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Article ; Online: Nectin-2 Acts as a Viral Entry Mediated Molecule That Binds to Human Herpesvirus 6B Glycoprotein B.

Ogawa, Hirohito / Fujikura, Daisuke / Namba, Hikaru / Yamashita, Nobuko / Honda, Tomoyuki / Yamada, Masao

2022 Volume 14, Issue 1

Abstract: Human herpesvirus 6B (HHV-6B) is a T-lymphotropic virus and the etiological agent of exanthem subitum. HHV-6B is present in a latent or persistent form after primary infection and is produced in the salivary glands or transmitted to this organ. Infected ... ...

Abstract	Human herpesvirus 6B (HHV-6B) is a T-lymphotropic virus and the etiological agent of exanthem subitum. HHV-6B is present in a latent or persistent form after primary infection and is produced in the salivary glands or transmitted to this organ. Infected individuals continue to secrete the virus in their saliva, which is thus considered a source for virus transmission. HHV-6B primarily propagates in T cells because its entry receptor, CD134, is mainly expressed by activated T cells. The virus then spreads to the host's organs, including the salivary glands, nervous system, and liver. However, CD134 expression is not detected in these organs. Therefore, HHV-6B may be entering cells via a currently unidentified cell surface molecule, but the mechanisms for this have not yet been investigated. In this study, we investigated a CD134-independent virus entry mechanism in the parotid-derived cell line HSY. First, we confirmed viral infection in CD134-membrane unanchored HSY cells. We then determined that nectin cell adhesion molecule 2 (nectin-2) mediated virus entry and that HHV-6B-insensitive T-cells transduced with nectin-2 were transformed into virus-permissive cells. We also found that virus entry was significantly reduced in nectin-2 knockout parotid-derived cells. Furthermore, we showed that HHV-6B glycoprotein B (gB) interacted with the nectin-2 V-set domain. The results suggest that nectin-2 acts as an HHV-6B entry-mediated protein.
MeSH term(s)	Cell Line ; Gene Knockout Techniques ; Herpesvirus 6, Human/classification ; Herpesvirus 6, Human/genetics ; Herpesvirus 6, Human/metabolism ; Humans ; Nectins/genetics ; Nectins/metabolism ; Viral Envelope Proteins/metabolism ; Virus Attachment ; Virus Internalization
Chemical Substances	NECTIN2 protein, human ; Nectins ; Viral Envelope Proteins ; glycoprotein B, Simplexvirus
Language	English
Publishing date	2022-01-16
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v14010160
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Nectin-2 Acts as a Viral Entry Mediated Molecule That Binds to Human Herpesvirus 6B Glycoprotein B

Ogawa, Hirohito / Fujikura, Daisuke / Namba, Hikaru / Yamashita, Nobuko / Honda, Tomoyuki / Yamada, Masao

Viruses. 2022 Jan. 16, v. 14, no. 1

2022

Abstract	Human herpesvirus 6B (HHV-6B) is a T-lymphotropic virus and the etiological agent of exanthem subitum. HHV-6B is present in a latent or persistent form after primary infection and is produced in the salivary glands or transmitted to this organ. Infected individuals continue to secrete the virus in their saliva, which is thus considered a source for virus transmission. HHV-6B primarily propagates in T cells because its entry receptor, CD134, is mainly expressed by activated T cells. The virus then spreads to the host’s organs, including the salivary glands, nervous system, and liver. However, CD134 expression is not detected in these organs. Therefore, HHV-6B may be entering cells via a currently unidentified cell surface molecule, but the mechanisms for this have not yet been investigated. In this study, we investigated a CD134-independent virus entry mechanism in the parotid-derived cell line HSY. First, we confirmed viral infection in CD134-membrane unanchored HSY cells. We then determined that nectin cell adhesion molecule 2 (nectin-2) mediated virus entry and that HHV-6B-insensitive T-cells transduced with nectin-2 were transformed into virus-permissive cells. We also found that virus entry was significantly reduced in nectin-2 knockout parotid-derived cells. Furthermore, we showed that HHV-6B glycoprotein B (gB) interacted with the nectin-2 V-set domain. The results suggest that nectin-2 acts as an HHV-6B entry-mediated protein.
Keywords	Human betaherpesvirus 6B ; T-lymphocytes ; cell adhesion molecules ; cell lines ; etiological agents ; glycoproteins ; liver ; nervous system ; saliva ; virus transmission ; viruses
Language	English
Dates of publication	2022-0116
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2516098-9
ISSN	1999-4915
ISSN	1999-4915
DOI	10.3390/v14010160
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Article ; Online: Critical roles of the Cu

Shimada, Atsuhiro / Hara, Fumiyoshi / Shinzawa-Itoh, Kyoko / Kanehisa, Nobuko / Yamashita, Eiki / Muramoto, Kazumasa / Tsukihara, Tomitake / Yoshikawa, Shinya

The Journal of biological chemistry

2021 Volume 297, Issue 3, Page(s) 100967

Abstract: Mammalian cytochrome c oxidase (CcO) reduces ... ...

Abstract	Mammalian cytochrome c oxidase (CcO) reduces O
MeSH term(s)	Animals ; Catalysis ; Cattle ; Copper/metabolism ; Crystallography, X-Ray ; Electron Transport Complex IV/chemistry ; Electron Transport Complex IV/metabolism ; Mitochondria, Heart/enzymology ; Protein Conformation ; Proton Pumps/metabolism
Chemical Substances	Proton Pumps ; Copper (789U1901C5) ; Electron Transport Complex IV (EC 1.9.3.1)
Language	English
Publishing date	2021-07-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1016/j.jbc.2021.100967
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Article ; Online: Magnetically responsive antibacterial nanocrystalline jute cellulose nanocomposites with moderate catalytic activity.

Rabbi, Mohammad Ahasanur / Rahman, Mohammad Mahbubor / Minami, Hideto / Yamashita, Nobuko / Habib, Mohammad Rowshanul / Ahmad, Hasan

Carbohydrate polymers

2020 Volume 251, Page(s) 117024

Abstract: Nanocrystalline jute cellulose (NCJC) particles were prepared from bleached jute pulp by a modified acid hydrolysis. The surface of NCJC particles were first modified with iron oxide nanoparticles and then with Ag nanoparticles to prepare antibacterial ... ...

Abstract	Nanocrystalline jute cellulose (NCJC) particles were prepared from bleached jute pulp by a modified acid hydrolysis. The surface of NCJC particles were first modified with iron oxide nanoparticles and then with Ag nanoparticles to prepare antibacterial NCJC/Fe
MeSH term(s)	Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Antioxidants/chemistry ; Antioxidants/pharmacology ; Cellulose/chemistry ; Corchorus/chemistry ; Gram-Negative Bacteria/drug effects ; Magnetite Nanoparticles/chemistry ; Nanocomposites/chemistry ; Silver/pharmacology ; Staphylococcus aureus/drug effects
Chemical Substances	Anti-Bacterial Agents ; Antioxidants ; Magnetite Nanoparticles ; Silver (3M4G523W1G) ; Cellulose (9004-34-6)
Language	English
Publishing date	2020-09-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1501516-6
ISSN	1879-1344 ; 0144-8617
ISSN (online)	1879-1344
ISSN	0144-8617
DOI	10.1016/j.carbpol.2020.117024
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Article ; Online: Correction: Local structure of a highly concentrated NaClO

Sakamoto, Ryo / Yamashita, Maho / Nakamoto, Kosuke / Zhou, Yongquan / Yoshimoto, Nobuko / Fujii, Kenta / Yamaguchi, Toshio / Kitajou, Ayuko / Okada, Shigeto

Physical chemistry chemical physics : PCCP

2020 Volume 23, Issue 16, Page(s) 10130–10131

Abstract: Correction for 'Local structure of a highly concentrated NaClO4 aqueous solution-type electrolyte for sodium ion batteries' by Ryo Sakamoto et al., Phys. Chem. Chem. Phys., 2020, 22, 26452-26458, DOI: 10.1039/D0CP04376A. ...

Abstract	Correction for 'Local structure of a highly concentrated NaClO4 aqueous solution-type electrolyte for sodium ion batteries' by Ryo Sakamoto et al., Phys. Chem. Chem. Phys., 2020, 22, 26452-26458, DOI: 10.1039/D0CP04376A.
Language	English
Publishing date	2020-12-10
Publishing country	England
Document type	Published Erratum
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d1cp90077c
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Article: Magnetically responsive antibacterial nanocrystalline jute cellulose nanocomposites with moderate catalytic activity

Rabbi, Mohammad Ahasanur / Rahman, Mohammad Mahbubor / Minami, Hideto / Yamashita, Nobuko / Habib, Mohammad Rowshanul / Ahmad, Hasan

Carbohydrate polymers. 2021 Jan. 01, v. 251

2021

Abstract	Nanocrystalline jute cellulose (NCJC) particles were prepared from bleached jute pulp by a modified acid hydrolysis. The surface of NCJC particles were first modified with iron oxide nanoparticles and then with Ag nanoparticles to prepare antibacterial NCJC/Fe₃O₄/Ag nanocomposite particles. The successive structural modification of NCJC particles with Fe₃O₄ and Ag nanoparticles was confirmed. NCJC/Fe₃O₄/Ag nanocomposite particles responded well in external magnetic field. The SEM and TEM images of NCJC particles were in the nanometer range. NCJC/Fe₃O₄/Ag nanocomposite particles (0.005 mg mL⁻¹) completely degraded 20 mL of 0.1 mM congo red aqueous solution within 13 min aided by NaBH₄ reducing agent. NCJC/Fe₃O₄/Ag nanocomposite particles were moderately active against both Gram positive and Gram negative bacteria. A maximum inhibition zone of 21 mm was observed against Gram negative Shigella boydii bacteria with 60 mg/disc of nanocomposite particles. The antioxidant property of nanocomposite particles was also positive.
Keywords	Shigella boydii ; acid hydrolysis ; antioxidant activity ; aqueous solutions ; catalytic activity ; cellulose ; iron oxides ; jute ; magnetic fields ; nanocomposites ; nanocrystals ; nanosilver ; pulp
Language	English
Dates of publication	2021-0101
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	1501516-6
ISSN	1879-1344 ; 0144-8617
ISSN (online)	1879-1344
ISSN	0144-8617
DOI	10.1016/j.carbpol.2020.117024
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Article ; Online: Huge multiple spinal extradural meningeal cysts in infancy.

Tsuchimochi, Kohei / Morioka, Takato / Murakami, Nobuya / Yamashita, Fumiya / Kawamura, Nobuko

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

2018 Volume 35, Issue 3, Page(s) 535–540

Abstract: Background: Multiple spinal extradural meningeal cysts (SEMCs) are rare lesions. SEMCs communicate with the subarachnoid space through multiple dural defects and expand into the extradural space with progressive spinal cord compression.: Case ... ...

Abstract	Background: Multiple spinal extradural meningeal cysts (SEMCs) are rare lesions. SEMCs communicate with the subarachnoid space through multiple dural defects and expand into the extradural space with progressive spinal cord compression. Case presentation: We report a 5-month-old boy with hydronephrosis involving nine huge SEMCs that were distributed from the T1-L5 levels. Eight SEMCs, except for one small noncommunicating cyst, were exposed through laminoplastic laminotomy at the T10-L5 and T3-5 levels. Five transdural communications with dural defects were packed with a piece of autologous muscle and fibrin glue. Tenting sutures to lift up the dura to the vertebral arch were added to minimize the extradural dead space. Postoperatively, cord compression was relieved and hydronephrosis improved. Conclusion: In conclusion, packing of all dural defects and dural tenting sutures at a one-staged operation is useful in the surgical management of huge and multiple SEMCs in infancy.
MeSH term(s)	Central Nervous System Cysts/congenital ; Central Nervous System Cysts/pathology ; Central Nervous System Cysts/surgery ; Humans ; Infant ; Male ; Meninges/pathology ; Meninges/surgery ; Spinal Cord/pathology ; Spinal Cord/surgery ; Spinal Cord Diseases/congenital ; Spinal Cord Diseases/pathology ; Spinal Cord Diseases/surgery
Language	English
Publishing date	2018-11-23
Publishing country	Germany
Document type	Case Reports ; Journal Article
ZDB-ID	605988-0
ISSN	1433-0350 ; 0302-2803 ; 0256-7040
ISSN (online)	1433-0350
ISSN	0302-2803 ; 0256-7040
DOI	10.1007/s00381-018-4009-1
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Zs.A 2036: Show issues

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Article ; Online: Local structure of a highly concentrated NaClO

Sakamoto, Ryo / Yamashita, Maho / Nakamoto, Kosuke / Zhou, Yongquan / Yoshimoto, Nobuko / Fujii, Kenta / Yamaguchi, Toshio / Kitajou, Ayuko / Okada, Shigeto

Physical chemistry chemical physics : PCCP

2020 Volume 22, Issue 45, Page(s) 26452–26458

Abstract: Aqueous Na-ion batteries with highly concentrated NaClO4 aq. electrolytes are drawing attention as candidates for large-scale rechargeable batteries with a high safety level. However, the detailed mechanism by which the potential window in 17 m NaClO4 aq. ...

Abstract	Aqueous Na-ion batteries with highly concentrated NaClO4 aq. electrolytes are drawing attention as candidates for large-scale rechargeable batteries with a high safety level. However, the detailed mechanism by which the potential window in 17 m NaClO4 aq. electrolyte was expanded remains unclear. Therefore, we investigated the local structure around a Na+ ion or a ClO4- ion using X-ray diffraction combined with empirical potential structure refinement (EPSR) modelling and Raman spectroscopy. The results showed that in 17 m NaClO4 aq. electrolyte, most of the water molecules were coordinated to Na+ ions and few free water molecules were present. The 17 m NaClO4 aq. electrolyte could be interpreted as widening the potential window because almost all water molecules participated in hydration of the Na+ ions.
Language	English
Publishing date	2020-11-12
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d0cp04376a
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Article ; Online: Fetal sex and maternal insulin resistance during mid-pregnancy: a retrospective cohort study.

Yamashita, Hiroshi / Yasuhi, Ichiro / Koga, Megumi / Sugimi, So / Umezaki, Yasushi / Fukuoka, Misao / Suga, Sachie / Fukuda, Masashi / Kusuda, Nobuko

BMC pregnancy and childbirth

2020 Volume 20, Issue 1, Page(s) 560

Abstract: Background: Recent studies have suggested that fetal sex influences maternal glucose and insulin metabolism during pregnancy. We examined whether fetal sex is associated with maternal insulin resistance and the β-cell function during mid-pregnancy.: ... ...

Abstract	Background: Recent studies have suggested that fetal sex influences maternal glucose and insulin metabolism during pregnancy. We examined whether fetal sex is associated with maternal insulin resistance and the β-cell function during mid-pregnancy. Methods: This retrospective study included singleton pregnant women who underwent a 75-g oral glucose tolerance test (OGTT) at 24-34 weeks of gestation due to positive diabetic screening. In addition to plasma glucose (PG), we measured plasma insulin during the OGTT to obtain surrogate indices associated with insulin resistance (IR), including homeostasis assessment model (HOMA) -IR and insulin sensitivity index (IsOGTT), and β-cell function, including insulinogenic index (II), HOMA-β, and area under the curve of insulin response. We compared these indices between women carrying male fetuses to those carrying female fetuses. Results: The study population included 617 women (mean age, 32.4 ± 4.9 years) with a mean pre-pregnancy body mass index (BMI) of 22.6±4.5. They underwent the 75g-OGTT at 29.0 ± 2.5 weeks. Two hundred fifty-eight (42%) women were diagnosed with gestational diabetes (GDM). There was no significant difference in maternal age, pre-pregnancy BMI, gestational age at OGTT, PG at OGTT, or the prevalence of GDM between women with a male fetus (n=338) (male group) and those with a female fetus (n=279) (female group). Regarding the indices of IR, IR was significantly higher and insulin sensitivity was lower in the female group than in the male group (HOMA-IR: 7.0 [5-9.6] vs. 6.2 [4.6-8.8], p< 0.05; IsOGTT: 5.86 [4.29-7.83] vs. 6.29 [4.59-8.84], p< 0.01) (median [quartile range]). These differences remained significant after adjustment for maternal age, pre-pregnancy BMI, gestational age and fasting PG at OGTT, and the diagnosis of GDM. In contrast, the β-cell function did not differ between the two groups. Conclusion: Maternal IR during mid-pregnancy was significantly higher in women carrying a female fetus than in those with a male fetus. The sex of the fetus may affect maternal insulin sensitivity during mid-pregnancy.
MeSH term(s)	Adult ; Cohort Studies ; Female ; Fetus ; Glucose Tolerance Test ; Humans ; Insulin Resistance ; Insulin-Secreting Cells/physiology ; Male ; Pregnancy ; Pregnancy Trimester, Second/blood ; Pregnancy Trimester, Second/metabolism ; Retrospective Studies ; Sex Factors
Language	English
Publishing date	2020-09-24
Publishing country	England
Document type	Journal Article
ISSN	1471-2393
ISSN (online)	1471-2393
DOI	10.1186/s12884-020-03242-x
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Article ; Online: Renal expression and urinary excretion of liver-type fatty acid-binding protein in cats with renal disease.

Katayama, Masaaki / Ohata, Keiichi / Miyazaki, Tamako / Katayama, Rieko / Wakamatsu, Nobuko / Ohno, Misa / Yamashita, Tetsuro / Oikawa, Tsuyoshi / Sugaya, Takeshi / Miyazaki, Masao

Journal of veterinary internal medicine

2020 Volume 34, Issue 2, Page(s) 761–769

Abstract: Background: Liver-type fatty acid-binding protein (L-FABP) is a biomarker for early detection of renal disease in humans. Liver-type fatty acid-binding protein is cytotoxic oxidation products secreted from proximal tubules under ischemia and oxidative ... ...

Abstract	Background: Liver-type fatty acid-binding protein (L-FABP) is a biomarker for early detection of renal disease in humans. Liver-type fatty acid-binding protein is cytotoxic oxidation products secreted from proximal tubules under ischemia and oxidative stress. Objective: To examine renal expression and quantify urinary excretion of L-FABP in catswith renal disease. Animals: One hundred and thirty-four client-owned cats including 34 cats with serum creatinine (sCre) values >1.6 mg/dL and 10 other cats that died in clinics. Methods: Tissue expressions of L-FABP were examined by reverse transcription polymerase chain reaction and Western blotting. Urinary L-FABP (uL-FABP) and serum L-FABP (sL-FABP) levels were determined by enzyme-linked immunosorbent assay. Anti-liver-type fatty acid-binding protein antibody immunostained renal sections. Results: Feline kidneys express L-FABP. Strong L-FABP signals were observed in the lumens of proximal tubular cells in 5 cats with high uL-FABP excretion, but not in 5 cats with low uL-FABP excretion. In 9 normal cats, uL-FABP index was <1.2 μg/g urinary creatinine (uCre). High uL-FABP indexes (>10.0 μg/g uCre) were detected in 7 of 100 cats with low sCre (<1.6 mg/dL) and 18 of 44 cats with high sCre (>1.6 mg/dL). There was a weak correlation between L-FABP index and sCre, serum symmetric dimethylarginine (SDMA), or blood urea nitrogen (BUN), and these correlation coefficients were increased by analyzing only data of cats with sCre >1.6 mg/dL. There was a weak correlation between u L-FABP index and sL-FABP in all tested cats, but not in cats with high sCre. Conclusions and clinical importance: This study demonstrates correlations between L-FABP and current renal biomarkers for chronic kidney disease in cats, such as sCre and SDMA. Liver-type fatty acid-binding protein may be a potential biomarker to predict early pathophysiological events in feline kidneys.
MeSH term(s)	Animals ; Biomarkers/urine ; Cat Diseases/blood ; Cat Diseases/urine ; Cats ; Fatty Acid-Binding Proteins/urine ; Female ; Kidney Diseases/urine ; Kidney Diseases/veterinary ; Male ; Urinalysis/veterinary
Chemical Substances	Biomarkers ; Fatty Acid-Binding Proteins
Language	English
Publishing date	2020-02-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	92798-3
ISSN	1939-1676 ; 0891-6640
ISSN (online)	1939-1676
ISSN	0891-6640
DOI	10.1111/jvim.15721
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Zs.A 4095: Show issues

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