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  1. Article ; Online: Virtual medication tours with a pharmacist as part of a cystic fibrosis telehealth visit.

    Warda, Nicole / Rotolo, Shannon M

    Journal of the American Pharmacists Association : JAPhA

    2021  Volume 61, Issue 5, Page(s) e119–e125

    Abstract: Background: As a result of the coronavirus disease 2019 (COVID-19) pandemic, institutions needed innovative solutions to provide care. With implementation of telehealth, a cystic fibrosis (CF) pharmacist was able to incorporate a virtual medication tour ...

    Abstract Background: As a result of the coronavirus disease 2019 (COVID-19) pandemic, institutions needed innovative solutions to provide care. With implementation of telehealth, a cystic fibrosis (CF) pharmacist was able to incorporate a virtual medication tour during appointments.
    Objective: The purpose of our study was to describe the uptake and impact of pharmacist-led virtual medication tours during telehealth visits in the CF clinic setting.
    Practice description: Before the COVID-19 pandemic, a CF pharmacist participated in in-person multidisciplinary team visits to complete medication history reconciliation, assess adherence, assess efficacy and address possible adverse effects of medications, and work collaboratively with the CF care team and patient to create therapeutic plans. The virtual medication tour described in this study was completed in addition or as a complement to these pre-existing pharmacist roles and responsibilities.
    Practice innovation: Patients seen via telehealth visit were asked to provide a virtual tour of their medications. A pharmacist completed medication history and evaluated whether storage conditions were appropriate in regard to temperature, humidity, light exposure, and accessibility to children.
    Evaluation methods: A pharmacist recorded findings from the virtual medication tours and made interventions when appropriate. Descriptive statistics were used for analysis.
    Results: Of 20 patients seen via telehealth for a quarterly visit during the first 3 months after implementation, 13 were willing to participate in a virtual medication tour. Before the visit, 25% had information missing from their medication list. Virtual medication tour allowed for resolution of this information 80% of the time. Three of the 4 participating patients with a child under 12 years old had medications stored in a location accessible to children.
    Conclusion: A virtual medication tour led by a pharmacist can be successfully incorporated into telehealth visits and was accepted by a majority of patients. Most patients stored medications appropriately but might benefit from education on poison prevention practices.
    MeSH term(s) COVID-19 ; Child ; Cystic Fibrosis/drug therapy ; Humans ; Pandemics ; Pharmacists ; SARS-CoV-2 ; Telemedicine
    Language English
    Publishing date 2021-04-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2118585-2
    ISSN 1544-3450 ; 1544-3191 ; 1086-5802
    ISSN (online) 1544-3450
    ISSN 1544-3191 ; 1086-5802
    DOI 10.1016/j.japh.2021.04.005
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  2. Article: Patterns in Relationship Violence Among African American Women: Future Research and Implications for Intervention.

    Williams, John K / Wyatt, Gail E / Myers, Hector F / Green, K Nicole Presley / Warda, Umme S

    Journal of aggression, maltreatment & trauma

    2013  Volume 16, Issue 3, Page(s) 296–310

    Abstract: The impact of intimate partner violence (IPV) on those most at risk, HIV-positive women of color, has received little attention. This study examined IPV in HIV-positive and HIV-negative African American women. Victim characteristics and factors ... ...

    Abstract The impact of intimate partner violence (IPV) on those most at risk, HIV-positive women of color, has received little attention. This study examined IPV in HIV-positive and HIV-negative African American women. Victim characteristics and factors contributing to IPV and psychological sequelae were identified. Structured interviews were administered and analyzed at baseline, at 6 months, and at 12 months. HIV-positive women were less educated, were less employed, had lower incomes, had more depressive symptoms at all time points, and were more likely to report IPV at baseline and 6 months compared to HIV-negative women. Among HIV-positive depressed women, those reporting IPV were more depressed than those without IPV. Suggestions for studies with couples examining relationship dynamics, including risks for IPV and HIV transmission, and for interventions are discussed.
    Language English
    Publishing date 2013-11-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1405764-5
    ISSN 1092-6771
    ISSN 1092-6771
    DOI 10.1080/10926770801925726
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  3. Article: Utilization of primary health care services among Syrian refugee and Lebanese women targeted by the ICRC program in Lebanon: a cross-sectional study.

    Truppa, Claudia / Leresche, Enrica / Fuller, Arlan F / Marnicio, Ariana S / Abisaab, Josyann / El Hayek, Nicole / Zmeter, Carla / Toma, Warda S / Harb, Hilda / Hamadeh, Randa S / Leaning, Jennifer

    Conflict and health

    2019  Volume 13, Page(s) 7

    Abstract: Background: The Syrian crisis has put tremendous strain on the Lebanese health system, particularly in the historically underserved border region. The ICRC Primary Health Care program has focused on refugee and host communities in these areas. This ... ...

    Abstract Background: The Syrian crisis has put tremendous strain on the Lebanese health system, particularly in the historically underserved border region. The ICRC Primary Health Care program has focused on refugee and host communities in these areas. This study objectives were: 1) to determine whether the ICRC program was reaching the most vulnerable populations; 2) to understand the key perceived health needs in the catchment areas of the ICRC supported facilities; and 3) to identify barriers to utilization of health care services.
    Methods: Between July and September 2017 we conducted two cross-sectional studies - one randomized household survey and one clinic-based - in the catchment areas of three ICRC-supported facilities, targeting women of reproductive age and caretakers of children under five. Differences between groups were analysed with t-test or chi-squared test.
    Results: In the household survey, similar socio-demographic profiles were observed between Syrian refugee women and vulnerable Lebanese hosts. With regard to the study objectives:The most vulnerable populations were those seen in the ICRC-supported facilities.For both populations, the most common reasons for seeking care were non-communicable diseases (40.6%) and sexual and reproductive health issues (28.6%). Yet the people reaching the ICRC supported facilities were more likely to seek care for communicable diseases affecting their children (37.8%), rather than for the most common reasons expressed in the household survey.In the catchment areas, reported gaps included low immunization coverage and low levels of antenatal care and family planning both for Syrian and Lebanese. Dental care also emerged as an issue. Out of pocket expenditures was reported as a critical barrier for utilization of primary health care services for both populations, while the most important barrier for utilization of ICRC-supported services was lack of awareness.
    Conclusions: Despite the ICRC reaching the most vulnerable Syrian and Lebanese communities, the population-based survey revealed that important gaps exist in terms of utilization of health care services among women of reproductive age and their children. A stronger outreach component is needed to address lack of awareness. Innovative solutions are also needed to address cost barriers at the levels of both facility and individual user.
    Language English
    Publishing date 2019-03-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2273783-2
    ISSN 1752-1505
    ISSN 1752-1505
    DOI 10.1186/s13031-019-0190-4
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  4. Article ; Online: Altered synaptic ultrastructure in the prefrontal cortex of Shank3-deficient rats.

    Jacot-Descombes, Sarah / Keshav, Neha U / Dickstein, Dara L / Wicinski, Bridget / Janssen, William G M / Hiester, Liam L / Sarfo, Edward K / Warda, Tahia / Fam, Matthew M / Harony-Nicolas, Hala / Buxbaum, Joseph D / Hof, Patrick R / Varghese, Merina

    Molecular autism

    2020  Volume 11, Issue 1, Page(s) 89

    Abstract: Background: Deletion or mutations of SHANK3 lead to Phelan-McDermid syndrome and monogenic forms of autism spectrum disorder (ASD). SHANK3 encodes its eponymous scaffolding protein at excitatory glutamatergic synapses. Altered morphology of dendrites ... ...

    Abstract Background: Deletion or mutations of SHANK3 lead to Phelan-McDermid syndrome and monogenic forms of autism spectrum disorder (ASD). SHANK3 encodes its eponymous scaffolding protein at excitatory glutamatergic synapses. Altered morphology of dendrites and spines in the hippocampus, cerebellum, and striatum have been associated with behavioral impairments in Shank3-deficient animal models. Given the attentional deficit in these animals, our study explored whether deficiency of Shank3 in a rat model alters neuron morphology and synaptic ultrastructure in the medial prefrontal cortex (mPFC).
    Methods: We assessed dendrite and spine morphology and spine density in mPFC layer III neurons in Shank3-homozygous knockout (Shank3-KO), heterozygous (Shank3-Het), and wild-type (WT) rats. We used electron microscopy to determine the density of asymmetric synapses in mPFC layer III excitatory neurons in these rats. We measured postsynaptic density (PSD) length, PSD area, and head diameter (HD) of spines at these synapses.
    Results: Basal dendritic morphology was similar among the three genotypes. Spine density and morphology were comparable, but more thin and mushroom spines had larger head volumes in Shank3-Het compared to WT and Shank3-KO. All three groups had comparable synapse density and PSD length. Spine HD of total and non-perforated synapses in Shank3-Het rats, but not Shank3-KO rats, was significantly larger than in WT rats. The total and non-perforated PSD area was significantly larger in Shank3-Het rats compared to Shank3-KO rats. These findings represent preliminary evidence for synaptic ultrastructural alterations in the mPFC of rats that lack one copy of Shank3 and mimic the heterozygous loss of SHANK3 in Phelan-McDermid syndrome.
    Limitations: The Shank3 deletion in the rat model we used does not affect all isoforms of the protein and would only model the effect of mutations resulting in loss of the N-terminus of the protein. Given the higher prevalence of ASD in males, the ultrastructural study focused only on synaptic structure in male Shank3-deficient rats.
    Conclusions: We observed increased HD and PSD area in Shank3-Het rats. These observations suggest the occurrence of altered synaptic ultrastructure in this animal model, further pointing to a key role of defective expression of the Shank3 protein in ASD and Phelan-McDermid syndrome.
    MeSH term(s) Animals ; Dendritic Spines/ultrastructure ; Female ; Heterozygote ; Male ; Nerve Tissue Proteins/deficiency ; Nerve Tissue Proteins/metabolism ; Post-Synaptic Density/metabolism ; Prefrontal Cortex/pathology ; Rats ; Synapses/ultrastructure
    Chemical Substances Nerve Tissue Proteins ; Shank3 protein, rat
    Keywords covid19
    Language English
    Publishing date 2020-11-17
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2540930-X
    ISSN 2040-2392 ; 2040-2392
    ISSN (online) 2040-2392
    ISSN 2040-2392
    DOI 10.1186/s13229-020-00393-8
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  5. Article ; Online: Droplet digital PCR allows vector copy number assessment and monitoring of experimental CAR T cells in murine xenograft models or approved CD19 CAR T cell-treated patients.

    Haderbache, Rafik / Warda, Walid / Hervouet, Eric / da Rocha, Mathieu Neto / Trad, Rim / Allain, Vincent / Nicod, Clementine / Thieblemeont, Catherine / Boissel, Nicolas / Varlet, Pauline / Agha, Ibrahim Yakoub / Bouquet, Lucie / Guiot, Melanie / Venet, Fabienne / Sujobert, Pierre / Roussel, Xavier / Rouzaire, Paul-Oliver / Caillot, Denis / Casasnovas, Olivier /
    Bories, Jean Christophe / Bachy, Emmanuel / Caillat-Zucman, Sophie / Deschamps, Marina / Ferrand, Christophe

    Journal of translational medicine

    2021  Volume 19, Issue 1, Page(s) 265

    Abstract: Background: Genetically engineered chimeric antigen receptor (CAR) T lymphocytes are promising therapeutic tools for cancer. Four CAR T cell drugs, including tisagenlecleucel (tisa-cel) and axicabtagene-ciloleucel (axi-cel), all targeting CD19, are ... ...

    Abstract Background: Genetically engineered chimeric antigen receptor (CAR) T lymphocytes are promising therapeutic tools for cancer. Four CAR T cell drugs, including tisagenlecleucel (tisa-cel) and axicabtagene-ciloleucel (axi-cel), all targeting CD19, are currently approved for treating B cell malignancies. Flow cytometry (FC) remains the standard for monitoring CAR T cells using a recombinant biotinylated target protein. Nevertheless, there is a need for additional tools, and the challenge is to develop an easy, relevant, highly sensitive, reproducible, and inexpensive detection method. Molecular tools can meet this need to specifically monitor long-term persistent CAR T cells.
    Methods: Based on 2 experimental CAR T cell constructs, IL-1RAP and CS1, we designed 2 quantitative digital droplet (ddPCR) PCR assays. By targeting the 4.1BB/CD3z (28BBz) or 28/CD3z (28z) junction area, we demonstrated that PCR assays can be applied to approved CD19 CAR T drugs. Both 28z and 28BBz ddPCR assays allow determination of the average vector copy number (VCN) per cell. We confirmed that the VCN is dependent on the multiplicity of infection and verified that the VCN of our experimental or GMP-like IL-1RAP CAR T cells met the requirement (< 5 VCN/cell) for delivery to the clinical department, similar to approved axi-cel or tisa-cel drugs.
    Results: 28BBz and 28z ddPCR assays applied to 2 tumoral (acute myeloid leukemia (AML) or multiple myeloma (MM) xenograft humanized NSG mouse models allowed us to quantify the early expansion (up to day 30) of CAR T cells after injection. Interestingly, following initial expansion, when circulating CAR T cells were challenged with the tumor, we noted a second expansion phase. Investigation of the bone marrow, spleen and lung showed that CAR T cells disseminated more within these tissues in mice previously injected with leukemic cell lines. Finally, circulating CAR T cell ddPCR monitoring of R/R acute lymphoid leukemia or diffuse large B cell lymphoma (n = 10 for tisa-cel and n = 7 for axi-cel) patients treated with both approved CAR T cells allowed detection of early expansion, which was highly correlated with FC, as well as long-term persistence (up to 450 days), while FC failed to detect these events.
    Conclusion: Overall, we designed and validated 2 ddPCR assays allowing routine or preclinical monitoring of early- and long-term circulating approved or experimental CAR T cells, including our own IL-1RAP CAR T cells, which will be evaluated in an upcoming phase I clinical trial.
    MeSH term(s) Animals ; Antigens, CD19 ; DNA Copy Number Variations ; Heterografts ; Humans ; Immunotherapy, Adoptive ; Lymphoma, Large B-Cell, Diffuse ; Mice ; Polymerase Chain Reaction ; T-Lymphocytes
    Chemical Substances Antigens, CD19
    Language English
    Publishing date 2021-06-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1479-5876
    ISSN (online) 1479-5876
    DOI 10.1186/s12967-021-02925-z
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  6. Article ; Online: Autism spectrum disorder: neuropathology and animal models.

    Varghese, Merina / Keshav, Neha / Jacot-Descombes, Sarah / Warda, Tahia / Wicinski, Bridget / Dickstein, Dara L / Harony-Nicolas, Hala / De Rubeis, Silvia / Drapeau, Elodie / Buxbaum, Joseph D / Hof, Patrick R

    Acta neuropathologica

    2017  Volume 134, Issue 4, Page(s) 537–566

    Abstract: Autism spectrum disorder (ASD) has a major impact on the development and social integration of affected individuals and is the most heritable of psychiatric disorders. An increase in the incidence of ASD cases has prompted a surge in research efforts on ... ...

    Abstract Autism spectrum disorder (ASD) has a major impact on the development and social integration of affected individuals and is the most heritable of psychiatric disorders. An increase in the incidence of ASD cases has prompted a surge in research efforts on the underlying neuropathologic processes. We present an overview of current findings in neuropathology studies of ASD using two investigational approaches, postmortem human brains and ASD animal models, and discuss the overlap, limitations, and significance of each. Postmortem examination of ASD brains has revealed global changes including disorganized gray and white matter, increased number of neurons, decreased volume of neuronal soma, and increased neuropil, the last reflecting changes in densities of dendritic spines, cerebral vasculature and glia. Both cortical and non-cortical areas show region-specific abnormalities in neuronal morphology and cytoarchitectural organization, with consistent findings reported from the prefrontal cortex, fusiform gyrus, frontoinsular cortex, cingulate cortex, hippocampus, amygdala, cerebellum and brainstem. The paucity of postmortem human studies linking neuropathology to the underlying etiology has been partly addressed using animal models to explore the impact of genetic and non-genetic factors clinically relevant for the ASD phenotype. Genetically modified models include those based on well-studied monogenic ASD genes (NLGN3, NLGN4, NRXN1, CNTNAP2, SHANK3, MECP2, FMR1, TSC1/2), emerging risk genes (CHD8, SCN2A, SYNGAP1, ARID1B, GRIN2B, DSCAM, TBR1), and copy number variants (15q11-q13 deletion, 15q13.3 microdeletion, 15q11-13 duplication, 16p11.2 deletion and duplication, 22q11.2 deletion). Models of idiopathic ASD include inbred rodent strains that mimic ASD behaviors as well as models developed by environmental interventions such as prenatal exposure to sodium valproate, maternal autoantibodies, and maternal immune activation. In addition to replicating some of the neuropathologic features seen in postmortem studies, a common finding in several animal models of ASD is altered density of dendritic spines, with the direction of the change depending on the specific genetic modification, age and brain region. Overall, postmortem neuropathologic studies with larger sample sizes representative of the various ASD risk genes and diverse clinical phenotypes are warranted to clarify putative etiopathogenic pathways further and to promote the emergence of clinically relevant diagnostic and therapeutic tools. In addition, as genetic alterations may render certain individuals more vulnerable to developing the pathological changes at the synapse underlying the behavioral manifestations of ASD, neuropathologic investigation using genetically modified animal models will help to improve our understanding of the disease mechanisms and enhance the development of targeted treatments.
    MeSH term(s) Animals ; Autism Spectrum Disorder/genetics ; Autism Spectrum Disorder/metabolism ; Autism Spectrum Disorder/pathology ; Brain/metabolism ; Brain/pathology ; Disease Models, Animal ; Humans ; Neurons/metabolism ; Neurons/pathology
    Language English
    Publishing date 2017-06-05
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1079-0
    ISSN 1432-0533 ; 0001-6322
    ISSN (online) 1432-0533
    ISSN 0001-6322
    DOI 10.1007/s00401-017-1736-4
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  7. Article ; Online: Droplet digital PCR allows vector copy number assessment and monitoring of experimental CAR T cells in murine xenograft models or approved CD19 CAR T cell-treated patients

    Rafik Haderbache / Walid Warda / Eric Hervouet / Mathieu Neto da Rocha / Rim Trad / Vincent Allain / Clementine Nicod / Catherine Thieblemeont / Nicolas Boissel / Pauline Varlet / Ibrahim Yakoub Agha / Lucie Bouquet / Melanie Guiot / Fabienne Venet / Pierre Sujobert / Xavier Roussel / Paul-Oliver Rouzaire / Denis Caillot / Olivier Casasnovas /
    Jean Christophe Bories / Emmanuel Bachy / Sophie Caillat-Zucman / Marina Deschamps / Christophe Ferrand

    Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-

    2021  Volume 13

    Abstract: Abstract Background Genetically engineered chimeric antigen receptor (CAR) T lymphocytes are promising therapeutic tools for cancer. Four CAR T cell drugs, including tisagenlecleucel (tisa-cel) and axicabtagene-ciloleucel (axi-cel), all targeting CD19, ... ...

    Abstract Abstract Background Genetically engineered chimeric antigen receptor (CAR) T lymphocytes are promising therapeutic tools for cancer. Four CAR T cell drugs, including tisagenlecleucel (tisa-cel) and axicabtagene-ciloleucel (axi-cel), all targeting CD19, are currently approved for treating B cell malignancies. Flow cytometry (FC) remains the standard for monitoring CAR T cells using a recombinant biotinylated target protein. Nevertheless, there is a need for additional tools, and the challenge is to develop an easy, relevant, highly sensitive, reproducible, and inexpensive detection method. Molecular tools can meet this need to specifically monitor long-term persistent CAR T cells. Methods Based on 2 experimental CAR T cell constructs, IL-1RAP and CS1, we designed 2 quantitative digital droplet (ddPCR) PCR assays. By targeting the 4.1BB/CD3z (28BBz) or 28/CD3z (28z) junction area, we demonstrated that PCR assays can be applied to approved CD19 CAR T drugs. Both 28z and 28BBz ddPCR assays allow determination of the average vector copy number (VCN) per cell. We confirmed that the VCN is dependent on the multiplicity of infection and verified that the VCN of our experimental or GMP-like IL-1RAP CAR T cells met the requirement (< 5 VCN/cell) for delivery to the clinical department, similar to approved axi-cel or tisa-cel drugs. Results 28BBz and 28z ddPCR assays applied to 2 tumoral (acute myeloid leukemia (AML) or multiple myeloma (MM) xenograft humanized NSG mouse models allowed us to quantify the early expansion (up to day 30) of CAR T cells after injection. Interestingly, following initial expansion, when circulating CAR T cells were challenged with the tumor, we noted a second expansion phase. Investigation of the bone marrow, spleen and lung showed that CAR T cells disseminated more within these tissues in mice previously injected with leukemic cell lines. Finally, circulating CAR T cell ddPCR monitoring of R/R acute lymphoid leukemia or diffuse large B cell lymphoma (n = 10 for tisa-cel and n = 7 for ...
    Keywords Chimeric antigen receptor ; Droplet digital PCR ; IL-1RAP ; Tisa-cel ; Axi-cel ; Monitoring ; Medicine ; R
    Subject code 380
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
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  8. Article ; Online: A systematic global stocktake of evidence on human adaptation to climate change

    Berrang-Ford, Lea / Siders, A.R / Lesnikowski, Alexandra / Fischer, Alexandra Paige / Callaghan, Max W. / Haddaway, Neal R. / Mach, Katharine J / Araos, Malcolm / Shah, Mohammad Aminur Rahman / Wannewitz, Mia / Doshi, Deepal / Leiter, Timo / Matavel, Custodio / Musah-Surugu, Justice Issah / Wong-Parodi, Gabrielle / Antwi-Agyei, Philip / Ajibade, Idowu / Chauhan, Neha / Kakenmaster, William /
    Grady, Caitlin / Chalastani, Vasiliki I / Jagannathan, Kripa / Galappaththi, Eranga K. / Sitati, Asha / Scarpa, Giulia / Totin, Edmond / Davis, Katy / Hamilton, Nikita Charles / Kirchhoff, Christine J. / Kumar, Praveen / Pentz, Brian / Simpson, . Nicholas P. / Theokritoff, Emily / Deryng, Delphine / Reckien, Diana / Zavaleta-Cortijo, Carol / Ulibarri, Nicola / Segnon, Alcade C. / Khavhagali, Vhalinavho / Shang, Yuanyuan / Zvobgo, Luckson / Zommers, Zinta / Xu, Jiren / Williams, Portia Adade / Canosa, Ivan Villaverde / van Maanen, Nicole / Bavel, Bianca van / Aalst, Maarten van / Turek-Hankins, Lynée L / Trivedi, Hasti / Trisos, Christopher H. / Thomas, Adelle / Thakur, Shinny / Templeman, Sienna / Stringer, Lindsay C. / Sotnik, Garry / Sjostrom, Kathryn Dana / Singh, Chandni / Siña, Mariella Z. / Shukla, Roopam / Sardans, Jordi / Salubi, Eunice A. / Safaee Chalkasra, Lolita Shaila / Ruiz-Díaz, Raquel / Richards, Carys / Pokharel, Pratik / Petzold, Jan / Penuelas, Josep / Pelaez Avila, Julia / Murillo, Julia B. Pazmino / Ouni, Souha / Niemann, Jennifer / Nielsen, Miriam / New, Mark G. / Nayna Schwerdtle, Patricia / Nagle Alverio, Gabriela / Mullin, Cristina A / Mullenite, Joshua / Mosurska, Anuszka / Morecroft, Mike D. / Minx, Jan C. / Maskell, Gina / Nunbogu, Abraham Marshall / Magnan, Alexandre K / Lwasa, Shuaib / Lukas-Sithole, Megan / Lissner, Tabea / Lilford, Oliver / Koller, Steven F. / Jurjonas, Matthew / Joe, Elphin Tom / Huynh, Lam T.M. / Hill, Avery / Hernandez, Rebecca R. / Hegde, Greeshma / Hawxwell, Tom / Harper, Sherilee / Harden, Alexandra / Haasnoot, Marjolijn / Gilmore, Elisabeth A / Gichuki, Leah / Gatt, Alyssa / Garschagen, Matthias / Ford, James D / Forbes, Andrew / Farrell, Aidan D / Enquist, Carolyn A. F / Elliott, Susan / Duncan, Emily / Coughlan de Perez, Erin / Coggins, Shaugn / Chen, Tara / Campbell, Donovan / Browne, Katherine E / Bowen, Kathryn J / Biesbroek, Robbert / Bhatt, Indra D. / Bezner Kerr, Rachel / Barr, Stephanie L / Baker, Emily / Austin, Stephanie E / Arotoma-Rojas, Ingrid / Anderson, Christa / Ajaz, Warda / Thelma Zulfawu / Agrawal, Tanvi / Abu, Thelma Zulfawu

    2021  

    Abstract: Assessing global progress on human adaptation to climate change is an urgent priority. Although the literature on adaptation to climate change is rapidly expanding, little is known about the actual extent of implementation. We systematically screened >48, ...

    Abstract Assessing global progress on human adaptation to climate change is an urgent priority. Although the literature on adaptation to climate change is rapidly expanding, little is known about the actual extent of implementation. We systematically screened >48,000 articles using machine learning methods and a global network of 126 researchers. Our synthesis of the resulting 1,682 articles presents a systematic and comprehensive global stocktake of implemented human adaptation to climate change. Documented adaptations were largely fragmented, local and incremental, with limited evidence of transformational adaptation and negligible evidence of risk reduction outcomes. We identify eight priorities for global adaptation research: assess the effectiveness of adaptation responses, enhance the understanding of limits to adaptation, enable individuals and civil society to adapt, include missing places, scholars and scholarship, understand private sector responses, improve methods for synthesizing different forms of evidence, assess the adaptation at different temperature thresholds, and improve the inclusion of timescale and the dynamics of responses.
    Keywords climate change ; adaptation ; agriculture
    Language English
    Publishing date 2021-11-18T14:15:49Z
    Publisher Springer
    Publishing country fr
    Document type Article ; Online
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  9. Article ; Online: A systematic global stocktake of evidence on human adaptation to climate change

    Berrang-Ford, Lea / Siders, A.R. / Lesnikowski, Alexandra / Fischer, Alexandra Paige / Callaghan, Max W. / Haddaway, Neal R. / Mach, Katharine J. / Araos, Malcolm / Shah, Mohammad Aminur Rahman / Wannewitz, Mia / Doshi, Deepal / Leiter, Timo / Matavel, Custodio / Musah-Surugu, Justice Issah / Wong-Parodi, Gabrielle / Antwi-Agyei, Philip / Ajibade, Idowu / Chauhan, Neha / Kakenmaster, William /
    Grady, Caitlin / Chalastani, Vasiliki I. / Jagannathan, Kripa / Galappaththi, Eranga K. / Sitati, Asha / Scarpa, Giulia / Totin, Edmond / Davis, Katy / Hamilton, Nikita Charles / Kirchhoff, Christine J. / Kumar, Praveen / Pentz, Brian / Simpson, Nicholas P. / Theokritoff, Emily / Deryng, Delphine / Reckien, Diana / Zavaleta-Cortijo, Carol / Ulibarri, Nicola / Segnon, Alcade C. / Khavhagali, Vhalinavho / Shang, Yuanyuan / Zvobgo, Luckson / Zommers, Zinta / Xu, Jiren / Williams, Portia Adade / Canosa, Ivan Villaverde / van Maanen, Nicole / van Bavel, Bianca / van Aalst, Maarten / Turek-Hankins, Lynée L. / Trivedi, Hasti / Trisos, Christopher H. / Thomas, Adelle / Thakur, Shinny / Templeman, Sienna / Stringer, Lindsay C. / Sotnik, Garry / Sjostrom, Kathryn Dana / Singh, Chandni / Siña, Mariella Z. / Shukla, Roopam / Sardans, Jordi / Salubi, Eunice A. / Safaee Chalkasra, Lolita S. / Ruiz-Díaz, Raquel / Richards, Carys / Pokharel, Pratik / Petzold, Jan / Penuelas, Josep / Pelaez Avila, Julia / Pazmino Murillo, Julia B. / Ouni, Souha / Niemann, Jennifer / Nielsen, Miriam / New, Mark / Schwerdtle, Patricia N. / Nagle Alverio, Gabriela / Mullin, Cristina A. / Mullenite, Joshua / Mosurska, Anuszka / Morecroft, Mike D. / Minx, Jan C. / Maskell, Gina / Nunbogu, Abraham Marshall / Magnan, Alexandre K. / Lwasa, Shuaib / Lukas-Sithole, Megan / Lissner, Tabea / Lilford, Oliver / Koller, Steven F. / Jurjonas, Matthew / Joe, Elphin T. / Huynh, Lam T.M. / Hill, Avery / Hernandez, Rebecca R. / Hegde, Greeshma / Hawxwell, Tom / Harper, Sherilee / Harden, Alexandra / Haasnoot, Marjolijn / Gilmore, Elisabeth A. / Gichuki, Leah / Gatt, Alyssa / Garschagen, Matthias / Ford, James D. / Forbes, Andrew / Farrell, Aidan D. / Enquist, Carolyn A.F. / Elliott, Susan / Duncan, Emily / Coughlan de Perez, Erin / Coggins, Shaugn / Chen, Tara / Campbell, Donovan / Browne, Katherine E. / Bowen, Kathryn J. / Biesbroek, Robbert / Bhatt, Indra D. / Bezner Kerr, Rachel / Barr, Stephanie L. / Baker, Emily / Austin, Stephanie E. / Arotoma-Rojas, Ingrid / Anderson, Christa / Ajaz, Warda / Agrawal, Tanvi / Abu, Thelma Zulfawu

    Nature Climate Change

    2021  Volume 11, Issue 11

    Abstract: Assessing global progress on human adaptation to climate change is an urgent priority. Although the literature on adaptation to climate change is rapidly expanding, little is known about the actual extent of implementation. We systematically screened >48, ...

    Abstract Assessing global progress on human adaptation to climate change is an urgent priority. Although the literature on adaptation to climate change is rapidly expanding, little is known about the actual extent of implementation. We systematically screened >48,000 articles using machine learning methods and a global network of 126 researchers. Our synthesis of the resulting 1,682 articles presents a systematic and comprehensive global stocktake of implemented human adaptation to climate change. Documented adaptations were largely fragmented, local and incremental, with limited evidence of transformational adaptation and negligible evidence of risk reduction outcomes. We identify eight priorities for global adaptation research: assess the effectiveness of adaptation responses, enhance the understanding of limits to adaptation, enable individuals and civil society to adapt, include missing places, scholars and scholarship, understand private sector responses, improve methods for synthesizing different forms of evidence, assess the adaptation at different temperature thresholds, and improve the inclusion of timescale and the dynamics of responses.
    Keywords Life Science
    Subject code 306
    Language English
    Publishing country nl
    Document type Article ; Online
    ZDB-ID 2614383-5
    ISSN 1758-6798 ; 1758-678X
    ISSN (online) 1758-6798
    ISSN 1758-678X
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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