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  1. Article: Molecular Characterization and Treatment Approaches for Pediatric

    Damodharan, Sudarshawn / Abbott, Alexandra / Kellar, Kaitlyn / Zhao, Qianqian / Dey, Mahua

    Cancers

    2023  Volume 15, Issue 13

    Abstract: Diffuse midline glioma (DMG), ...

    Abstract Diffuse midline glioma (DMG),
    Language English
    Publishing date 2023-07-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15133478
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Transcriptomic and Proteomic Spatial Profiling of Pediatric and Adult Diffuse Midline Glioma H3 K27-Altered, Reveals Region Specific Differences and Limited Overlap between mRNA and Protein.

    Damodharan, Sudarshawn / Shireman, Jack M / Xie, Elliot / Distler, Emily / Kendziorski, Christina / Dey, Mahua

    Research square

    2024  

    Abstract: Diffuse midline glioma, ...

    Abstract Diffuse midline glioma,
    Language English
    Publishing date 2024-04-05
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-4139314/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Neoadjuvant anti-PD-1 immunotherapy for recurrent glioblastoma.

    Mitchell, Dana / Dey, Mahua

    Translational cancer research

    2020  Volume 8, Issue Suppl 6, Page(s) S577–S579

    Language English
    Publishing date 2020-08-22
    Publishing country China
    Document type Journal Article ; Comment
    ZDB-ID 2901601-0
    ISSN 2219-6803 ; 2218-676X
    ISSN (online) 2219-6803
    ISSN 2218-676X
    DOI 10.21037/tcr.2019.05.24
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Surgical Neuro-Oncology: Management of Glioma.

    Mitchell, Dana / Shireman, Jack M / Dey, Mahua

    Neurologic clinics

    2022  Volume 40, Issue 2, Page(s) 437–453

    Abstract: Gliomas are the most common intrinsic brain tumor in adults. Although maximal tumor resection improves survival, this must be balanced with preservation of neurologic function. Technological advancements have greatly expanded our ability to safely ... ...

    Abstract Gliomas are the most common intrinsic brain tumor in adults. Although maximal tumor resection improves survival, this must be balanced with preservation of neurologic function. Technological advancements have greatly expanded our ability to safely maximize tumor resection and design innovative therapeutic trials that take advantage of intracavitary delivery of therapeutic agents after resection. In this article, we review the role of surgical intervention for both low-grade and high-grade gliomas and the innovations that are driving and expanding the role of surgery in this therapeutically challenging group of malignancies.
    MeSH term(s) Adult ; Brain Neoplasms/pathology ; Brain Neoplasms/surgery ; Glioma/surgery ; Humans
    Language English
    Publishing date 2022-03-31
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 1013148-6
    ISSN 1557-9875 ; 0733-8619
    ISSN (online) 1557-9875
    ISSN 0733-8619
    DOI 10.1016/j.ncl.2021.11.003
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    In stock of ZB MED Cologne/Königswinter

    Se 854: Show issues Location:
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  5. Article ; Online: Sexual dimorphism of the immune system predicts clinical outcomes in glioblastoma immunotherapy: A systematic review and meta-analysis.

    Shireman, Jack M / Ammanuel, Simon / Eickhoff, Jens C / Dey, Mahua

    Neuro-oncology advances

    2022  Volume 4, Issue 1, Page(s) vdac082

    Abstract: Background: Biological differences based on sex have been documented throughout the scientific literature. Glioblastoma (GBM), the most common primary malignant brain tumor in adults, has a male sex incidence bias, however, no clinical trial data ... ...

    Abstract Background: Biological differences based on sex have been documented throughout the scientific literature. Glioblastoma (GBM), the most common primary malignant brain tumor in adults, has a male sex incidence bias, however, no clinical trial data examining differential effects of treatment between sexes currently exists.
    Method: We analyzed genomic data, as well as clinical trials, to delineate the effect of sex on the immune system and GBM outcome following immunotherapy.
    Results: We found that in general females possess enriched immunological signatures on gene set enrichment analysis, which also stratified patient survival when delineated by sex. Female GBM patients treated with immunotherapy had a statistically significant survival advantage at the 1-year compared to males (relative risk [RR] = 1.15;
    Conclusions: Our study shows a meaningful difference in the immunobiology between males and females that also influences the overall response to immunotherapy in the setting of GBM.
    Language English
    Publishing date 2022-05-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 3009682-0
    ISSN 2632-2498 ; 2632-2498
    ISSN (online) 2632-2498
    ISSN 2632-2498
    DOI 10.1093/noajnl/vdac082
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Polyacrylate-magnetite nanocomposite as a potential multifunctional additive for lube oil.

    Dey, Koushik / Karmakar, Gobinda / Upadhyay, Mahua / Ghosh, Pranab

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 19151

    Abstract: The application of polymer nanocomposites (PNCs) in lubricant industry has attracted considerable interest due to their much enhanced properties compared to neat polymers. In this study, magnetite ( ... ...

    Abstract The application of polymer nanocomposites (PNCs) in lubricant industry has attracted considerable interest due to their much enhanced properties compared to neat polymers. In this study, magnetite (Fe
    Language English
    Publishing date 2020-11-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-76246-4
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  7. Article: Diffuse Intrinsic Pontine Glioma: Molecular Landscape, Evolving Treatment Strategies and Emerging Clinical Trials.

    Damodharan, Sudarshawn / Lara-Velazquez, Montserrat / Williamsen, Brooke Carmen / Helgager, Jeffrey / Dey, Mahua

    Journal of personalized medicine

    2022  Volume 12, Issue 5

    Abstract: Diffuse intrinsic pontine glioma (DIPG) is a type of intrinsic brainstem glial tumor that occurs primarily in the pediatric population. DIPG is initially diagnosed based on clinical symptoms and the characteristic location on imaging. Histologically, ... ...

    Abstract Diffuse intrinsic pontine glioma (DIPG) is a type of intrinsic brainstem glial tumor that occurs primarily in the pediatric population. DIPG is initially diagnosed based on clinical symptoms and the characteristic location on imaging. Histologically, these tumors are characterized by a heterogenous population of cells with multiple genetic mutations and high infiltrative capacity. The most common mutation seen in this group is a lysine to methionine point mutation seen at position 27 (K27M) within histone 3 (H3). Tumors with the
    Language English
    Publishing date 2022-05-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm12050840
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  8. Article ; Online: Polyacrylate-magnetite nanocomposite as a potential multifunctional additive for lube oil

    Koushik Dey / Gobinda Karmakar / Mahua Upadhyay / Pranab Ghosh

    Scientific Reports, Vol 10, Iss 1, Pp 1-

    2020  Volume 10

    Abstract: Abstract The application of polymer nanocomposites (PNCs) in lubricant industry has attracted considerable interest due to their much enhanced properties compared to neat polymers. In this study, magnetite (Fe3O4) nanoparticles (NPs) were synthesized. ... ...

    Abstract Abstract The application of polymer nanocomposites (PNCs) in lubricant industry has attracted considerable interest due to their much enhanced properties compared to neat polymers. In this study, magnetite (Fe3O4) nanoparticles (NPs) were synthesized. Then PNCs were prepared by reinforcing these NPs in the homopolymer of dodecyl acrylate in different percentages. The characterization of the prepared NPs and PNCs was done by different analytical techniques. Thermal stability is determined through thermogravimetric analysis (TGA). Performance evaluation of the PNCs as viscosity index improver, pour point depressant and antiwear additive was carried out by blending them with a mineral base stock at different percentage ratios. Standard ASTM methods are followed to carry out the evaluations. It is found that with increasing the percentage of nanocomposites in the base stock, the overall performance of the furnished lubricant is enhanced.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: 'Art at Safe Homes': A pioneer study among COVID-19 patients and their treatment team.

    Bhattacharya, Nandan / Choudhury, Sonali / Roychowdhury, Mahua / Sinha, Meghanil / Mistri, Paromita / Bhattacharya, Ritwika / Maity, Sreya / Ghosh, Moumita / Dey, Pritam / Banik, Anirban

    Work (Reading, Mass.)

    2022  Volume 72, Issue 3, Page(s) 807–817

    MeSH term(s) COVID-19/epidemiology ; Humans ; Nursing Homes ; SARS-CoV-2
    Language English
    Publishing date 2022-06-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1394194-x
    ISSN 1875-9270 ; 1051-9815
    ISSN (online) 1875-9270
    ISSN 1051-9815
    DOI 10.3233/WOR-211220
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4810: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Spatial transcriptomics in glioblastoma: is knowing the right zip code the key to the next therapeutic breakthrough?

    Shireman, Jack M / Cheng, Lingxin / Goel, Amiti / Garcia, Diogo Moniz / Partha, Sanil / Quiñones-Hinojosa, Alfredo / Kendziorski, Christina / Dey, Mahua

    Frontiers in oncology

    2023  Volume 13, Page(s) 1266397

    Abstract: Spatial transcriptomics, the technology of visualizing cellular gene expression landscape in a cells native tissue location, has emerged as a powerful tool that allows us to address scientific questions that were elusive just a few years ago. This ... ...

    Abstract Spatial transcriptomics, the technology of visualizing cellular gene expression landscape in a cells native tissue location, has emerged as a powerful tool that allows us to address scientific questions that were elusive just a few years ago. This technological advance is a decisive jump in the technological evolution that is revolutionizing studies of tissue structure and function in health and disease through the introduction of an entirely new dimension of data, spatial context. Perhaps the organ within the body that relies most on spatial organization is the brain. The central nervous system's complex microenvironmental and spatial architecture is tightly regulated during development, is maintained in health, and is detrimental when disturbed by pathologies. This inherent spatial complexity of the central nervous system makes it an exciting organ to study using spatial transcriptomics for pathologies primarily affecting the brain, of which Glioblastoma is one of the worst. Glioblastoma is a hyper-aggressive, incurable, neoplasm and has been hypothesized to not only integrate into the spatial architecture of the surrounding brain, but also possess an architecture of its own that might be actively remodeling the surrounding brain. In this review we will examine the current landscape of spatial transcriptomics in glioblastoma, outline novel findings emerging from the rising use of spatial transcriptomics, and discuss future directions and ultimate clinical/translational avenues.
    Language English
    Publishing date 2023-10-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1266397
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