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Article ; Online: MOF-based nanozyme grafted with cooperative Pt(IV) prodrug for synergistic anticancer therapy.

Wu, Ping-Hsuan / Cheng, Pei-Fen / Kaveevivitchai, Watchareeya / Chen, Teng-Hao

2023 Volume 225, Page(s) 113264

Abstract: Manipulating Fenton chemistry in tumor microenvironment (TME) for the generation of reactive oxygen species is an effective strategy for chemodynamic therapy. However, this is usually restricted by limited intracellular content of ... ...

Abstract	Manipulating Fenton chemistry in tumor microenvironment (TME) for the generation of reactive oxygen species is an effective strategy for chemodynamic therapy. However, this is usually restricted by limited intracellular content of H
MeSH term(s)	Humans ; Cisplatin/pharmacology ; Cisplatin/chemistry ; Metal-Organic Frameworks/chemistry ; Prodrugs/chemistry ; Ferric Compounds/therapeutic use ; Hydrogen Peroxide/chemistry ; Neoplasms/drug therapy ; Glucose ; Glucose Oxidase/chemistry ; Tumor Microenvironment ; Cell Line, Tumor
Chemical Substances	Cisplatin (Q20Q21Q62J) ; Metal-Organic Frameworks ; Prodrugs ; Ferric Compounds ; Hydrogen Peroxide (BBX060AN9V) ; Glucose (IY9XDZ35W2) ; Glucose Oxidase (EC 1.1.3.4)
Language	English
Publishing date	2023-03-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1500523-9
ISSN	1873-4367 ; 0927-7765
ISSN (online)	1873-4367
ISSN	0927-7765
DOI	10.1016/j.colsurfb.2023.113264
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A network approach to compute hypervolume under receiver operating characteristic manifold for multi-class biomarkers.

Feng, Qunqiang / Liu, Pan / Kuan, Pei-Fen / Zou, Fei / Chen, Jianan / Li, Jialiang

Statistics in medicine

2023

Abstract: Computation of hypervolume under ROC manifold (HUM) is necessary to evaluate biomarkers for their capability to discriminate among multiple disease types or diagnostic groups. However the original definition of HUM involves multiple integration and thus ... ...

Abstract	Computation of hypervolume under ROC manifold (HUM) is necessary to evaluate biomarkers for their capability to discriminate among multiple disease types or diagnostic groups. However the original definition of HUM involves multiple integration and thus a medical investigation for multi-class receiver operating characteristic (ROC) analysis could suffer from huge computational cost when the formula is implemented naively. We introduce a novel graph-based approach to compute HUM efficiently in this article. The computational method avoids the time-consuming multiple summation when sample size or the number of categories is large. We conduct extensive simulation studies to demonstrate the improvement of our method over existing R packages. We apply our method to two real biomedical data sets to illustrate its application.
Language	English
Publishing date	2023-01-03
Publishing country	England
Document type	Journal Article
ZDB-ID	843037-8
ISSN	1097-0258 ; 0277-6715
ISSN (online)	1097-0258
ISSN	0277-6715
DOI	10.1002/sim.9646
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Article ; Online: MOF-based nanozyme grafted with cooperative Pt(IV) prodrug for synergistic anticancer therapy

Wu, Ping-Hsuan / Cheng, Pei-Fen / Kaveevivitchai, Watchareeya / Chen, Teng-Hao

Colloids and Surfaces B: Biointerfaces. 2023 May, v. 225 p.113264-

2023

Abstract	Manipulating Fenton chemistry in tumor microenvironment (TME) for the generation of reactive oxygen species is an effective strategy for chemodynamic therapy. However, this is usually restricted by limited intracellular content of H₂O₂ and insufficient acidic environment at the tumor site. Herein, a ferric metal–organic framework (MOF) is covalently grafted with a prodrug of cisplatin (Pt(IV) prodrug) and loaded with a biocatalyst glucose oxidase (GOx) to afford a nanozyme MOF-Pt(IV)@GOx for cascade reactions. In this system, the attached Pt(IV) prodrug on MOF plays a significant role in the cooperative enhancement of GOx loading and chemotherapy. The high concentration of glutathione in TME reduces Fe(III) to Fe(II) for Fenton reaction, and converts Pt(IV) prodrug to cisplatin for DNA targeting and H₂O₂ production. Meanwhile, glucose oxidation catalyzed by GOx not only consumes glucose for starvation therapy, but also promotes the intracellular acidity and H₂O₂ supply in TME, which are in favor of Fenton reaction. Both in vitro and in vivo studies demonstrate that MOF-Pt(IV)@GOx enables remarkable anticancer efficacy due to the synergistic trimodal therapy consisting of ferroptosis, starvation therapy, and chemotherapy.
Keywords	DNA ; acidity ; biocatalysts ; cancer therapy ; chemical bonding ; cisplatin ; coordination polymers ; drug therapy ; ferroptosis ; glucose ; glucose oxidase ; glutathione ; neoplasms ; oxidation ; reactive oxygen species ; starvation ; Metal–organic frameworks ; Nanozyme ; Pt(IV) prodrug ; Synergistic anticancer therapy
Language	English
Dates of publication	2023-05
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	1500523-9
ISSN	1873-4367 ; 0927-7765
ISSN (online)	1873-4367
ISSN	0927-7765
DOI	10.1016/j.colsurfb.2023.113264
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Key quality factors for Chinese herbal medicines entering the EU market

Mei Wang / Pei-Fen Yao / Peng-Yue Sun / Wen Liang / Xiao-Jia Chen

Chinese Medicine, Vol 17, Iss 1, Pp 1-

2022 Volume 13

Abstract: Abstract Chinese herbal medicines (CHMs) have unique advantages in the prevention and treatment of diseases, which are widely recognized in the world. More and more CHMs are becoming increasingly popular in the international markets. However, the quality ...

Abstract	Abstract Chinese herbal medicines (CHMs) have unique advantages in the prevention and treatment of diseases, which are widely recognized in the world. More and more CHMs are becoming increasingly popular in the international markets. However, the quality control of CHMs is a significant issue for their acceptance and recognition in the international market. This review mainly focuses on the quality requirements for CHMs to enter the European Union (EU) market. Both Chinese and European regulations and quality controls are compared. Firstly, the EU medicinal regulatory system and relevant regulations were reviewed. Secondly, the key factors of the quality control of CHMs, including Chinese herbal drugs, extracts and products were compared with those of European herbal medicines in the EU market. Subsequently, three main registration routes for herbal medicinal products including Chinese herbal medicinal products entering the EU were introduced. Furthermore, the legal status of traditional Chinese medicine granules in the EU was also discussed. Through the comparison of the key quality factors for CHMs in China and the EU, the similarities and differences in terms of quality requirements and regulations are addressed, which provides a reference for the development of CHMs into the EU market.
Keywords	Chinese herbal medicines ; European Pharmacopoeia ; Chinese Pharmacopoeia ; Quality requirements ; European herbal medicine legislation ; European market ; Other systems of medicine ; RZ201-999
Subject code	028
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Exercise Test for Patients with Long QT Syndrome.

Chan, Cheng-Han / Hu, Yu-Feng / Chen, Pei-Fen / Wu, I-Chien / Chen, Shih-Ann

Acta Cardiologica Sinica

2022 Volume 38, Issue 2, Page(s) 124–133

Abstract: Congenital long QT syndrome (LQTS) causes life-threatening cardiac arrhythmias and is the leading cause of sudden cardiac death in young people. Measurements of QT prolongation during exercise or postural change have been recommended to assist in the ... ...

Abstract	Congenital long QT syndrome (LQTS) causes life-threatening cardiac arrhythmias and is the leading cause of sudden cardiac death in young people. Measurements of QT prolongation during exercise or postural change have been recommended to assist in the diagnosis of LQTS, particularly in those with hidden phenotypes. However, most evidence has come from single-center studies without external validation in an independent cohort. Inter-study heterogeneity leads to significant difficulties in interpreting and applying consistent diagnostic criteria for LQTS. A comprehensive systematic review is critically needed to summarize the evidence and validate the diagnostic performance of QT intervals during exercise or postural change across a variety of studies. In this study, we review cross-sectional and cohort studies evaluating the efficacy and feasibility of exercise tests or postural changes in diagnosing LQTS, and propose possible problems resulting from exercise tests.
Language	English
Publishing date	2022-03-07
Publishing country	China (Republic : 1949- )
Document type	Journal Article ; Review
ZDB-ID	1051394-2
ISSN	1011-6842
ISSN	1011-6842
DOI	10.6515/ACS.202203_38(2).20211101A
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Zs.A 3059: Show issues

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Article ; Online: The METTL3-m

Qiu, Yue / Tian, Zhen / Miao, Ting-Yu / Shen, Lin / Chen, Jing / Li, Pei-Fen / Zhu, Zi-Xuan / Zhu, Zi-Fan / Wu, Wen-Juan / Xu, Xiao / Shen, Wei-Gan

Gene

2024 Volume 908, Page(s) 148281

Abstract: The upregulation of methyltransferase-like 3 (METTL3) has been associated with the progression of esophageal cancer. However, METTL3-induced ... ...

Abstract	The upregulation of methyltransferase-like 3 (METTL3) has been associated with the progression of esophageal cancer. However, METTL3-induced N
MeSH term(s)	Humans ; Esophageal Squamous Cell Carcinoma/genetics ; Esophageal Squamous Cell Carcinoma/pathology ; Esophageal Neoplasms/pathology ; RNA Precursors/metabolism ; Cell Proliferation/genetics ; Up-Regulation ; Methyltransferases/genetics ; Methyltransferases/metabolism ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; RNA Splicing Factors/genetics
Chemical Substances	RNA Precursors ; Methyltransferases (EC 2.1.1.-) ; METTL3 protein, human (EC 2.1.1.62) ; AMIGO2 protein, human ; Nerve Tissue Proteins ; YTHDC1 protein, human ; RNA Splicing Factors
Language	English
Publishing date	2024-02-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2024.148281
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1357: Show issues

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Article: Key quality factors for Chinese herbal medicines entering the EU market.

Wang, Mei / Yao, Pei-Fen / Sun, Peng-Yue / Liang, Wen / Chen, Xiao-Jia

Chinese medicine

2022 Volume 17, Issue 1, Page(s) 29

Abstract: Chinese herbal medicines (CHMs) have unique advantages in the prevention and treatment of diseases, which are widely recognized in the world. More and more CHMs are becoming increasingly popular in the international markets. However, the quality control ... ...

Abstract	Chinese herbal medicines (CHMs) have unique advantages in the prevention and treatment of diseases, which are widely recognized in the world. More and more CHMs are becoming increasingly popular in the international markets. However, the quality control of CHMs is a significant issue for their acceptance and recognition in the international market. This review mainly focuses on the quality requirements for CHMs to enter the European Union (EU) market. Both Chinese and European regulations and quality controls are compared. Firstly, the EU medicinal regulatory system and relevant regulations were reviewed. Secondly, the key factors of the quality control of CHMs, including Chinese herbal drugs, extracts and products were compared with those of European herbal medicines in the EU market. Subsequently, three main registration routes for herbal medicinal products including Chinese herbal medicinal products entering the EU were introduced. Furthermore, the legal status of traditional Chinese medicine granules in the EU was also discussed. Through the comparison of the key quality factors for CHMs in China and the EU, the similarities and differences in terms of quality requirements and regulations are addressed, which provides a reference for the development of CHMs into the EU market.
Language	English
Publishing date	2022-02-22
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2260322-0
ISSN	1749-8546
ISSN	1749-8546
DOI	10.1186/s13020-022-00583-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Early fish domestication affects methylation of key genes involved in the rapid onset of the farmed phenotype.

Podgorniak, Tomasz / Dhanasiri, Anusha / Chen, Xianquan / Ren, Xu / Kuan, Pei-Fen / Fernandes, Jorge

Epigenetics

2022 Volume 17, Issue 10, Page(s) 1281–1298

Abstract: Animal domestication is a process of environmental modulation and artificial selection leading to permanent phenotypic modifications. Recent studies showed that phenotypic changes occur very early in domestication, i.e., within the first generation in ... ...

Abstract	Animal domestication is a process of environmental modulation and artificial selection leading to permanent phenotypic modifications. Recent studies showed that phenotypic changes occur very early in domestication, i.e., within the first generation in captivity, which raises the hypothesis that epigenetic mechanisms may play a critical role on the early onset of the domestic phenotype. In this context, we applied reduced representation bisulphite sequencing to compare methylation profiles between wild Nile tilapia females and their offspring reared under farmed conditions. Approximately 700 differentially methylated CpG sites were found, many of them associated not only with genes involved in muscle growth, immunity, autophagy and diet response but also related to epigenetic mechanisms, such as RNA methylation and histone modifications. This bottom-up approach showed that the phenotypic traits often related to domestic animals (e.g., higher growth rate and different immune status) may be regulated epigenetically and prior to artificial selection on gene sequences. Moreover, it revealed the importance of diet in this process, as reflected by differential methylation patterns in genes critical to fat metabolism. Finally, our study highlighted that the TGF-β1 signalling pathway may regulate and be regulated by several differentially methylated CpG-associated genes. This could be an important and multifunctional component in promoting adaptation of fish to a domestic environment while modulating growth and immunity-related traits.
MeSH term(s)	Animals ; DNA Methylation ; Domestication ; Female ; Phenotype ; RNA ; Transforming Growth Factor beta1
Chemical Substances	Transforming Growth Factor beta1 ; RNA (63231-63-0)
Language	English
Publishing date	2022-01-10
Publishing country	United States
Document type	Journal Article
ISSN	1559-2308
ISSN (online)	1559-2308
DOI	10.1080/15592294.2021.2017554
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Lower HbA1C of glycemic control is associated with higher risk of depressive symptoms in elderly with type 2 diabetes mellitus-A Nationwide Community-based study.

Liu, Yen-Tze / Wu, Wan-Hui / Tseng, Wei-Ting / Lin, Hsien-Chih / Wu, Ming-Shiang / Chen, Pei-Fen / Wu, I-Chien

Journal of psychosomatic research

2023 Volume 174, Page(s) 111492

Abstract: Objective: We investigated the correlation between glycemic control status and depressive symptoms in type 2 diabetes elderly.: Methods: A total of 1527 participants with type 2 diabetes aged 55 years and older from the Healthy Aging Longitudinal ... ...

Abstract	Objective: We investigated the correlation between glycemic control status and depressive symptoms in type 2 diabetes elderly. Methods: A total of 1527 participants with type 2 diabetes aged 55 years and older from the Healthy Aging Longitudinal Study in Taiwan study were included in this cross-sectional study. The Center for Epidemiologic Studies Depression Scale (CESD) (20 items) score of ≥16 was indicative of depressive symptoms. The participants were divided into HbA1c ≥ 6.5% and < 6.5% representing the glycemic control. Multiple logistic regression (MLR) and Generalized linear model (GLM) were used. Results: The MLR analysis showed that the low HbA1c group had significant two-fold increased odds of depressive symptoms compared to the high HbA1c group (OR 1.89, 95% CI 1.17-3.05). The risk of depressive symptoms was lower among males (OR 0.49, 95% CI 0.30-0.80) and those with higher BMI (OR 0.93, 95% CI 0.86-1.00); whereas the risk was higher among those who lived alone (OR 2.37, 95% CI 1.31-4.27) and with ADL disability (OR 3.01, 95% CI 1.85-4.89). The GLM showed that the dimension of depressive affect reached statistical significance with lower HbA1c. Conclusion: This nationwide community-based study shows that depressive symptoms are associated with lower HbA1C, reminding us that more attention should be paid to the presence of depressive symptoms in those with lower HbA1C. Further research is needed to clarify the causal relationship.
Language	English
Publishing date	2023-09-09
Publishing country	England
Document type	Journal Article
ZDB-ID	80166-5
ISSN	1879-1360 ; 0022-3999
ISSN (online)	1879-1360
ISSN	0022-3999
DOI	10.1016/j.jpsychores.2023.111492
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Article: US fiscal sustainability and the causality relationship between government expenditures and revenues

Chen, Pei-Fen

Fiscal studies : the journal of the Institute for Fiscal Studies Vol. 37, No. 2 , p. 301-320

a new approach based on quantile cointegration

2016 Volume 37, Issue 2, Page(s) 301–320

Author's details	Pei-Fen Chen
Keywords	fiscal sustainability ; quantile regression ; Johansen causality ; government expenditures ; government revenues
Language	English
Publisher	Wiley-Blackwell
Publishing place	Oxford
Document type	Article
ZDB-ID	875401-9 ; 2044782-6
ISSN	1475-5890 ; 0143-5671
ISSN (online)	1475-5890
ISSN	0143-5671
Database	ECONomics Information System

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