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  1. Article: Human Papilloma Virus (HPV) driven oropharyngeal cancer in current or previous heavy smokers: should we look for a different treatment paradigm?

    Lorini, Luigi / Bossi, Paolo / Psyrri, Amanda / Bonomo, Pierluigi

    Frontiers in oncology

    2024  Volume 14, Page(s) 1383019

    Abstract: Introduction: Human papillomavirus Virus (HPV)-associated oropharyngeal squamous cell carcinoma (OSCC) has increased in incidence in recent decades and represents a heterogeneous disease entity in the context of Head and Neck Squamous Cell Carcinoma ( ... ...

    Abstract Introduction: Human papillomavirus Virus (HPV)-associated oropharyngeal squamous cell carcinoma (OSCC) has increased in incidence in recent decades and represents a heterogeneous disease entity in the context of Head and Neck Squamous Cell Carcinoma (HNSCC), in terms of disease prognosis. Treatment of locoregionally advanced OSCC is mainly based on concurrent chemoradiotherapy. Given the younger age of patients, if compared with HPV-negative counterparts, and the high cure rates, the acute- and long-term toxicity in survivors represents a field of interest. However, patient selection for de-escalation trials remains a major challenge due to the lack of robust validated prognostic indicators within the HPV-associated OSCC.
    Discussion: The impact of smoking status on HPV-associated OSCC prognosis has been demonstrated in the majority of studies. However, the magnitude of the association is unclear due to variability in smoking metrics and study outcomes. Smoking status has been identified as a potential confounding factor in HPV-positive de-escalation trials. Smokers with HPV-positive OSCC have a worse prognosis in most studies than non-smokers and may require different and more aggressive therapeutic strategies.
    Language English
    Publishing date 2024-04-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2024.1383019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Editorial: Women in head and neck cancer, volume II: 2022.

    Economopoulou, Panagiota / Kotsantis, Ioannis / Psyrri, Amanda

    Frontiers in oncology

    2023  Volume 13, Page(s) 1278798

    Language English
    Publishing date 2023-09-12
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1278798
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  3. Article: Clinical Significance of PD-L1 Status in Circulating Tumor Cells for Cancer Management during Immunotherapy.

    Strati, Areti / Economopoulou, Panagiota / Lianidou, Evi / Psyrri, Amanda

    Biomedicines

    2023  Volume 11, Issue 6

    Abstract: The approval of monoclonal antibodies against programmed death-ligand 1 (PD-L1) and programmed cell death protein (PD1) has changed the landscape of cancer treatment. To date, many immune checkpoint inhibitors (ICIs) have been approved by the FDA for the ...

    Abstract The approval of monoclonal antibodies against programmed death-ligand 1 (PD-L1) and programmed cell death protein (PD1) has changed the landscape of cancer treatment. To date, many immune checkpoint inhibitors (ICIs) have been approved by the FDA for the treatment of metastatic cancer as well as locally recurrent advanced cancer. However, immune-related adverse events (irAEs) of ICIs highlight the need for biomarker analysis with strong predictive value. Liquid biopsy is an important tool for clinical oncologists to monitor cancer patients and administer or change appropriate therapy. CTCs frequently express PD-L1, and this constitutes a clinically useful and non-invasive method to assess PD-L1 status in real-time. This review summarizes all the latest findings about the clinical significance of CTC for the management of cancer patients during the administration of immunotherapy and mainly focuses on the assessment of PD-L1 expression in CTCs.
    Language English
    Publishing date 2023-06-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11061768
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  4. Article ; Online: Radiotherapy and immunotherapy combination in head and neck cancer: Does current failure qualify as an ending or is it a key to future success?

    Economopoulou, Panagiota / Kotsantis, Ioannis / Psyrri, Amanda

    Oral oncology

    2022  Volume 125, Page(s) 105717

    MeSH term(s) Head and Neck Neoplasms/radiotherapy ; Humans ; Immunotherapy ; Squamous Cell Carcinoma of Head and Neck
    Language English
    Publishing date 2022-01-14
    Publishing country England
    Document type Editorial
    ZDB-ID 1120465-5
    ISSN 1879-0593 ; 0964-1955 ; 1368-8375
    ISSN (online) 1879-0593
    ISSN 0964-1955 ; 1368-8375
    DOI 10.1016/j.oraloncology.2022.105717
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4869: Show issues Location:
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  5. Article: Editorial: Immunology and Immunotherapy of Head and Neck Cancer.

    Gavrielatou, Niki / Economopoulou, Panagiota / Kotsantis, Ioannis / Psyrri, Amanda

    Frontiers in oncology

    2021  Volume 11, Page(s) 815763

    Language English
    Publishing date 2021-12-06
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2021.815763
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  6. Article ; Online: Clinical Significance of PD-L1 Status in Circulating Tumor Cells for Cancer Management during Immunotherapy

    Areti Strati / Panagiota Economopoulou / Evi Lianidou / Amanda Psyrri

    Biomedicines, Vol 11, Iss 1768, p

    2023  Volume 1768

    Abstract: The approval of monoclonal antibodies against programmed death-ligand 1 (PD-L1) and programmed cell death protein (PD1) has changed the landscape of cancer treatment. To date, many immune checkpoint inhibitors (ICIs) have been approved by the FDA for the ...

    Abstract The approval of monoclonal antibodies against programmed death-ligand 1 (PD-L1) and programmed cell death protein (PD1) has changed the landscape of cancer treatment. To date, many immune checkpoint inhibitors (ICIs) have been approved by the FDA for the treatment of metastatic cancer as well as locally recurrent advanced cancer. However, immune-related adverse events (irAEs) of ICIs highlight the need for biomarker analysis with strong predictive value. Liquid biopsy is an important tool for clinical oncologists to monitor cancer patients and administer or change appropriate therapy. CTCs frequently express PD-L1, and this constitutes a clinically useful and non-invasive method to assess PD-L1 status in real-time. This review summarizes all the latest findings about the clinical significance of CTC for the management of cancer patients during the administration of immunotherapy and mainly focuses on the assessment of PD-L1 expression in CTCs.
    Keywords PD-L1 ; CTCs ; immunotherapy ; immune checkpoint inhibitors ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Exceptional Response to Copanlisib in a Heavily Pretreated Patient With

    Spathas, Nikolaos / Economopoulou, Panagiota / Kotsantis, Ioannis / Oikonomopoulos, Nikolaos / Psyrri, Amanda

    JCO precision oncology

    2022  Volume 4, Page(s) 335–340

    Language English
    Publishing date 2022-01-20
    Publishing country United States
    Document type Journal Article
    ISSN 2473-4284
    ISSN (online) 2473-4284
    DOI 10.1200/PO.19.00049
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  8. Article ; Online: B cells and their role in shaping the immune response in squamous cell carcinoma of the head and neck.

    Economopoulou, Panagiota / Kotsantis, Ioannis / Psyrri, Amanda

    Immunotherapy

    2021  Volume 13, Issue 9, Page(s) 723–726

    MeSH term(s) B-Lymphocytes/immunology ; Head and Neck Neoplasms/immunology ; Humans ; Immunity/immunology ; Squamous Cell Carcinoma of Head and Neck/immunology ; Tumor Microenvironment/immunology
    Language English
    Publishing date 2021-04-29
    Publishing country England
    Document type Editorial
    ZDB-ID 2495964-9
    ISSN 1750-7448 ; 1750-743X
    ISSN (online) 1750-7448
    ISSN 1750-743X
    DOI 10.2217/imt-2021-0070
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  9. Article ; Online: De-Escalating Strategies in HPV-Associated Head and Neck Squamous Cell Carcinoma.

    Economopoulou, Panagiota / Kotsantis, Ioannis / Psyrri, Amanda

    Viruses

    2021  Volume 13, Issue 9

    Abstract: HPV-related head and neck squamous cell carcinoma (HNSCC) has emerged as a diverse clinical and biological disease entity, mainly in young patients with oropharyngeal tumors who are nonsmokers and nondrinkers. Indeed, during the past few years, the ... ...

    Abstract HPV-related head and neck squamous cell carcinoma (HNSCC) has emerged as a diverse clinical and biological disease entity, mainly in young patients with oropharyngeal tumors who are nonsmokers and nondrinkers. Indeed, during the past few years, the pendulum has shifted towards a new epidemiological reality, the "HPV pandemic", where the majority of oropharyngeal squamous cell carcinomas (OPSCCs) are attributed to HPV. The oncogenic potential of the virus is associated to its capacity of integrating oncogenes
    MeSH term(s) Carcinoma, Squamous Cell/virology ; Head and Neck Neoplasms/virology ; Humans ; Oncogenes ; Oropharyngeal Neoplasms/virology ; Papillomaviridae/classification ; Papillomaviridae/genetics ; Papillomaviridae/pathogenicity ; Papillomavirus E7 Proteins/genetics ; Papillomavirus Infections/complications ; Prognosis ; Repressor Proteins/genetics ; Squamous Cell Carcinoma of Head and Neck/virology
    Chemical Substances Papillomavirus E7 Proteins ; Repressor Proteins
    Language English
    Publishing date 2021-09-08
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v13091787
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  10. Article: Clear-cell renal cell carcinoma - A comprehensive review of agents used in the contemporary management of advanced/metastatic disease.

    Gkolfinopoulos, Stavros / Psyrri, Amanda / Bamias, Aristotelis

    Oncology reviews

    2021  Volume 15, Issue 1, Page(s) 530

    Abstract: Renal cell carcinoma represents the most common malignancy of the kidney and the majority of cases are categorized as clear cell carcinomas. The elucidation of the specific alterations in key molecular and metabolic pathways responsible for cancer ... ...

    Abstract Renal cell carcinoma represents the most common malignancy of the kidney and the majority of cases are categorized as clear cell carcinomas. The elucidation of the specific alterations in key molecular and metabolic pathways responsible for cancer development and progression have prompted the rationalization of our classification of this disease and have provided specific targetable molecules implicated in carcinogenesis. Although immunotherapy has been an established option in the treatment of metastatic renal cell cancer for many years, its role has been renewed and upgraded with the implementation of anti-angiogenic agents and immune checkpoint inhibitors in our treatment armamentarium. The future holds promise, as newer agents become available and combination regimens of immunotherapy with anti-angiogenic agents have become the standard of care in the management of metastatic disease and are currently being evaluated in earlier settings. Proper patient selection and individualization of our treatment strategies are of utmost importance in order to provide optimal care to patients suffering from renal cell carcinoma.
    Language English
    Publishing date 2021-02-26
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2390302-8
    ISSN 1970-5565 ; 1970-5565 ; 1970-5557
    ISSN (online) 1970-5565
    ISSN 1970-5565 ; 1970-5557
    DOI 10.4081/oncol.2021.530
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