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  1. Article ; Online: Immuno-oncology drug development forges on despite COVID-19.

    Upadhaya, Samik / Hubbard-Lucey, Vanessa M / Yu, Jia Xin

    Nature reviews. Drug discovery

    2020  Volume 19, Issue 11, Page(s) 751–752

    MeSH term(s) Allergy and Immunology/trends ; COVID-19 ; Clinical Trials as Topic/statistics & numerical data ; Coronavirus Infections ; Drug Development ; Humans ; Medical Oncology/trends ; Neoplasms/therapy ; Pandemics ; Pneumonia, Viral
    Keywords covid19
    Language English
    Publishing date 2020-09-18
    Publishing country England
    Document type News
    ZDB-ID 2062954-0
    ISSN 1474-1784 ; 1474-1776
    ISSN (online) 1474-1784
    ISSN 1474-1776
    DOI 10.1038/d41573-020-00166-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5564: Show issues Location:
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  3. Article ; Online: The global pipeline of cell therapies for cancer.

    Xin Yu, Jia / Hubbard-Lucey, Vanessa M / Tang, Jun

    Nature reviews. Drug discovery

    2019  Volume 18, Issue 11, Page(s) 821–822

    MeSH term(s) Cell- and Tissue-Based Therapy/methods ; Humans ; International Cooperation ; Neoplasms/therapy
    Language English
    Publishing date 2019-10-31
    Publishing country England
    Document type News
    ZDB-ID 2062954-0
    ISSN 1474-1784 ; 1474-1776
    ISSN (online) 1474-1784
    ISSN 1474-1776
    DOI 10.1038/d41573-019-00090-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5564: Show issues Location:
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  4. Article ; Online: Cancer cell therapies: the clinical trial landscape.

    Yu, Jia Xin / Upadhaya, Samik / Tatake, Revati / Barkalow, Fern / Hubbard-Lucey, Vanessa M

    Nature reviews. Drug discovery

    2020  Volume 19, Issue 9, Page(s) 583–584

    MeSH term(s) Cell- and Tissue-Based Therapy/methods ; Clinical Trials as Topic ; Humans ; Neoplasms/therapy
    Keywords covid19
    Language English
    Publishing date 2020-05-23
    Publishing country England
    Document type News
    ZDB-ID 2062954-0
    ISSN 1474-1784 ; 1474-1776
    ISSN (online) 1474-1784
    ISSN 1474-1776
    DOI 10.1038/d41573-020-00099-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  5. Article ; Online: Immuno-oncology drug development forges on despite COVID-19

    Upadhaya, Samik / Hubbard-Lucey, Vanessa M. / Yu, Jia Xin

    Nature Reviews Drug Discovery ; ISSN 1474-1776 1474-1784

    2020  

    Keywords Pharmacology ; Drug Discovery ; General Medicine ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    DOI 10.1038/d41573-020-00166-1
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Immuno-oncology drug development goes global.

    Xin Yu, Jia / Hubbard-Lucey, Vanessa M / Tang, Jun

    Nature reviews. Drug discovery

    2019  Volume 18, Issue 12, Page(s) 899–900

    MeSH term(s) Antineoplastic Agents, Immunological/therapeutic use ; Drug Development ; Humans ; Immunotherapy/methods ; Molecular Targeted Therapy ; Neoplasms/drug therapy ; Neoplasms/immunology
    Chemical Substances Antineoplastic Agents, Immunological
    Language English
    Publishing date 2019-11-28
    Publishing country England
    Document type News
    ZDB-ID 2062954-0
    ISSN 1474-1784 ; 1474-1776
    ISSN (online) 1474-1784
    ISSN 1474-1776
    DOI 10.1038/d41573-019-00167-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5564: Show issues Location:
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  7. Article ; Online: Impact of COVID-19 on oncology clinical trials.

    Upadhaya, Samik / Yu, Jia Xin / Oliva, Cristina / Hooton, Megan / Hodge, Jeffrey / Hubbard-Lucey, Vanessa M

    Nature reviews. Drug discovery

    2020  Volume 19, Issue 6, Page(s) 376–377

    MeSH term(s) COVID-19 ; Clinical Trials as Topic/legislation & jurisprudence ; Clinical Trials as Topic/statistics & numerical data ; Coronavirus Infections ; Humans ; Medical Oncology/statistics & numerical data ; Pandemics ; Pneumonia, Viral ; Research Design ; Risk
    Keywords covid19
    Language English
    Publishing date 2020-05-18
    Publishing country England
    Document type News
    ZDB-ID 2062954-0
    ISSN 1474-1784 ; 1474-1776
    ISSN (online) 1474-1784
    ISSN 1474-1776
    DOI 10.1038/d41573-020-00093-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5564: Show issues Location:
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  8. Article ; Online: Trends in clinical development for PD-1/PD-L1 inhibitors.

    Xin Yu, Jia / Hodge, Jeffrey P / Oliva, Cristina / Neftelinov, Svetoslav T / Hubbard-Lucey, Vanessa M / Tang, Jun

    Nature reviews. Drug discovery

    2020  Volume 19, Issue 3, Page(s) 163–164

    Language English
    Publishing date 2020-03-03
    Publishing country England
    Document type News
    ZDB-ID 2062954-0
    ISSN 1474-1784 ; 1474-1776
    ISSN (online) 1474-1784
    ISSN 1474-1776
    DOI 10.1038/d41573-019-00182-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  9. Article ; Online: Immunotherapy and targeted therapy combinations in metastatic breast cancer.

    Esteva, Francisco J / Hubbard-Lucey, Vanessa M / Tang, Jun / Pusztai, Lajos

    The Lancet. Oncology

    2019  Volume 20, Issue 3, Page(s) e175–e186

    Abstract: Immunotherapy is emerging as a new treatment modality in breast cancer. After long-standing use of endocrine therapy and targeted biological therapy, improved understanding of immune evasion by cancer cells and the discovery of selective immune ... ...

    Abstract Immunotherapy is emerging as a new treatment modality in breast cancer. After long-standing use of endocrine therapy and targeted biological therapy, improved understanding of immune evasion by cancer cells and the discovery of selective immune checkpoint inhibitors have created novel opportunities for treatment. Single-drug therapies with monoclonal antibodies against programmed death-1 (PD-1) and programmed death ligand-1 (PD-L1) have shown little efficacy in patients with metastatic breast cancer, in part because of the low number of tumour-infiltrating lymphocytes in most breast cancers. There is growing interest in the development of combinations of immunotherapy and molecularly targeted therapies for metastatic breast cancer. In this Personal View, we review the available data and ongoing efforts to establish the safety and efficacy of immunotherapeutic approaches in combination with HER2-targeted therapy, inhibitors of cyclin-dependent kinases 4 and 6, angiogenesis inhibitors, poly(ADP-ribose) polymerase inhibitors, as well as chemotherapy and radiotherapy.
    MeSH term(s) B7-H1 Antigen/antagonists & inhibitors ; B7-H1 Antigen/immunology ; Breast Neoplasms/drug therapy ; Breast Neoplasms/immunology ; Breast Neoplasms/pathology ; Combined Modality Therapy ; Cyclin-Dependent Kinase 4/antagonists & inhibitors ; Cyclin-Dependent Kinase 4/genetics ; Cyclin-Dependent Kinase 6/antagonists & inhibitors ; Cyclin-Dependent Kinase 6/genetics ; Female ; Humans ; Immunotherapy ; Molecular Targeted Therapy ; Neoplasm Metastasis ; Programmed Cell Death 1 Receptor/antagonists & inhibitors ; Programmed Cell Death 1 Receptor/immunology ; Receptor, ErbB-2/antagonists & inhibitors ; Receptor, ErbB-2/genetics
    Chemical Substances B7-H1 Antigen ; CD274 protein, human ; PDCD1 protein, human ; Programmed Cell Death 1 Receptor ; ERBB2 protein, human (EC 2.7.10.1) ; Receptor, ErbB-2 (EC 2.7.10.1) ; CDK4 protein, human (EC 2.7.11.22) ; CDK6 protein, human (EC 2.7.11.22) ; Cyclin-Dependent Kinase 4 (EC 2.7.11.22) ; Cyclin-Dependent Kinase 6 (EC 2.7.11.22)
    Language English
    Publishing date 2019-03-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(19)30026-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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