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  1. Article: Steroidal lactones from

    Srivastava, Aditi / Ahmad, Rumana / Wani, Irshad A / Siddiqui, Sahabjada / Yadav, Kusum / Trivedi, Anchal / Upadhyay, Shivbrat / Husain, Ishrat / Ahamad, Tanveer / Dudhagi, Shivanand S

    In silico pharmacology

    2024  Volume 12, Issue 1, Page(s) 14

    Language English
    Publishing date 2024-02-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2702993-1
    ISSN 2193-9616
    ISSN 2193-9616
    DOI 10.1007/s40203-023-00184-y
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  2. Article: Correction: Antimicrobial peptide moricin induces ROS mediated caspase-dependent apoptosis in human triple-negative breast cancer via suppression of notch pathway.

    Ahmad, Imran / Pal, Saurabh / Singh, Ranjana / Ahmad, Khursheed / Dey, Nilanjan / Srivastava, Aditi / Ahmad, Rumana / Suliman, Muath / Alshahrani, Mohammad Y / Barkat, Md Abul / Siddiqui, Sahabjada

    Cancer cell international

    2023  Volume 23, Issue 1, Page(s) 139

    Language English
    Publishing date 2023-07-15
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2091573-1
    ISSN 1475-2867
    ISSN 1475-2867
    DOI 10.1186/s12935-023-02988-6
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  3. Article ; Online: Genistein contributes to cell cycle progression and regulates oxidative stress in primary culture of osteoblasts along with osteoclasts attenuation

    Sahabjada Siddiqui / Abbas Ali Mahdi / Md Arshad

    BMC Complementary Medicine and Therapies, Vol 20, Iss 1, Pp 1-

    2020  Volume 11

    Abstract: Abstract Background The present study was designed to examine the role of isoflavone genistein (GS) on bone formation, regulating oxidative stress and cell cycle in primary osteoblasts, as well as attenuation of osteoclast formation. Methods Primary ... ...

    Abstract Abstract Background The present study was designed to examine the role of isoflavone genistein (GS) on bone formation, regulating oxidative stress and cell cycle in primary osteoblasts, as well as attenuation of osteoclast formation. Methods Primary calvaria osteoblasts were isolated from 2 to 3 days old neonatal rat pups (n = 6–8) of Sprague Dawley rats. Osteoblasts were incubated with varying concentrations of GS and different assays viz. cell proliferation, differentiation, calcium deposition, cell cycle progression, antioxidant ability, and osteogenic gene expression were performed. Tartrate-resistant acid phosphatase (TRAP) staining and immunolocalization of cathepsin K protein were assessed in bone marrow-derived osteoclasts. Results Results revealed that GS markedly induced cell growth and osteoblast differentiation depending upon dose. The fluorescent dye DCFH-DA staining data proved the antioxidant ability of GS, which reduced the H2O2- induced intracellular oxidative stress in osteoblasts. Quantitative real-time PCR analysis revealed that GS treatment upregulated the expression of osteoblastic genes of Runt-related transcription factor 2 (Runx2), bone morphogenetic proteins 2 (BMP2), and osteocalcin. Immunolocalization of BMP2 also indicated the osteogenic efficacy of GS. Furthermore, TRAP staining and cathepsin K expression depicted that GS inhibited multinucleated osteoclasts formation. Conclusions In conclusion, GS isoflavone might impart protective effects against oxidative stress-induced bone loss and thus, could maintain skeletal growth.
    Keywords Cell cycle ; Isoflavone ; Oxidative stress ; Primary bone cells ; Other systems of medicine ; RZ201-999
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Flavonoid Myricetin as Potent Anticancer Agent: A Possibility towards Development of Potential Anticancer Nutraceuticals.

    Trivedi, Anchal / Hasan, Adria / Ahmad, Rumana / Siddiqui, Sahabjada / Srivastava, Aditi / Misra, Aparna / Mir, Snober S

    Chinese journal of integrative medicine

    2023  Volume 30, Issue 1, Page(s) 75–84

    Abstract: Good nutrition plays a crucial role in maintaining a balanced lifestyle. The beneficial effects of nutrition have been found to counteract nutritional disturbances with the expanded use of nutraceuticals to treat and manage cardiovascular diseases, ... ...

    Abstract Good nutrition plays a crucial role in maintaining a balanced lifestyle. The beneficial effects of nutrition have been found to counteract nutritional disturbances with the expanded use of nutraceuticals to treat and manage cardiovascular diseases, cancer, and other developmental defects over the last decade. Flavonoids are found abundantly in plant-derived foods such as fruits, vegetables, tea, cocoa, and wine. Fruits and vegetables contain phytochemicals like flavonoids, phenolics, alkaloids, saponins, and terpenoids. Flavonoids can act as anti-inflammatory, anti-allergic, anti-microbial (antibacterial, antifungal, and antiviral) antioxidant, anti-cancer, and anti-diarrheal agents. Flavonoids are also reported to upregulate apoptotic activity in several cancers such as hepatic, pancreatic, breast, esophageal, and colon. Myricetin is a flavonol which is naturally present in fruits and vegetables and has shown possible nutraceutical value. Myricetin has been portrayed as a potent nutraceutical that may protect against cancer. The focus of the present review is to present an updated account of studies demonstrating the anticancer potential of myricetin and the molecular mechanisms involved therein. A better understanding of the molecular mechanism(s) underlying its anticancer activity would eventually help in its development as a novel anticancer nutraceutical having minimal side effects.
    MeSH term(s) Humans ; Flavonoids/pharmacology ; Flavonoids/therapeutic use ; Flavonoids/chemistry ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Antineoplastic Agents/chemistry ; Dietary Supplements ; Antioxidants/pharmacology ; Neoplasms/drug therapy
    Chemical Substances myricetin (76XC01FTOJ) ; Flavonoids ; Antineoplastic Agents ; Antioxidants
    Language English
    Publishing date 2023-06-21
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2171254-2
    ISSN 1993-0402 ; 1672-0415
    ISSN (online) 1993-0402
    ISSN 1672-0415
    DOI 10.1007/s11655-023-3701-5
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5823: Show issues Location:
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  5. Article ; Online: Genistein contributes to cell cycle progression and regulates oxidative stress in primary culture of osteoblasts along with osteoclasts attenuation.

    Siddiqui, Sahabjada / Mahdi, Abbas Ali / Arshad, Md

    BMC complementary medicine and therapies

    2020  Volume 20, Issue 1, Page(s) 277

    Abstract: Background: The present study was designed to examine the role of isoflavone genistein (GS) on bone formation, regulating oxidative stress and cell cycle in primary osteoblasts, as well as attenuation of osteoclast formation.: Methods: Primary ... ...

    Abstract Background: The present study was designed to examine the role of isoflavone genistein (GS) on bone formation, regulating oxidative stress and cell cycle in primary osteoblasts, as well as attenuation of osteoclast formation.
    Methods: Primary calvaria osteoblasts were isolated from 2 to 3 days old neonatal rat pups (n = 6-8) of Sprague Dawley rats. Osteoblasts were incubated with varying concentrations of GS and different assays viz. cell proliferation, differentiation, calcium deposition, cell cycle progression, antioxidant ability, and osteogenic gene expression were performed. Tartrate-resistant acid phosphatase (TRAP) staining and immunolocalization of cathepsin K protein were assessed in bone marrow-derived osteoclasts.
    Results: Results revealed that GS markedly induced cell growth and osteoblast differentiation depending upon dose. The fluorescent dye DCFH-DA staining data proved the antioxidant ability of GS, which reduced the H
    Conclusions: In conclusion, GS isoflavone might impart protective effects against oxidative stress-induced bone loss and thus, could maintain skeletal growth.
    MeSH term(s) Animals ; Antioxidants/chemistry ; Antioxidants/pharmacology ; Cell Cycle/drug effects ; Genistein/chemistry ; Genistein/pharmacology ; Molecular Structure ; Osteoblasts/drug effects ; Osteoclasts/drug effects ; Osteogenesis/drug effects ; Oxidative Stress/drug effects ; Rats ; Rats, Sprague-Dawley
    Chemical Substances Antioxidants ; Genistein (DH2M523P0H)
    Language English
    Publishing date 2020-09-11
    Publishing country England
    Document type Journal Article
    ISSN 2662-7671
    ISSN (online) 2662-7671
    DOI 10.1186/s12906-020-03065-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Cytotoxicity of Moringa oleifera fruits on human liver cancer and molecular docking analysis of bioactive constituents against caspase-3 enzyme.

    Siddiqui, Sahabjada / Upadhyay, Shivbrat / Ahmad, Imran / Hussain, Arshad / Ahamed, Maqusood

    Journal of food biochemistry

    2021  Volume 45, Issue 5, Page(s) e13720

    Abstract: Moringa oleifera is an excellent source of phenolics and flavonoids comprise various pharmacological activities. The fourth widespread leading cause of the patients' death is liver cancer. This study was formulated to perform the antiproliferative ... ...

    Abstract Moringa oleifera is an excellent source of phenolics and flavonoids comprise various pharmacological activities. The fourth widespread leading cause of the patients' death is liver cancer. This study was formulated to perform the antiproliferative activity of Moringa oleifera fruit (MOF) extract on human liver cancer HepG2 cells and computational validation of cell death. HepG2 cell line was treated with 25, 50, 75, 100, and 200 µg/ml of MOF extract for 48 hr, and antiproliferative activity was analyzed using MTT assay, nuclear condensation, annexin V-FITC/PI double stain, ROS generation, and apoptosis executioner enzyme caspase-3. MOF extract reduced the cell viability significantly (p ˂ .05) by increasing cellular apoptosis which was confirmed by annexin V-FITC/PI staining assay. In addition, MOF stimulated intracellular ROS production and subsequently induced caspase-3 activity depending upon dose. In silico analysis revealed the good binding interaction between amino acid residues of caspase-3 (PDB ID: 1GFW) protein and selected active constituents of MOF. PASS analyses of the phytoconstituents showed no violation of Lipinski's rule of five. Analysis of drug-likeness and toxicity measurement exhibited drug-like candidates with no predicted toxicity. In conclusion, this study showed the potential anticancer activity of MOF extract which may be valuable source for anticancer drug development. PRACTICAL APPLICATIONS: Moringa oleifera fruit extract induced the anti-proliferative activity against human hepatocellular carcinoma HepG2 cells through ROS-mediated apoptosis and activation of caspase-3 enzyme. Structure-based virtual screening study between bioactive components of Moringa oleifera fruits and apoptosis executioner caspase-3 enzyme has validated the anti-proliferative activity of Moringa oleifera fruit extract. Interestingly, active phytoconstituents of Moringa oleifera fruit exhibited drug-like candidates with no predicted toxicity. Thus, Moringa oleifera fruit could be used as valuable source for anticancer drug development against human liver cancer with relatively non-toxic to healthy cells.
    MeSH term(s) Caspase 3 ; Fruit ; Hep G2 Cells ; Humans ; Liver Neoplasms/drug therapy ; Molecular Docking Simulation ; Moringa oleifera ; Plant Extracts/pharmacology ; Plant Leaves
    Chemical Substances Plant Extracts ; CASP3 protein, human (EC 3.4.22.-) ; Caspase 3 (EC 3.4.22.-)
    Language English
    Publishing date 2021-04-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 433846-7
    ISSN 1745-4514 ; 0145-8884
    ISSN (online) 1745-4514
    ISSN 0145-8884
    DOI 10.1111/jfbc.13720
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    In stock of ZB MED Bonn / Germany

    Z 3310: Show issues

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  7. Article ; Online: Genistein contributes to cell cycle progression and regulates oxidative stress in primary culture of osteoblasts along with osteoclasts attenuation

    Siddiqui, Sahabjada / Mahdi, Abbas Ali / Arshad, Md

    BMC Complement Med Ther. 2020 Dec., v. 20, no. 1 p.277-277

    2020  

    Abstract: BACKGROUND: The present study was designed to examine the role of isoflavone genistein (GS) on bone formation, regulating oxidative stress and cell cycle in primary osteoblasts, as well as attenuation of osteoclast formation. METHODS: Primary calvaria ... ...

    Abstract BACKGROUND: The present study was designed to examine the role of isoflavone genistein (GS) on bone formation, regulating oxidative stress and cell cycle in primary osteoblasts, as well as attenuation of osteoclast formation. METHODS: Primary calvaria osteoblasts were isolated from 2 to 3 days old neonatal rat pups (n = 6–8) of Sprague Dawley rats. Osteoblasts were incubated with varying concentrations of GS and different assays viz. cell proliferation, differentiation, calcium deposition, cell cycle progression, antioxidant ability, and osteogenic gene expression were performed. Tartrate-resistant acid phosphatase (TRAP) staining and immunolocalization of cathepsin K protein were assessed in bone marrow-derived osteoclasts. RESULTS: Results revealed that GS markedly induced cell growth and osteoblast differentiation depending upon dose. The fluorescent dye DCFH-DA staining data proved the antioxidant ability of GS, which reduced the H₂O₂- induced intracellular oxidative stress in osteoblasts. Quantitative real-time PCR analysis revealed that GS treatment upregulated the expression of osteoblastic genes of Runt-related transcription factor 2 (Runx2), bone morphogenetic proteins 2 (BMP2), and osteocalcin. Immunolocalization of BMP2 also indicated the osteogenic efficacy of GS. Furthermore, TRAP staining and cathepsin K expression depicted that GS inhibited multinucleated osteoclasts formation. CONCLUSIONS: In conclusion, GS isoflavone might impart protective effects against oxidative stress-induced bone loss and thus, could maintain skeletal growth.
    Keywords acid phosphatase ; antioxidant activity ; bone formation ; bone resorption ; calcium ; cathepsin K ; cell cycle ; cell growth ; cell proliferation ; complement ; fluorescent dyes ; gene expression ; genistein ; osteoblasts ; osteocalcin ; osteoclasts ; oxidative stress ; quantitative polymerase chain reaction ; rats ; skull ; transcription factors
    Language English
    Dates of publication 2020-12
    Size p. 277.
    Publishing place BioMed Central
    Document type Article ; Online
    ISSN 2662-7671
    DOI 10.1186/s12906-020-03065-5
    Database NAL-Catalogue (AGRICOLA)

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  8. Article: Correction: Shoaib et al. Neuroprotective Effects of Dried Tubers of

    Shoaib, Ambreen / Siddiqui, Hefazat Hussain / Dixit, Rakesh Kumar / Siddiqui, Sahabjada / Deen, Badrud / Khan, Andleeb / Alrokayan, Salman H / Khan, Haseeb A / Ahmad, Parvaiz

    Plants (Basel, Switzerland)

    2021  Volume 11, Issue 1

    Abstract: We are sorry to report that some images in Figure 1 reported in our recently published paper [ ... ]. ...

    Abstract We are sorry to report that some images in Figure 1 reported in our recently published paper [...].
    Language English
    Publishing date 2021-12-28
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants11010080
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  9. Article: Neuroprotective Effects of Dried Tubers of

    Shoaib, Ambreen / Siddiqui, Hefazat Hussain / Dixit, Rakesh Kumar / Siddiqui, Sahabjada / Deen, Badrud / Khan, Andleeb / Alrokayan, Salman H / Khan, Haseeb A / Ahmad, Parvaiz

    Plants (Basel, Switzerland)

    2020  Volume 9, Issue 3

    Abstract: The present study was designed to explore the neuroprotective properties ... ...

    Abstract The present study was designed to explore the neuroprotective properties of
    Language English
    Publishing date 2020-03-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants9030356
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  10. Article ; Online: Zinc Oxide Nanoparticle Induces Apoptosis in Human Epidermoid Carcinoma Cells Through Reactive Oxygen Species and DNA Degradation.

    Khan, Mohd Jahir / Ahmad, Abrar / Khan, Mahmood Ahmad / Siddiqui, Sahabjada

    Biological trace element research

    2020  Volume 199, Issue 6, Page(s) 2172–2181

    Abstract: Zinc oxide nanoparticles (ZnO-NPs) are used immensely in technology and medicine, but very less is known about toxicity mechanism to human epidermal cells. The objective of this study was to evaluate possible anticancer properties of ZnO-NPs on human ... ...

    Abstract Zinc oxide nanoparticles (ZnO-NPs) are used immensely in technology and medicine, but very less is known about toxicity mechanism to human epidermal cells. The objective of this study was to evaluate possible anticancer properties of ZnO-NPs on human epidermoid carcinoma cells using MTT assay, measurement of reactive oxygen species, DNA fragmentation, and nuclear condensation. ZnO-NPs were synthesized by sol-gel method using zinc acetate dihydrate, ethylene glycol, and 2-propyl alcohol. Numerous characterization techniques such as UV-visible spectroscopy, X-ray powder diffraction, transmission electron microscopy, and dynamic light scattering spectroscopy were used to confirm synthesis, purity, optical, and surface characteristics, size, shape, and distribution of ZnO-NPs. Our finding showed that ZnO-NPs considerably decreased cell viability of human epidermoid carcinoma A431 cells with a parallel increase in nuclear condensation and DNA fragmentation in a dose dependent manner. Moreover, real time PCR expression study showed that treatment of human epidermoid carcinoma cells with ZnO-NPs trigger increased expression of tumor suppressor gene p53, bax, and caspase-3 while downregulate antiapoptotic gene bcl-2. Thus ZnO-NPs induce apoptosis in A431 cells through DNA degradation and generation of reactive oxygen species via p53, bax/bcl-2, and caspase pathways.
    MeSH term(s) Apoptosis ; Carcinoma, Squamous Cell/drug therapy ; Cell Survival ; DNA ; Humans ; Metal Nanoparticles ; Nanoparticles ; Reactive Oxygen Species ; Zinc Oxide/pharmacology
    Chemical Substances Reactive Oxygen Species ; DNA (9007-49-2) ; Zinc Oxide (SOI2LOH54Z)
    Language English
    Publishing date 2020-08-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 445336-0
    ISSN 1559-0720 ; 0163-4984
    ISSN (online) 1559-0720
    ISSN 0163-4984
    DOI 10.1007/s12011-020-02323-4
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2323: Show issues Location:
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