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  1. Article ; Online: In vivo development of cefiderocol resistance in carbapenem-resistant Acinetobacter baumannii associated with the downregulation of a TonB-dependent siderophore receptor, PiuA.

    Findlay, Jacqueline / Bianco, Gabriele / Boattini, Matteo / Nordmann, Patrice

    The Journal of antimicrobial chemotherapy

    2024  Volume 79, Issue 4, Page(s) 928–930

    MeSH term(s) Cefiderocol ; Acinetobacter baumannii/genetics ; Down-Regulation ; Anti-Bacterial Agents/pharmacology ; Cephalosporins ; Carbapenems/pharmacology ; Microbial Sensitivity Tests
    Chemical Substances Cefiderocol (SZ34OMG6E8) ; Anti-Bacterial Agents ; Cephalosporins ; Carbapenems
    Language English
    Publishing date 2024-01-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkae018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1197: Show issues Location:
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    Zs.MO 124: Show issues

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  2. Article: Observations on primary liver carcinoma in West African soldiers.

    FINDLAY, G M

    Journal. Royal Microscopical Society (Great Britain)

    2014  Volume 70, Issue 2, Page(s) 166–172

    MeSH term(s) Carcinoma ; Humans ; Liver ; Liver Neoplasms ; Military Personnel ; Neoplasms
    Language English
    Publishing date 2014-02-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 219261-5
    ISSN 0368-3974
    ISSN 0368-3974
    DOI 10.1111/j.1365-2818.1950.tb04422.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 838: Show issues Location:
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  3. Article: Expression of TIMPs and MMPs in Ovarian Tumors, Ascites, Ascites-Derived Cells, and Cancer Cell Lines: Characteristic Modulatory Response Before and After Chemotherapy Treatment.

    Escalona, Ruth M / Kannourakis, George / Findlay, Jock K / Ahmed, Nuzhat

    Frontiers in oncology

    2022  Volume 11, Page(s) 796588

    Abstract: Background: The tissue inhibitors of metalloproteinase (TIMPs) and their associated metalloproteinase (MMPs) are essential regulators of tissue homeostasis and are essential for cancer progression. This study analyzed the expression of TIMP-1,-2,-3 and ... ...

    Abstract Background: The tissue inhibitors of metalloproteinase (TIMPs) and their associated metalloproteinase (MMPs) are essential regulators of tissue homeostasis and are essential for cancer progression. This study analyzed the expression of TIMP-1,-2,-3 and the associated MMPs (MMP-2,-9,-11,-14) in different Stages, Grades and World Health Organization (WHO) classifications of serous ovarian tumors, ascites, ascites-derived cells from chemo-naïve (CN) and relapsed (CR) patients, and in ovarian cancer cell lines. The status of TIMPs and associated MMPs in response to chemotherapy treatment was assessed in cancer cell lines; TCGA data was interrogated to gauge TIMPs and associated MMPs as prognostic and platinum-response indicators.
    Methods: The levels of TIMP-1, -2 and -3 were assessed by immunohistochemistry. The mRNA expression of TIMPs and MMPs was quantified by real time PCR (qRT-PCR). The chemosensitivity (IC
    Results: The expression of TIMP-2 was significantly upregulated in Type 2 compared to Type 1 tumors and normal/benign ovarian tissues. TIMP-3 expression was significantly enhanced in Stage III, Grade 3 and Type 2 tumors compared to normal/benign ovarian tissues. The mRNA expression of MMP-9,-11 and -14 was significantly upregulated in Stage IV compared to normal/benign ovarian tissues. The expression of TIMP-1 was highest, followed by TIMP-2 and then TIMP-3 in CN ascites. At the cellular level, TIMP-2 mRNA expression was significantly higher in CN compared to CR epithelial cells in patients. The expression of TIMP-1 and -2, MMPs and cancer stem cells (CSCs) were upregulated in response to chemotherapy treatments in cancer cell lines. Interrogation of the TCGA dataset suggests shifts in platinum responses in patients consistent with genetic alterations in TIMP-2, -3 and MMP-2, -11 genes in tumors; and decreased overall survival (OS) and progression-free survival (PFS) in patients with altered MMP-14 genes.
    Conclusions: TIMPs and related MMPs are differentially expressed in serous ovarian tumors, ascites, ascites-derived cells and ovarian cancer cell lines. Chemotherapy treatment modulates expression of TIMPs and MMPs in association with increased expression of genes related to cancer stem cells.
    Language English
    Publishing date 2022-01-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2021.796588
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Chromatin targeting of the RNF12/RLIM E3 ubiquitin ligase controls transcriptional responses.

    Espejo-Serrano, Carmen / Aitken, Catriona / Tan, Beatrice F / May, Danielle G / Chrisopulos, Rachel J / Roux, Kyle J / Demmers, Jeroen Aa / Mackintosh, Samuel G / Gribnau, Joost / Bustos, Francisco / Gontan, Cristina / Findlay, Greg M

    Life science alliance

    2024  Volume 7, Issue 3

    Abstract: Protein ubiquitylation regulates key biological processes including transcription. This is exemplified by the E3 ubiquitin ligase RNF12/RLIM, which controls developmental gene expression by ubiquitylating the REX1 transcription factor and is mutated in ... ...

    Abstract Protein ubiquitylation regulates key biological processes including transcription. This is exemplified by the E3 ubiquitin ligase RNF12/RLIM, which controls developmental gene expression by ubiquitylating the REX1 transcription factor and is mutated in an X-linked intellectual disability disorder. However, the precise mechanisms by which ubiquitylation drives specific transcriptional responses are not known. Here, we show that RNF12 is recruited to specific genomic locations via a consensus sequence motif, which enables co-localisation with REX1 substrate at gene promoters. Surprisingly, RNF12 chromatin recruitment is achieved via a non-catalytic basic region and comprises a previously unappreciated N-terminal autoinhibitory mechanism. Furthermore, RNF12 chromatin targeting is critical for REX1 ubiquitylation and downstream RNF12-dependent gene regulation. Our results demonstrate a key role for chromatin in regulation of the RNF12-REX1 axis and provide insight into mechanisms by which protein ubiquitylation enables programming of gene expression.
    MeSH term(s) Humans ; Chromatin/genetics ; Ubiquitin-Protein Ligases/genetics ; Ubiquitination ; Genomics ; Intellectual Disability
    Chemical Substances Chromatin ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; RLIM protein, human (EC 2.3.2.27)
    Language English
    Publishing date 2024-01-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2575-1077
    ISSN (online) 2575-1077
    DOI 10.26508/lsa.202302282
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Resolution of Virtual Depth Sectioning from Four-Dimensional Scanning Transmission Electron Microscopy.

    Terzoudis-Lumsden, E W C / Petersen, T C / Brown, H G / Pelz, P M / Ophus, C / Findlay, S D

    Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada

    2023  Volume 29, Issue 4, Page(s) 1409–1421

    Abstract: One approach to three-dimensional structure determination using the wealth of scattering data in four-dimensional (4D) scanning transmission electron microscopy (STEM) is the parallax method proposed by Ophus et al. (2019. Advanced phase reconstruction ... ...

    Abstract One approach to three-dimensional structure determination using the wealth of scattering data in four-dimensional (4D) scanning transmission electron microscopy (STEM) is the parallax method proposed by Ophus et al. (2019. Advanced phase reconstruction methods enabled by 4D scanning transmission electron microscopy, Microsc Microanal25, 10-11), which determines the scattering matrix and uses it to synthesize a virtual depth-sectioning reconstruction of the sample structure. Drawing on an equivalence with a hypothetical confocal imaging mode, we derive contrast transfer and point spread functions for this parallax method applied to weakly scattering objects, showing them identical to earlier depth-sectioning STEM modes when only bright field signal is used, but that improved depth resolution is possible if dark field signal can be used. Through a simulation-based study of doped Si, we show that this depth resolution is preserved for thicker samples, explore the impact of shot noise on the parallax reconstructions, discuss challenges to making use of dark field signal, and identify cases where the interpretation of the parallax reconstruction breaks down.
    Language English
    Publishing date 2023-07-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 1385710-1
    ISSN 1435-8115 ; 1431-9276
    ISSN (online) 1435-8115
    ISSN 1431-9276
    DOI 10.1093/micmic/ozad068
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  6. Article: Caseous Intracardiac Calcification: A Diagnostic Enigma.

    Findlay, Simon G / Child, Nicholas M / Muir, Douglas F

    Case reports in cardiology

    2019  Volume 2019, Page(s) 6707690

    Abstract: Intramyocardial calcification is a rare phenomenon often only discovered on postmortem. We describe the case of a healthy 69-year-old lady diagnosed with idiopathic caseous intracardiac calcification extending from the mitral valve annulus. We present ... ...

    Abstract Intramyocardial calcification is a rare phenomenon often only discovered on postmortem. We describe the case of a healthy 69-year-old lady diagnosed with idiopathic caseous intracardiac calcification extending from the mitral valve annulus. We present high-quality images and propose an investigatory template for future cases.
    Language English
    Publishing date 2019-04-14
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2627627-6
    ISSN 2090-6412 ; 2090-6404
    ISSN (online) 2090-6412
    ISSN 2090-6404
    DOI 10.1155/2019/6707690
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Article ; Online: Sendas de infección y vías de transmisión de los virus

    Findlay, G. M

    2015  

    Keywords Viroses ; Reino Unido
    Publishing date 2015-12-08T03:06:40Z
    Document type Book ; Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: CHEMOTHERAPY: NEW REMEDIES IN THE TREATMENT OF SYPHILIS.

    Findlay, G M

    The British journal of venereal diseases

    2011  Volume 8, Issue 3, Page(s) 155–180

    Language English
    Publishing date 2011-03-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 80086-7
    ISSN 0007-134X
    ISSN 0007-134X
    DOI 10.1136/sti.8.3.155
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui VI Zs.108: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Unexpected

    Jones, B / Burns, G J / Cavanagh, H V / Findlay, D J S / Karbassi, S / Nilsson, N A / Škoro, G P / Wright, P N M

    Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

    2022  Volume 182, Page(s) 110139

    Abstract: The specific activity of air in the large open room housing the 800-MeV proton synchrotron of the ISIS Spallation Neutron and Muon Source has been measured. Air from several positions within the ISIS synchrotron room was sucked through a long flexible ... ...

    Abstract The specific activity of air in the large open room housing the 800-MeV proton synchrotron of the ISIS Spallation Neutron and Muon Source has been measured. Air from several positions within the ISIS synchrotron room was sucked through a long flexible tube, and run past a shielded HPGe gamma-ray detector outside the synchrotron room. In spite of an expectation that
    MeSH term(s) Air Pollutants, Radioactive/analysis ; Argon/analysis ; Carbon Isotopes/analysis ; Nitrogen Radioisotopes/analysis ; Protons ; Synchrotrons
    Chemical Substances Air Pollutants, Radioactive ; Carbon Isotopes ; Nitrogen Radioisotopes ; Protons ; Argon (67XQY1V3KH)
    Language English
    Publishing date 2022-02-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1142596-9
    ISSN 1872-9800 ; 0883-2889 ; 0969-8043
    ISSN (online) 1872-9800
    ISSN 0883-2889 ; 0969-8043
    DOI 10.1016/j.apradiso.2022.110139
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ue I Zs.279: Show issues Location:
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  10. Article ; Online: Reply.

    Raymond, J / Létourneau-Guillon, L / Darsaut, T E / Findlay, J M / Chow, M M / Keough, M B / Chan, A M / Farzin, Bezhad / Gevry, G / Chagnon, M / Zehr, J

    AJNR. American journal of neuroradiology

    2022  Volume 43, Issue 3, Page(s) E4

    Language English
    Publishing date 2022-03-03
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 603808-6
    ISSN 1936-959X ; 0195-6108
    ISSN (online) 1936-959X
    ISSN 0195-6108
    DOI 10.3174/ajnr.A7454
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1580: Show issues Location:
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