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  1. Article: Intensive Care during the COVID-19 Pandemic.

    Wang, Ying / Jin, Yuefei / Yang, Haiyan

    Vaccines

    2023  Volume 11, Issue 1

    Abstract: The novel coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in a sudden sharp rise in hospitalizations for pneumonia with multiorgan disease [ ... ]. ...

    Abstract The novel coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in a sudden sharp rise in hospitalizations for pneumonia with multiorgan disease [...].
    Language English
    Publishing date 2023-01-04
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11010125
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Hand, Foot, and Mouth Disease Challenges and Its Antiviral Therapeutics.

    Li, Zijie / Ji, Wangquan / Chen, Shuaiyin / Duan, Guangcai / Jin, Yuefei

    Vaccines

    2023  Volume 11, Issue 3

    Abstract: Hand, Foot, and Mouth Disease (HFMD) is an infectious disease caused by enteroviruses (EVs) and is extremely contagious and prevalent among infants and children under 5 years old [ ... ]. ...

    Abstract Hand, Foot, and Mouth Disease (HFMD) is an infectious disease caused by enteroviruses (EVs) and is extremely contagious and prevalent among infants and children under 5 years old [...].
    Language English
    Publishing date 2023-03-01
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11030571
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Hand, Foot, and Mouth Disease Challenges and Its Antiviral Therapeutics

    Zijie Li / Wangquan Ji / Shuaiyin Chen / Guangcai Duan / Yuefei Jin

    Vaccines, Vol 11, Iss 571, p

    2023  Volume 571

    Abstract: Hand, Foot, and Mouth Disease (HFMD) is an infectious disease caused by enteroviruses (EVs) and is extremely contagious and prevalent among infants and children under 5 years old [.] ...

    Abstract Hand, Foot, and Mouth Disease (HFMD) is an infectious disease caused by enteroviruses (EVs) and is extremely contagious and prevalent among infants and children under 5 years old [.]
    Keywords n/a ; Medicine ; R
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Emerging concerns of blood-brain barrier dysfunction caused by neurotropic enteroviral infections.

    Han, Shujie / Ji, Wangquan / Duan, Guangcai / Chen, Shuaiyin / Yang, Haiyan / Jin, Yuefei

    Virology

    2024  Volume 591, Page(s) 109989

    Abstract: Enteroviruses (EVs), comprise a genus in the Picornaviridae family, which have been shown to be neurotropic and can cause various neurological disorders or long-term neurological condition, placing a huge burden on society and families. The blood-brain ... ...

    Abstract Enteroviruses (EVs), comprise a genus in the Picornaviridae family, which have been shown to be neurotropic and can cause various neurological disorders or long-term neurological condition, placing a huge burden on society and families. The blood-brain barrier (BBB) is a protective barrier that prevents dangerous substances from entering the central nervous system (CNS). Recently, numerous EVs have been demonstrated to have the ability to disrupt BBB, and further lead to severe neurological damage. However, the precise mechanisms of BBB disruption associated with these EVs remain largely unknown. In this Review, we focus on the molecular mechanisms of BBB dysfunction caused by EVs, emphasizing the invasiveness of enterovirus A71 (EVA71), which will provide a research direction for further treatment and prevention of CNS disorders.
    MeSH term(s) Humans ; Blood-Brain Barrier ; Enterovirus Infections ; Enterovirus/physiology ; Central Nervous System ; Biological Transport
    Language English
    Publishing date 2024-01-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 200425-2
    ISSN 1096-0341 ; 0042-6822
    ISSN (online) 1096-0341
    ISSN 0042-6822
    DOI 10.1016/j.virol.2024.109989
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  5. Article ; Online: A Recombinant CVA6 Infection Aggravates Left Ventricular Dysfunction and Myocardial Injury in a Child With Cardiomyopathy.

    Chen, Yu / Chen, Shouhang / Duan, Guangcai / Ji, Wangquan / Zhang, Yaodong / Zhang, Xiaolong / Wang, Fang / Jin, Yuefei

    The Pediatric infectious disease journal

    2024  Volume 43, Issue 5, Page(s) e191–e193

    MeSH term(s) Child ; Humans ; Cardiomyopathies/genetics ; Ventricular Dysfunction, Left ; Ventricular Function, Left
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392481-6
    ISSN 1532-0987 ; 0891-3668
    ISSN (online) 1532-0987
    ISSN 0891-3668
    DOI 10.1097/INF.0000000000004283
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    Zs.A 1852: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article ; Online: Update on Omicron variant and its threat to vulnerable populations.

    Dai, Bowen / Ji, Wangquan / Zhu, Peiyu / Han, Shujie / Chen, Yu / Jin, Yuefei

    Public health in practice (Oxford, England)

    2024  Volume 7, Page(s) 100494

    Abstract: Objective: To reduce the incidence of severe illness and fatalities, and promote the awareness of protection and precaution, increased vaccination, strengthen the physical fitness, frequent ventilation, and health education should be enhanced among ... ...

    Abstract Objective: To reduce the incidence of severe illness and fatalities, and promote the awareness of protection and precaution, increased vaccination, strengthen the physical fitness, frequent ventilation, and health education should be enhanced among vulnerable populations as essential measures for the future control of COVID-19.
    Study design: Systematic review.
    Method: The search was done using PubMed, EMBASE and Web of Science for studies without language restrictions, published up through March 2023, since their authoritative and comprehensive literature search database. Eighty articles were included. Extraction of articles and quality assessment of included reviews was performed independently by two authors using the AMSTAR 2 score.
    Results: The articles in the final data set included research on epidemiological characteristics, pathogenicity, available vaccines, treatments and epidemiological features in special populations including the elders, pregnant women, kids, people with chronic diseases concerning Omicron.
    Conclusion: Although less pathogenic potential is found in Omicron, highly mutated forms have enhanced the ability of immune evasion and resistance to existing vaccines compared with former variants. Severe complications and outcomes may occur in vulnerable populations. Infected pregnant women are more likely to give birth prematurely, and fatal implications in children infected with Omicron are hyperimmune response and severe neurological disorders. In immunocompromised patients, there is a greater reported mortality and complication compared to patients with normal immune systems. Therefore, maintain social distancing, wear masks, and receive vaccinations are effective long-term measures.
    Language English
    Publishing date 2024-03-25
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2666-5352
    ISSN (online) 2666-5352
    DOI 10.1016/j.puhip.2024.100494
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A meta-analysis of immunogenicity and safety of two versus single-doses of influenza A (H1N1) vaccine in person living with HIV.

    Zhang, Teng / Geng, Juan / Du, Yazhe / Yang, Haiyan / Jin, Yuefei / Chen, Shuaiyin / Duan, Guangcai

    International journal of STD & AIDS

    2023  Volume 35, Issue 5, Page(s) 326–336

    Abstract: Purpose: ...

    Abstract Purpose:
    MeSH term(s) Humans ; Adjuvants, Immunologic ; Antibodies, Viral ; Immunogenicity, Vaccine ; Influenza A Virus, H1N1 Subtype ; Influenza Vaccines/immunology ; Influenza, Human/prevention & control ; Vaccination ; HIV Infections
    Chemical Substances Adjuvants, Immunologic ; Antibodies, Viral ; Influenza Vaccines
    Language English
    Publishing date 2023-12-12
    Publishing country England
    Document type Meta-Analysis ; Journal Article ; Review
    ZDB-ID 1018089-8
    ISSN 1758-1052 ; 0956-4624
    ISSN (online) 1758-1052
    ISSN 0956-4624
    DOI 10.1177/09564624231220424
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    Zs.A 2829: Show issues Location:
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  8. Article ; Online: Latest Advances in the Application of Humanized Mouse Model for Staphylococcus aureus.

    Zheng, Ping / Liu, Fang / Long, Jinzhao / Jin, Yuefei / Chen, Shuaiyin / Duan, Guangcai / Yang, Haiyan

    The Journal of infectious diseases

    2023  Volume 228, Issue 6, Page(s) 800–809

    Abstract: Staphylococcus aureus (S. aureus) is an important pathogen for humans and can cause a wide range of diseases, from mild skin infections, severe osteomyelitis to fatal pneumonia, sepsis, and septicemia. The mouse models have greatly facilitated the ... ...

    Abstract Staphylococcus aureus (S. aureus) is an important pathogen for humans and can cause a wide range of diseases, from mild skin infections, severe osteomyelitis to fatal pneumonia, sepsis, and septicemia. The mouse models have greatly facilitated the development of S. aureus studies. However, due to the substantial differences in immune system between mice and humans, the conventional mouse studies are not predictive of success in humans, in which case humanized mice may overcome this limitation to some extent. Humanized mice can be used to study the human-specific virulence factors produced by S. aureus and the mechanisms by which S. aureus interacts with humans. This review outlined the latest advances in humanized mouse models used in S. aureus studies.
    MeSH term(s) Mice ; Humans ; Animals ; Staphylococcus aureus ; Staphylococcal Infections ; Osteomyelitis ; Virulence Factors ; Sepsis ; Disease Models, Animal
    Chemical Substances Virulence Factors
    Language English
    Publishing date 2023-06-30
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiad253
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    Uh II Zs.50: Show issues Location:
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    Zs.MO 445: Show issues

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  9. Article ; Online: TBK1 and IRF3 are potential therapeutic targets in Enterovirus A71-associated diseases.

    Wangquan Ji / Tiantian Sun / Dong Li / Shuaiyin Chen / Haiyan Yang / Yuefei Jin / Guangcai Duan

    PLoS Neglected Tropical Diseases, Vol 17, Iss 1, p e

    2023  Volume 0011001

    Abstract: Background Enterovirus A71 (EV-A71) is an important causative agent of hand-foot-and-mouth disease (HFMD) associated with enormous healthcare and socioeconomic burden. Although a range of studies about EV-A71 pathogenesis have been well described, the ... ...

    Abstract Background Enterovirus A71 (EV-A71) is an important causative agent of hand-foot-and-mouth disease (HFMD) associated with enormous healthcare and socioeconomic burden. Although a range of studies about EV-A71 pathogenesis have been well described, the underlying molecular mechanism in terms of innate immune response is still not fully understood, especially the roles of TANK-binding kinase 1 (TBK1) and interferon-regulatory factor 3 (IRF3). Methodology/principal findings Here, we applied TBK1 inhibitor and IRF3 agonist, for the first time, to evaluate the antiviral activities of TBK1 and IRF3 in vivo. We found that, through regulating EV-A71-induced type I interferon (IFN) response, IRF3 agonist effectively alleviated EV-A71-induced illness, while TBK1 inhibitor aggravated disease progression. In addition, EV-A71 replication was suppressed in EVA-71-infected mice administrated with IRF3 agonist. On the other hand, more severe pathological alterations of neuronal degeneration, muscle fiber breaks, fractured or fused alveolar walls, and diffuse congestion occurred in EVA-71-infected mice treated with TBK1 inhibitor administration. Furthermore, we determined the concentrations of interleukin (IL)-6, tumor necrosis factor-alpha (TNF-α), IL-1β, monocyte chemotactic protein-1 (MCP-1), and IL-10 in both lungs and brains of mice and found that TBK1 inhibitor promoted EV-A71-induced inflammatory response, while IRF3 agonist alleviated it, which was consistent with clinical manifestations and pathological alterations. Conclusions Collectively, our findings suggest that TBK1 and IRF3 are potential therapeutic targets in EV-A71-induced illness.
    Keywords Arctic medicine. Tropical medicine ; RC955-962 ; Public aspects of medicine ; RA1-1270
    Subject code 610
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Emerging concerns of atypical hand foot and mouth disease caused by recombinant Coxsackievirus A6 variants in Henan, China.

    Chen, Shouhang / Chen, Yu / Ji, Wangquan / Wang, Fang / Zhang, Xiaolong / Jin, Yuefei / Liu, Yufeng

    Journal of medical virology

    2023  Volume 95, Issue 12, Page(s) e29316

    Abstract: An increasing number of studies have reported that atypical hand, foot, and mouth disease (HFMD) is becoming a new concern for children's health. At present, there is no official definition for atypical HFMD, but some studies have defined that it occurs ... ...

    Abstract An increasing number of studies have reported that atypical hand, foot, and mouth disease (HFMD) is becoming a new concern for children's health. At present, there is no official definition for atypical HFMD, but some studies have defined that it occurs at anatomic sites not listed in the definition of HFMD issued by the World Health Organization. Several pathogens have been reported to cause atypical HFMD, such as Coxsackievirus (CV)A6. As one of the most prevalent enteroviruses in the world, CVA6 seems to affect a wider range of children and causes more severe and prolonged illness than other enteroviruses. The early lesions of atypical HFMD are very similar to the clinical presentations of other diseases, such as eczema, which poses a challenge for clinicians aiming to identify and diagnose HFMD in a timely manner. Here, we report on six atypical HFMD patients caused by recombinant CVA6 variants, and the atypical manifestations include eczema coxsackium, large herpes, rice-like red papules and herpes, purpuric rash, and onychomadesis, as well as and large red herpes on scalp, perianal, testicles, shoulders and neck, and other atypical eruption sites, hoping to draw the attention of other pediatricians. This study will provide scientific guidance for timely diagnosis of HFMD to prevent serious complications.
    MeSH term(s) Child ; Humans ; Hand, Foot and Mouth Disease/diagnosis ; Phylogeny ; Enterovirus/genetics ; China ; Eczema ; Antibodies, Viral ; Exanthema
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2023-12-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.29316
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    Zs.A 1320: Show issues Location:
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