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  1. Article ; Online: How to train and evaluate minimally invasive pancreas surgery.

    Vining, Charles C / Hogg, Melissa E

    Journal of surgical oncology

    2020  Volume 122, Issue 1, Page(s) 41–48

    Abstract: Training for minimally invasive pancreas surgery is critical as an evolving body of literature supports its use with acceptable outcomes during training and improved short term outcomes following completion. Although case volume needed to achieve mastery ...

    Abstract Training for minimally invasive pancreas surgery is critical as an evolving body of literature supports its use with acceptable outcomes during training and improved short term outcomes following completion. Although case volume needed to achieve mastery remains unclear, improved outcomes for both laparoscopic and robotic pancreatectomy are demonstrated following a learning curve and inflection point. Therefore, dedicated training curricula for both laparoscopic and robotic pancreatectomy have been developed to mitigate this learning curve and improve outcomes.
    MeSH term(s) Computer Simulation ; Computer-Assisted Instruction ; Education, Medical, Graduate/methods ; Education, Medical, Graduate/standards ; Humans ; Laparoscopy/education ; Laparoscopy/methods ; Laparoscopy/standards ; Minimally Invasive Surgical Procedures/education ; Minimally Invasive Surgical Procedures/methods ; Minimally Invasive Surgical Procedures/standards ; Pancreas/surgery ; Pancreatectomy/education ; Pancreatectomy/methods ; Pancreatectomy/standards ; Pancreatic Neoplasms/surgery ; Robotic Surgical Procedures/education ; Robotic Surgical Procedures/methods ; Robotic Surgical Procedures/standards
    Language English
    Publishing date 2020-03-25
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 82063-5
    ISSN 1096-9098 ; 0022-4790
    ISSN (online) 1096-9098
    ISSN 0022-4790
    DOI 10.1002/jso.25912
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 706: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Unsuspected gastric glomus tumour.

    Stahl, Caleb / Wong, William G / Fanburg-Smith, Julie C / Vining, Charles C

    BMJ case reports

    2023  Volume 16, Issue 1

    Abstract: Gastric glomus tumours (GGTs) are rare predominantly benign, mesenchymal neoplasms that commonly arise from the muscularis or submucosa of the gastric antrum and account for <1% of gastrointestinal soft-tissue tumours. Historically, GGT has been ... ...

    Abstract Gastric glomus tumours (GGTs) are rare predominantly benign, mesenchymal neoplasms that commonly arise from the muscularis or submucosa of the gastric antrum and account for <1% of gastrointestinal soft-tissue tumours. Historically, GGT has been difficult to diagnose preoperatively due to the lack of unique clinical, endoscopic and CT features. We present a case of an incidentally identified GGT in an asymptomatic man that was initially considered a neuroendocrine tumour (NET) by preoperative fine-needle aspiration biopsy with focal synaptophysin reactivity. An elective robotic distal gastrectomy and regional lymphadenectomy were performed. Postoperative review by pathology confirmed the diagnosis of GGT. GGTs should be considered by morphology as a differential diagnosis of gastric NET on cytology biopsy, especially if there is focal synaptophysin reactivity. Additional staining for SMA and BRAF, if atypical/malignant, can help with this distinction. Providers should be aware of the biological behaviour and treatment of GGTs.
    MeSH term(s) Male ; Humans ; Synaptophysin ; Glomus Tumor/diagnosis ; Glomus Tumor/surgery ; Glomus Tumor/pathology ; Stomach Neoplasms/diagnostic imaging ; Stomach Neoplasms/surgery ; Pyloric Antrum/pathology ; Biopsy, Fine-Needle
    Chemical Substances Synaptophysin
    Language English
    Publishing date 2023-01-27
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2022-253020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Ampullary adenocarcinoma: the current state of adjuvant therapies.

    Vining, Charles C / Schuitevoerder, Darryl / Turaga, Kiran K

    Hepatobiliary surgery and nutrition

    2020  Volume 9, Issue 5, Page(s) 647–649

    Language English
    Publishing date 2020-10-09
    Publishing country China (Republic : 1949- )
    Document type Editorial ; Comment
    ZDB-ID 2812398-0
    ISSN 2304-389X ; 2304-3881
    ISSN (online) 2304-389X
    ISSN 2304-3881
    DOI 10.21037/hbsn.2019.11.37
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  4. Article ; Online: Robotic gastrointestinal surgery: learning curve, educational programs and outcomes.

    Vining, Charles C / Skowron, Kinga B / Hogg, Melissa E

    Updates in surgery

    2021  Volume 73, Issue 3, Page(s) 799–814

    Abstract: The use of the robotic platform for gastrointestinal surgery was introduced nearly 20 years ago. However, significant growth and advancement has occurred primarily in the last decade. This is due to several advantages over traditional laparoscopic ... ...

    Abstract The use of the robotic platform for gastrointestinal surgery was introduced nearly 20 years ago. However, significant growth and advancement has occurred primarily in the last decade. This is due to several advantages over traditional laparoscopic surgery allowing for more complex dissections and reconstructions. Several randomized controlled trials and retrospective reviews have demonstrated equivalent oncologic outcomes compared to open surgery with improved short-term outcomes. Unfortunately, there are currently no universally accepted or implemented training programs for robotic surgery and robotic surgery experience varies greatly. Additionally, several limitations to the robotic platform exist resulting in a distinct learning curve associated with various procedures. Therefore, implementation of robotic surgery requires a multidisciplinary team approach with commitment and investment from clinical faculty, operating room staff and hospital administrators. Additionally, there is a need for wider distribution of educational modules to train more surgeons and reduce the associated learning curve. This article will focus on the implementation of the robotic platform for surgery of the pancreas, stomach, liver, colon and rectum with an emphasis on the associated learning curve, educational platforms to develop proficiency and perioperative outcomes.
    MeSH term(s) Clinical Competence ; Digestive System Surgical Procedures ; Humans ; Laparoscopy ; Learning Curve ; Retrospective Studies ; Robotic Surgical Procedures
    Language English
    Publishing date 2021-01-23
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 2572692-4
    ISSN 2038-3312 ; 2038-131X
    ISSN (online) 2038-3312
    ISSN 2038-131X
    DOI 10.1007/s13304-021-00973-0
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    Zs.B 101: Show issues Location:
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  5. Article ; Online: ASO Author Reflections: The Utility of Circulating-Tumor DNA in Selecting Patients for Locoregional, Metastases-Directed Therapies in Oligometastatic Foregut Adenocarcinoma.

    Dhiman, Ankit / Witmer, Hunter D D / Vining, Charles C / Polite, Blase / Turaga, Kiran K

    Annals of surgical oncology

    2022  

    Language English
    Publishing date 2022-04-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-022-11404-8
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    Zs.A 4042: Show issues Location:
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  6. Article ; Online: The Problem of Multiple Comparisons.

    Takvorian, Katherine S / Hardin, Charles C / Muller, Daniel / Vining, Tim / Normand, Sharon-Lise / Sacks, Chana A

    NEJM evidence

    2022  Volume 1, Issue 7, Page(s) EVIDstat2200171

    Abstract: The Problem of Multiple Comparisons This animated video reviews the problem of multiple comparisons in research studies and explains how performing multiple statistical hypothesis tests can produce associations simply by chance. ...

    Abstract The Problem of Multiple Comparisons This animated video reviews the problem of multiple comparisons in research studies and explains how performing multiple statistical hypothesis tests can produce associations simply by chance.
    Language English
    Publishing date 2022-06-28
    Publishing country United States
    Document type Video-Audio Media
    ISSN 2766-5526
    ISSN (online) 2766-5526
    DOI 10.1056/EVIDstat2200171
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  7. Article ; Online: Adjuvant Therapy for Cutaneous Melanoma.

    Schuitevoerder, Darryl / Vining, Charles C / Tseng, Jennifer

    Surgical oncology clinics of North America

    2020  Volume 29, Issue 3, Page(s) 455–465

    Abstract: This article presents the current data supporting adjuvant therapy for patients with cutaneous melanoma. With the recent development of novel immunotherapy agents as well as targeted therapy, there are strong data to support the use of these therapies in ...

    Abstract This article presents the current data supporting adjuvant therapy for patients with cutaneous melanoma. With the recent development of novel immunotherapy agents as well as targeted therapy, there are strong data to support the use of these therapies in patients at high risk of developing recurrent or metastatic disease.
    MeSH term(s) Antineoplastic Agents/therapeutic use ; Chemotherapy, Adjuvant/methods ; Humans ; Melanoma/drug therapy ; Melanoma/pathology ; Molecular Targeted Therapy ; Neoplasm Recurrence, Local/drug therapy ; Neoplasm Recurrence, Local/pathology ; Skin Neoplasms/drug therapy ; Skin Neoplasms/pathology
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2020-05-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1196919-2
    ISSN 1558-5042 ; 1055-3207
    ISSN (online) 1558-5042
    ISSN 1055-3207
    DOI 10.1016/j.soc.2020.02.009
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    Se 1339: Show issues Location:
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  8. Article ; Online: Comparison of epidural infusion versus intrathecal morphine block as part of enhanced recovery after open pancreatoduodenectomy.

    El-Mallah, Jessica C / Greene, Alicia C / Clegg, Taylor J / Shah, Sejal J / El-Mallah, Saif N / Vining, Charles C / Dixon, Matthew E B / Peng, June S

    Journal of surgical oncology

    2024  Volume 129, Issue 5, Page(s) 869–875

    Abstract: Background and objectives: The accepted approach to pain management following open pancreatoduodenectomy (PD) remains controversial, with the most recent enhanced recovery after surgery (ERAS) protocols recommending epidural anesthesia (EA). Few studies ...

    Abstract Background and objectives: The accepted approach to pain management following open pancreatoduodenectomy (PD) remains controversial, with the most recent enhanced recovery after surgery (ERAS) protocols recommending epidural anesthesia (EA). Few studies have investigated intrathecal (IT) morphine, combined with transversus abdominis plane (TAP) blocks. We aim to compare the different approaches to pain management for open PD.
    Methods: Patients who underwent open PD at our institution from 2020 to 2022 were included in the study. Patient characteristics, pain management, and postoperative outcomes between EA, IT morphine with TAP blocks, and TAP blocks only were compared using univariate analysis.
    Results: Fifty patients were included in the study (58% male, median age 66 years [interquartile range, IQR: 58-73]). Most patients received IT morphine (N = 24, 48%) or EA (N = 18, 36%). The TAP block-only group required higher doses of postoperative narcotics while hospitalized (p = 0.004) and at discharge (p = 0.017). The IT morphine patients had a shorter median time to Foley removal (p = 0.007). Postoperative pain scores, non-opioid administration, postoperative bolus requirements, postoperative outcomes, and length of stay were similar between pain modalities.
    Conclusions: IT morphine and EA showed comparable efficacy with superior results compared to TAP blocks alone. Integration of IT morphine into PD ERAS protocols should be considered.
    MeSH term(s) Humans ; Male ; Aged ; Female ; Morphine ; Analgesics, Opioid ; Pancreaticoduodenectomy/adverse effects ; Abdominal Muscles/surgery ; Pain, Postoperative/drug therapy ; Pain, Postoperative/etiology ; Pain, Postoperative/prevention & control ; Anesthesia, Epidural
    Chemical Substances Morphine (76I7G6D29C) ; Analgesics, Opioid
    Language English
    Publishing date 2024-01-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 82063-5
    ISSN 1096-9098 ; 0022-4790
    ISSN (online) 1096-9098
    ISSN 0022-4790
    DOI 10.1002/jso.27574
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    Zs.A 706: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Risk factors and outcomes in patients undergoing minimally invasive hepatectomy with unplanned conversion: a contemporary NSQIP analysis.

    Vining, Charles C / Al Abbas, Amr I / Kuchta, Kristine / Paterakos, Pierce / Choi, Sung H / Talamonti, Mark / Hogg, Melissa E

    HPB : the official journal of the International Hepato Pancreato Biliary Association

    2023  Volume 25, Issue 5, Page(s) 577–588

    Abstract: Background: Minimally invasive techniques are growing for hepatectomies. Laparoscopic and robotic liver resections have been shown to differ in conversions. We hypothesize that robotic approach will have decreased conversion to open and complications ... ...

    Abstract Background: Minimally invasive techniques are growing for hepatectomies. Laparoscopic and robotic liver resections have been shown to differ in conversions. We hypothesize that robotic approach will have decreased conversion to open and complications despite being a newer technique than laparoscopy.
    Methods: ACS NSQIP study using the targeted Liver PUF from 2014 to 2020. Patients grouped based on hepatectomy type and approach. Multivariable and propensity scored matching (PSM) was used to analyze the groups.
    Results: Of 7767 patients who underwent hepatectomy, 6834 were laparoscopic and 933 were robotic. The rate of conversions was significantly lower in robotic vs laparoscopic (7.8% vs 14.7%; p < 0.001). Robotic hepatectomy was associated with decreased conversion for minor (6.2% vs 13.1%; p < 0.001), but not major, right, or left hepatectomy. Operative factors associated with conversion included Pringle (OR = 2.09 [95% CI 1.05-4.19]; p = 0.0369), and a laparoscopic approach (OR = 1.96 [95% CI 1.53-2.52]; p < 0.001). Undergoing conversion was associated with increases in bile leak (13.7% vs 4.9%; p < 0.001), readmission (11.5% vs 6.1%; p < 0.001), mortality (2.1% vs 0.6%; p < 0.001), length of stay (5 days vs 3 days; p < 0.001), and surgical (30.5% vs 10.1%; p < 0.001), wound (4.9% vs 1.5%; p < 0.001) and medical (17.5% vs 6.7%; p < 0.001) complications.
    Conclusion: Minimally invasive hepatectomy with conversion is associated with increased complications, and conversion is increased in the laparoscopic compared to a robotic approach.
    MeSH term(s) Humans ; Hepatectomy/adverse effects ; Hepatectomy/methods ; Robotic Surgical Procedures/adverse effects ; Risk Factors ; Liver Neoplasms ; Laparoscopy/adverse effects ; Laparoscopy/methods ; Postoperative Complications/etiology ; Postoperative Complications/surgery ; Length of Stay ; Retrospective Studies ; Treatment Outcome
    Language English
    Publishing date 2023-02-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2131251-5
    ISSN 1477-2574 ; 1365-182X
    ISSN (online) 1477-2574
    ISSN 1365-182X
    DOI 10.1016/j.hpb.2023.01.018
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    Zs.A 6326: Show issues Location:
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  10. Article ; Online: Threats to Blinding.

    Davies, O M / Takvorian, Katherine S / Muller, Daniel / Vining, Tim / Burke, Alison / Sacks, Chana A / Hardin, Charles C

    NEJM evidence

    2022  Volume 1, Issue 11, Page(s) EVIDstat2200284

    Abstract: Blinding is a critical strategy used to limit certain types of bias in randomized controlled trials. This animated video explores the rationale and examines potential threats to keeping group allocation concealed - from study participants and ... ...

    Abstract Blinding is a critical strategy used to limit certain types of bias in randomized controlled trials. This animated video explores the rationale and examines potential threats to keeping group allocation concealed - from study participants and investigators.
    Language English
    Publishing date 2022-10-25
    Publishing country United States
    Document type Video-Audio Media
    ISSN 2766-5526
    ISSN (online) 2766-5526
    DOI 10.1056/EVIDstat2200284
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