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  1. Article ; Online: Virus fuels NK cell killing of leukemia.

    Thorne, Steve H

    Blood

    2016  Volume 127, Issue 21, Page(s) 2509

    MeSH term(s) Cytotoxicity, Immunologic ; Humans ; Killer Cells, Natural ; Leukemia
    Language English
    Publishing date 2016-05-26
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2016-03-704247
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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.140: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
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  2. Article: Adding STING to the Tale of Oncolytic Virotherapy.

    Thorne, Steve H

    Trends in cancer

    2016  Volume 2, Issue 2, Page(s) 67–68

    Abstract: The identification of STING as a key cytoplasmic innate recognition molecule for DNA viruses whose function is lost in a variety of cancers has coincided with the approval of IMLYGIC for metastatic melanoma. This represents the first replication ... ...

    Abstract The identification of STING as a key cytoplasmic innate recognition molecule for DNA viruses whose function is lost in a variety of cancers has coincided with the approval of IMLYGIC for metastatic melanoma. This represents the first replication competent viral therapy approved for the treatment of any cancer in the US. The role of STING pathway in the selectivity of HSV has been addressed for the first time in Xia et al (1).
    Language English
    Publishing date 2016-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2852626-0
    ISSN 2405-8033 ; 2405-8025 ; 2405-8033
    ISSN (online) 2405-8033 ; 2405-8025
    ISSN 2405-8033
    DOI 10.1016/j.trecan.2016.01.002
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  3. Article: Immunotherapeutic potential of oncolytic vaccinia virus.

    Thorne, Steve H

    Frontiers in oncology

    2014  Volume 4, Page(s) 155

    Abstract: The concept of oncolytic viral therapy was based on the hypothesis that engineering tumor-selectivity into the replication potential of viruses would permit direct destruction of tumor cells as a result of viral-mediated lysis, resulting in amplification ...

    Abstract The concept of oncolytic viral therapy was based on the hypothesis that engineering tumor-selectivity into the replication potential of viruses would permit direct destruction of tumor cells as a result of viral-mediated lysis, resulting in amplification of the therapy exclusively within the tumor environment. The immune response raised by the virus was not only considered to be necessary for the safety of the approach, but also something of a hindrance to optimal therapeutic activity and repeat dosing. However, the pre-clinical and subsequent clinical success of several oncolytic viruses expressing selected cytokines has demonstrated the potential for harnessing the immune response as an additional and beneficial mechanism of therapeutic activity within the platform. Over the last few years, a variety of novel approaches have been incorporated to try to enhance this immunotherapeutic activity. Several innovative and subtle approaches have moved far beyond the expression of a single cytokine transgene, with the hope of optimizing anti-tumor immunity while having minimal detrimental impact on viral oncolytic activity.
    Language English
    Publishing date 2014-06-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2014.00155
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  4. Article ; Online: The role of GM-CSF in enhancing immunotherapy of cancer.

    Thorne, Steve H

    Immunotherapy

    2013  Volume 5, Issue 8, Page(s) 817–819

    Abstract: Evaluation of: Kanerva A, Nokisalmi P, Diaconu I et al. Antiviral and anti-tumor T-cell immunity in patients treated with GM-CSF coding oncolytic adenovirus. Clin. Cancer Res. 19(10), 2734-2744 (2013). The field of oncolytic viral therapy has been ... ...

    Abstract Evaluation of: Kanerva A, Nokisalmi P, Diaconu I et al. Antiviral and anti-tumor T-cell immunity in patients treated with GM-CSF coding oncolytic adenovirus. Clin. Cancer Res. 19(10), 2734-2744 (2013). The field of oncolytic viral therapy has been reinvigorated recently with publication of clinical data from two leading vectors, one based on HSV and one on Vaccinia, both of which express GM-CSF. Part of the reason for the improved clinical results with these vectors appears to be the enhanced immunotherapeutic mechanism of tumor destruction mediated by GM-CSF expression itself. The article by Kanerva et al. extends this work to describe early clinical use of an oncolytic adenovirus expressing GM-CSF, although the data are too preliminary to describe significant therapeutic benefits of GM-CSF expression in this backbone. However, the description of enhanced antitumor immunity in those patients that developed greater antiviral immunity after treatment provides a potent demonstration of the immunotherapeutic potential of epitope spreading after treatment with oncolytic viral therapies.
    MeSH term(s) Female ; Humans ; Male ; Neoplasms/immunology ; Neoplasms/therapy ; Oncolytic Virotherapy/methods ; T-Lymphocytes/immunology
    Language English
    Publishing date 2013-08
    Publishing country England
    Document type Comment ; Journal Article
    ISSN 1750-7448
    ISSN (online) 1750-7448
    DOI 10.2217/imt.13.65
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  5. Article ; Online: Next-generation oncolytic vaccinia vectors.

    Thorne, Steve H

    Methods in molecular biology (Clifton, N.J.)

    2012  Volume 797, Page(s) 205–215

    Abstract: Oncolytic vaccinia viruses have made some impressive advances over the last 5 years, with a range of -different backbones displaying significant antitumor responses in preclinical models, and some exciting clinical results being reported against liver ... ...

    Abstract Oncolytic vaccinia viruses have made some impressive advances over the last 5 years, with a range of -different backbones displaying significant antitumor responses in preclinical models, and some exciting clinical results being reported against liver cancers. Because the virus is capable of rapid spread within the tumor, has evolved to spread relatively undetected within the blood stream, does not integrate into the host cell chromosome, and can infect almost any cell type, it is well-suited to the requirements for a successful oncolytic. In addition, the extensive clinical use of this virus means that contraindications to its use are known, and approved and experimental antivirals are available. Furthermore, because the virus has a large array of virulence genes whose deletion may target different properties of the cancer cell, and a large cloning capacity allowing for insertion of multiple transgenes, the possibilities for further development of novel and next-generation oncolytic vectors are multitude.
    MeSH term(s) Animals ; Cell Line ; Cell Line, Tumor ; Genetic Vectors ; HeLa Cells ; Humans ; Mice ; Neoplasms/therapy ; Oncolytic Virotherapy/methods ; Oncolytic Viruses/genetics ; Transgenes/genetics ; Vaccinia virus/genetics ; Virus Replication/genetics
    Language English
    Publishing date 2012
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-61779-340-0_14
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  6. Article ; Online: Noninvasive Imaging of Fluorescent Reporters in Small Rodent Models Using Fluorescence Molecular Tomography.

    Hou, Weizhou / Thorne, Steve H

    Methods in molecular biology (Clifton, N.J.)

    2016  Volume 1444, Page(s) 67–72

    Abstract: The capacity to combine noninvasive whole animal imaging of genetic reporters and exogenously added probes in a single animal makes fluorescence imaging a powerful tool for investigating molecular events in live animals in preclinical research. However, ... ...

    Abstract The capacity to combine noninvasive whole animal imaging of genetic reporters and exogenously added probes in a single animal makes fluorescence imaging a powerful tool for investigating molecular events in live animals in preclinical research. However, the adsorption and diffraction properties of light passing through tissues mean that the choice of reporters, models, and imaging systems needs to be carefully considered. Here, we describe approaches to design and run experiments incorporating noninvasive whole animal fluorescence imaging into small animal imaging studies.
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-3721-9_7
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  7. Article ; Online: Immunotherapeutic potential of oncolytic vaccinia virus.

    Thorne, Steve H

    Immunologic research

    2011  Volume 50, Issue 2-3, Page(s) 286–293

    Abstract: There has recently been resurgence in interest for the use of replication-selective (oncolytic) viruses for the treatment of cancers. This has been fueled by positive clinical data and the promise provided by next-generation vectors that are better ... ...

    Abstract There has recently been resurgence in interest for the use of replication-selective (oncolytic) viruses for the treatment of cancers. This has been fueled by positive clinical data and the promise provided by next-generation vectors that are better targeted and display enhanced therapeutic potential. One factor that has led to more effective oncolytic vectors has been a greater appreciation of their immunotherapeutic potential. This is especially true for strains of vaccinia virus, where the capability for rapid and destructive spread through a target tissue makes this virus the ideal backbone for an oncolytic agent, while its known ability to produce a potent immune response makes it a powerful immunotherapeutic. Approaches to developing next-generation vectors that are capable of effectively harnessing both of these mechanisms of action are discussed here.
    MeSH term(s) Animals ; Combined Modality Therapy ; Humans ; Immunotherapy, Adoptive ; Neoplasms/therapy ; Oncolytic Virotherapy ; Oncolytic Viruses/genetics ; Oncolytic Viruses/immunology ; Vaccinia virus/genetics ; Vaccinia virus/immunology
    Language English
    Publishing date 2011-07-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 632857-x
    ISSN 1559-0755 ; 0257-277X
    ISSN (online) 1559-0755
    ISSN 0257-277X
    DOI 10.1007/s12026-011-8211-4
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1755: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Enhancing biological therapy through conditional regulation of protein stability.

    Thorne, Steve H

    Expert reviews in molecular medicine

    2010  Volume 12, Page(s) e2

    Abstract: The ability to externally regulate the expression or function of a gene product has proven to be a powerful tool in the study of proteins and disease in vitro, and more recently in transgenic animal models. The transfer of these technologies to regulate ... ...

    Abstract The ability to externally regulate the expression or function of a gene product has proven to be a powerful tool in the study of proteins and disease in vitro, and more recently in transgenic animal models. The transfer of these technologies to regulate a therapeutic, adoptively transferred gene product in a clinical setting may provide a means to exert additional control over a large variety of therapies for many diseases, leading to increased safety and effectiveness. This could be applied to any biological therapy, including gene therapy, viral therapies, cellular therapies (such as immune cell therapies, stem cell therapies and bone marrow transplant), some vaccines and even organ transplant. A variety of systems have been used in a basic research setting to conditionally regulate the function of a protein, including control of transcription and mRNA stability, and the use of protein inhibitors. However, most of these have disadvantages for medical use, where a simple, specific, tunable, reversible and broadly applicable means to regulate protein function is needed. Recent advances in controlling the stability or function of proteins through the interaction of small-molecule effectors and fusion domains on the protein have raised the possibility that direct and highly specific external control of therapeutic protein function in humans will be feasible.
    MeSH term(s) Animals ; Biological Therapy/methods ; Disease ; Humans ; Protein Stability ; Proteins/chemistry ; Proteins/genetics ; Proteins/metabolism
    Chemical Substances Proteins
    Language English
    Publishing date 2010-01-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 1462-3994
    ISSN (online) 1462-3994
    DOI 10.1017/S1462399409001331
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Novel therapeutic strategies in human malignancy: combining immunotherapy and oncolytic virotherapy.

    Sampath, Padma / Thorne, Steve H

    Oncolytic virotherapy

    2015  Volume 4, Page(s) 75–82

    Abstract: Results from randomized clinical trials over the last several years have finally begun to demonstrate the potential of oncolytic viral therapies to treat a variety of cancers. One reason for these successes has been the realization that this platform is ... ...

    Abstract Results from randomized clinical trials over the last several years have finally begun to demonstrate the potential of oncolytic viral therapies to treat a variety of cancers. One reason for these successes has been the realization that this platform is most effective when considered primarily as an immunotherapy. Cancer immunotherapy has also made dramatic strides recently with antibodies capable of blocking immune checkpoint inhibitors and adoptive T-cell therapies, notably CAR T-cells, leading a panel of novel and highly clinically effective therapies. It is clear therefore that an understanding of how and when these complementary approaches can most effectively be combined offers the real hope of moving beyond simply treating the disease and toward starting to talk about curative therapies. In this review we discuss approaches to combining these therapeutic platforms, both through engineering the viral vectors to more beneficially interact with the host immune response during therapy, as well as through the direct combinations of different therapeutics. This primarily, but not exclusively focuses on strains of oncolytic vaccinia virus. Some of the results reported to date, primarily in pre-clinical models but also in early clinical trials, are dramatic and hold great promise for the future development of similar therapies and their translation into cancer therapies.
    Language English
    Publishing date 2015-06-18
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2799361-9
    ISSN 2253-1572
    ISSN 2253-1572
    DOI 10.2147/OV.S54738
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  10. Article ; Online: Giving oncolytic vaccinia virus more BiTE.

    Albelda, Steven M / Thorne, Steve H

    Molecular therapy : the journal of the American Society of Gene Therapy

    2014  Volume 22, Issue 1, Page(s) 6–8

    MeSH term(s) Animals ; Genetic Vectors/immunology ; Humans ; Neoplasms/immunology ; Neoplasms/therapy ; Oncolytic Viruses/immunology ; T-Lymphocytes/immunology ; Vaccinia virus/immunology
    Language English
    Publishing date 2014-01-02
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2010592-7
    ISSN 1525-0024 ; 1525-0016
    ISSN (online) 1525-0024
    ISSN 1525-0016
    DOI 10.1038/mt.2013.271
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5640: Show issues Location:
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