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Article ; Online: Tei Index and its Relation to Outcome of Critically Ill Children on Continuous Renal Replacement Therapy.

Fadel, Fatina I / Badr, Ahmed M / Abdelkareem, Marwa M / Samir, Mohammad / Abdallah, Mohammad / Atia, Fatma Mohammad / Ramadan, Yasmin M

Indian journal of pediatrics

2023

Abstract: Objectives: To evaluate echocardiographic parameters, especially the Tei index as a predictor of outcome in critically ill children on continuous renal replacement therapy (CRRT).: Methods: This cohort study included all critically ill patients ... ...

Abstract	Objectives: To evaluate echocardiographic parameters, especially the Tei index as a predictor of outcome in critically ill children on continuous renal replacement therapy (CRRT). Methods: This cohort study included all critically ill patients admitted at the Pediatric intensive care unit (PICU) and underwent CRRT. Functional echocardiography and Pediatric Risk of Mortality Index (PRISM) III were used to evaluate the participants. Both the Tei index and the Vasoactive inotropic score (VIS) were estimated. Results: The study included 35 patients with an age range of 6 mo to 14 y. The Tei indexes, VIS, and PRISM III were reported as predictors of mortality with a sensitivity of 88%, 83%, and 94% and a specificity of 73%, 79%, and 89% respectively. In survivors, the mean Tei index score, median VIS, and mean PRISM values were 0.44 ± 0.1, 3.8 (0-40), and 12.06 ± 3.35, respectively. However, in non-survivors, the mean Tei index, median VIS, and mean PRISM score were 0.59 ± 0.16, 0.60 (0-342.5), and 22.94 ± 8.93, respectively. Conclusions: The Tei index could be used as a predictor for poor outcomes in children receiving CRRT. It is correlated to the PRISM score and VIS.
Language	English
Publishing date	2023-12-22
Publishing country	India
Document type	Journal Article
ZDB-ID	218231-2
ISSN	0973-7693 ; 0019-5456
ISSN (online)	0973-7693
ISSN	0019-5456
DOI	10.1007/s12098-023-04903-3
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Article ; Online: Native vs. active vitamin D in children with chronic kidney disease: a cross-over study.

Sawires, Happy / Fadel, Fatina / Hussein, Ahmed / Helmy, Rasha

Pediatric nephrology (Berlin, Germany)

2020 Volume 36, Issue 2, Page(s) 443–450

Abstract: Background: The rationale for the prescription of vitamin D analogues in patients with chronic kidney disease (CKD) is still a matter of debate. We aimed to compare native vs. active forms of vitamin D on pre-dialysis children with CKD and evaluate ... ...

Abstract	Background: The rationale for the prescription of vitamin D analogues in patients with chronic kidney disease (CKD) is still a matter of debate. We aimed to compare native vs. active forms of vitamin D on pre-dialysis children with CKD and evaluate effects on calcium (Ca), phosphorus (P), and parathyroid hormone (PTH). Methods: Thirty children with pre-dialysis CKD were enrolled in a prospective cross-over study. Patients were randomly classified into two groups. Group A received native cholecalciferol while group B received alfacalcidol for 3 months. After 1 month (washout period), patients were switched to receive the opposite form for another 3 months. Serum Ca, P, alkaline phosphatase (ALP), PTH, and 25(OH)D Results: There was significant increase in levels of 25(OH)D Conclusion: Alfacalcidol and native vitamin D3 were equally effective in decreasing PTH levels and increasing serum 25(OH)D
MeSH term(s)	Calcium ; Child ; Cholecalciferol ; Cross-Over Studies ; Humans ; Parathyroid Hormone ; Prospective Studies ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/drug therapy ; Vitamin D
Chemical Substances	Parathyroid Hormone ; Vitamin D (1406-16-2) ; Cholecalciferol (1C6V77QF41) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2020-08-26
Publishing country	Germany
Document type	Journal Article
ZDB-ID	631932-4
ISSN	1432-198X ; 0931-041X
ISSN (online)	1432-198X
ISSN	0931-041X
DOI	10.1007/s00467-020-04721-1
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Article ; Online: Vascular access challenges in hemodialysis children.

Salah, Doaa M / Fadel, Fatina I / Abdel Mawla, Mohamed A / Mooty, Hesham NAbdel / Ghobashy, Mohamed El / Salem, Amr M / Fathallah, Mohamed Gamal / Abd Alazem, Eman Abobakr

Italian journal of pediatrics

2024 Volume 50, Issue 1, Page(s) 11

Abstract: Background: Hemodialysis (HD) success is dependent mainly on vascular access (VA). The aim of this study is to share the experience of Pediatric Nephrology Unit (PNU), Cairo University Children's Hospital (CUCH), with VA-related obstacles in end stage ... ...

Abstract	Background: Hemodialysis (HD) success is dependent mainly on vascular access (VA). The aim of this study is to share the experience of Pediatric Nephrology Unit (PNU), Cairo University Children's Hospital (CUCH), with VA-related obstacles in end stage kidney disease (ESKD) HD children. Methods: This is a retrospective analysis of VA related data of 187 ESKD children received regular HD over 3 year duration (2019-2021). Kaplan-Meier curves were used to present arteriovenous fistula (AVF) and cuffed catheters survivals. Results: Uncuffed central venous catheter (CVC) was the primary VA for HD in up to 97.3% with 2.7% of patients had AVF performed and attained maturation before initiation of regular HD. Fifty-six (29.9%) patients have inserted 120 tunneled CVCs. AVFs & AV grafts (AVF) were performed in 79 (42.2%) and 6 (3.2%) patients respectively. There were 112 uncuffed CVCs implanted beneath the screen in Rt internal jugular vein (IJV) (44%) Lt IJV (17%), right internal mammary vein (2.7%) while Trans hepatic (TH) technique was used to place 39 uncuffed CVCs (34%) in the inferior vena cava (IVC). Catheter-related bacteremia (CRB) was the most frequent complication in uncuffed and cuffed CVCs (2.58 / 100 catheters day and 10.1 /1000 catheter days respectively). AVFs achieved a high success rate (83%) after 757.71 ± 512.3 functioning days. Conclusion: Native AVF is the preferred VA for pediatric HD but its creation is limited by the small sized vessels where non-cuffed CVC could be a reasonable relatively long-term alternative. Challenging situations (occluded central veins) could benefit from TH technique of CVC insertion in IVC.
MeSH term(s)	Humans ; Child ; Retrospective Studies ; Renal Dialysis ; Kidney Failure, Chronic/therapy ; Bacteremia ; Catheters
Language	English
Publishing date	2024-01-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2088556-8
ISSN	1824-7288 ; 1720-8424
ISSN (online)	1824-7288
ISSN	1720-8424
DOI	10.1186/s13052-024-01590-4
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Article ; Online: Next-generation sequencing in identification of pathogenic variants in primary hyperoxaluria among 21 Egyptian families: Identification of two novel AGXT gene mutations.

Ahmed, Hoda A / Fadel, Fatina I / Abdel Mawla, Mohamed A / Salah, Doaa M / Fathallah, Mohamed Gamal / Amr, Khalda

Molecular genetics & genomic medicine

2022 Volume 10, Issue 8, Page(s) e1992

Abstract: Background: Primary hyperoxaluria (PH) is a rare heterogeneous, autosomal recessive disorder of glyoxylate metabolism. It is characterized by excessive hepatic production of oxalate resulting in a wide spectrum of clinical, imaging, and functional ... ...

Abstract	Background: Primary hyperoxaluria (PH) is a rare heterogeneous, autosomal recessive disorder of glyoxylate metabolism. It is characterized by excessive hepatic production of oxalate resulting in a wide spectrum of clinical, imaging, and functional presentation. The characteristic features of PH comprise of recurrent urolithiasis, renal stones, and/or nephrocalcinosis. Three known types of PH have been identified PH1, PH2, and PH3. Pathogenic variants in AGXT, GRHPR, and HOGA1 cause the phenotypic expression of PH. Methods: In this study, we describe the clinical and genetic findings of 22 patients from 21 unrelated Egyptian families with the distinctive clinical features of PH. A thorough clinical evaluation followed by an NGS custom panel of AGXT, GRHPR, and HOGA1 genes was done. Results: Two novel mutations (p.Gly27Glu and p.Gln256Serfs17) and six previously reported mutations (p.Lys12Glnfs156, p.Lys12Argfs34, p.Ile244Thr, p.Asn22Ser, p.Pro11Leu, and p.Ile340Met) were identified in AGXT gene. The NGS panel results were validated thereafter using Sanger sequencing. Conclusion:* Our results extend the number of AGXT mutations identified so far and emphasize the important role of genetic testing in providing proper counseling and patients management.
MeSH term(s)	Egypt ; Genetic Testing ; High-Throughput Nucleotide Sequencing ; Humans ; Hyperoxaluria, Primary/genetics ; Mutation ; Transaminases/genetics
Chemical Substances	Transaminases (EC 2.6.1.-) ; Alanine-glyoxylate transaminase (EC 2.6.1.44)
Language	English
Publishing date	2022-06-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2734884-2
ISSN	2324-9269 ; 2324-9269
ISSN (online)	2324-9269
ISSN	2324-9269
DOI	10.1002/mgg3.1992
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Article ; Online: Pediatric focal segmental glomerulosclerosis: favorable transplantation outcome with plasma exchange.

Fadel, Fatina I / Bazaraa, Hafez M / Abdel Mawla, Mohamed A / Salah, Doaa M

Italian journal of pediatrics

2021 Volume 47, Issue 1, Page(s) 236

Abstract: Background: Although kidney transplantation (KTX) is the treatment of choice for pediatric end stage kidney disease (ESKD); concerns for recurrence in cases of focal segmental glomerulosclerosis (FSGS) are still present. This study aimed to investigate ... ...

Abstract	Background: Although kidney transplantation (KTX) is the treatment of choice for pediatric end stage kidney disease (ESKD); concerns for recurrence in cases of focal segmental glomerulosclerosis (FSGS) are still present. This study aimed to investigate the outcome of KTX in children with ESKD secondary to FSGS, with implementation of preemptive perioperative plasma exchange (PE) for non-genetically proven patients. Methods: Forty FSGS pediatric kidney transplant recipients were studied. Of them: 12 patients (30%) had genetically proven NPHS2 mutations/familial and 28 (70%) were sporadic FSGS patients. All sporadic patients electively received 6 perioperative PE sessions. Patients with recurrence of proteinuria (n = 13; including 3 patients with genetic/familial and 10 patients with sporadic FSGS) were managed with PE and Rituximab (RTX). Kaplan-Meier curves were used to analyze graft and recurrence free survival data. Results: The mean follow-up duration after KTX was 3.8 ± 2.86 years. Recurrence of proteinuria was encountered early postoperative in 11 patients (27.5%) and late (1.6 and 2.9 years after KTX) in 2 patients (5%). All patients with early recurrence achieved complete remission, while patients with late recurrence developed graft failure. Current serum creatinine and proteinuria levels were not different in patients received PE (n = 31) and patients did not PE (n = 9) (p = 0.308 and 0.287 respectively). Current serum creatinine and proteinuria levels in sporadic patients (n = 28) after prophylactic perioperative PE were not different from those of genetic/ familial patients (n = 12) (p = 0.303 and 0.144 respectively). Proteinuria was less in patients underwent native nephrectomy than others immediately postoperative and at assessment (p = 0.002 & 0.0031 respectively). One-year graft and patient survival was 93.8% with a mean 1-year serum creatinine of 0.67 ± 0.25 mg/dl. Three graft losses (7.5%) were due to chronic rejection 3.3, 3.75 and 4.17 years after KTX and 2 patients' mortality (5%) occurred early postoperative (first 2 weeks). Conclusion: FSGS transplanted children have favorable outcomes with perioperative PE for non-genetically proven cases. Early recurrence after KTX can be successfully managed with PE and RTX.
MeSH term(s)	Child ; Cohort Studies ; Creatinine/blood ; Female ; Follow-Up Studies ; Glomerulosclerosis, Focal Segmental/therapy ; Graft Rejection ; Graft Survival ; Humans ; Kidney Failure, Chronic/etiology ; Kidney Failure, Chronic/therapy ; Kidney Transplantation ; Male ; Plasma Exchange ; Proteinuria/therapy ; Recurrence ; Remission Induction ; Retrospective Studies
Chemical Substances	Creatinine (AYI8EX34EU)
Language	English
Publishing date	2021-12-14
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	2088556-8
ISSN	1824-7288 ; 1720-8424
ISSN (online)	1824-7288
ISSN	1720-8424
DOI	10.1186/s13052-021-01188-0
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Article: Genetic polymorphisms in CLDN14 (rs219780) and ALP (rs1256328) genes are associated with risk of nephrolithiasis in Egyptian children.

Elshamaa, Manal F / Fadel, Fatina I / Kamel, Soal / Farouk, Hebatallah / Alahmady, Mostafa / Ramadan, Yasim

Turkish journal of urology

2020 Volume 47, Issue 1, Page(s) 73–80

Abstract: Objective: Nephrolithiasis results from metabolic and anatomic abnormalities together with genetic factors. Claudin 14 (CLDN14) is a protein that regulates the passage of small solutes through the kidneys. Alkaline phosphatase (ALPL) hydrolyzes the ... ...

Abstract	Objective: Nephrolithiasis results from metabolic and anatomic abnormalities together with genetic factors. Claudin 14 (CLDN14) is a protein that regulates the passage of small solutes through the kidneys. Alkaline phosphatase (ALPL) hydrolyzes the pyrophosphate to free phosphate, proposing its enabling role in nephrolithiasis development. Solute carrier family 13 member 2 (SLC13A2) encodes Na+-Pi cotransporter 2a, which is responsible for the renal absorption of phosphate. We aimed to detect the association between CLDN14, ALPL, and SLC13A2 genetic variants and susceptibility to nephrolithiasis in the Egyptian pediatric population. Material and methods: We enrolled 204 consecutive pediatric patients with nephrolithiasis, and 126 normal individuals served as controls. Real-time polymerase chain reaction analysis of CLDN14 rs219780, ALPL rs1256328, and SLC34A1 rs11746443 single-nucleotide polymorphisms (SNPs) was performed. Results: We found that individuals carrying the T allele of CLDN14 rs219780 and ALPL rs1256328 SNPs had a significantly higher risk of nephrolithiasis than the controls (p=0.001 and 0.001, respectively). Genetic association analyses identified that CLDN14 rs219780 and ALPL rs1256328SNPs were significantly associated with the nephrolithiasis status (odds ratio [OR] =4.51; 95% confidence interval [CI]=2.758-7.374; p=0.001 and OR=6.088; 95% CI=3.651-10.152; p=0.001, respectively). The sequence variant ALPL rs1256328 T allele had a significant correlation with the increased serum alkaline phosphatase levels in children with nephrolithiasis (p=0.02). No significant association was found between SLC34A1 rs11746443 SNP and the risk of nephrolithiasis (p=0.5). Conclusion: CLDN14 rs219780 and ALPL rs1256328 SNPs might raise the risk of nephrolithiasis in Egyptian children, and might be used as genetic markers in these patients.
Language	English
Publishing date	2020-10-09
Publishing country	Turkey
Document type	Journal Article
ISSN	2149-3235
ISSN	2149-3235
DOI	10.5152/tud.2020.20141
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Article ; Online: Covid-19 in Egyptian hemodialysis and kidney transplant children: retrospective analysis of single center experience.

Fadel, Fatina I / Sabry, Samar / Mawla, Mohamed A Abdel / Galal, Rasha Essam Eldin / Salah, Doaa M / Helmy, Rasha / Ramadan, Yasmen / Elzayat, Wessam / Abdelfattah, May / Abd Alazem, Eman Abobakr

Italian journal of pediatrics

2022 Volume 48, Issue 1, Page(s) 149

Abstract: Background: Chronic kidney disease stage 5 (CKD 5) populations have peculiar risk for severe Covid-19 infection. Moreover; pediatric data are sparse and lacking. The aim of this study is to report our experience in CKD 5 children treated by hemodialysis ...

Abstract	Background: Chronic kidney disease stage 5 (CKD 5) populations have peculiar risk for severe Covid-19 infection. Moreover; pediatric data are sparse and lacking. The aim of this study is to report our experience in CKD 5 children treated by hemodialysis (CKD 5D) and CKD 5 children after kidney transplantation (KTR) during one year of Covid-19 pandemic. Methods: Retrospective analysis of 57 CKD 5 children with Covid-19 like symptoms during 1 year pandemic was performed. A cohort of 19 confirmed patients (13 CKD 5D and 6 KTR) was analyzed in details as regard clinical, laboratory, radiological criteria, management and their short term outcome. Results: CONCLUSION: Pediatric patients on regular HD (CKD 5D) are at higher risk and worse outcome of Covid-19 infection than KT recipients (KTR). Pre-existing HTN and shorter duration after KT are potential risk factors. Reversible AGD after KT and CVC related infections in HD patients are additional presenting features of Covid-19 infection.
MeSH term(s)	COVID-19/epidemiology ; Child ; Egypt/epidemiology ; Humans ; Kidney Failure, Chronic/epidemiology ; Kidney Failure, Chronic/surgery ; Kidney Transplantation/adverse effects ; Pandemics ; Renal Dialysis/adverse effects ; Retrospective Studies
Language	English
Publishing date	2022-08-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2088556-8
ISSN	1824-7288 ; 1720-8424
ISSN (online)	1824-7288
ISSN	1720-8424
DOI	10.1186/s13052-022-01345-z
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Article ; Online: Assessment of Quality of Life among Children with End-Stage Renal Disease

Arwa M. El Shafei / Ibrahim Soliman Hegazy / Fatina Ibrahim Fadel / Eman M. Nagy

Journal of Environmental and Public Health, Vol

A Cross-Sectional Study

2018 Volume 2018

Abstract: Background. Measuring health-related quality of life is considered an important outcome indicator in evaluating health-care interventions and treatments and in understanding the burden of diseases. Objectives. This study aimed at assessing quality of ... ...

Abstract	Background. Measuring health-related quality of life is considered an important outcome indicator in evaluating health-care interventions and treatments and in understanding the burden of diseases. Objectives. This study aimed at assessing quality of life among children with end-stage renal disease, either undergoing hemodialysis or had renal transplantation therapy and comparing it with healthy controls. Methods. A cross-sectional study was conducted between December 2016 and May 2017 in Abo El-Reesh Pediatric Hospital using parent/child reports of generic module for QoL assessment: PedsQLTM Inventory version 4 for both cases and controls. Disease-specific module: PedsQLTM ESRD version 3 was used for ESRD cases. 55 ESRD cases and 86 controls were enrolled in the study. Results. Statistically significant difference between ESRD cases and controls regarding all aspects of QoL was found; total QoL mean score was 58.4 ± 15.3 and 86.8 ± 10 among cases and controls, respectively. All individual QoL domains were significantly worse in ESRD cases. Transplantation group had better Spearman’s correlation between child and parents’ scores which showed significant positive moderate correlation. Conclusions. ESRD and its treatment modalities are affecting negatively all aspects of quality of life; incorporating QoL assessment and management is highly recommended.
Keywords	Public aspects of medicine ; RA1-1270
Subject code	360
Language	English
Publishing date	2018-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
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Article ; Online: Assessment of Quality of Life among Children with End-Stage Renal Disease: A Cross-Sectional Study.

El Shafei, Arwa M / Soliman Hegazy, Ibrahim / Fadel, Fatina Ibrahim / Nagy, Eman M

Journal of environmental and public health

2018 Volume 2018, Page(s) 8565498

Abstract: Background: Measuring health-related quality of life is considered an important outcome indicator in evaluating health-care interventions and treatments and in understanding the burden of diseases.: Objectives: This study aimed at assessing quality ... ...

Abstract	Background: Measuring health-related quality of life is considered an important outcome indicator in evaluating health-care interventions and treatments and in understanding the burden of diseases. Objectives: This study aimed at assessing quality of life among children with end-stage renal disease, either undergoing hemodialysis or had renal transplantation therapy and comparing it with healthy controls. Methods: A cross-sectional study was conducted between December 2016 and May 2017 in Abo El-Reesh Pediatric Hospital using parent/child reports of generic module for QoL assessment: PedsQL Results: Statistically significant difference between ESRD cases and controls regarding all aspects of QoL was found; total QoL mean score was 58.4 ± 15.3 and 86.8 ± 10 among cases and controls, respectively. All individual QoL domains were significantly worse in ESRD cases. Transplantation group had better Spearman's correlation between child and parents' scores which showed significant positive moderate correlation. Conclusions: ESRD and its treatment modalities are affecting negatively all aspects of quality of life; incorporating QoL assessment and management is highly recommended.
MeSH term(s)	Adolescent ; Child ; Child, Preschool ; Cross-Sectional Studies ; Female ; Humans ; Kidney Failure, Chronic/psychology ; Kidney Transplantation/statistics & numerical data ; Male ; Quality of Life ; Renal Dialysis/statistics & numerical data
Language	English
Publishing date	2018-09-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2526611-1
ISSN	1687-9813 ; 1687-9805
ISSN (online)	1687-9813
ISSN	1687-9805
DOI	10.1155/2018/8565498
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Article ; Online: Hearing assessment in Egyptian children with chronic renal failure on regular hemodialysis and renal transplantation children.

Fadel, Fatina I / Yamamah, Gamal Abdel Naser / Hasanin, Rasha M / Mostafa, Eman A / Abdalgeleel, Shaimaa Abdalaleem / Salah, Mohab M / Galal, Rasha E E / Abdel Mawla, Mohamed A

Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy

2021 Volume 26, Issue 5, Page(s) 960–968

Abstract: Introduction: Hearing impairment is frequent in patients with end-stage renal disease (ESRD). We aimed to assess the prevalence of hearing impairment in children on regular hemodialysis and renal transplantation.: Materials and methods: Transient- ... ...

Abstract	Introduction: Hearing impairment is frequent in patients with end-stage renal disease (ESRD). We aimed to assess the prevalence of hearing impairment in children on regular hemodialysis and renal transplantation. Materials and methods: Transient-evoked otoacoustic emissions (TEOAEs) has been done for 80 children on regular hemodialysis and 40 with renal transplant. Results: In hemodialysis group, TEOAEs showed that 53.8% children had hearing affection, it was significantly related to dialysis duration, dialysis adequacy, vascular access infection, hepatitis C virus (HCV) infection, and ototoxic drugs (p = 0.001, 0.037, 0.011, 0.004, 0.030, 0.007, and 0.044, respectively). In renal transplant group hearing impairment was 25%. There was significant relation with period of dialysis before transplantation and biopsy proved rejection (p = 0.008, <0.001, respectively). Conclusion: Hearing impairment is a common finding in ESRD patients. Thus audiological assessment must be done in these patients.
MeSH term(s)	Child ; Egypt/epidemiology ; Hearing ; Hearing Loss/diagnosis ; Hearing Loss/epidemiology ; Hepacivirus ; Hepatitis C ; Humans ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/epidemiology ; Kidney Failure, Chronic/therapy ; Kidney Transplantation ; Renal Dialysis ; Renal Insufficiency, Chronic
Language	English
Publishing date	2021-12-30
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2119809-3
ISSN	1744-9987 ; 1091-6660 ; 1744-9979
ISSN (online)	1744-9987
ISSN	1091-6660 ; 1744-9979
DOI	10.1111/1744-9987.13783
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