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Article ; Online: Duloxetine in Reducing Catheter-Related Bladder Discomfort: A Prospective, Randomized, Double-Blind, Placebo-Controlled Study.

Rath, Amrita / Reena, R / Yadav, Ghanshyam

Urology research & practice

2023 Volume 49, Issue 1, Page(s) 48–52

Abstract: Objective: The excessive desire to void with discomfort in the supra-pubic region, which is experienced postoperatively by patients who underwent urinary catheterization, is known as catheter-related bladder discomfort. In this study, we evaluated ... ...

Abstract	Objective: The excessive desire to void with discomfort in the supra-pubic region, which is experienced postoperatively by patients who underwent urinary catheterization, is known as catheter-related bladder discomfort. In this study, we evaluated duloxetine, a selective serotonin and norepinephrine reuptake inhibitor, in preventing catheter-related bladder discomfort. Material and methods: Around 64 adults (18-60 years), of either sex, with American Society of American Society of Anesthesiologists (ASA) physical status I and II, scheduled to undergo elective gastrointestinal carcinoma surgeries under general anesthesia were analyzed in the final assessment of 2 comparative groups C and D of 32 patients each. Group D received 1 ranitidine tablet of 150 mg and 1 duloxetine tablet of 60 mg, while group C patients received 2 tablets of ranitidine of 75 mg 2 hours prior to induction. A 16 F Foley catheter was used to catheterize bladder intra-operatively, and 10 mL of distilled water was used to fill the balloon. At 0, 1, 2, and 6 hours, the catheter-related bladder discomfort was evaluated, and categorized into none, mild, moderate, and severe. The study drug's adverse effects, if any, were reported. Results: At all-time intervals, group D had lower incidence and severity of catheterrelated bladder discomfort than group C (P < .05). Compared to group C, patients in group D had a higher incidence of nausea, dizziness, and vomiting; nevertheless, the difference was statistically insignificant (P > .05). Conclusion: Duloxetine of 60 mg given orally 2 hours before induction decreases the incidence and severity of catheter-related bladder discomfort.
Language	English
Publishing date	2023-10-25
Publishing country	Turkey
Document type	Journal Article
ISSN	2980-1478
ISSN (online)	2980-1478
DOI	10.5152/tud.2023.22195
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Article: Serum Zinc Levels in Women with Polycystic Ovarian Syndrome are Lower as Compared to Those without Polycystic Ovarian Syndrome: A Cohort Study.

Dhar, Swati / Yadav, Reena / Tomar, Akash

Journal of human reproductive sciences

2024 Volume 17, Issue 1, Page(s) 25–32

Abstract: Background: Zinc is an essential micronutrient, a vital stabiliser and a cofactor in many enzymes such as superoxide dismutase and phospholipase C and also acts as an antioxidant by protecting the sulfhydryl groups of different proteins and enzymes ... ...

Abstract	Background: Zinc is an essential micronutrient, a vital stabiliser and a cofactor in many enzymes such as superoxide dismutase and phospholipase C and also acts as an antioxidant by protecting the sulfhydryl groups of different proteins and enzymes against free radicals. It is unclear if serum zinc levels are correlated with polycystic ovary syndrome (PCOS) and its pathophysiology, although relation between diabetes and insulin resistance has been established. Aims: This study aimed to investigate circulating serum zinc levels in PCOS subjects compared with non-PCOS subjects. Settings and design: In this cohort study, PCOS subjects were compared with normal subjects aged between 18 and 35. Materials and methods: All the included subjects underwent measurement of anthropometric parameters, fasting insulin, luteinising hormone, follicle-stimulating hormone, thyroid-stimulating hormone, prolactin, progesterone, oestrogen and serum zinc levels. These values were taken on days 2-5 of the menstrual cycle. Statistical analysis used: Univariate analysis and linear regression were performed for serum zinc levels and fasting insulin levels in PCOS subjects and non-PCOS subjects using SPSS (version 21) and Microsoft Excel (2019). Results: Serum zinc levels in the PCOS group were lower than in the control group ( Conclusion: The data suggest that serum zinc levels were found to be lower in PCOS subjects as compared to normal controls and evaluation of these levels may indicate that zinc has a vital role in PCOS pathophysiology.
Language	English
Publishing date	2024-03-28
Publishing country	India
Document type	Journal Article
ZDB-ID	2418984-4
ISSN	1998-4766 ; 0974-1208
ISSN (online)	1998-4766
ISSN	0974-1208
DOI	10.4103/jhrs.jhrs_8_24
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Article: High-volume cataract surgery in Lahan, Nepal.

Yadav, Reena / Roshan, Abhishek / Singh, Sanjay Kumar

Community eye health

2022 Volume 35, Issue 116, Page(s) 10–11

Language	English
Publishing date	2022-12-16
Publishing country	England
Document type	Journal Article
ZDB-ID	1036859-0
ISSN	0953-6833
ISSN	0953-6833
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Zs.B 3298: Show issues

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Article: Efficacy of Estradiol Cream for Venipuncture Pain in Obese Female Patients: A Pilot Study.

Jayanthi, Abhinay / Yadav, Ghanshyam / Reena / Rath, Amrita

Cureus

2022 Volume 14, Issue 3, Page(s) e23557

Abstract: Introduction: Venipuncture is often a painful procedure causing significant anxiety, distress, and psychological consequences. We evaluated the efficacy of estradiol cream and compared it with a eutectic mixture of local anesthetics (EMLA) cream for ... ...

Abstract	Introduction: Venipuncture is often a painful procedure causing significant anxiety, distress, and psychological consequences. We evaluated the efficacy of estradiol cream and compared it with a eutectic mixture of local anesthetics (EMLA) cream for alleviation of venipuncture pain and to make cannulation easy in female obese patients. Materials and methods: The clearance from the Institutional Ethical Committee as well as prior written and informed consent were obtained from the participants. A total of 105 obese female adult patients aged between 25 and 64 years belonging to the American Society of Anesthesiologists (ASA) physical status I and II with body mass index (BMI) > 30 kg/m Result: The final analysis was carried out on 25 patients in group I, 27 patients in group II, and 33 patients in group III. There was no significant improvement in the ease of cannulation in group II when compared to group I. The mean VAS was similar in group I and group II, whereas it was significantly reduced in group III (p < 0.05). Conclusion: EMLA cream was found to significantly reduce the pain of venipuncture in comparison to placebo and estradiol cream. There is no beneficial effect of estradiol cream in reducing the pain from venipuncture or in ease of cannulation compared to placebo.
Language	English
Publishing date	2022-03-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.23557
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Article ; Online: An image analysis approach to characterize micronuclei differences in different subtypes of breast cancer.

Kumari, Laxmi / Yadav, Reena / Kaur, Deepinder / Dey, Pranab / Bhatia, Alka

Pathology, research and practice

2024 Volume 254, Page(s) 155126

Abstract: Background: Micronuclei (MN) have been used as screening, diagnostic and prognostic markers in multiple cancer types, including breast cancer (BC). However, the question that the MN present in all subtypes of BC are similar or different remains ... ...

Abstract	Background: Micronuclei (MN) have been used as screening, diagnostic and prognostic markers in multiple cancer types, including breast cancer (BC). However, the question that the MN present in all subtypes of BC are similar or different remains unanswered. We thus hypothesized that MN present in different subtypes of BC may differ in their contents which may be visible as differences in their morphologic and morphometric features. This study was thus carried out with the aim to identify the differences between MN morphometry, complexity, and texture in different subtypes of BC, such as estrogen and progesterone receptor-positive (ER+/PR+; MCF-7, T-47D), human epidermal growth factor receptor-positive (Her2 +;SKBR3) and triple-negative BC (TNBC; MDA-MB-231, MDA-MB-468) cell lines (CLs) by ImageJ software. Methods: For analysis of MN dimensions, MN irregularity, and texture, we used morphometry and two mathematical computer-assisted algorithms, i.e., fractal dimension (FD) and grey level co-occurrence matrix (GLCM) of ImageJ software. Results: MN area and perimeter values showed differences in the size of MN in different subtypes of BC, with the largest MN in TNBC CLs. GLCM parameters (entropy, angular second moment, inverse difference moment, contrast, and correlation) showed highly heterogenous texture in case of TNBC MN as compared to the others. FD analysis also revealed more complexity and irregularity in MN found in TNBC cells. Conclusion: The study for the first time showed morphometric, architectural and texture related differences amongst MN present in different subtypes of BC. The above may reflect differences in their composition and contents. Further, these differences may point towards the distinct mechanisms involved in the formation of MN in different subtypes of BC that need to be explored further.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Triple Negative Breast Neoplasms/genetics ; Algorithms ; Estrogens ; Cell Line ; Software
Chemical Substances	Estrogens
Language	English
Publishing date	2024-01-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	391889-0
ISSN	1618-0631 ; 0344-0338
ISSN (online)	1618-0631
ISSN	0344-0338
DOI	10.1016/j.prp.2024.155126
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Ud III Zs.20: Show issues

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Article ; Online: Aspirin as a potential drug repurposing candidate targeting estrogen receptor alpha in breast cancer: a molecular dynamics and in-vitro study.

Kaur, Deepinder / Choudhury, Chinmayee / Yadav, Reena / Kumari, Laxmi / Bhatia, Alka

Journal of biomolecular structure & dynamics

2024 , Page(s) 1–12

Abstract: Estrogen receptor alpha (ERα) is expressed by 70% of breast cancers (BCs). Any deregulation in ERα signaling is crucial for the initiation and progression of BC. Because of development of resistance to anti-estrogenic compounds, repurposing existing ... ...

Abstract	Estrogen receptor alpha (ERα) is expressed by 70% of breast cancers (BCs). Any deregulation in ERα signaling is crucial for the initiation and progression of BC. Because of development of resistance to anti-estrogenic compounds, repurposing existing drugs is an apt strategy to avoid a long drug-discovery process. Substantial epidemiologic evidence suggests that Aspirin use reduces the risk of different cancers including BC, while its role as an adjuvant or a possible antineoplastic agent in cancer treatment is being investigated. In this study, we attempted to explore possibilities of ERα inhibition by Aspirin which may act through competitive binding to the ligand binding domain (LBD) of ERα. A list of 48 ERα-LBD crystal structures bound with agonists, antagonists, and selective ER modulators (SERMs) was thoroughly analysed to determine interaction patterns specific to each ligand category. Exhaustive docking and 500 ns molecular dynamics (MD) studies were performed on three ERα - Aspirin complexes generated using agonist, antagonist, and SERM-bound crystal structures. Besides, three ERα crystal structures bound to agonist, antagonist, and SERM respectively were also subjected to MD simulations. Aspirin showed good affinity to LBD of ERα. Comparative analyses of binding patterns, conformational changes and molecular interaction profiles from the docking results and MD trajectories suggests that Aspirin was most stable in complex generated using SERM bound crystal structure of ERα and showed interactions with Gly-521, Ala-350, Leu-525 and Thr-347 like SERMs. In addition, in-vitro assays, qPCR, and immunofluorescent assay demonstrated the decline in the expression of ERα in MCF-7 upon treatment with Aspirin. These preliminary bioinformatical and in-vitro findings may form the basis to consider Aspirin as a potential candidate for targeting ERα, especially in tamoxifen-resistant cancers.Communicated by Ramaswamy H. Sarma.
Language	English
Publishing date	2024-01-27
Publishing country	England
Document type	Journal Article
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2024.2308780
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Zs.A 2093: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
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Article ; Online: Harnessing the potential of fatty Acid-Surfactant-Based micellar gel for enhanced topical delivery of Apremilast in psoriasis treatment.

Sontakke, Arun / Dighe, Sayali / Sharma, Reena / Yadav, Vivek / Jain, Sanyog

International journal of pharmaceutics

2024 Volume 655, Page(s) 124026

Abstract: Apremilast (APR) is a potent anti-psoriatic agent that inhibits the phosphodiesterase 4 enzyme. Due to the poor oral bioavailability and associated systemic side effects the clinical applicability of APR has been constrained. Nanotechnology-based carrier ...

Abstract	Apremilast (APR) is a potent anti-psoriatic agent that inhibits the phosphodiesterase 4 enzyme. Due to the poor oral bioavailability and associated systemic side effects the clinical applicability of APR has been constrained. Nanotechnology-based carrier system presents a novel option to increase the efficacy of the topical treatment of APR. The current investigation deals with the development of fatty acid-surfactant conjugate-based hybrid mixed micellar gel (HMMG) for the topical delivery of APR. The developed micelles exhibited an average size of 83.59 ± 4.46 nm, PDI of 0.239 ± 0.047, % entrapment efficiency of ∼ 94.78 ± 3.98 %, with % practical drug loading of ∼11.37 ± 3.14 %. TEM analysis revealed the spherical shape of micelles. The hybrid micelles were further loaded in a carbopol®934P gel base for ease of application. Ex vivo permeation study revealed enhanced permeation and ∼ 38-fold higher retention in deeper layers of skin from a hybrid micellar gel. In vivo, assessment demonstrated augmented efficacy of APR-HMMG as compared to 0.1 % betamethasone valerate. Also, APR-HMMG showed no sign of irritation, suggesting superior safety as a topical application. Thus, the proposed formulation strategy represents a viable avenue for enhancing the therapeutic efficacy of various anti-psoriatic moieties.
MeSH term(s)	Humans ; Micelles ; Fatty Acids ; Drug Carriers ; Surface-Active Agents ; Skin ; Gels ; Pulmonary Surfactants ; Psoriasis/drug therapy ; Particle Size ; Thalidomide/analogs & derivatives
Chemical Substances	Micelles ; Fatty Acids ; Drug Carriers ; Surface-Active Agents ; apremilast (UP7QBP99PN) ; Gels ; Pulmonary Surfactants ; Thalidomide (4Z8R6ORS6L)
Language	English
Publishing date	2024-03-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	428962-6
ISSN	1873-3476 ; 0378-5173
ISSN (online)	1873-3476
ISSN	0378-5173
DOI	10.1016/j.ijpharm.2024.124026
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Zs.A 1409: Show issues

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Article ; Online: Study of impact of WHO option B+ on maternal and perinatal outcome in HIV-positive women delivering at a tertiary care hospital, Delhi.

Yadav, Reena / Chopra, Kanika / Jaiswal, Nishtha

Indian journal of sexually transmitted diseases and AIDS

2022 Volume 43, Issue 1, Page(s) 90–91

Language	English
Publishing date	2022-06-07
Publishing country	India
Document type	Journal Article
ZDB-ID	2622183-4
ISSN	2589-0565 ; 2589-0565
ISSN (online)	2589-0565
ISSN	2589-0565
DOI	10.4103/ijstd.ijstd_24_21
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Article ; Online: Preclinical safety assessment of photoluminescent metal quantum clusters stabilized with autologous serum proteins for host specific theranostics.

Sood, Kritika / Yadav, Pranjali / Jamwal, Manu / Das, Reena / Shanavas, Asifkhan

Nanotheranostics

2023 Volume 7, Issue 3, Page(s) 316–326

Abstract: Host derived serum proteome stabilised red-emitting gold quantum clusters (or Au-QC-NanoSera or QCNS) of size range ~2 nm have been synthesised in a first reported study. The host serum was taken from bovine, murine and human origins to establish the ... ...

Abstract	Host derived serum proteome stabilised red-emitting gold quantum clusters (or Au-QC-NanoSera or QCNS) of size range ~2 nm have been synthesised in a first reported study. The host serum was taken from bovine, murine and human origins to establish the proof of concept.
MeSH term(s)	Animals ; Cattle ; Humans ; Mice ; Precision Medicine ; Tissue Distribution ; Mice, Inbred C57BL ; Cell Line ; Blood Proteins
Chemical Substances	Blood Proteins
Language	English
Publishing date	2023-03-27
Publishing country	Australia
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2206-7418
ISSN (online)	2206-7418
DOI	10.7150/ntno.82978
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Article ; Online: Effect of leakage location on pressure deficiency index of water distribution network

Pandya, Nidhi C / Popawala, Reena / Yadav, S.M.

ISH Journal of Hydraulic Engineering. 2023 Aug. 08, v. 29, no. 4 p.427-436

2023

Abstract: Hydraulic assessment of water distribution networks (WDNs) is the fundamental process to check their efficiency in providing sufficient water with desirable pressure at the consumer end. The presence of leakage leads to reduction in the efficiency of the ...

Abstract	Hydraulic assessment of water distribution networks (WDNs) is the fundamental process to check their efficiency in providing sufficient water with desirable pressure at the consumer end. The presence of leakage leads to reduction in the efficiency of the system. The relationship between leakage location and its effect on network behavior has not yet been analyzed effectively. In the present study, influence of leakage and its location is analyzed for the purpose of hydraulic assessment and leakage management. A network with leakages at different locations is developed in the laboratory and its leakage rates are analyzed using pressure-driven demand and leakage (PDDL) approach. The same method is applied to a real-life distribution system for verification. To check the effect of the leakage location, a pressure deficiency index (PDI) is considered as a hydraulic performance indicator in this study. Results show the relationship between the leakage location and variation in PDI. Findings of this study provide an effective reference for real-life WDN leakage management.
Keywords	hydraulic engineering ; journals ; methodology ; water distribution ; Water distribution network ; leakage management ; pressure deficiency index
Language	English
Dates of publication	2023-0808
Size	p. 427-436.
Publishing place	Taylor & Francis
Document type	Article ; Online
ISSN	2164-3040
DOI	10.1080/09715010.2022.2094731
Database	NAL-Catalogue (AGRICOLA)

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