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  1. Article ; Online: C-F Bond Activation by a Saturated N-Heterocyclic Carbene: Mesoionic Compound Formation and Adduct Formation with B(C

    Pait, Moumita / Kundu, Gargi / Tothadi, Srinu / Karak, Suvendu / Jain, Shailja / Vanka, Kumar / Sen, Sakya S

    Angewandte Chemie (International ed. in English)

    2019  Volume 58, Issue 9, Page(s) 2804–2808

    Abstract: The reaction of SIPr, [1,3-bis(2,6-diisopropylphenyl)-imidazolin-2-ylidene] (1), with C ...

    Abstract The reaction of SIPr, [1,3-bis(2,6-diisopropylphenyl)-imidazolin-2-ylidene] (1), with C
    Language English
    Publishing date 2019-01-29
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.201814616
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  2. Article ; Online: Predicting COVID-19 in very large countries: The case of Brazil.

    Parro, V C / Lafetá, M L M / Pait, F / Ipólito, F B / Toporcov, T N

    PloS one

    2021  Volume 16, Issue 7, Page(s) e0253146

    Abstract: This work presents a practical proposal for estimating health system utilization for COVID-19 cases. The novel methodology developed is based on the dynamic model known as Susceptible, Infected, Removed and Dead (SIRD). The model was modified to focus on ...

    Abstract This work presents a practical proposal for estimating health system utilization for COVID-19 cases. The novel methodology developed is based on the dynamic model known as Susceptible, Infected, Removed and Dead (SIRD). The model was modified to focus on the healthcare system dynamics, rather than modeling all cases of the disease. It was tuned using data available for each Brazilian state and updated with daily figures. A figure of merit that assesses the quality of the model fit to the data was defined and used to optimize the free parameters. The parameters of an epidemiological model for the whole of Brazil, comprising a linear combination of the models for each state, were estimated considering the data available for the 26 Brazilian states. The model was validated, and strong adherence was demonstrated in most cases.
    MeSH term(s) Brazil/epidemiology ; COVID-19/epidemiology ; Delivery of Health Care ; Humans ; Machine Learning ; Models, Statistical ; SARS-CoV-2/isolation & purification
    Language English
    Publishing date 2021-07-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0253146
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  3. Article ; Online: Predicting COVID-19 in very large countries

    V C Parro / M L M Lafetá / F Pait / F B Ipólito / T N Toporcov

    PLoS ONE, Vol 16, Iss 7, p e

    The case of Brazil.

    2021  Volume 0253146

    Abstract: This work presents a practical proposal for estimating health system utilization for COVID-19 cases. The novel methodology developed is based on the dynamic model known as Susceptible, Infected, Removed and Dead (SIRD). The model was modified to focus on ...

    Abstract This work presents a practical proposal for estimating health system utilization for COVID-19 cases. The novel methodology developed is based on the dynamic model known as Susceptible, Infected, Removed and Dead (SIRD). The model was modified to focus on the healthcare system dynamics, rather than modeling all cases of the disease. It was tuned using data available for each Brazilian state and updated with daily figures. A figure of merit that assesses the quality of the model fit to the data was defined and used to optimize the free parameters. The parameters of an epidemiological model for the whole of Brazil, comprising a linear combination of the models for each state, were estimated considering the data available for the 26 Brazilian states. The model was validated, and strong adherence was demonstrated in most cases.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Resistance of convalescent Macaca mulatta to challenge with homologous and heterologous strains of poliomyelitis virus.

    KESSEL, J F / PAIT, C F

    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)

    2008  Volume 68, Issue 3, Page(s) 606–608

    MeSH term(s) Animals ; Macaca mulatta ; Poliomyelitis ; Poliovirus ; Viruses
    Language English
    Publishing date 2008-10-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 4015-0
    ISSN 1535-3699 ; 1525-1373 ; 0037-9727
    ISSN (online) 1535-3699 ; 1525-1373
    ISSN 0037-9727
    DOI 10.3181/00379727-68-16570
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  5. Article: Differentiation of three groups of poliomyelitis virus.

    KESSEL, J F / PAIT, C F

    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)

    2007  Volume 70, Issue 2, Page(s) 315

    MeSH term(s) Cell Differentiation ; Poliomyelitis ; Poliovirus ; Viruses
    Language English
    Publishing date 2007-12-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 4015-0
    ISSN 1535-3699 ; 1525-1373 ; 0037-9727
    ISSN (online) 1535-3699 ; 1525-1373
    ISSN 0037-9727
    DOI 10.3181/00379727-70-16911
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  6. Article: Differences among strains of poliomyelitis virus in Macaca mulatta.

    KESSEL, J F / MOORE, F J / PAIT, C F

    American journal of hygiene

    2010  Volume 43, Page(s) 82–89

    MeSH term(s) Animals ; Macaca mulatta ; Poliomyelitis ; Poliovirus ; Sprains and Strains ; Viruses
    Language English
    Publishing date 2010-06-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2938-5
    ISSN 0096-5294
    ISSN 0096-5294
    DOI 10.1093/oxfordjournals.aje.a119054
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  7. Article: Rabies vaccine encephalomyelitis in relation to the incidence of animal rabies in Los Angeles.

    PAIT, C F / PEARSON, H E

    American journal of public health and the nation's health

    2007  Volume 39, Issue 7, Page(s) 875–877

    MeSH term(s) Animals ; Encephalomyelitis ; Humans ; Incidence ; Los Angeles ; Rabies ; Rabies Vaccines ; Vaccines
    Chemical Substances Rabies Vaccines ; Vaccines
    Language English
    Publishing date 2007-08-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 121100-6
    ISSN 1541-0048 ; 0002-9572 ; 0090-0036
    ISSN (online) 1541-0048
    ISSN 0002-9572 ; 0090-0036
    DOI 10.2105/ajph.39.7.875
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  8. Article: Immunologic groups of poliomyelitis viruses.

    KESSEL, J F / PAIT, C R

    American journal of hygiene

    2004  Volume 51, Issue 1, Page(s) 76–84

    MeSH term(s) Humans ; Poliomyelitis ; Poliovirus
    Language English
    Publishing date 2004-09-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2938-5
    ISSN 0096-5294
    ISSN 0096-5294
    DOI 10.1093/oxfordjournals.aje.a119378
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  9. Article: The neutralization of the mouse-adapted poliomyelitis virus by the sera of patients, family contacts, and normal children in Los Angeles.

    PAIT, C F / KESSEL, J F / GROSSMAN, P

    American journal of hygiene

    2008  Volume 47, Issue 3, Page(s) 335–344

    MeSH term(s) Los Angeles ; Maus Elberfeld virus ; Oxidation-Reduction ; Poliomyelitis ; Poliovirus ; Viruses
    Language English
    Publishing date 2008-08-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2938-5
    ISSN 0096-5294
    ISSN 0096-5294
    DOI 10.1093/oxfordjournals.aje.a119211
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  10. Article ; Online: Blast waves from detonated military explosive reduce GluR1 and synaptophysin levels in hippocampal slice cultures.

    Smith, Marquitta / Piehler, Thuvan / Benjamin, Richard / Farizatto, Karen L / Pait, Morgan C / Almeida, Michael F / Ghukasyan, Vladimir V / Bahr, Ben A

    Experimental neurology

    2016  Volume 286, Page(s) 107–115

    Abstract: Explosives create shockwaves that cause blast-induced neurotrauma, one of the most common types of traumatic brain injury (TBI) linked to military service. Blast-induced TBIs are often associated with reduced cognitive and behavioral functions due to a ... ...

    Abstract Explosives create shockwaves that cause blast-induced neurotrauma, one of the most common types of traumatic brain injury (TBI) linked to military service. Blast-induced TBIs are often associated with reduced cognitive and behavioral functions due to a variety of factors. To study the direct effects of military explosive blasts on brain tissue, we removed systemic factors by utilizing rat hippocampal slice cultures. The long-term slice cultures were briefly sealed air-tight in serum-free medium, lowered into a 37°C water-filled tank, and small 1.7-gram assemblies of cyclotrimethylene trinitramine (RDX) were detonated 15cm outside the tank, creating a distinct shockwave recorded at the culture plate position. Compared to control mock-treated groups of slices that received equal submerge time, 1-3 blast impacts caused a dose-dependent reduction in the AMPA receptor subunit GluR1. While only a small reduction was found in hippocampal slices exposed to a single RDX blast and harvested 1-2days later, slices that received two consecutive RDX blasts 4min apart exhibited a 26-40% reduction in GluR1, and the receptor subunit was further reduced by 64-72% after three consecutive blasts. Such loss correlated with increased levels of HDAC2, a histone deacetylase implicated in stress-induced reduction of glutamatergic transmission. No evidence of synaptic marker recovery was found at 72h post-blast. The presynaptic marker synaptophysin was found to have similar susceptibility as GluR1 to the multiple explosive detonations. In contrast to the synaptic protein reductions, actin levels were unchanged, spectrin breakdown was not detected, and Fluoro-Jade B staining found no indication of degenerating neurons in slices exposed to three RDX blasts, suggesting that small, sub-lethal explosives are capable of producing selective alterations to synaptic integrity. Together, these results indicate that blast waves from military explosive cause signs of synaptic compromise without producing severe neurodegeneration, perhaps explaining the cognitive and behavioral changes in those blast-induced TBI sufferers that have no detectable neuropathology.
    MeSH term(s) Analysis of Variance ; Animals ; Animals, Newborn ; Blast Injuries/etiology ; Blast Injuries/pathology ; Explosive Agents/adverse effects ; Fluoresceins/pharmacokinetics ; Hippocampus/injuries ; Hippocampus/metabolism ; Histone Deacetylase 2/metabolism ; In Vitro Techniques ; Mitogen-Activated Protein Kinase Kinases/metabolism ; Models, Theoretical ; Organ Culture Techniques ; Rats ; Rats, Sprague-Dawley ; Receptors, AMPA/metabolism ; Synaptophysin/metabolism ; Time Factors ; Triazines/adverse effects
    Chemical Substances Explosive Agents ; Fluoresceins ; Receptors, AMPA ; Synaptophysin ; Triazines ; fluoro jade ; glutamate receptor ionotropic, AMPA 1 ; Mitogen-Activated Protein Kinase Kinases (EC 2.7.12.2) ; Hdac2 protein, rat (EC 3.5.1.98) ; Histone Deacetylase 2 (EC 3.5.1.98) ; cyclonite (W91SSV5831)
    Language English
    Publishing date 2016-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207148-4
    ISSN 1090-2430 ; 0014-4886
    ISSN (online) 1090-2430
    ISSN 0014-4886
    DOI 10.1016/j.expneurol.2016.10.002
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