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  1. Article ; Online: The TEG 5000 System: System Description and Protocol for Measurements.

    Volod, Oksana / Runge, Alice

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2663, Page(s) 725–733

    Abstract: The thromboelastograph (TEG) has undergone several modifications, but the concept on which the original TEG was based (cup and pin technology) remained up to the TEG 5000 analyzer (Haemonetics, Braintree, MA). In a previous chapter, we reviewed the ... ...

    Abstract The thromboelastograph (TEG) has undergone several modifications, but the concept on which the original TEG was based (cup and pin technology) remained up to the TEG 5000 analyzer (Haemonetics, Braintree, MA). In a previous chapter, we reviewed the advantages and limitations of TEG 5000 as well as factors that affect TEG and which must be considered when interpreting tracings. In the present chapter, we provide a description of the TEG 5000 principle and its operation protocol.
    MeSH term(s) Thrombelastography/methods ; Technology ; Review Literature as Topic
    Language English
    Publishing date 2023-05-18
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3175-1_48
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Quantra System: System Description and Protocols for Measurements.

    Volod, Oksana / Viola, Francesco

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2663, Page(s) 743–761

    Abstract: Over the past two decades, the TEG 5000 (Haemonetics Corp, Braintree, MA) and ROTEM delta (Werfen, Bedford, MA) have been the principal viscoelastic (VET) technologies. These legacy technologies are based on the "cup and pin" principle. The Quantra ... ...

    Abstract Over the past two decades, the TEG 5000 (Haemonetics Corp, Braintree, MA) and ROTEM delta (Werfen, Bedford, MA) have been the principal viscoelastic (VET) technologies. These legacy technologies are based on the "cup and pin" principle. The Quantra System (HemoSonics, LLC, Durham, NC) is a new device that assesses blood viscoelastic properties by ultrasound (SEER Sonorheometry). It is cartridge based, automated device that provides simplified specimen management and increased results reproducibility. In the present chapter, we provide a description of the Quantra and its principle of operation, currently available cartridges/assays with their respective clinical indications, device operation, and results interpretation.
    MeSH term(s) Blood Coagulation ; Thrombelastography/methods ; Reproducibility of Results ; Prospective Studies ; Blood Coagulation Tests/methods
    Language English
    Publishing date 2023-05-18
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3175-1_50
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The TEG 6s System: System Description and Protocol for Measurements.

    Volod, Oksana / Runge, Alice

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2663, Page(s) 735–742

    Abstract: A new generation of thromboelastography, TEG 6s (Haemonetics, Boston, MA), that assesses blood viscoelastic properties by resonance technology has recently been developed. This newer methodology represents a cartridge-based, automated assay aimed to ... ...

    Abstract A new generation of thromboelastography, TEG 6s (Haemonetics, Boston, MA), that assesses blood viscoelastic properties by resonance technology has recently been developed. This newer methodology represents a cartridge-based, automated assay aimed to improve on historical TEG performance and precision. In a previous chapter, we reviewed the advantages and limitations of TEG 6s as well as factors that affect TEG 6s and which must be considered when interpreting tracings. In the present chapter, we provide a description of the TEG 6s principle and its operation protocol.
    MeSH term(s) Thrombelastography/methods ; Blood Coagulation ; Vibration ; Review Literature as Topic
    Language English
    Publishing date 2023-05-19
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3175-1_49
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  4. Article ; Online: Measurement of Blood Viscoelasticity Using Thromboelastography.

    Volod, Oksana / Runge, Alice

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2663, Page(s) 709–724

    Abstract: Thromboelastography (TEG) was the first viscoelastic test (VET), invented in Germany in 1948 by Dr. Hartert, and which evaluates the hemostatic competence of whole blood. Thromboelastography was introduced before the activated partial thromboplastin time ...

    Abstract Thromboelastography (TEG) was the first viscoelastic test (VET), invented in Germany in 1948 by Dr. Hartert, and which evaluates the hemostatic competence of whole blood. Thromboelastography was introduced before the activated partial thromboplastin time (aPTT), which was devised in 1953. TEG was not widely used until the introduction of a cell-based model of hemostasis (1994) showing the importance of platelets and tissue factor in hemostasis. Nowadays, VET has become an essential method for assessing hemostatic competence in cardiac surgery, liver transplantation, and trauma. TEG has undergone several modifications, but the concept on which the original TEG was based (cup and pin technology) remained in up to the TEG 5000 analyzer (Haemonetics, Braintree, MA). A new generation of thromboelastography, TEG 6s (Haemonetics, Boston, MA), that assesses blood viscoelastic properties by resonance technology has recently been developed. This newer methodology represents a cartridge-based, automated assay aimed to improve on historical TEG performance and precision. In the present chapter, we will review the advantages and limitations of TEG 5000 and TEG 6s systems as well as factors that affect TEG and which must be considered when interpreting TEG tracings.
    MeSH term(s) Humans ; Thrombelastography/methods ; Hemostasis ; Blood Coagulation Disorders ; Hemostatics ; Partial Thromboplastin Time
    Chemical Substances Hemostatics
    Language English
    Publishing date 2023-05-18
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3175-1_47
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Viscoelastic Testing in the Management of Adult Patients on Mechanical Circulatory Support Devices with Focus on Extracorporeal Membrane Oxygenation.

    Volod, Oksana / Wegner, Julie

    Seminars in thrombosis and hemostasis

    2022  Volume 48, Issue 7, Page(s) 814–827

    Abstract: Thromboembolic and hemorrhagic complications continue to remain frequent complications that significantly impact the morbidity and mortality of patients implanted with mechanical circulatory support devices (MCSDs). The severe acute respiratory syndrome ... ...

    Abstract Thromboembolic and hemorrhagic complications continue to remain frequent complications that significantly impact the morbidity and mortality of patients implanted with mechanical circulatory support devices (MCSDs). The severe acute respiratory syndrome caused by coronavirus 2 (SARS-CoV-2) has resulted in a number of COVID-19 patients being supported by MCSDs, specifically extracorporeal membrane oxygenation (ECMO), which in turn has created a crucial need for rapid assessment of hemostatic status in these patients to avoid bleeding and thrombotic complications. Currently, conventional plasma-based coagulation assays such as prothrombin time and activated partial thromboplastin time (aPTT) are used to assess hemostasis, and the activated clotting time (ACT) and aPTT are the most common tests used to monitor heparin anticoagulation in patients on ECMO. Unfractionated heparin remains the mainstay anticoagulation therapy for patients on ECMO. Extracorporeal Life Support Organization (ELSO) offers little guidance on the subject but does state that each institution should create its internal anticoagulation protocols. Viscoelastic assays (VEAs) are increasingly recognized by ELSO and ECMO community for their potential to assess hemostatic derangements in patients implanted with MCSDs as well as guidance for appropriate hemostatic therapy. This review focuses on the evidence for the use of viscoelastic assays to assess overall hemostasis and to guide the treatment of adult patients connected to an ECMO circuit. Limitations of the use of conventional assays, ACT, and VEA are also discussed.
    MeSH term(s) Adult ; Humans ; Extracorporeal Membrane Oxygenation/adverse effects ; Heparin/therapeutic use ; Anticoagulants/therapeutic use ; SARS-CoV-2 ; COVID-19/therapy ; Hemostatics ; Retrospective Studies
    Chemical Substances Heparin (9005-49-6) ; Anticoagulants ; Hemostatics
    Language English
    Publishing date 2022-09-15
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 196901-8
    ISSN 1098-9064 ; 0094-6176
    ISSN (online) 1098-9064
    ISSN 0094-6176
    DOI 10.1055/s-0042-1756303
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1259: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article ; Online: In Search of the Holy Grail of Artificial Hearts: Are We There Yet?

    Volod, Oksana / Colon, Modesto J / Arabía, Francisco A

    Seminars in thrombosis and hemostasis

    2023  Volume 50, Issue 1, Page(s) 104–114

    Abstract: The total artificial heart (TAH) has a long and rich history, being the product of decades of innovation, hard work, and dedication. This review examines the history of the TAH, a device that has revolutionized the treatment of end-stage biventricular ... ...

    Abstract The total artificial heart (TAH) has a long and rich history, being the product of decades of innovation, hard work, and dedication. This review examines the history of the TAH, a device that has revolutionized the treatment of end-stage biventricular heart failure. It reviews the development of the device from early concepts to the current state-of-the-art device, the SynCardia TAH, which has been implanted in over 2,000 patients worldwide. The article also discusses the challenges and successes experienced by researchers, clinicians, and patients throughout the development of TAH devices. Our focus will also be on discussing the hemostatic alterations in patients implanted with TAH and anticoagulation strategies to decrease associated thromboembolic risks. The article concludes with a look at other novel TAH devices and the future of TAH as an increasingly viable treatment for end-stage heart failure.
    MeSH term(s) Humans ; Heart Failure/therapy ; Heart Transplantation ; Heart, Artificial
    Language English
    Publishing date 2023-08-21
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 196901-8
    ISSN 1098-9064 ; 0094-6176
    ISSN (online) 1098-9064
    ISSN 0094-6176
    DOI 10.1055/s-0043-1772456
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1259: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Diagnosis and management of new onset severe coagulopathy during after-hours with thromboelastography.

    Lee, Hannah / Martin-Stone, Sylvia / Volod, Oksana

    American journal of hematology

    2022  Volume 97, Issue 3, Page(s) 375–382

    MeSH term(s) Blood Coagulation Disorders/blood ; Blood Coagulation Disorders/diagnosis ; Blood Coagulation Disorders/therapy ; Humans ; Male ; Middle Aged ; Thrombelastography
    Language English
    Publishing date 2022-01-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.26435
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1251: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article: Viscoelastic Testing in the Management of Adult Patients on Mechanical Circulatory Support Devices with Focus on Extracorporeal Membrane Oxygenation

    Volod, Oksana / Wegner, Julie

    Seminars in Thrombosis and Hemostasis

    (Emerging Use of Viscoelastography in Thrombosis and Hemostasis: A Challenge to Conventional Coagulation Tests?)

    2022  Volume 48, Issue 07, Page(s) 814–827

    Abstract: Thromboembolic and hemorrhagic complications continue to remain frequent complications that significantly impact the morbidity and mortality of patients implanted with mechanical circulatory support devices (MCSDs). The severe acute respiratory syndrome ... ...

    Series title Emerging Use of Viscoelastography in Thrombosis and Hemostasis: A Challenge to Conventional Coagulation Tests?
    Abstract Thromboembolic and hemorrhagic complications continue to remain frequent complications that significantly impact the morbidity and mortality of patients implanted with mechanical circulatory support devices (MCSDs). The severe acute respiratory syndrome caused by coronavirus 2 (SARS-CoV-2) has resulted in a number of COVID-19 patients being supported by MCSDs, specifically extracorporeal membrane oxygenation (ECMO), which in turn has created a crucial need for rapid assessment of hemostatic status in these patients to avoid bleeding and thrombotic complications. Currently, conventional plasma-based coagulation assays such as prothrombin time and activated partial thromboplastin time (aPTT) are used to assess hemostasis, and the activated clotting time (ACT) and aPTT are the most common tests used to monitor heparin anticoagulation in patients on ECMO. Unfractionated heparin remains the mainstay anticoagulation therapy for patients on ECMO. Extracorporeal Life Support Organization (ELSO) offers little guidance on the subject but does state that each institution should create its internal anticoagulation protocols. Viscoelastic assays (VEAs) are increasingly recognized by ELSO and ECMO community for their potential to assess hemostatic derangements in patients implanted with MCSDs as well as guidance for appropriate hemostatic therapy. This review focuses on the evidence for the use of viscoelastic assays to assess overall hemostasis and to guide the treatment of adult patients connected to an ECMO circuit. Limitations of the use of conventional assays, ACT, and VEA are also discussed.
    Keywords mechanical circulatory support ; ECMO ; viscoelastic assays ; SARS-CoV-2 ; COVID-19 ; heparin monitoring
    Language English
    Publishing date 2022-09-15
    Publisher Thieme Medical Publishers, Inc.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 196901-8
    ISSN 1098-9064 ; 0094-6176
    ISSN (online) 1098-9064
    ISSN 0094-6176
    DOI 10.1055/s-0042-1756303
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1259: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

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  9. Article: In Search of the Holy Grail of Artificial Hearts: Are We There Yet?

    Volod, Oksana / Colon, Modesto J. / Arabía, Francisco A.

    Seminars in Thrombosis and Hemostasis

    (Celebrating 50 Years of Seminars in Thrombosis and Hemostasis—Part III)

    2023  Volume 50, Issue 01, Page(s) 104–114

    Abstract: The total artificial heart (TAH) has a long and rich history, being the product of decades of innovation, hard work, and dedication. This review examines the history of the TAH, a device that has revolutionized the treatment of end-stage biventricular ... ...

    Series title Celebrating 50 Years of Seminars in Thrombosis and Hemostasis—Part III
    Abstract The total artificial heart (TAH) has a long and rich history, being the product of decades of innovation, hard work, and dedication. This review examines the history of the TAH, a device that has revolutionized the treatment of end-stage biventricular heart failure. It reviews the development of the device from early concepts to the current state-of-the-art device, the SynCardia TAH, which has been implanted in over 2,000 patients worldwide. The article also discusses the challenges and successes experienced by researchers, clinicians, and patients throughout the development of TAH devices. Our focus will also be on discussing the hemostatic alterations in patients implanted with TAH and anticoagulation strategies to decrease associated thromboembolic risks. The article concludes with a look at other novel TAH devices and the future of TAH as an increasingly viable treatment for end-stage heart failure.
    Keywords total artificial heart ; history ; anticoagulation
    Language English
    Publishing date 2023-08-21
    Publisher Thieme Medical Publishers, Inc.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 196901-8
    ISSN 1098-9064 ; 0094-6176
    ISSN (online) 1098-9064
    ISSN 0094-6176
    DOI 10.1055/s-0043-1772456
    Database Thieme publisher's database

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1259: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Antithrombotic therapy for patients with total artificial hearts.

    Volod, Oksana / Lam, Lee D / Arabia, Francisco A

    Annals of cardiothoracic surgery

    2020  Volume 9, Issue 2, Page(s) 110–112

    Language English
    Publishing date 2020-04-11
    Publishing country China
    Document type Editorial
    ZDB-ID 2713627-9
    ISSN 2304-1021 ; 2225-319X
    ISSN (online) 2304-1021
    ISSN 2225-319X
    DOI 10.21037/acs.2019.12.01
    Database MEDical Literature Analysis and Retrieval System OnLINE

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