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Article: A forensic population database of autosomal STR and X-STR markers in the Qiang ethnic minority of China.

Wang, Zefei / Song, Mengyuan / Lyu, Qiang / Ying, Jun / Wu, Qian / Song, Feng / Jiang, Lanrui / Wei, Xiaowen / Wang, Shuangshuang / Wang, Fei / Zhou, Yuxiang / Song, Xingbo / Luo, Haibo

Heliyon

2023 Volume 9, Issue 11, Page(s) e21823

Abstract: The Qiang ethnic group is one of the oldest ethnic groups in China and is the most active ethnic ... nationally and internationally. The paternal and maternal genetic feature of the Qiang ethnic group has been ... Microreader™ 19X System) for application in the Qiang population and to elucidate their genetic diversity ...

Abstract	The Qiang ethnic group is one of the oldest ethnic groups in China and is the most active ethnic group among all the populations along the Tibetan-Yi corridor. They have had a profound impact nationally and internationally. The paternal and maternal genetic feature of the Qiang ethnic group has been revealed, leaving the question of the genetic characteristics from autosomes and X chromosome not answered. The aim of this study was to explore the potential of 36 A-STR (Microreader™ 36A ID System) and 19 X-STR (Microreader™ 19X System) for application in the Qiang population and to elucidate their genetic diversity in southwest China. The cumulative probability of exclusion (CPE) for autosomal STRs is 1-1.3814 × 10
Language	English
Publishing date	2023-11-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e21823
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Article ; Online: Genetic analysis of 29 Y-STR loci in Qiang population from Beichuan Qiang Autonomous County in China.

Wu, Qian / Ying, Jun / Xue, Chenglan / Lv, Qiang / Song, Feng / Wang, Jun / Song, Xingbo / Chen, Jie

Legal medicine (Tokyo, Japan)

2020 Volume 45, Page(s) 101714

Abstract: This study reported the forensic parameters of the 29 Y-STR loci of 242 unrelated Qiang males ... in Beichuan Qiang Autonomous County. Qiang population is a minority with small size populations and has never ... been reported. The overall haplotype diversity of Qiang population was measured to be 0.9992 ...

Abstract	This study reported the forensic parameters of the 29 Y-STR loci of 242 unrelated Qiang males in Beichuan Qiang Autonomous County. Qiang population is a minority with small size populations and has never been reported. The overall haplotype diversity of Qiang population was measured to be 0.9992 while a discrimination capacity was 0.9215. According to the haplotypic analysis of the 29 Y-STR loci, 223 different haplotypes were obtained, of which 207 (92.83%) were unique. A total of 242 different alleles were checked at all loci, the corresponding allele frequencies ranged from 0.0041 to 0.7603. In addition, pairwise genetic distances, multidimensional scaling plots and neighbor-joining dendrogram were performed to analyze interpopulation differentiation between Qiang population and 16 other ethnic groups. These data can fill the gap in the Y-STR Haplotype Reference Database of the Qiang population and may be of reference value for forensic and population genetic analysis.
Language	English
Publishing date	2020-05-05
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	2019555-2
ISSN	1873-4162 ; 1344-6223
ISSN (online)	1873-4162
ISSN	1344-6223
DOI	10.1016/j.legalmed.2020.101714
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Article ; Online: Paternal genetic structure of the Qiang ethnic group in China revealed by high-resolution Y-chromosome STRs and SNPs.

Song, Mengyuan / Wang, Zefei / Lyu, Qiang / Ying, Jun / Wu, Qian / Jiang, Lanrui / Wang, Fei / Zhou, Yuxiang / Song, Feng / Luo, Haibo / Hou, Yiping / Song, Xingbo / Ying, Binwu

Forensic science international. Genetics

2022 Volume 61, Page(s) 102774

Abstract: The Qiang population mainly lived in Beichuan Qiang Autonomous County of Sichuan Province. It is ... one of the nomads in China, distributed along the Minjiang River. The Qiang population was assumed ... STRs) panels to study the Qiang ethnic group to unravel their paternal genetic, forensic and ...

Abstract	The Qiang population mainly lived in Beichuan Qiang Autonomous County of Sichuan Province. It is one of the nomads in China, distributed along the Minjiang River. The Qiang population was assumed to have great affinity with the Han, the largest ethnic group in China, when it refers to the genetic origin. Whereas, it is deeply understudied, especially from the Y chromosome. Here in this study, we used validated high-resolution Y-chromosome single nucleotide polymorphisms (Y-SNPs) and short tandem repeats (Y-STRs) panels to study the Qiang ethnic group to unravel their paternal genetic, forensic and phylogenetic characteristics. A total of 422 male samples of the Qiang ethnic group were genotyped by 233 Y-SNPs and 29 Y-STRs. Haplogroup O-M175 (N = 312) was the most predominant haplogroup in the Qiang ethnic group, followed by D-M174 (N = 32) and C-M130 (N = 32), N-M231 (N = 27), and Q-M242 (N = 15). After further subdivision, O2a-M324 (N = 213) accounted for the majority of haplogroup O. Haplogroup C2b-Z1338 (N = 29), D1a-CTS11577 (N = 30). O2a2b1a1a1-F42 (N = 48), O2a1b1a1a1a-F11 (N = 35), and O2a2b1a1-M117 (N = 21) represented other large terminal haplogroups. The results unveiled that Qiang ethnic group was a population with a high percentage of haplogroup O2a2b1a1a1-F42 (48/422) and O2a1b1a1a1a-F11 (35/422), and O2a2b1a1-M117 (21/422), which has never been reported. Its haplogroup distribution pattern was different from any of the Han populations, implying that the Qiang ethnic group had its unique genetic pattern. Mismatch analysis indicated that the biggest mismatch number in haplogroup O2a2b1a1a1-F42 was 21, while that of haplogroup O2a1b1a1a1a-F11 was 20. The haplotype diversity of the Qiang ethnic group equaled 0.999788, with 392 haplotypes observed, of which 367 haplotypes were unique. The haplogroup diversity of the Qiang ethnic group reached 0.9767, and 53 terminal haplogroups were observed (The haplogroup diversity of the Qiang ethnic group was the highest among Qiang and all Han subgroups, indicating the larger genetic diversity of the Qiang ethnic group.). Haplogroup O2a2b1a1a1-F42 was the most predominant haplogroup, including 11.37 % of the Qiang individuals. Median-joining trees showed gene flow between the Qiang and Han individuals. Our results indicated that 1) the highest genetic diversity was observed in the Qiang ethnic group compared to any of the former studied Chinese population, suggesting that the Qiang might be an older paternal branch; 2) the haplogroup D-M174 individuals of Qiang, Tibetans and Japanese distributed in three different subclades, which was unable to identify through low-resolution Y-SNP panel; and 3) the Qiang had lower proportion of haplogroup D compared to Yi and Tibetan ethnic groups, showing that the Qiang had less genetic communication with them than with Han Chinese.
MeSH term(s)	Humans ; Ethnicity/genetics ; Chromosomes, Human, Y ; Polymorphism, Single Nucleotide ; Genetics, Population ; Phylogeny ; Haplotypes ; Microsatellite Repeats ; China
Language	English
Publishing date	2022-09-13
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2493339-9
ISSN	1878-0326 ; 1872-4973
ISSN (online)	1878-0326
ISSN	1872-4973
DOI	10.1016/j.fsigen.2022.102774
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Article: Analysis of Genetic Polymorphism and Population Genetic Structure of 57 Autosomal InDel Loci in Beichuan Qiang Population.

Jiang, Chun-Yue / Ma, Hao / Fan, Qing-Wei / Yang, Hui-Ling / Xu, Dong-Dong / Wang, Yun / DU, Bing

Fa yi xue za zhi

2023 Volume 38, Issue 6, Page(s) 739–746

Abstract: ... in AGCU InDel 60 fluorescence detection kit in the Beichuan Qiang population of Sichuan Province and ... individuals from Beichuan Qiang population of Sichuan Province were typing detected by AGCU InDel 60 ... InDel 60 fluorescence detection kit have a good genetic polymorphism in Beichuan Qiang population ...

Abstract	Objectives: To investigate the genetic information of 57 autosomal InDel loci (A-InDels) included in AGCU InDel 60 fluorescence detection kit in the Beichuan Qiang population of Sichuan Province and evaluate its application value in forensic medicine. Methods: A total of 200 unrelated healthy individuals from Beichuan Qiang population of Sichuan Province were typing detected by AGCU InDel 60 fluorescence detection kit. Allele frequencies and population genetic parameters of the 57 A-InDels were statistically analyzed and compared with the available data of 26 populations. Results: After Bonferroni correction, there was no linkage disequilibrium between the 57 A-InDels, and all loci were in Hardy-Weinberg equilibrium. Except for rs66595817 and rs72085595, the minor allele frequencies of 55 A-InDels were above 0.3. PIC ranged from 0.298 3 to 0.375 0, CDP was 1-2.974 8×10 Conclusions: The 57 A-InDels in AGCU InDel 60 fluorescence detection kit have a good genetic polymorphism in Beichuan Qiang population of Sichuan Province, which can be used as effective supplemental for individual identification and paternity identification in forensic medicine.
MeSH term(s)	Humans ; Genetics, Population ; Asian People/genetics ; Polymorphism, Genetic ; Gene Frequency ; INDEL Mutation ; China ; Microsatellite Repeats ; Genetic Loci
Language	Chinese
Publishing date	2023-02-02
Publishing country	China
Document type	Journal Article
ISSN	1004-5619
ISSN	1004-5619
DOI	10.12116/j.issn.1004-5619.2021.511102
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Article ; Online: Levels of vitamin A and selenium of children with cystic echinococcosis in Aba Tibetan and Qiang and Garze Tibetan Autonomous Prefecture, Sichuan, China.

Zheng, Qinxin / Gong, Yao / Wang, Qian / Jin, Chuan / Guo, Qulian / Zeng, Mingcai / Luo, Yong / Luorong, Chumu / Li, Cheng

Nutrition (Burbank, Los Angeles County, Calif.)

2023 Volume 111, Page(s) 112023

Abstract: Objective: The aim of this study was to review the levels of vitamin A and selenium in children with echinococcosis in Ganzi and Aba.: Methods: Twenty-six children with cystic echinococcosis and 104 apparently healthy controls from the Aba and Garze ... ...

Abstract	Objective: The aim of this study was to review the levels of vitamin A and selenium in children with echinococcosis in Ganzi and Aba. Methods: Twenty-six children with cystic echinococcosis and 104 apparently healthy controls from the Aba and Garze Tibetan Autonomous Prefecture of Sichuan province in China were recruited. The serum levels of selenium and vitamin A of the cases and controls were detected and stratified by sex and age. Results: The results showed that the ratio of boys to girls was 1:1.36. Compared with the healthy controls, the vitamin A serum levels of the cases significantly declined. The rate of selenium deficiency was high in the cases, but there was no significant difference compared with the control group. Additionally, the lower the vitamin A serum level, the higher the risk for developing echinococcosis. Conclusions: To improve management strategies in children with cystic echinococcosis, or possibly to prevent the disease, children living in high-risk areas for cystic echinococcosis should be given supplemental vitamin A and encouraged to consume a vitamin A-rich diet containing paw-paw, carrot, palm oil, or fish. Children with vitamin A deficiency in high-risk areas should be screened for cystic echinococcosis.
MeSH term(s)	Animals ; Selenium ; Vitamin A ; Tibet ; Prevalence ; Echinococcosis ; China/epidemiology
Chemical Substances	Selenium (H6241UJ22B) ; Vitamin A (11103-57-4)
Language	English
Publishing date	2023-03-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639259-3
ISSN	1873-1244 ; 0899-9007
ISSN (online)	1873-1244
ISSN	0899-9007
DOI	10.1016/j.nut.2023.112023
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Article ; Online: Erratum: SHENGBO ZHOU (), LI HE (), SIYU MA (), SHUJUN XU (), QIANG ZHAI (), PING GUAN (), HUI WANG ()amp; JINGSONG SHI () (2022)Taxonomic status of Rana nigromaculata mongolia and the validity of Pelophylax tenggerensis (Anura, Ranidae) Zootaxa 5165 (4): 486500.

Zhou, Shengbo / He, L I / Ma, Siyu / Xu, Shujun / Zhai, Qiang / Guan, Ping / Wang, Hui / Shi, Jingsong

Zootaxa

2022 Volume 5174, Issue 5, Page(s) 600

Language	English
Publishing date	2022-08-12
Publishing country	New Zealand
Document type	Journal Article
ISSN	1175-5334
ISSN (online)	1175-5334
DOI	10.11646/zootaxa.5174.5.8
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Article: Study on the Flavor Compounds of Fo Tiao Qiang under Different Thawing Methods Based on GC-IMS and Electronic Tongue Technology.

Lin, Ruirong / Yuan, Hongfei / Wang, Changrong / Yang, Qingyu / Guo, Zebin

Foods (Basel, Switzerland)

2022 Volume 11, Issue 9

Abstract: Fo Tiao Qiang" is a famous dish with Chinese characteristics. It is delicious, rich in materials ... characteristics and flavor differences of Fo Tiao Qiang by using different thawing methods (natural thawing ... slightly higher in Fo Tiao Qiang with ultrasonic thawing than others. The fat content of the microwave ...

Abstract	"Fo Tiao Qiang" is a famous dish with Chinese characteristics. It is delicious, rich in materials, and high in nutritional value. Through physical and chemical analysis, electronic tongue, gas chromatography-ion mobility spectroscopy, and other technologies, the present study explored the quality characteristics and flavor differences of Fo Tiao Qiang by using different thawing methods (natural thawing, ultrasonic thawing, microwave thawing, and water bath thawing). The results show that the protein content was slightly higher in Fo Tiao Qiang with ultrasonic thawing than others. The fat content of the microwave-thawed Fo Tiao Qiang was significantly lower than the other three kinds of samples. After ultrasonic thawing, the number of free amino acids in the samples were the highest and the umami taste was the best. Compared with natural thawing, most of the flavor substances decreased in ultrasonic thawing, microwave thawing, and water bath thawing. However, several substances increased, such as alpha-terpineol, beta-phenylethyl alcohol, phenylacetaldehyde,
Language	English
Publishing date	2022-05-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods11091330
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Article ; Online: Erratum: GUI-QIANG HUANG amp; FA-LEI WANG (2019) Two new and one newly recorded species of Anomala Samouelle, 1819 (Coleoptera: Scarabaeidae: Rutelinae) from Yunnan, China. Zootaxa, 4706: 366-374.

Huang, Gui-Qiang / Wang, Fa-Lei

Zootaxa

2020 Volume 4750, Issue 4, Page(s) zootaxa.4750.4.13

Language	English
Publishing date	2020-03-13
Publishing country	New Zealand
Document type	Journal Article ; Published Erratum
ISSN	1175-5334
ISSN (online)	1175-5334
DOI	10.11646/zootaxa.4750.4.13
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Article ; Online: Uncovering the Molecular Mechanism of the Qiang-Xin 1 Formula on Sepsis-Induced Cardiac Dysfunction Based on Systems Pharmacology.

He, Shasha / Zhao, Jingxia / Xu, Xiaolong / Cui, Xuran / Wang, Ning / Han, Xuyang / Guo, Yuhong / Liu, Qingquan

Oxidative medicine and cellular longevity

2020 Volume 2020, Page(s) 3815185

Abstract: ... Qiang-Xin 1 (QX1), ameliorates cardiac tissue damage in septic mice; however, the underlying ...

Abstract	Cardiac dysfunction is a critical manifestation of sepsis-induced multiorgan failure and results in the high mortality of sepsis. Our previous study demonstrated that a traditional Chinese medicine formula, Qiang-Xin 1 (QX1), ameliorates cardiac tissue damage in septic mice; however, the underlying pharmacology mechanism remains to be elucidated. The present study was aimed at clarifying the protective mechanism of the QX1 formula on sepsis-induced cardiac dysfunction. The moderate sepsis model of mice was established by cecal ligation and puncture surgery. Treatment with the QX1 formula improved the 7-day survival outcome, attenuated cardiac dysfunction, and ameliorated the disruption of myocardial structure in septic mice. Subsequent systems pharmacology analysis found that 63 bioactive compounds and the related 79 candidate target proteins were screened from the QX1 formula. The network analysis showed that the QX1 active components quercetin, formononetin, kaempferol, taxifolin, cryptotanshinone, and tanshinone IIA had a good binding activity with screened targets. The integrating pathway analysis indicated the calcium, PI3K/AKT, MAPK, and Toll-like receptor signaling pathways may be involved in the protective effect of the QX1 formula on sepsis-induced cardiac dysfunction. Further, experimental validation showed that the QX1 formula inhibited the activity of calcium/calmodulin-dependent protein kinase II (CaMKII), MAPK (P38, ERK1/2, and JNK), and TLR4/NF-
MeSH term(s)	Animals ; Cytokines/blood ; Disease Models, Animal ; Drug Delivery Systems ; Drug Evaluation, Preclinical ; Drugs, Chinese Herbal/analysis ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Heart/drug effects ; Heart/physiopathology ; Heart Diseases/blood ; Heart Diseases/drug therapy ; Heart Diseases/pathology ; Heart Diseases/physiopathology ; Male ; Mice, Inbred BALB C ; Sepsis/complications ; Tissue Distribution/drug effects
Chemical Substances	Cytokines ; Drugs, Chinese Herbal
Language	English
Publishing date	2020-08-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2455981-7
ISSN	1942-0994 ; 1942-0994
ISSN (online)	1942-0994
ISSN	1942-0994
DOI	10.1155/2020/3815185
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Article ; Online: Prevalence and risk factors associated with hypertension in the Chinese Qiang population.

Huang, Xiao-Bo / Chen, Fei / Dai, Wen / Song, Lei / Tu, Jiao / Xu, Jun-Bo / Liu, Jian-Xiong / Yi, Yan-Jing / Liu, Ya / Chen, Yong / Wang, Tzung-Dau / Zhao, Shui-Ping

Clinical and experimental hypertension (New York, N.Y. : 1993)

2017 Volume 40, Issue 5, Page(s) 427–433

Abstract: ... among the Chinese Qiang population. From September 2012 to March 2013, a cross-sectional study was conducted ... in urban and rural communities of the Qiang population using multistage cluster sampling. A total of 2676 ... overweight and obesity, family history of hypertension. The prevalence of hypertension in Chinese Qiang ...

Abstract	Our aim is to investigate the prevalence and risk factors associated with hypertension among the Chinese Qiang population. From September 2012 to March 2013, a cross-sectional study was conducted in urban and rural communities of the Qiang population using multistage cluster sampling. A total of 2676 people aged above 20 years were enrolled in the analysis. Standardized mercury sphygmomanometer was used to measure the blood pressure twice after a 10-minute seated rest, and the average blood pressure was obtained. The hypertension prevalence among the population aged above 20 years was 13.9%, and age-standardized prevalence was 12.3%. Male and female prevalence of hypertension, as well as the prevalence in urban and rural areas, all increased with age. There were no significant differences between males and females and between urban and rural residents. Among hypertensive patients, 44.2% were aware of their hypertension, 38.0% were undergoing antihypertensive treatment, but only 10.5% achieved blood pressure control. Multivariate logistic regression analysis showed that the risk factors of hypertension included age, low income, overweight and obesity, family history of hypertension. The prevalence of hypertension in Chinese Qiang adults is significantly lower than the national level. Awareness, treatment, and control rates of hypertension were low in the Qiang population. Thus, hypertension-related health knowledge should be more aggressively delivered to improve public awareness and the capacity of community health services should be strengthened.
MeSH term(s)	Adult ; Age Factors ; Aged ; Antihypertensive Agents/therapeutic use ; Asian Continental Ancestry Group/statistics & numerical data ; Blood Pressure ; China/epidemiology ; Cross-Sectional Studies ; Female ; Health Knowledge, Attitudes, Practice ; Humans ; Hypertension/drug therapy ; Hypertension/ethnology ; Hypertension/genetics ; Income ; Male ; Middle Aged ; Obesity/epidemiology ; Prevalence ; Risk Factors ; Rural Population/statistics & numerical data ; Urban Population/statistics & numerical data ; Young Adult
Chemical Substances	Antihypertensive Agents
Language	English
Publishing date	2017-11-06
Publishing country	England
Document type	Journal Article
ZDB-ID	604757-9
ISSN	1525-6006 ; 0730-0077
ISSN (online)	1525-6006
ISSN	0730-0077
DOI	10.1080/10641963.2017.1392553
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