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  1. Article ; Online: Virus-associated ribozymes and nano carriers against COVID-19.

    Dönmüş, Beyza / Ünal, Sinan / Kirmizitaş, Fatma Ceren / Türkoğlu Laçin, Nelisa

    Artificial cells, nanomedicine, and biotechnology

    2021  Volume 49, Issue 1, Page(s) 204–218

    Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a zoo tonic, highly pathogenic virus. The new type of coronavirus with contagious nature spread from Wuhan (China) to the whole world in a very short time and caused the new coronavirus ... ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a zoo tonic, highly pathogenic virus. The new type of coronavirus with contagious nature spread from Wuhan (China) to the whole world in a very short time and caused the new coronavirus disease (COVID-19). COVID-19 has turned into a global public health crisis due to spreading by close person-to-person contact with high transmission capacity. Thus, research about the treatment of the damages caused by the virus or prevention from infection increases everyday. Besides, there is still no approved and definitive, standardized treatment for COVID-19. However, this disaster experienced by human beings has made us realize the significance of having a system ready for use to prevent humanity from viral attacks without wasting time. As is known, nanocarriers can be targeted to the desired cells
    MeSH term(s) Angiotensin-Converting Enzyme 2/antagonists & inhibitors ; COVID-19/drug therapy ; Clinical Trials as Topic ; Drug Carriers ; Drug Compounding ; Drug Design ; HIV Infections/drug therapy ; HIV-1/drug effects ; HIV-1/genetics ; Humans ; Middle East Respiratory Syndrome Coronavirus/drug effects ; Middle East Respiratory Syndrome Coronavirus/genetics ; Models, Molecular ; Nanoparticles/administration & dosage ; Nucleic Acid Conformation ; RNA Interference ; RNA, Catalytic/administration & dosage ; RNA, Catalytic/chemistry ; RNA, Catalytic/classification ; RNA, Catalytic/therapeutic use ; RNA, Untranslated/classification ; RNA, Untranslated/genetics ; RNA, Untranslated/therapeutic use ; RNA, Viral/antagonists & inhibitors ; Receptors, Coronavirus/antagonists & inhibitors ; SARS Virus/drug effects ; SARS Virus/genetics ; SARS-CoV-2/drug effects ; SARS-CoV-2/genetics ; SARS-CoV-2/physiology ; Spike Glycoprotein, Coronavirus/physiology ; Virus Replication/drug effects
    Chemical Substances Drug Carriers ; RNA, Catalytic ; RNA, Untranslated ; RNA, Viral ; Receptors, Coronavirus ; Spike Glycoprotein, Coronavirus ; hammerhead ribozyme ; spike protein, SARS-CoV-2 ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Language English
    Publishing date 2021-03-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2723095-8
    ISSN 2169-141X ; 2169-1401
    ISSN (online) 2169-141X
    ISSN 2169-1401
    DOI 10.1080/21691401.2021.1890103
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Host variations in SARS-CoV-2 infection.

    Altiok, Doruk / Savci, Elif Zeynep / Özkara, Büşra / Alkan, Kamil / Namdar, Dilara Sultan / Tunçer, Gizem / Kilinç, Buğrahan Regaip / Suiçmez, Evren / Çetin, Güneysu / Ünal, Sinan / Dönmüş, Beyza / Karagülleoğlu, Zeynep Yağmur / Uncuoğlu, Dilruba Beyza / Tekeli, Cansu / Mendi, Hanife Ayşegül / Bengi, Vahdi Umut / Cengiz Seval, Güldane / Kiliç, Pelin / Güneş Altuntaş, Evrim /
    Demir-Dora, Devrim

    Turkish journal of biology = Turk biyoloji dergisi

    2021  Volume 45, Issue 4, Page(s) 404–424

    Abstract: The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the zoonotic pathogen that causes the "Coronavirus Disease of 2019 (COVID-19)", and COVID-19 itself is yet to be thoroughly understood. Both the disease as well as the mechanisms by ... ...

    Abstract The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the zoonotic pathogen that causes the "Coronavirus Disease of 2019 (COVID-19)", and COVID-19 itself is yet to be thoroughly understood. Both the disease as well as the mechanisms by which the host interacts with the SARS-CoV-2 have not been fully enlightened. The epidemiological factors -e.g. age, sex, race-, the polymorphisms of the host proteins, the blood types and individual differences have all been in discussions about affecting the progression and the course of COVID-19 both individually and collectively, as their effects are mostly interwoven. We focused mainly on the effect of polymorphic variants of the host proteins that have been shown to take part in and/or affect the pathogenesis of COVID-19. Additionally, how the procedures of diagnosing and treating COVID-19 are affected by these variants and what possible changes can be implemented are the other questions, which are sought to be answered.
    Language English
    Publishing date 2021-08-30
    Publishing country Turkey
    Document type Journal Article ; Review
    ZDB-ID 2046470-8
    ISSN 1303-6092 ; 1303-6092
    ISSN (online) 1303-6092
    ISSN 1303-6092
    DOI 10.3906/biy-2104-67
    Database MEDical Literature Analysis and Retrieval System OnLINE

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