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  1. Book ; Online ; E-Book: Methods of mathematical oncology

    Suzuki, Takashi

    Fusion of Mathematics and Biology, Osaka, Japan, October 26-28, 2020

    (Springer Proceedings in Mathematics & Statistics ; Volume 370)

    2021  

    Author's details Takashi Suzuki [and three others] editors
    Series title Springer Proceedings in Mathematics & Statistics ; Volume 370
    Keywords Oncology/Mathematics ; Oncologia ; Matemàtica
    Subject code 616.99400285
    Language English
    Size 1 online resource (317 pages)
    Publisher Springer
    Publishing place Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 981-16-4866-2 ; 981-16-4865-4 ; 978-981-16-4866-3 ; 978-981-16-4865-6
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Primary epiploic appendagitis: a rare cause of localised abdominal pain.

    Suzuki, Morika / Watari, Takashi

    BMJ case reports

    2024  Volume 17, Issue 2

    MeSH term(s) Humans ; Abdominal Pain/etiology ; Colitis/diagnosis ; Colitis/diagnostic imaging ; Colitis, Ischemic/complications
    Language English
    Publishing date 2024-02-21
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2023-259403
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Solid-Phase Binding Assay for Ganglioside Binding of Human Respiroviruses.

    Suzuki, Takashi

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2556, Page(s) 179–186

    Abstract: Human parainfluenza virus types 1 (hPIV-1) and 3 (hPIV-3) belong to the family Paramyxoviridae, subfamily Paramyxoviridae, and genus Respirovirus. The viruses enter by utilizing glycoproteins or glycosphingolipids (gangliosides) containing sialic acid on ...

    Abstract Human parainfluenza virus types 1 (hPIV-1) and 3 (hPIV-3) belong to the family Paramyxoviridae, subfamily Paramyxoviridae, and genus Respirovirus. The viruses enter by utilizing glycoproteins or glycosphingolipids (gangliosides) containing sialic acid on the cell membrane. We developed a solid-phase binding assay to evaluate hPIV-1, hPIV-3, and Sendai virus' abilities to bind to different types of gangliosides. hPIV1 and hPIV3 show strong binding to neolacto-series gangliosides containing a non-reducing terminal sialic acid residue and different specificity regarding the sialic acid linkages. This solid-phase binding assay is suitable to evaluate other orthomyxoviruses and paramyxoviruses' binding specificities utilizing sialic acids.
    MeSH term(s) Biological Assay ; Gangliosides ; Humans ; N-Acetylneuraminic Acid ; Respirovirus ; Sendai virus
    Chemical Substances Gangliosides ; N-Acetylneuraminic Acid (GZP2782OP0)
    Language English
    Publishing date 2022-09-29
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2635-1_14
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: [Role of Glycoconjugates and Mammalian Sialidases Involved in Viral Infection and Neural Function].

    Suzuki, Takashi

    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

    2022  Volume 142, Issue 4, Page(s) 381–388

    Abstract: Glycoconjugates are present in various organisms, ranging from animals to viruses. Glycoconjugates are involved in several biologically significant functions, including viral infection and neurotransmission. However, the role of glycoconjugates in virus ... ...

    Abstract Glycoconjugates are present in various organisms, ranging from animals to viruses. Glycoconjugates are involved in several biologically significant functions, including viral infection and neurotransmission. However, the role of glycoconjugates in virus replication and neural function remains unknown. We discovered that the influenza A virus (IAV) binds to sulfatide, which lacks a sialic acid residue, and that delivering sulfatide combined with newly synthesized IAV hemagglutinin (HA) to the target plasma membrane induces the translocation of viral ribonucleoprotein complexes from the nucleus to the cytoplasm. Molecular species of sialic acid are largely classified as N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc). We discovered that two amino acids in IAV H3 HA play a critical role in the recognition of Neu5Ac and Neu5Gc. Also, we observed that human parainfluenza virus types 1 (hPIV-1) and 3 (hPIV-3) bind to different forms of gangliosides. These viruses preferentially recognized oligosaccharides containing branched N-acetyllactosaminoglycans with terminal Neu5Acα2-3Gal. Neu5Gcα2-3Gal- and NeuAcα2-6Gal-containing receptors were identified by hPIV-3, but not by hPIV-1. We constructed a novel sialidase fluorescent substrate, 2-benzothiazol-2-yl-phenol derivative-based N-acetylneuraminic acid (BTP3-Neu5Ac), which detects sialidase activity in living mammalian tissues and virus-infected cells expressing viral neuraminidase. We discovered that neural activity-dependent desialylation by sialidase contributes to rat hippocampal memory processing. Using BTP3-Neu5Ac, we developed a rapid and sensitive approach for detecting and isolating drug-resistant influenza viruses. This review summarizes the role of sialylglycoconjugates and sulfatide in virus replication as well as mammalian sialidases involved in neural function and insulin secretion.
    MeSH term(s) Animals ; Benzothiazoles ; Glycoconjugates/metabolism ; Mammals/metabolism ; Neuraminidase ; Rats ; Sialic Acids ; Virus Diseases
    Chemical Substances BTP3-Neu5Ac ; Benzothiazoles ; Glycoconjugates ; Sialic Acids ; Neuraminidase (EC 3.2.1.18)
    Language Japanese
    Publishing date 2022-03-31
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 200514-1
    ISSN 1347-5231 ; 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    ISSN (online) 1347-5231
    ISSN 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    DOI 10.1248/yakushi.21-00212
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 643: Show issues Location:
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  5. Article ; Online: Idiopathic segmental anhidrosis in an older patient presenting with recurrent dizziness.

    Suzuki, Morika / Watari, Takashi

    BMJ case reports

    2024  Volume 17, Issue 1

    Abstract: Dizziness is one of the most common complaints encountered in the outpatient clinic, which is difficult to diagnose, especially in older patients because of the multifactorial nature of the disease. Although not commonly recognised, anhidrosis can also ... ...

    Abstract Dizziness is one of the most common complaints encountered in the outpatient clinic, which is difficult to diagnose, especially in older patients because of the multifactorial nature of the disease. Although not commonly recognised, anhidrosis can also cause dizziness.We report a case of a woman in her 70s who presented with long-term recurrent dizziness. She had a history of frequent hospitalisations for heatstroke. Physical examination revealed markedly less sweating in the left axilla and soles than in the right. Minol test revealed that most of the left side of her body, including the face, was anhidrotic. She was diagnosed with idiopathic segmental anhidrosis. We administered steroid pulse therapy without observing any significant effects.Although anhidrosis is a rare disorder, a careful interview and physical examination should be conducted to confirm a history of heatstroke and the absence of sweating to avoid missing the disease.
    MeSH term(s) Female ; Humans ; Aged ; Hypohidrosis/diagnosis ; Hypohidrosis/etiology ; Dizziness/etiology ; Sweating ; Vertigo ; Heat Stroke/complications
    Language English
    Publishing date 2024-01-16
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2023-258324
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Use of Endoscopy to Remove Fish Bone that Caused Sigmoid Colon Perforation.

    Ueda, Takashi / Sato, Hirohiko / Ogimi, Takashi / Deguchi, Ryuzo / Suzuki, Hidekazu

    Internal medicine (Tokyo, Japan)

    2024  

    Abstract: An 87-year-old man experiencing lower abdominal discomfort resulting from the ingestion of a fish bone underwent conservative management involving endoscopic extraction of the fish bone lodged in the sigmoid colon. Most patients with lower ... ...

    Abstract An 87-year-old man experiencing lower abdominal discomfort resulting from the ingestion of a fish bone underwent conservative management involving endoscopic extraction of the fish bone lodged in the sigmoid colon. Most patients with lower gastrointestinal tract perforations typically develop peritonitis or abscesses, necessitating surgical intervention. Notably, endoscopic management of lower gastrointestinal tract perforations is infrequently employed. Patients presenting with localized abdominal symptoms along with a stable overall health condition may benefit from conservative therapeutic approaches that utilize endoscopic methods. Notably, the transition from endoscopic procedures for foreign body removal to surgical intervention requires close collaboration with a surgeon and must be executed judiciously.
    Language English
    Publishing date 2024-02-19
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.3063-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 240: Show issues Location:
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  7. Article ; Online: How Can We Interpret Insomnia as a "Risk Factor" on Behavioral Symptom? Comments on the Article by Chekani et al.

    Matsushita, Takashi / Suzuki, Ryuji / Ito, Hideyuki / Yamamoto, Ryohei

    Journal of the American Medical Directors Association

    2024  Volume 25, Issue 3, Page(s) 552–553

    MeSH term(s) Humans ; Sleep Initiation and Maintenance Disorders ; Behavioral Symptoms ; Risk Factors
    Language English
    Publishing date 2024-01-03
    Publishing country United States
    Document type Letter
    ZDB-ID 2171030-2
    ISSN 1538-9375 ; 1525-8610
    ISSN (online) 1538-9375
    ISSN 1525-8610
    DOI 10.1016/j.jamda.2023.11.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5971: Show issues Location:
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  8. Article ; Online: Draft genome of

    Nishida, Shiho / Suzuki, Jota / Inoue, Masao / Kamikawa, Ryoma / Yoshida, Takashi

    Microbiology resource announcements

    2024  Volume 13, Issue 2, Page(s) e0079523

    Abstract: Parageobacillus ... ...

    Abstract Parageobacillus thermoglucosidasius
    Language English
    Publishing date 2024-01-17
    Publishing country United States
    Document type Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/mra.00795-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Morbihan Syndrome.

    Suzuki, Morika / Watari, Takashi

    Journal of general internal medicine

    2022  Volume 38, Issue 1, Page(s) 233

    MeSH term(s) Humans ; Edema ; Syndrome
    Language English
    Publishing date 2022-11-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639008-0
    ISSN 1525-1497 ; 0884-8734
    ISSN (online) 1525-1497
    ISSN 0884-8734
    DOI 10.1007/s11606-022-07858-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2205: Show issues Location:
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  10. Article ; Online: [Research on Analysis of Final Diagnosis and Prognostic Factors, and Development of New Therapeutic Drugs for Malignant Tumors (Especially Malignant Pediatric Tumors)].

    Suzuki, Takashi

    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

    2020  Volume 140, Issue 2, Page(s) 229–271

    Abstract: Outcomes of treatment for malignant pediatric tumors including leukemia are improving by conventional multimodal treatment with strong chemotherapy, surgical resection, radiotherapy, and bone marrow transplantation. However, patients with advanced ... ...

    Abstract Outcomes of treatment for malignant pediatric tumors including leukemia are improving by conventional multimodal treatment with strong chemotherapy, surgical resection, radiotherapy, and bone marrow transplantation. However, patients with advanced neuroblastoma, metastatic Ewing's sarcoma family of tumor (ESFT), and metastatic osteosarcoma continue to have an extremely poor prognosis. Therefore novel therapeutic strategies are urgently needed to improve their survival. Apoptotic cell death is a key mechanism for normal cellular homeostasis. Intact apoptotic mechanisms are pivotal for embryonic development, tissue remodeling, immune regulation, and tumor regression. Genetic aberrations disrupting programmed cell death often underpin tumorigenesis and drug resistance. Moreover, it has been suggested that apoptosis or cell differentiation proceeds to spontaneous regression in early stage neuroblastoma. Therefore apoptosis or cell differentiation is a critical event in this cancer. We extracted many compounds from natural plants (Angelica keiskei, Alpinia officiarum, Lycaria puchury-major, Brassica rapa) or synthesized cyclophane pyridine, indirubin derivatives, vitamin K3 derivatives, burchellin derivatives, and GANT61, and examined their effects on apoptosis, cell differentiation, and cell cycle in neuroblastoma and ESFT cell lines compared with normal cells. Some compounds were very effective against these tumor cells. These results suggest that they may be applicable as an efficacious and safe drug for the treatment of malignant pediatric tumors.
    MeSH term(s) Apoptosis ; Cell Differentiation ; Child ; Child, Preschool ; Drug Development ; Genes, Tumor Suppressor ; Humans ; Infant ; Leukemia/drug therapy ; Leukemia/pathology ; Neoplasms/diagnosis ; Neoplasms/drug therapy ; Neoplasms/pathology ; Plant Extracts ; Prognosis
    Chemical Substances Plant Extracts
    Language Japanese
    Publishing date 2020-01-23
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 200514-1
    ISSN 1347-5231 ; 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    ISSN (online) 1347-5231
    ISSN 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    DOI 10.1248/yakushi.19-00178
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 643: Show issues Location:
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