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  1. Article ; Online: Live and Replication-Competent SARS-CoV-2 in Ocular Fluids.

    Colavita, Francesca / Curiale, Salvatore / Lapa, Daniele / Castilletti, Concetta

    JAMA ophthalmology

    2021  Volume 139, Issue 9, Page(s) 1041

    MeSH term(s) COVID-19 ; Eye ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2021-06-27
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2701705-9
    ISSN 2168-6173 ; 2168-6165
    ISSN (online) 2168-6173
    ISSN 2168-6165
    DOI 10.1001/jamaophthalmol.2021.2681
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  2. Article ; Online: Biomimetic nanoplasmonic sensor for rapid evaluation of neutralizing SARS-CoV-2 monoclonal antibodies as antiviral therapy.

    Batool, Razia / Soler, Maria / Colavita, Francesca / Fabeni, Lavinia / Matusali, Giulia / Lechuga, Laura M

    Biosensors & bioelectronics

    2023  Volume 226, Page(s) 115137

    Abstract: Monoclonal antibody (mAb) therapy is one of the most promising immunotherapies that have shown the potential to prevent or neutralize the effects of COVID-19 in patients at very early stages, with a few formulations recently approved by the European and ... ...

    Abstract Monoclonal antibody (mAb) therapy is one of the most promising immunotherapies that have shown the potential to prevent or neutralize the effects of COVID-19 in patients at very early stages, with a few formulations recently approved by the European and American medicine agencies. However, a main bottleneck for their general implementation resides in the time-consuming, laborious, and highly-specialized techniques employed for the manufacturing and assessing of these therapies, excessively increasing their prices and delaying their administration to the patients. We propose a biomimetic nanoplasmonic biosensor as a novel analytical technique for the screening and evaluation of COVID-19 mAb therapies in a simpler, faster, and reliable manner. By creating an artificial cell membrane on the plasmonic sensor surface, our label-free sensing approach enables real-time monitoring of virus-cell interactions as well as direct analysis of antibody blocking effects in only 15 min assay time. We have achieved detection limits in the 10
    MeSH term(s) Humans ; Biomimetics ; SARS-CoV-2 ; Biosensing Techniques ; COVID-19 ; Antibodies, Viral ; Antiviral Agents
    Chemical Substances Antibodies, Viral ; Antiviral Agents
    Language English
    Publishing date 2023-02-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 1011023-9
    ISSN 1873-4235 ; 0956-5663
    ISSN (online) 1873-4235
    ISSN 0956-5663
    DOI 10.1016/j.bios.2023.115137
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  3. Article ; Online: Monkeypox virus in human body sites and fluids: evidence for transmission.

    Colavita, Francesca / Antinori, Andrea / Nicastri, Emanuele / Focosi, Daniele / Girardi, Enrico / Vaia, Francesco / Maggi, Fabrizio

    The Lancet. Infectious diseases

    2022  Volume 23, Issue 1, Page(s) 6–8

    MeSH term(s) Humans ; Monkeypox virus ; Human Body ; Mpox (monkeypox)/epidemiology ; Disease Outbreaks ; Feces
    Language English
    Publishing date 2022-09-29
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(22)00639-9
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  4. Article ; Online: Correction to: Safety and efficacy of COVID-19 vaccines in patients on dialysis: a multicentre cohort study in Italy.

    Menniti-Ippolito, Francesca / Mele, Alfonso / Da Cas, Roberto / De Masi, Salvatore / Chiarotti, Flavia / Fabiani, Massimo / Baglio, Giovanni / Traversa, Giuseppe / Colavita, Francesca / Castilletti, Concetta / Salomone, Mario / Zoccali, Carmine / Messa, Piergiorgio

    Journal of nephrology

    2023  Volume 37, Issue 1, Page(s) 259–260

    Language English
    Publishing date 2023-12-19
    Publishing country Italy
    Document type Published Erratum
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-023-01864-w
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  5. Article ; Online: Asymptomatic Mpox Virus Infection in Subjects Presenting for MVA-BN Vaccine.

    Matusali, Giulia / Mazzotta, Valentina / Piselli, Pierluca / Bettini, Aurora / Colavita, Francesca / Coen, Sabrina / Vaia, Francesco / Girardi, Enrico / Antinori, Andrea / Maggi, Fabrizio

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2023  Volume 77, Issue 10, Page(s) 1483–1484

    MeSH term(s) Humans ; Monkeypox virus/immunology ; Mpox (monkeypox) ; Smallpox Vaccine/immunology ; Vaccinia virus/immunology ; Antibodies, Neutralizing
    Chemical Substances smallpox and monkeypox vaccine modified vaccinia ankara-bavarian nordic (TU8J357395) ; Smallpox Vaccine ; Antibodies, Neutralizing
    Language English
    Publishing date 2023-07-03
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciad414
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  6. Article ; Online: Poor durability of the neutralizing response against XBB sublineages after a bivalent mRNA COVID-19 booster dose in persons with HIV.

    Matusali, Giulia / Vergori, Alessandra / Cimini, Eleonora / Mariotti, Davide / Mazzotta, Valentina / Lepri, Alessandro Cozzi / Colavita, Francesca / Gagliardini, Roberta / Notari, Stefania / Meschi, Silvia / Fusto, Marisa / Tartaglia, Eleonora / Girardi, Enrico / Maggi, Fabrizio / Antinori, Andrea

    Journal of medical virology

    2024  Volume 96, Issue 4, Page(s) e29598

    Abstract: We estimated the dynamics of the neutralizing response against XBB sublineages and T cell response in persons with HIV (PWH) with previous AIDS and/or CD4 < 200/ ... ...

    Abstract We estimated the dynamics of the neutralizing response against XBB sublineages and T cell response in persons with HIV (PWH) with previous AIDS and/or CD4 < 200/mm
    MeSH term(s) Humans ; COVID-19/prevention & control ; Immunization Programs ; RNA, Messenger ; Seasons ; mRNA Vaccines ; HIV Infections ; Antibodies, Neutralizing ; Antibodies, Viral
    Chemical Substances RNA, Messenger ; mRNA Vaccines ; Antibodies, Neutralizing ; Antibodies, Viral
    Language English
    Publishing date 2024-04-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.29598
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    Zs.A 1320: Show issues Location:
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  7. Article ; Online: SARS-CoV-2 Infection of Airway Epithelium Triggers Pulmonary Endothelial Cell Activation and Senescence Associated with Type I IFN Production.

    Bordoni, Veronica / Mariotti, Davide / Matusali, Giulia / Colavita, Francesca / Cimini, Eleonora / Ippolito, Giuseppe / Agrati, Chiara

    Cells

    2022  Volume 11, Issue 18

    Abstract: Airway epithelial cells represent the main target of SARS-CoV-2 replication but several pieces of evidence suggest that endothelial cells (ECs), lining pulmonary blood vessels, are key players in lung injury in COVID-19 patients. Although in vivo ... ...

    Abstract Airway epithelial cells represent the main target of SARS-CoV-2 replication but several pieces of evidence suggest that endothelial cells (ECs), lining pulmonary blood vessels, are key players in lung injury in COVID-19 patients. Although in vivo evidence of SARS-CoV-2 affecting the vascular endothelium exists, in vitro data are limited. In the present study, we set up an organotypic model to dissect the crosstalk between airway epithelium and pulmonary endothelial cells during SARS-CoV-2 infection. We showed that SARS-CoV-2 infected airway epithelium triggers the induction of endothelial adhesion molecules in ECs, suggesting a bystander effect of dangerous soluble signals from the infected epithelium. The endothelial activation was correlated with inflammatory cytokines (IL-1β, IL-6, IL-8) and with the viral replication in the airway epithelium. Interestingly, SARS-CoV-2 infection determined a modulation of endothelial p21, which could be partially reversed by inhibiting IFN-β production from ECs when co-cultured with HAE. Altogether, we demonstrated that SARS-CoV-2 infected epithelium triggers activation/senescence processes in ECs involving type I IFN-β production, suggesting possible antiviral/damage mechanisms occurring in the endothelium.
    MeSH term(s) COVID-19/immunology ; Cellular Senescence ; Endothelial Cells/immunology ; Epithelium ; Humans ; Interferon Type I/immunology ; Interleukin-6 ; Interleukin-8 ; Lung ; SARS-CoV-2
    Chemical Substances Interferon Type I ; Interleukin-6 ; Interleukin-8
    Language English
    Publishing date 2022-09-17
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11182912
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  8. Article ; Online: Biomimetic nanoplasmonic sensor for rapid evaluation of neutralizing SARS-CoV-2 monoclonal antibodies as antiviral therapy

    Batool, Razia / Soler, Maria / Colavita, Francesca / Fabeni, Lavinia / Matusali, Giulia / Lechuga, Laura M.

    Biosensors and Bioelectronics. 2023 Feb. 08, p.115137-

    2023  , Page(s) 115137–

    Abstract: Monoclonal antibody (mAb) therapy is one of the most promising immunotherapies that have shown the potential to prevent or neutralize the effects of COVID-19 in patients at very early stages, with a few formulations recently approved by the European and ... ...

    Abstract Monoclonal antibody (mAb) therapy is one of the most promising immunotherapies that have shown the potential to prevent or neutralize the effects of COVID-19 in patients at very early stages, with a few formulations recently approved by the European and American medicine agencies. However, a main bottleneck for their general implementation resides in the time-consuming, laborious, and highly-specialized techniques employed for the manufacturing and assessing of these therapies, excessively increasing their prices and delaying their administration to the patients. We propose a biomimetic nanoplasmonic biosensor as a novel analytical technique for the screening and evaluation of COVID-19 mAb therapies in a simpler, faster, and reliable manner. By creating an artificial cell membrane on the plasmonic sensor surface, our label-free sensing approach enables real-time monitoring of virus-cell interactions as well as direct analysis of antibody blocking effects in only 15 minutes assay time. We have achieved detection limits in the 10² TCID50/mL range for the study of SARS-CoV-2 viruses, which allows to perform neutralization assays by only employing a low-volume sample with common viral loads. We have demonstrated the accuracy of the biosensor for the evaluation of two different neutralizing antibodies targeting both Delta and Omicron variants of SARS-CoV-2, with half maximal inhibitory concentrations (IC₅₀) determined in the ng/mL range. Our user-friendly and reliable technology could be employed in biomedical and pharmaceutical laboratories to accelerate, cheapen, and simplify the development of effective immunotherapies for COVID-19 and other serious infectious diseases or cancer.
    Keywords COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; analytical methods ; biomimetics ; biosensors ; cell membranes ; medicine ; monoclonal antibodies ; neutralization ; therapeutics ; Surface plasmon resonance ; COVID-19 ; Immunotherapy ; Neutralization assay ; Supported lipid bilayer ; Label-free analysis
    Language English
    Dates of publication 2023-0208
    Publishing place Elsevier B.V.
    Document type Article ; Online
    Note Pre-press version ; Use and reproduction
    ZDB-ID 1011023-9
    ISSN 1873-4235 ; 0956-5663
    ISSN (online) 1873-4235
    ISSN 0956-5663
    DOI 10.1016/j.bios.2023.115137
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  9. Article ; Online: Viral replication and infectivity of monkeypox through semen - Authors' reply.

    Lapa, Daniele / Carletti, Fabrizio / Colavita, Francesca / Nicastri, Emanuele / Girardi, Enrico / Antinori, Andrea / Vaia, Francesco / Maggi, Fabrizio

    The Lancet. Infectious diseases

    2022  Volume 22, Issue 11, Page(s) 1532–1533

    MeSH term(s) Humans ; Mpox (monkeypox) ; Semen ; Monkeypox virus ; Virus Replication
    Language English
    Publishing date 2022-09-29
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(22)00613-2
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  10. Article ; Online: Safety and efficacy of COVID-19 vaccines in patients on dialysis: a multicentre cohort study in Italy.

    Menniti-Ippolito, Francesca / Mele, Alfonso / Da Cas, Roberto / De Masi, Salvatore / Chiarotti, Flavia / Fabiani, Massimo / Baglio, Giovanni / Traversa, Giuseppe / Colavita, Francesca / Castilletti, Concetta / Salomone, Mario / Zoccali, Carmine / Messa, Piergiorgio

    Journal of nephrology

    2023  Volume 36, Issue 7, Page(s) 2013–2022

    Abstract: Background: The aim of this study was to evaluate the efficacy and safety of COVID-19 vaccines in patients undergoing haemodialysis in Italy compared to the general population.: Methods: In this cohort study, 118 dialysis centres from 18 Italian ... ...

    Abstract Background: The aim of this study was to evaluate the efficacy and safety of COVID-19 vaccines in patients undergoing haemodialysis in Italy compared to the general population.
    Methods: In this cohort study, 118 dialysis centres from 18 Italian Regions participated. Individuals older than 16 years on dialysis treatment for at least 3 months, who provided informed consent were included. We collected demographic and clinical information, as well as data on vaccination status, hospitalisations, access to intensive care units and adverse events. We calculated the incidence, hospitalisation, mortality, and fatality rates in the vaccinated dialysis cohort, adjusted for several covariates. The incidence rates of infection in the dialysis cohort and the general population were compared through Standardised Incidence Rate Ratio.
    Results: The study included 6555 patients vaccinated against SARS-CoV-2 infection according to the schedule recommended in Italy. Between March 2021 and May 2022, there were 1096 cases of SARS-CoV-2 infection, with an incidence rate after completion of the three-dose vaccination cycle of 37.7 cases per 100 person-years. Compared to the general population, we observed a 14% reduction in the risk of infection for patients who received three vaccine doses (Standardised Incidence Rate Ratio: 0.86; 95% Confidence Interval: 0.81-0.91), whereas no statistically significant differences were found for COVID-19-related hospitalisations, intensive care unit admissions or death. No safety signals emerged from the reported adverse events.
    Conclusions: The vaccination program against SARS-CoV-2 in the haemodialysis population showed an effectiveness and safety profile comparable to that seen in the general population.
    MeSH term(s) Humans ; Cohort Studies ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Vaccines ; Italy/epidemiology ; Renal Dialysis
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2023-07-25
    Publishing country Italy
    Document type Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-023-01708-7
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