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  1. Article: Circadian Rhythm, Sleep, and Immune Response and the Fight against COVID-19.

    Al-Abri, Mohammed A / Al-Yaarubi, Saif / Said, Elias A

    Oman medical journal

    2023  Volume 38, Issue 2, Page(s) e477

    Abstract: Sleep is an imperative physiological aspect that plays a vital role in maintaining hormonal and humeral functions of the body and hence a healthy life. Circadian rhythms are daily oscillations in human activities and physiology that prepare human beings ... ...

    Abstract Sleep is an imperative physiological aspect that plays a vital role in maintaining hormonal and humeral functions of the body and hence a healthy life. Circadian rhythms are daily oscillations in human activities and physiology that prepare human beings to better react to and anticipate challenges in the surrounding environment, which are a consequence of diurnal changes of day and night. The sleep/wake cycle is one of the most prominent manifestations of the circadian rhythm and communicates tightly with the immune system with daily oscillation of immunity. Sleep deprivation is now recognized as a common condition inherent to modern society, and it is detrimental to certain body functions, particularly immune function. The aim of this review is to explore the role of sleep in maintaining a healthy immune system during the COVID-19 pandemic. The review discusses sleep-regulatory substances that are linked to host defense mechanisms such as interleukin-1β, interleukin-6, tumor necrosis factor alpha, and interferon gamma. Cytokine levels also fluctuate with sleep/wake homeostasis and our review explores the relationship between sleep and cytokines and proposed therapeutics. The review will also cover sleep and immune response in children, adolescents, and healthcare workers, and finally it will touch on the effect of obstructive sleep apnea on immune response and the severity of COVID-19.
    Language English
    Publishing date 2023-03-31
    Publishing country Oman
    Document type Journal Article ; Review
    ZDB-ID 2571431-4
    ISSN 2070-5204 ; 1999-768X
    ISSN (online) 2070-5204
    ISSN 1999-768X
    DOI 10.5001/omj.2023.38
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  2. Article: A huge left buttock mass in an old female.

    Farida, Abdoulkader / Yudy, Cespedes / Elias, Said

    Journal of orthopaedics

    2024  Volume 54, Page(s) 116–119

    Abstract: Introduction: Myxofibrosarcoma also known as myxoid malignant fibrous histiocytoma is a rare soft tissue sarcoma that has a predilection for the elderly (beyond the 6th decade).: Clinical observation: We report a case of a 64 years old patient that ... ...

    Abstract Introduction: Myxofibrosarcoma also known as myxoid malignant fibrous histiocytoma is a rare soft tissue sarcoma that has a predilection for the elderly (beyond the 6th decade).
    Clinical observation: We report a case of a 64 years old patient that presented gradual appearance of huge tumor on her left buttock. Radiologic examination (MRI) concluded to MFS. There was no evidence of systemic involvement. The patient was directed in an oncology center, where the diagnostis of MFS was confirmed through surgical biopsy.
    Discussion: MFS is one of the most frequent sarcoma of soft tissue that occurs in elderly patients. This is an infiltrant tumor that is extending through muscular fascia. MRI is the gold standard in characterisation; it makes the positive diagnosis of MFS thanks to the myxoid signal, triple signal and the tail sign that is corresponding to the extension of the tumor into the muscular fascia and peri nervous spaces.
    Conclusion: Cross-sectionnal imaging in particular MRI plays a key role in the positive diagnosis of soft tissue tumors. It makes possible to approach with great precision the exact nature of the tumor thanks to specific radiological semiology without however claiming to replace histology.
    Language English
    Publishing date 2024-03-19
    Publishing country India
    Document type Journal Article
    ZDB-ID 2240839-3
    ISSN 0972-978X
    ISSN 0972-978X
    DOI 10.1016/j.jor.2024.03.011
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  3. Article: Vaccine Efficacy, Impact, Hesitancy, and Acceptance: Trends for Public Health.

    Said, Elias A / Noto, Alessandra / Cardinaud, Sylvain / Al-Jabri, Ali A

    Vaccines

    2024  Volume 12, Issue 4

    Abstract: Vaccines are indispensable tools in the battle against infectious diseases and hold great potential in combating a myriad of other diseases [ ... ]. ...

    Abstract Vaccines are indispensable tools in the battle against infectious diseases and hold great potential in combating a myriad of other diseases [...].
    Language English
    Publishing date 2024-04-11
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines12040406
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  4. Article ; Online: Editorial: Modulation of the adaptive immune responses and chronicity of infections with enveloped viruses.

    Said, Elias A / Ancuta, Petronela / Routy, Jean-Pierre / Vartanian, Jean-Pierre / Al-Jabri, Ali A

    Frontiers in immunology

    2023  Volume 14, Page(s) 1137399

    MeSH term(s) Animals ; Swine ; Immunity, Innate ; Porcine Reproductive and Respiratory Syndrome ; Immunity, Humoral ; Viruses
    Language English
    Publishing date 2023-02-07
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1137399
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  5. Article ; Online: Coronary computed tomography angiography in the evaluation of acute chest pain in patients with elevated high sensitive cardiac troponin I (hs-cTn) level.

    Qasum, Majd / Massalha, Samia / Marcusohn, Erez / Elias, Adi / Darawshi, Said / Zukermann, Robert

    American heart journal plus : cardiology research and practice

    2023  Volume 27, Page(s) 100276

    Abstract: Aims CCTA is a well-established and safe imaging modality for the diagnosis of CAD and is gate keeping for invasive coronary angiography (ICA). We aimed to examine CCTA performance in patients presenting with ACP and dynamic hs-cTn elevation compatible ... ...

    Abstract Aims CCTA is a well-established and safe imaging modality for the diagnosis of CAD and is gate keeping for invasive coronary angiography (ICA). We aimed to examine CCTA performance in patients presenting with ACP and dynamic hs-cTn elevation compatible with MI but not exceeding 7 folds of the URL. We also examined the performance of GRACE and PTP consortium scores in this population of patients.
    Language English
    Publishing date 2023-02-17
    Publishing country United States
    Document type Journal Article
    ISSN 2666-6022
    ISSN (online) 2666-6022
    DOI 10.1016/j.ahjo.2023.100276
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  6. Article ; Online: NHANES cross sectional study of aspirin and fractures in the elderly.

    Swed, Sarya / El-Sakka, Amro A / Abouainain, Yasmeen / Lee, Ka Yiu / Sawaf, Bisher / Albuni, Mhd Kutaiba / Battikh, Elias / Ahmad, Eman Mohammed Sharif / Elkalagi, Nashaat Kamal Hamdy / Abbas, Kirellos Said / Hafez, Wael / Rakab, Amine

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 1879

    Abstract: Bone fractures are a global public health concern, yet no thorough investigation of low-dose aspirin usage to prevent fractures in the elderly has been conducted. Many interventional human and animal studies have tried to detect the correct role of low- ... ...

    Abstract Bone fractures are a global public health concern, yet no thorough investigation of low-dose aspirin usage to prevent fractures in the elderly has been conducted. Many interventional human and animal studies have tried to detect the correct role of low-dose aspirin on fractures in elderly persons. The literature doesn't consist of a retrospective observational study that includes a large number of older individuals and evaluates the accurate effect of aspirin on the fractures post falling from low heights. This cross-sectional includes 7132 elderly persons and aimed to detect if there was a link between taking low-dose aspirin to prevent fractures in the elderly. Data was extracted from the National Health and Nutrition Examination Survey (NHANES) database for 2017-2020 and 2013-2014. Demographic and examination data were collected during in-home interviews and study visits to a mobile examination center. Standardized questionnaires were used to collect information such as age, gender, race, educational level, and family income-to-poverty ratio. Body mass index (BMI), weight, standing height, upper leg length, upper arm length, arm circumference, and wrist circumference were all measured during the examination. The study examined 8127 patients, with 7132 elderly patients suitable for data analysis. The odds ratio of fractures due to a fall from standing height or less was 0.963 (95 percent confidence interval 0.08-1.149) in low-dose aspirin users, while having parents with osteoporosis had a related risk of 1.23. (95 percent confidence interval 0.81-1.8). The total number of fractures was 1295; with hip fractures constituting up to 13.82%, wrist fractures of 66.56%, and spine fractures of 19.61%. There was no significant difference in femur and spine bone mineral density (BMD) in the two groups (use low dose aspirin and don't use). Females had a 5.6 times greater fracture risk related to a fall from standing height or less (1 time or more) than males (P-value < 0.001). Furthermore, taking aspirin had no effect on the occurrence of fractures from standing height or less in older people (P-value = 0.468). In addition, the logistic regression after performing the propensity matching score confirmed that there was no impact of taking aspirin on the occurrence of fractures (P-value > 0.05). This cross-sectional study reveals that taking low-dose aspirin to prevent fractures in the elderly is statistically insignificant. However, fractures are more common in older persons, especially in older women; thus, more widespread injury prevention initiatives and access to osteoporosis prevention and diagnosis for older people should improve to minimize the overall burden.
    MeSH term(s) Male ; Humans ; Female ; Aged ; Aged, 80 and over ; Cross-Sectional Studies ; Nutrition Surveys ; Aspirin/adverse effects ; Risk Factors ; Fractures, Bone/epidemiology ; Fractures, Bone/prevention & control ; Osteoporosis/epidemiology ; Bone Density ; Hip Fractures
    Chemical Substances Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2023-02-01
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-29029-6
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  7. Article ; Online: NHANES cross sectional study of aspirin and fractures in the elderly

    Sarya Swed / Amro A. El-Sakka / Yasmeen Abouainain / Ka Yiu Lee / Bisher Sawaf / Mhd Kutaiba Albuni / Elias Battikh / Eman Mohammed sharif Ahmad / Nashaat Kamal Hamdy Elkalagi / Kirellos Said Abbas / Wael Hafez / Amine Rakab

    Scientific Reports, Vol 13, Iss 1, Pp 1-

    2023  Volume 9

    Abstract: Abstract Bone fractures are a global public health concern, yet no thorough investigation of low-dose aspirin usage to prevent fractures in the elderly has been conducted. Many interventional human and animal studies have tried to detect the correct role ...

    Abstract Abstract Bone fractures are a global public health concern, yet no thorough investigation of low-dose aspirin usage to prevent fractures in the elderly has been conducted. Many interventional human and animal studies have tried to detect the correct role of low-dose aspirin on fractures in elderly persons. The literature doesn't consist of a retrospective observational study that includes a large number of older individuals and evaluates the accurate effect of aspirin on the fractures post falling from low heights. This cross-sectional includes 7132 elderly persons and aimed to detect if there was a link between taking low-dose aspirin to prevent fractures in the elderly. Data was extracted from the National Health and Nutrition Examination Survey (NHANES) database for 2017–2020 and 2013–2014. Demographic and examination data were collected during in-home interviews and study visits to a mobile examination center. Standardized questionnaires were used to collect information such as age, gender, race, educational level, and family income-to-poverty ratio. Body mass index (BMI), weight, standing height, upper leg length, upper arm length, arm circumference, and wrist circumference were all measured during the examination. The study examined 8127 patients, with 7132 elderly patients suitable for data analysis. The odds ratio of fractures due to a fall from standing height or less was 0.963 (95 percent confidence interval 0.08–1.149) in low-dose aspirin users, while having parents with osteoporosis had a related risk of 1.23. (95 percent confidence interval 0.81–1.8). The total number of fractures was 1295; with hip fractures constituting up to 13.82%, wrist fractures of 66.56%, and spine fractures of 19.61%. There was no significant difference in femur and spine bone mineral density (BMD) in the two groups (use low dose aspirin and don't use). Females had a 5.6 times greater fracture risk related to a fall from standing height or less (1 time or more) than males (P-value < 0.001). Furthermore, taking aspirin had ...
    Keywords Medicine ; R ; Science ; Q
    Subject code 616
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Differential Production of Midkine and Pleiotrophin by Innate APCs upon Stimulation through Nucleic Acid-Sensing TLRs.

    Said, Elias A / Al-Dughaishi, Sumaya / Al-Hatmi, Wadha / Al-Reesi, Iman / Al-Balushi, Mohammed S / Al-Bimani, Atika / Al-Busaidi, Juma Z / Al-Riyami, Marwa / Al-Khabori, Murtadha / Al-Kindi, Salam / Procopio, Francesco A / Al-Sinawi, Shadia / Al-Ansari, Aliyaa / Koh, Crystal Y / Al-Naamani, Khalid / Al-Jabri, Ali A

    Journal of immunology research

    2023  Volume 2023, Page(s) 7944102

    Abstract: Midkine (MK) and pleiotrophin (PTN) belong to the same family of cytokines. They have similar sequences and functions. Both have important roles in cellular proliferation, tumors, and diseases. They regulate and are expressed by some immune cells. We ... ...

    Abstract Midkine (MK) and pleiotrophin (PTN) belong to the same family of cytokines. They have similar sequences and functions. Both have important roles in cellular proliferation, tumors, and diseases. They regulate and are expressed by some immune cells. We have recently demonstrated MK production by some human innate antigen-presenting cells (iAPCs), i.e., monocyte-derived dendritic cells (MDDCs) and macrophages stimulated through Toll-like receptor (TLR)-4, and plasmacytoid dendritic cells (pDCs) stimulated through TLR 7. While PTN production was only documented in tissue macrophages. TLRs 3, 7, 8, and 9 are nucleic acid sensing (NAS) TLRs that detect nucleic acids from cell damage and infection and induce iAPC responses. We investigated whether NAS TLRs can induce MK and PTN production by human iAPCs, namely monocytes, macrophages, MDDCs, myeloid dendritic cells (mDCs), and pDCs. Our results demonstrated for the first time that PTN is produced by all iAPCs upon TLR triggering (
    MeSH term(s) Humans ; Cytokines ; Dendritic Cells ; Midkine ; Neoplasms
    Chemical Substances Cytokines ; Midkine (137497-38-2) ; pleiotrophin (134034-50-7) ; MDK protein, human
    Language English
    Publishing date 2023-10-09
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2817541-4
    ISSN 2314-7156 ; 2314-7156
    ISSN (online) 2314-7156
    ISSN 2314-7156
    DOI 10.1155/2023/7944102
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  9. Article: Association of the Magnitude of Anti-SARS-CoV-2 Vaccine Side Effects with Sex, Allergy History, Chronic Diseases, Medication Intake, and SARS-CoV-2 Infection.

    Said, Elias A / Al-Rubkhi, Afnan / Jaju, Sanjay / Koh, Crystal Y / Al-Balushi, Mohammed S / Al-Naamani, Khalid / Al-Sinani, Siham / Al-Busaidi, Juma Z / Al-Jabri, Ali A

    Vaccines

    2024  Volume 12, Issue 1

    Abstract: Vaccination provides the best protection against the increasing infections of SARS-CoV-2. The magnitude and type of anti-SARS-CoV-2 vaccine side effects (SEs) depend on parameters that are not fully understood. In this cross-sectional study, the ... ...

    Abstract Vaccination provides the best protection against the increasing infections of SARS-CoV-2. The magnitude and type of anti-SARS-CoV-2 vaccine side effects (SEs) depend on parameters that are not fully understood. In this cross-sectional study, the associations between different anti-SARS-CoV-2 vaccine SEs and age, sex, the presence of chronic diseases, medication intake, history of allergies, and infections with SARS-CoV-2 were investigated. Our survey used the Google platform and had 866 participants, contacted through e-mails, social media and chain referral sampling (margin of error ≈ 4.38%, 99% confidence). More than 99% of the participants received the BNT162b2 and ChAdOx1-S vaccines. Being female, having chronic diseases, taking medicines routinely and the presence of a SARS-CoV-2 infection (
    Language English
    Publishing date 2024-01-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines12010104
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  10. Article ; Online: Measles on the Rise: The importance of vaccination.

    Said, Elias A / Al-Balushi, Mohamed S

    Sultan Qaboos University medical journal

    2019  Volume 19, Issue 2, Page(s) e89–e90

    MeSH term(s) Humans ; Male ; Measles/drug therapy ; Measles/epidemiology ; Measles/prevention & control ; Vaccination/methods ; Vaccination/standards ; Vaccination/statistics & numerical data ; Young Adult
    Language English
    Publishing date 2019-09-08
    Publishing country Oman
    Document type Case Reports ; Editorial
    ZDB-ID 2650196-X
    ISSN 2075-0528 ; 2075-051X
    ISSN (online) 2075-0528
    ISSN 2075-051X
    DOI 10.18295/squmj.2019.19.02.001
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