical and paramedical workers of medical colleges with (group A) or without (group B) eye bank and corneal transplant facilities. Results: Of the 4060 study participants, 2100 HCWs were in group A and the rest (1960) were in group B. For eight out of 13 questions assessing awareness and perception, a statistically insignificant difference in responses was observed between the two groups. Regarding questions related to attitude, although the majority of HCWs in both groups were comfortable talking about eye donation, they did feel that counseling relatives of a terminally ill patient about eye donation was insensitive. Less than half of HCWs showed a willingness to donate eyes, and about half of the participants wanted to acquire more knowledge about eye donation. Conclusion: Awareness regarding eye donation among HCWs was mostly found to be at dismal levels, irrespective of whether they worked in an institute with or without eye bank and corneal transplant services. This warrants an accelerated effort at sensitizing HCWs as a strengthening measure for HCRP.
Language	English
Publishing date	2024-03-08
Publishing country	India
Document type	Journal Article
ZDB-ID	187392-1
ISSN	1998-3689 ; 0301-4738
ISSN (online)	1998-3689
ISSN	0301-4738
DOI	10.4103/IJO.IJO_2188_23
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Article ; Online: Comparison of Patient's Procedural Tolerance of EBUS-TBNA Performed Through Nasal Versus Oral Route: The NO-EBUS Randomized Clinical Trial.

Mishra, Mayank / Chowdhury, Nilotpal / Krishnadas Padmanabhan, Ajeesh / Banerjee, Saikat / Kumar Saini, Lokesh / Sharma, Prakhar / Agrawal, Shruti / Sindhwani, Girish

Journal of bronchology & interventional pulmonology

2024 Volume 31, Issue 2, Page(s) 215–223

Abstract: Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a commonly performed procedure by the bronchoscopist for the evaluation of mediastinal lesions. However, evidence directly comparing the nasal and oral routes to ...

Abstract	Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a commonly performed procedure by the bronchoscopist for the evaluation of mediastinal lesions. However, evidence directly comparing the nasal and oral routes to guide the choice of an optimal insertion approach is scanty. Methods: In this prospective, parallel-group, open-label randomized clinical trial, adults posted for a linear EBUS-TBNA examination under conscious sedation were randomized to undergo the procedure via the nasal or oral route. The primary objective was to assess the equivalence of subject-rated tolerance of EBUS-TBNA procedure in the 2 groups. Key secondary objectives were to assess the equivalence of subject-rated overall experience, willingness for a repeat procedure, operator-rated subject's tolerance, and operator-rated ease of performing the procedure. Results: One hundred and eighty subjects were randomized in a 1:1 ratio to the nasal (n=98) or oral (n=82) group. Outcome measures were assessed by both per-protocol (PP) and intention-to-treat (ITT) analysis. Subject-rated procedural tolerance, overall satisfaction and operator's ease of performing the procedure were found to be equivalent in the 2 groups ( P <0.05 in all cases for PP and ITT analysis). The operator-rated subject's tolerance was, however, nonequivalent ( P =0.0596, 0.1286 for PP and ITT, respectively). Subject's willingness to undergo a repeat procedure was similar in both groups [90% CI of difference in proportions: (-0.023, 0.121) in PP and (-0.028, 0.115) in ITT analysis]. Conclusion: Nasal route for EBUS-TBNA could be considered where it is feasible and preferable for the patient as well as the operator.
MeSH term(s)	Adult ; Humans ; Prospective Studies ; Bronchoscopy/methods ; Endoscopic Ultrasound-Guided Fine Needle Aspiration/adverse effects ; Endoscopic Ultrasound-Guided Fine Needle Aspiration/methods ; Mediastinum/pathology ; Nose/pathology ; Lung Neoplasms/pathology
Language	English
Publishing date	2024-04-01
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2478320-1
ISSN	1948-8270 ; 1944-6586
ISSN (online)	1948-8270
ISSN	1944-6586
DOI	10.1097/LBR.0000000000000960
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Article ; Online: Survival analysis of phacomorphic glaucoma at a tertiary hospital in North India.

Gupta, Richa / Agrawal, Surabhi / Chauhan, Lokesh

Taiwan journal of ophthalmology

2021 Volume 12, Issue 1, Page(s) 61–67

Abstract: Purpose: To report the intraocular pressure (IOP) and visual outcomes in patients operated for phacomorphic glaucoma in a developing country.: Methods: Patients undergone surgery for phacomorphic glaucoma between January 2015 and February 2018 with a ...

Abstract	Purpose: To report the intraocular pressure (IOP) and visual outcomes in patients operated for phacomorphic glaucoma in a developing country. Methods: Patients undergone surgery for phacomorphic glaucoma between January 2015 and February 2018 with a minimum follow-up of 6 months were reviewed. Multinomial logistic regression was used to predict final visual acuity with different preoperative variables. A Kaplan-Meier analysis was done to calculate survival probabilities at different time points. Results: Presenting IOP of study eye was 38.3±13.4 mmHg with 97.91% (n=94/96) patients on AGMs (mean: 2.7±1.08). Mean duration of complaints was 7.7±6.3 days. The most common postoperative complication was severe anterior chamber inflammation with or without fibrin membrane (in 29.16% eyes). The mean follow-up period was 14.5±9.2 months. At the last visit, the CDVA was 20/30 or better in 54/96 (56.25%) eyes, the mean IOP was 13.6±2.6 mmHg and 30 (31.25%) eyes required additional AGM with the mean number being 1.5±0.6. Two eyes required trabeculectomies for IOP control. The mean survival time of complete and qualified success was 28.5±1.9 and 41.2±0.05 months respectively. The probability of complete and qualified success at month 42 was 11% and 98%. Duration of complains and VCDR were found to be associated with final visual acuity. Conclusions: There was a positive correlation between shorter duration of symptoms with post-operative visual gain, but the glaucomatous damage showed a plateau effect at the IOP of around 35 mmHg. It is not the level of IOP, rather its duration which determines the degree of visual loss.
Language	English
Publishing date	2021-04-15
Publishing country	India
Document type	Journal Article
ZDB-ID	2652841-1
ISSN	2211-5072 ; 2211-5072
ISSN (online)	2211-5072
ISSN	2211-5072
DOI	10.4103/tjo.tjo_87_20
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Article ; Online: Development of 3D culture scaffolds for directional neuronal growth using 2-photon lithography.

Agrawal, Lokesh / Saidani, Menouer / Guillaud, Laurent / Terenzio, Marco

Materials science & engineering. C, Materials for biological applications

2021 Volume 131, Page(s) 112502

Abstract: Conventional applications of transplant technology, applied to severe traumatic injuries of the nervous system, have met limited success in the clinics due to the complexity of restoring function to the damaged tissue. Neural tissue engineering aims to ... ...

Abstract	Conventional applications of transplant technology, applied to severe traumatic injuries of the nervous system, have met limited success in the clinics due to the complexity of restoring function to the damaged tissue. Neural tissue engineering aims to deploy scaffolds mimicking the physiological properties of the extracellular matrix to facilitate the elongation of axons and the repair of damaged nerves. However, the fabrication of ideal scaffolds with precisely controlled thickness, texture, porosity, alignment, and with the required mechanical strength, features needed for effective clinical applications, remains technically challenging. We took advantage of state-of-the-art 2-photon photolithography to fabricate highly ordered and biocompatible 3D nanogrid structures to enhance neuronal directional growth. First, we characterized the physical and chemical properties and proved the biocompatibility of said scaffolds by successfully culturing primary sensory and motor neurons on their surface. Interestingly, axons extended along the fibers with a high degree of alignment to the pattern of the nanogrid, as opposed to the lack of directionality observed on flat glass or polymeric surfaces, and could grow in 3D between different layers of the scaffold. The axonal growth pattern observed is highly desirable for the treatment of traumatic nerve damage occurring during peripheral and spinal cord injuries. Thus, our findings provide a proof of concept and explore the possibility of deploying aligned fibrous 3D scaffold/implants for the directed growth of axons, and could be used in the design of scaffolds targeted towards the restoration and repair of lost neuronal connections.
MeSH term(s)	Axons ; Nerve Regeneration ; Nerve Tissue ; Neurons ; Tissue Engineering ; Tissue Scaffolds
Language	English
Publishing date	2021-10-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2012160-X
ISSN	1873-0191 ; 0928-4931
ISSN (online)	1873-0191
ISSN	0928-4931
DOI	10.1016/j.msec.2021.112502
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Article ; Online: Evaluation of utility of Invasive Electroencephalography for definitive surgery in patients with Drug-Resistant epilepsy: A Systematic Review and Meta-analysis.

Patel, Mamta / Mittal, Amit K / Joshi, Vibha / Agrawal, Mohit / Babu Varthya, Shoban / Saini, Lokesh / Saravanan, Aswini / Anil, Abhishek / Rajial, Tanuja / Panda, Samhita / Bhaskar, Suryanarayanan / Tiwari, Sarbesh / Singh, Kuldeep

World neurosurgery

2024

Abstract: When non-invasive tests are unable to define the epileptogenic zone in patients, intracranial electroencephalography (iEEG) is a method of localising the epileptogenic zone. Compared to non-invasive evaluations, it offers more precise information about ... ...

Abstract	When non-invasive tests are unable to define the epileptogenic zone in patients, intracranial electroencephalography (iEEG) is a method of localising the epileptogenic zone. Compared to non-invasive evaluations, it offers more precise information about patterns of epileptiform activity, which results in useful diagnostic information that supports surgical decision-making. The primary aim of the present study was to assess the utility of iEEG for definitive surgery for patients suffering from drug-resistant epilepsy (DRE). Online databases like PubMed, Medline, Embase, Scopus, Cochrane Library, Web of Science and IEEE explorer were searched for MeSH terms and free-text keywords. ROBINS I critical appraisal tool was used for quality assessment. Prevalence from different studies was pooled together using the inverse variance heterogeneity method. Eggers regression analysis and funnel plot were used to evaluate publication bias. The systematic review included eighteen studies, while the meta-analysis included ten studies to estimate the prevalence of seizure freedom (class I Engel) in patients undergoing surgery after iEEG. There were 526 patients in all that were included in the meta-analysis. The period of follow-up ranged from one to ten years. The overall pooled estimate of the prevalence of seizure freedom (class I Engel) in patients undergoing surgery after iEEG was 53% (95% CI: 44, 62). The results additionally demonstrated that twelve studies had a moderate risk of bias, whereas six studies had a low risk. Future studies are crucial to enhance our understanding of iEEG, guiding patient choices and unraveling their implications.
Language	English
Publishing date	2024-04-20
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2024.04.079
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