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  1. Article: Editorial: The liver as an endocrine organ: Hepatokines and ketone bodies, novel hormones to be acknowledged.

    Risi, Renata / Postic, Catherine / Watanabe, Mikiko

    Frontiers in endocrinology

    2023  Volume 13, Page(s) 1117773

    MeSH term(s) Humans ; Ketone Bodies ; Non-alcoholic Fatty Liver Disease ; Hormones ; Abdomen
    Chemical Substances Ketone Bodies ; Hormones
    Language English
    Publishing date 2023-01-04
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2022.1117773
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  2. Article: Editorial: Nutrition and diet practices: impact on body components and functioning.

    Zupo, Roberta / Watanabe, Mikiko / De Pergola, Giovanni / Castellana, Fabio

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1179751

    MeSH term(s) Humans ; Nutritional Status ; Sarcopenia ; Diet
    Language English
    Publishing date 2023-04-14
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1179751
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  3. Article ; Online: Editorial for "The Role of Ketogenic Diet in Human Health and Diseases": The Multifaceted Impact of Ketogenic Diets on Health and Disease.

    Watanabe, Mikiko / Savastano, Silvia / Lubrano, Carla / Spera, Giovanni

    Nutrients

    2023  Volume 15, Issue 18

    Abstract: The ketogenic diet (KD), characterized by a very low carbohydrate intake and variable protein, fat and calorie intake, has long been in the spotlight for its potential therapeutic applications [ ... ]. ...

    Abstract The ketogenic diet (KD), characterized by a very low carbohydrate intake and variable protein, fat and calorie intake, has long been in the spotlight for its potential therapeutic applications [...].
    MeSH term(s) Humans ; Diet, Ketogenic ; Energy Intake
    Language English
    Publishing date 2023-09-17
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15184027
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  4. Article: Genome Editing and Obesity.

    Masi, Davide / Tozzi, Rossella / Watanabe, Mikiko

    Advances in experimental medicine and biology

    2022  Volume 1396, Page(s) 179–190

    Abstract: Defined as a condition of body fat excess leading to significant morbidity, obesity is a chronic metabolic illness associated with a significant number of diseases. The incidence of obesity does not solely depend on dietary habits, with energy balance ... ...

    Abstract Defined as a condition of body fat excess leading to significant morbidity, obesity is a chronic metabolic illness associated with a significant number of diseases. The incidence of obesity does not solely depend on dietary habits, with energy balance being regulated by the complex interactions between genetic, behavioural and environmental factors. Genome-wide association studies (GWASs) have demonstrated that several genes are linked to obesity, and these findings shed light on a growing number of novel potential therapeutics for weight management, including genome editing. In this regard, the cutting-edge technology known as clustered regularly interspaced palindromic repeats (CRISPR)/CRISPR-associated protein (Cas), thanks to its ability to edit DNA or modulate gene expression in eukaryotic cells, undoubtedly enables to understand the genetic mechanisms implicated in obesity and could be a promising tool for its treatment. This chapter summarizes the genetics underlying obesity and currently available obesity treatments, further discussing the research progress of genome editing in the knowledge and treatment of body fat excess.
    MeSH term(s) Humans ; Gene Editing ; Genome-Wide Association Study ; Obesity/genetics ; Obesity/therapy ; Adipose Tissue ; Eukaryotic Cells
    Language English
    Publishing date 2022-12-01
    Publishing country United States
    Document type Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-981-19-5642-3_12
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  5. Article ; Online: CAF-associated genes putatively representing distinct prognosis by in silico landscape of stromal components of colon cancer.

    Okuno, Kota / Ikemura, Kyonosuke / Okamoto, Riku / Oki, Keiko / Watanabe, Akiko / Kuroda, Yu / Kidachi, Mikiko / Fujino, Shiori / Nie, Yusuke / Higuchi, Tadashi / Chuman, Motohiro / Washio, Marie / Sakuraya, Mikiko / Niihara, Masahiro / Kumagai, Koshi / Sangai, Takafumi / Kumamoto, Yusuke / Naitoh, Takeshi / Hiki, Naoki /
    Yamashita, Keishi

    PloS one

    2024  Volume 19, Issue 4, Page(s) e0299827

    Abstract: Comprehensive understanding prognostic relevance of distinct tumor microenvironment (TME) remained elusive in colon cancer. In this study, we performed in silico analysis of the stromal components of primary colon cancer, with a focus on the markers of ... ...

    Abstract Comprehensive understanding prognostic relevance of distinct tumor microenvironment (TME) remained elusive in colon cancer. In this study, we performed in silico analysis of the stromal components of primary colon cancer, with a focus on the markers of cancer-associated fibroblasts (CAF) and tumor-associated endothelia (TAE), as well as immunological infiltrates like tumor-associated myeloid cells (TAMC) and cytotoxic T lymphocytes (CTL). The relevant CAF-associated genes (CAFG)(representing R index = 0.9 or beyond with SPARC) were selected based on stroma specificity (cancer stroma/epithelia, cS/E = 10 or beyond) and expression amounts, which were largely exhibited negative prognostic impacts. CAFG were partially shared with TAE-associated genes (TAEG)(PLAT, ANXA1, and PTRF) and TAMC-associated genes (TAMCG)(NNMT), but not with CTL-associated genes (CTLG). Intriguingly, CAFG were prognostically subclassified in order of fibrosis (representing COL5A2, COL5A1, and COL12A1) followed by exclusive TAEG and TAMCG. Prognosis was independently stratified by CD8A, a CTL marker, in the context of low expression of the strongest negative prognostic CAFG, COL8A1. CTLG were comprehensively identified as IFNG, B2M, and TLR4, in the group of low S/E, representing good prognosis. Our current in silico analysis of the micro-dissected stromal gene signatures with prognostic relevance clarified comprehensive understanding of clinical features of the TME and provides deep insights of the landscape.
    MeSH term(s) Humans ; Cancer-Associated Fibroblasts/metabolism ; Prognosis ; Colonic Neoplasms/pathology ; Tumor Microenvironment/genetics
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0299827
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  6. Article ; Online: Efficacy of high-frequency spinal cord stimulation for fibromyalgia syndrome in two cases: case reports.

    Horita, Mikiko / Yasuhira, Ayumi / Hirakawa, Mikako / Watanabe, Aisa / Higaki, Nobuhiro / Nishihara, Tasuku / Yorozuya, Toshihiro

    JA clinical reports

    2023  Volume 9, Issue 1, Page(s) 68

    Abstract: Background: Reports on the effectiveness of spinal cord stimulation (SCS) for the alleviation of fibromyalgia syndrome (FMS) pain are scarce. We report two cases of effective high-frequency SCS at 1000 Hz against upper- and lower-limb pain in patients ... ...

    Abstract Background: Reports on the effectiveness of spinal cord stimulation (SCS) for the alleviation of fibromyalgia syndrome (FMS) pain are scarce. We report two cases of effective high-frequency SCS at 1000 Hz against upper- and lower-limb pain in patients with FMS.
    Case presentation: Two women with widespread pain were diagnosed with FMS and the pain gradually worsened. A 1-week SCS trial was conducted in each patient. In both cases, the patients complained of unpleasant sensations during 10-Hz SCS. However, the pain was alleviated after 1000-Hz stimulation without irritation. Therefore, leads and a generator were implanted, after which they felt almost no pain. Moreover, the dose of the oral medication could be reduced and the patients returned to their daily lives.
    Conclusion: SCS at 1000 Hz may effectively treat pain associated with FMS. Therefore, performing an SCS trial for patients with FMS with intractable pain might be worthwhile.
    Language English
    Publishing date 2023-10-21
    Publishing country Germany
    Document type Journal Article
    ISSN 2363-9024
    ISSN (online) 2363-9024
    DOI 10.1186/s40981-023-00660-6
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  7. Article ; Online: Cycles of goal silencing and reactivation underlie complex problem-solving in primate frontal and parietal cortex.

    Watanabe, Kei / Kadohisa, Mikiko / Kusunoki, Makoto / Buckley, Mark J / Duncan, John

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 5054

    Abstract: While classic views proposed that working memory (WM) is mediated by sustained firing, recent evidence suggests a contribution of activity-silent states. Within WM, human neuroimaging studies suggest a switch between attentional foreground and background, ...

    Abstract While classic views proposed that working memory (WM) is mediated by sustained firing, recent evidence suggests a contribution of activity-silent states. Within WM, human neuroimaging studies suggest a switch between attentional foreground and background, with only the foregrounded item represented in active neural firing. To address this process at the cellular level, we recorded prefrontal (PFC) and posterior parietal (PPC) neurons in a complex problem-solving task, with monkeys searching for one or two target locations in a first cycle of trials, and retaining them for memory-guided revisits on subsequent cycles. When target locations were discovered, neither frontal nor parietal neurons showed sustained goal-location codes continuing into subsequent trials and cycles. Instead there were sequences of timely goal silencing and reactivation, and following reactivation, sustained states until behavioral response. With two target locations, goal representations in both regions showed evidence of transitions between foreground and background, but the PFC representation was more complete, extending beyond the current trial to include both past and future selections. In the absence of unbroken sustained codes, different neuronal states interact to support maintenance and retrieval of WM representations across successive trials.
    MeSH term(s) Humans ; Animals ; Goals ; Primates ; Parietal Lobe/diagnostic imaging ; Neurons ; Memory, Short-Term
    Language English
    Publishing date 2023-08-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-40676-1
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  8. Article ; Online: Evaluation of tornadic environments and their trends and projected changes in Japan

    Sho Kawazoe / Masaru Inatsu / Mikiko Fujita / Shiori Sugimoto / Yasuko Okada / Shingo Watanabe

    npj Climate and Atmospheric Science, Vol 6, Iss 1, Pp 1-

    2023  Volume 8

    Abstract: Abstract Tornadoes are responsible for several high-impact weather disasters in Japan. However, little is known about how these events have changed over the last several decades or how they may change in future climates. This study examines environmental ...

    Abstract Abstract Tornadoes are responsible for several high-impact weather disasters in Japan. However, little is known about how these events have changed over the last several decades or how they may change in future climates. This study examines environmental conditions associated with tornados in Japan using pseudo-soundings from the high-resolution fifth-generation ECMWF reanalysis. We first determine appropriate discriminators of F2+ tornadoes using thermodynamic (convective available potential energy, convective inhibition, lifting condensation level, and the K-index), kinematic (bulk wind difference and storm-relative helicity), and multivariate tornado parameters (energy helicity index, K-helicity index, and the significant tornado parameter), and confirm that F2+ tornadoes occur in environments with higher instability and helicity, but are better distinguished using multivariate parameters. Recent trends indicate that F2+ environments have increased significantly in some regions over the last four decades. We also examined future changes for each parameter using a large ensemble 2-K warming experiment. Robust increases in strong tornado environments are depicted in many regions in Japan, particularly on the Sea of Japan side and the Kanto region. This indicates that despite projected decreases in bulk wind difference and higher convective inhibition, significant increases in atmospheric instability compensate, leading to more days with F2+ tornado potential.
    Keywords Environmental sciences ; GE1-350 ; Meteorology. Climatology ; QC851-999
    Subject code 551 ; 950
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Diagnosis, treatment and predictors of prognosis of myocarditis. A narrative review.

    Piccirillo, Francesco / Watanabe, Mikiko / Di Sciascio, Germano

    Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology

    2021  Volume 54, Page(s) 107362

    Abstract: Although it has been recognized for almost two centuries, myocarditis is still a challenging diagnosis due to the wide heterogeneity of its clinical manifestations and evolution. Moreover, the diagnostic gold standard, endomyocardial biopsy (EMB), is ... ...

    Abstract Although it has been recognized for almost two centuries, myocarditis is still a challenging diagnosis due to the wide heterogeneity of its clinical manifestations and evolution. Moreover, the diagnostic gold standard, endomyocardial biopsy (EMB), is infrequently used, making hard to determine the exact incidence of myocarditis. Clinical presentation includes a wide range of symptoms, ranging from asymptomatic or subclinical disease with mild dyspnea and chest pain to sudden death, due to cardiogenic shock or malignant ventricular arrhythmias. Equally, the evolution of myocarditis largely varies: albeit short-term prognosis is usually good, with complete or partial recovery, dilated cardiomyopathy with chronic heart failure is the major long-term consequence of myocarditis, developing often several years after the acute onset. This narrative review aims to summarize the current knowledge about myocarditis, with a particular attention to predictors of short- and long-term prognosis, in order to provide a rational and practical approach to the diagnosis, evaluation and treatment of suspected myocarditis.
    MeSH term(s) Humans ; Myocarditis/diagnosis ; Myocarditis/therapy ; Prognosis
    Language English
    Publishing date 2021-06-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1134600-0
    ISSN 1879-1336 ; 1054-8807
    ISSN (online) 1879-1336
    ISSN 1054-8807
    DOI 10.1016/j.carpath.2021.107362
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  10. Article: Radiation Therapy for Malignant Lumbosacral Plexopathy: A Case Series.

    Sanuki, Naoko / Kodama, Shuji / Seta, Hidetoshi / Sakai, Mikiko / Watanabe, Hideki

    Cureus

    2022  Volume 14, Issue 1, Page(s) e20939

    Abstract: Background Malignant lumbosacral plexopathy is caused by a direct extension of an intrapelvic malignancy to involve the plexus nerves. In this report, we describe the effect of radiotherapy on patients with malignant lumbosacral plexopathy. Patients and ... ...

    Abstract Background Malignant lumbosacral plexopathy is caused by a direct extension of an intrapelvic malignancy to involve the plexus nerves. In this report, we describe the effect of radiotherapy on patients with malignant lumbosacral plexopathy. Patients and methods We performed a retrospective review of the medical records of patients who underwent radiation therapy for pain caused by malignant lumbosacral plexopathy between 2017 and 2020 at our institution. The pain was measured using a numeric rating scale (0-10) at initiation and completion of radiotherapy or at the time when the maximum response was observed. Results A total of 12 tumor sites in 11 patients were included. Eight of the tumors invaded the iliopsoas muscle, and the remaining four invaded or abutted the piriformis muscle. The mean duration of follow-up was 215 days (31-675 days). All patients achieved pain relief at the end of radiotherapy, with complete resolution of pain in nine patients. The maximum effect was seen at a mean of three weeks (1-12 weeks) after the initiation of radiotherapy. Toxicities related to radiotherapy included grade 1 diarrhea in four patients and grade 1 frequent urination in one patient. Two patients experienced a relapse of pain at one and two months, respectively, after achieving their maximal response. Conclusion Radiotherapy provides significant pain relief for patients with the malignant lumbosacral syndrome. The recognition and diagnosis of this syndrome, and the use of radiation therapy as a therapeutic option, are important. Patients should be offered all possible therapies, regardless of curative or palliative intent.
    Language English
    Publishing date 2022-01-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.20939
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