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Article: Vitamin A administration at birth promotes calf growth and intramuscular fat development in Angus beef cattle

Harris, Corrine L / Wang, Bo / Deavila, Jeneane M / Busboom, Jan R / Maquivar, Martin / Parish, Steven M / McCann, Brent / Nelson, Mark L / Du, Min

Journal of animal science and biotechnology. 2018 Dec., v. 9, no. 1

2018

Abstract: BACKGROUND: Marbling, or intramuscular fat, is an important factor contributing to the palatability of beef. Vitamin A, through its active metabolite, retinoic acid, promotes the formation of new fat cells (adipogenesis). As intramuscular adipogenesis is ...

Abstract	BACKGROUND: Marbling, or intramuscular fat, is an important factor contributing to the palatability of beef. Vitamin A, through its active metabolite, retinoic acid, promotes the formation of new fat cells (adipogenesis). As intramuscular adipogenesis is active during the neonatal stage, we hypothesized that vitamin A administration during the neonatal stage would enhance intramuscular adipogenesis and marbling. METHODS: Angus steer calves (n = 30), in a completely randomized design, were randomly allotted to three treatment groups at birth, receiving 0, 150,000, or 300,000 IU of vitamin A at both birth and one month of age. A biopsy of the biceps femoris muscle was collected at two months of age. After weaning at 210 d of age, steers were fed a backgrounding diet in a feedlot until 308 d of age, when they were transitioned to a high concentrate finishing diet and implanted with trenbolone/estradiol/tylosin mixture. Steers were harvested at an average of 438 d of age. All diets were formulated to meet nutrient requirements. RESULTS: Weaning weight and weight during the backgrounding phase were linearly increased (P < 0.05) by vitamin A level, though no difference in body weight was observed at harvest. Intramuscular fat of steers at 308 d of age, measured by ultrasound, quadratically increased (P < 0.05) with vitamin A level from 4.0±0.26 % to 4.9±0.26 %. Similarly, carcass marbling score in the ribeye quadratically increased (P < 0.05). CONCLUSION: Administration of vitamin A at birth increased weaning weight and enhanced marbling fat development. Thus, vitamin A administration provides a practical method for increasing marbling and early growth of beef cattle.
Keywords	Angus ; adipocytes ; adipogenesis ; animal growth ; beef ; beef cattle ; biopsy ; calves ; diet ; estradiol ; feedlots ; finishing ; intramuscular fat ; marbling ; meat cuts ; metabolites ; muscles ; nutrient requirements ; palatability ; retinoic acid ; steers ; trenbolone ; tylosin ; vitamin A ; weaning ; weaning weight
Language	English
Dates of publication	2018-12
Size	p. 55.
Publishing place	BioMed Central
Document type	Article
ZDB-ID	2630162-3
ISSN	2049-1891 ; 1674-9782
ISSN (online)	2049-1891
ISSN	1674-9782
DOI	10.1186/s40104-018-0268-7
Database	NAL-Catalogue (AGRICOLA)

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Article: Vitamin A administration at birth promotes calf growth and intramuscular fat development in Angus beef cattle.

Harris, Corrine L / Wang, Bo / Deavila, Jeneane M / Busboom, Jan R / Maquivar, Martin / Parish, Steven M / McCann, Brent / Nelson, Mark L / Du, Min

Journal of animal science and biotechnology

2018 Volume 9, Page(s) 55

Abstract: Background: Marbling, or intramuscular fat, is an important factor contributing to the palatability of beef. Vitamin A, through its active metabolite, retinoic acid, promotes the formation of new fat cells (adipogenesis). As intramuscular adipogenesis ... ...

Abstract	Background: Marbling, or intramuscular fat, is an important factor contributing to the palatability of beef. Vitamin A, through its active metabolite, retinoic acid, promotes the formation of new fat cells (adipogenesis). As intramuscular adipogenesis is active during the neonatal stage, we hypothesized that vitamin A administration during the neonatal stage would enhance intramuscular adipogenesis and marbling. Methods: Angus steer calves ( Results: Weaning weight and weight during the backgrounding phase were linearly increased ( Conclusion: Administration of vitamin A at birth increased weaning weight and enhanced marbling fat development. Thus, vitamin A administration provides a practical method for increasing marbling and early growth of beef cattle.
Language	English
Publishing date	2018-07-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2630162-3
ISSN	2049-1891 ; 1674-9782
ISSN (online)	2049-1891
ISSN	1674-9782
DOI	10.1186/s40104-018-0268-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Nutrigenomic regulation of adipose tissue development — role of retinoic acid: A review

Wang, Bo / Busboom, Jan R / Du, Min / Harris, Corrine L / Nelson, Mark L / Yang, Qiyuan / Zhu, Mei-Jun

Meat science. 2016 Oct., v. 120

2016

Abstract: To improve the efficiency of animal production, livestock have been extensively selected or managed to reduce fat accumulation and increase lean growth, which reduces intramuscular or marbling fat content. To enhance marbling, a better understanding of ... ...

Abstract	To improve the efficiency of animal production, livestock have been extensively selected or managed to reduce fat accumulation and increase lean growth, which reduces intramuscular or marbling fat content. To enhance marbling, a better understanding of the mechanisms regulating adipogenesis is needed. Vitamin A has recently been shown to have a profound impact on all stages of adipogenesis. Retinoic acid, an active metabolite of vitamin A, activates both retinoic acid receptors (RAR) and retinoid X receptors (RXR), inducing epigenetic changes in key regulatory genes governing adipogenesis. Additionally, Vitamin D and folates interact with the retinoic acid receptors to regulate adipogenesis. In this review, we discuss nutritional regulation of adipogenesis, focusing on retinoic acid and its impact on epigenetic modifications of key adipogenic genes.
Keywords	adipogenesis ; adipose tissue ; animal production ; epigenetics ; lipid content ; livestock ; marbling ; metabolites ; receptors ; regulator genes ; retinoic acid ; vitamin A ; vitamin D
Language	English
Dates of publication	2016-10
Size	p. 100-106.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	753319-6
ISSN	1873-4138 ; 0309-1740
ISSN (online)	1873-4138
ISSN	0309-1740
DOI	10.1016/j.meatsci.2016.04.003
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Nutrigenomic regulation of adipose tissue development - role of retinoic acid: A review.

Wang, Bo / Yang, Qiyuan / Harris, Corrine L / Nelson, Mark L / Busboom, Jan R / Zhu, Mei-Jun / Du, Min

Meat science

2016 Volume 120, Page(s) 100–106

Abstract	To improve the efficiency of animal production, livestock have been extensively selected or managed to reduce fat accumulation and increase lean growth, which reduces intramuscular or marbling fat content. To enhance marbling, a better understanding of the mechanisms regulating adipogenesis is needed. Vitamin A has recently been shown to have a profound impact on all stages of adipogenesis. Retinoic acid, an active metabolite of vitamin A, activates both retinoic acid receptors (RAR) and retinoid X receptors (RXR), inducing epigenetic changes in key regulatory genes governing adipogenesis. Additionally, Vitamin D and folates interact with the retinoic acid receptors to regulate adipogenesis. In this review, we discuss nutritional regulation of adipogenesis, focusing on retinoic acid and its impact on epigenetic modifications of key adipogenic genes.
MeSH term(s)	Adipogenesis/drug effects ; Adipogenesis/genetics ; Adipose Tissue/drug effects ; Adipose Tissue/metabolism ; Animals ; DNA Methylation/drug effects ; Epigenomics ; Fatty Acid-Binding Proteins/genetics ; Fatty Acid-Binding Proteins/metabolism ; Folic Acid/pharmacology ; Gene Expression Regulation ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/metabolism ; Nutrigenomics ; Receptors, Retinoic Acid/genetics ; Receptors, Retinoic Acid/metabolism ; Retinoid X Receptors/genetics ; Retinoid X Receptors/metabolism ; Tretinoin/pharmacology ; Vitamin D/pharmacology
Chemical Substances	Fatty Acid-Binding Proteins ; Receptors, Retinoic Acid ; Retinoid X Receptors ; Vitamin D (1406-16-2) ; Tretinoin (5688UTC01R) ; Folic Acid (935E97BOY8)
Language	English
Publishing date	2016-10
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	753319-6
ISSN	1873-4138 ; 0309-1740
ISSN (online)	1873-4138
ISSN	0309-1740
DOI	10.1016/j.meatsci.2016.04.003
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Vitamin A administration at birth promotes calf growth and intramuscular fat development in Angus beef cattle

Corrine L. Harris / Bo Wang / Jeneane M. Deavila / Jan R. Busboom / Martin Maquivar / Steven M. Parish / Brent McCann / Mark L. Nelson / Min Du

Journal of Animal Science and Biotechnology, Vol 9, Iss 1, Pp 1-

2018 Volume 9

Abstract: Abstract Background Marbling, or intramuscular fat, is an important factor contributing to the palatability of beef. Vitamin A, through its active metabolite, retinoic acid, promotes the formation of new fat cells (adipogenesis). As intramuscular ... ...

Abstract	Abstract Background Marbling, or intramuscular fat, is an important factor contributing to the palatability of beef. Vitamin A, through its active metabolite, retinoic acid, promotes the formation of new fat cells (adipogenesis). As intramuscular adipogenesis is active during the neonatal stage, we hypothesized that vitamin A administration during the neonatal stage would enhance intramuscular adipogenesis and marbling. Methods Angus steer calves (n = 30), in a completely randomized design, were randomly allotted to three treatment groups at birth, receiving 0, 150,000, or 300,000 IU of vitamin A at both birth and one month of age. A biopsy of the biceps femoris muscle was collected at two months of age. After weaning at 210 d of age, steers were fed a backgrounding diet in a feedlot until 308 d of age, when they were transitioned to a high concentrate finishing diet and implanted with trenbolone/estradiol/tylosin mixture. Steers were harvested at an average of 438 d of age. All diets were formulated to meet nutrient requirements. Results Weaning weight and weight during the backgrounding phase were linearly increased (P < 0.05) by vitamin A level, though no difference in body weight was observed at harvest. Intramuscular fat of steers at 308 d of age, measured by ultrasound, quadratically increased (P < 0.05) with vitamin A level from 4.0±0.26 % to 4.9±0.26 %. Similarly, carcass marbling score in the ribeye quadratically increased (P < 0.05). Conclusion Administration of vitamin A at birth increased weaning weight and enhanced marbling fat development. Thus, vitamin A administration provides a practical method for increasing marbling and early growth of beef cattle.
Keywords	Beef ; Calf ; Cattle ; Marbling fat ; Quality ; Vitamin A ; Animal culture ; SF1-1100 ; Veterinary medicine ; SF600-1100
Language	English
Publishing date	2018-07-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A small protein encoded by a putative lncRNA regulates apoptosis and tumorigenicity in human colorectal cancer cells.

Li, Xiao Ling / Pongor, Lőrinc / Tang, Wei / Das, Sudipto / Muys, Bruna R / Jones, Matthew F / Lazar, Sarah B / Dangelmaier, Emily A / Hartford, Corrine Cr / Grammatikakis, Ioannis / Hao, Qinyu / Sun, Qinyu / Schetter, Aaron / Martindale, Jennifer L / Tang, BinWu / Jenkins, Lisa M / Robles, Ana I / Walker, Robert L / Ambs, Stefan /

Chari, Raj / Shabalina, Svetlana A / Gorospe, Myriam / Hussain, S Perwez / Harris, Curtis C / Meltzer, Paul S / Prasanth, Kannanganattu V / Aladjem, Mirit I / Andresson, Thorkell / Lal, Ashish

eLife

2020 Volume 9

Abstract: Long noncoding RNAs (lncRNAs) are often associated with polysomes, indicating coding potential. However, only a handful of endogenous proteins encoded by putative lncRNAs have been identified and assigned a function. Here, we report the discovery of a ... ...

Abstract	Long noncoding RNAs (lncRNAs) are often associated with polysomes, indicating coding potential. However, only a handful of endogenous proteins encoded by putative lncRNAs have been identified and assigned a function. Here, we report the discovery of a putative gastrointestinal-tract-specific lncRNA (
MeSH term(s)	Apoptosis/genetics ; Carcinogenesis/genetics ; Cell Line, Tumor ; Cell Proliferation ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Endoplasmic Reticulum/metabolism ; Endoplasmic Reticulum Stress ; Gastrointestinal Tract/metabolism ; Genes, Reporter ; Hepatocyte Nuclear Factor 3-alpha/genetics ; Hepatocyte Nuclear Factor 3-alpha/metabolism ; Humans ; Molecular Sequence Annotation ; Organ Specificity ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism
Chemical Substances	FOXA1 protein, human ; Hepatocyte Nuclear Factor 3-alpha ; RNA, Long Noncoding ; long non-coding RNA Linc00675, human
Language	English
Publishing date	2020-10-28
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.53734
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A small protein encoded by a putative lncRNA regulates apoptosis and tumorigenicity in human colorectal cancer cells

Xiao Ling Li / Lőrinc Pongor / Wei Tang / Sudipto Das / Bruna R Muys / Matthew F Jones / Sarah B Lazar / Emily A Dangelmaier / Corrine CR Hartford / Ioannis Grammatikakis / Qinyu Hao / Qinyu Sun / Aaron Schetter / Jennifer L Martindale / BinWu Tang / Lisa M Jenkins / Ana I Robles / Robert L Walker / Stefan Ambs /

Raj Chari / Svetlana A Shabalina / Myriam Gorospe / S Perwez Hussain / Curtis C Harris / Paul S Meltzer / Kannanganattu V Prasanth / Mirit I Aladjem / Thorkell Andresson / Ashish Lal

eLife, Vol

2020 Volume 9

Abstract	Long noncoding RNAs (lncRNAs) are often associated with polysomes, indicating coding potential. However, only a handful of endogenous proteins encoded by putative lncRNAs have been identified and assigned a function. Here, we report the discovery of a putative gastrointestinal-tract-specific lncRNA (LINC00675) that is regulated by the pioneer transcription factor FOXA1 and encodes a conserved small protein of 79 amino acids which we termed FORCP (FOXA1-Regulated Conserved Small Protein). FORCP transcript is undetectable in most cell types but is abundant in well-differentiated colorectal cancer (CRC) cells where it functions to inhibit proliferation, clonogenicity, and tumorigenesis. The epitope-tagged and endogenous FORCP protein predominantly localizes to the endoplasmic reticulum (ER). In response to ER stress, FORCP depletion results in decreased apoptosis. Our findings on the initial characterization of FORCP demonstrate that FORCP is a novel, conserved small protein encoded by a mis-annotated lncRNA that regulates apoptosis and tumorigenicity in well-differentiated CRC cells.
Keywords	lncRNA ; ORF ; FOXA1 ; LINC00675 ; CRC ; micropeptide ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
Subject code	570
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	eLife Sciences Publications Ltd
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A problem-solving intervention for cardiovascular disease risk reduction in veterans: Protocol for a randomized controlled trial.

Nieuwsma, Jason A / Wray, Laura O / Voils, Corrine I / Gierisch, Jennifer M / Dundon, Margaret / Coffman, Cynthia J / Jackson, George L / Merwin, Rhonda / Vair, Christina / Juntilla, Karen / White-Clark, Courtney / Jeffreys, Amy S / Harris, Amy / Owings, Michael / Marr, Johnpatrick / Edelman, David

Contemporary clinical trials

2017 Volume 60, Page(s) 42–50

Abstract: Background: Health behaviors related to diet, tobacco usage, physical activity, medication adherence, and alcohol use are highly determinative of risk for developing cardiovascular disease. This paper describes a study protocol to evaluate a problem- ... ...

Abstract	Background: Health behaviors related to diet, tobacco usage, physical activity, medication adherence, and alcohol use are highly determinative of risk for developing cardiovascular disease. This paper describes a study protocol to evaluate a problem-solving intervention that aims to help patients at risk for developing cardiovascular disease address barriers to adopting positive health behaviors in order to reduce cardiovascular risk. Methods: Eligible patients are adults enrolled in Veterans Affairs (VA) health care who have not experienced a cardiovascular event but are at elevated risk based on their Framingham Risk Score (FRS). Participants in this two-site study are randomized to either the intervention or care as usual, with a target of 400 participants. The study intervention, Healthy Living Problem-Solving (HELPS), consists of six group sessions conducted approximately monthly interspersed with individualized coaching calls to help participants apply problem-solving principles. The primary outcome is FRS, analyzed at the beginning and end of the study intervention (6months). Participants also complete measures of physical activity, caloric intake, self-efficacy, group cohesion, problem-solving capacities, and demographic characteristics. Conclusion: Results of this trial will inform behavioral interventions to change health behaviors in those at risk for cardiovascular disease and other health conditions. Trial registration: ClinicalTrials.gov identifier NCT01838226.
MeSH term(s)	Blood Pressure ; Cardiovascular Diseases/prevention & control ; Diet ; Exercise ; Female ; Health Behavior ; Health Education/organization & administration ; Healthy Lifestyle ; Humans ; Lipids/blood ; Male ; Problem Solving ; Research Design ; Risk Factors ; Risk Reduction Behavior ; Smoking Cessation ; United States ; United States Department of Veterans Affairs ; Veterans
Chemical Substances	Lipids
Language	English
Publishing date	2017-06-23
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2182176-8
ISSN	1559-2030 ; 1551-7144
ISSN (online)	1559-2030
ISSN	1551-7144
DOI	10.1016/j.cct.2017.06.001
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Article ; Online: Personalizing health care: feasibility and future implications.

Godman, Brian / Finlayson, Alexander E / Cheema, Parneet K / Zebedin-Brandl, Eva / Gutiérrez-Ibarluzea, Inaki / Jones, Jan / Malmström, Rickard E / Asola, Elina / Baumgärtel, Christoph / Bennie, Marion / Bishop, Iain / Bucsics, Anna / Campbell, Stephen / Diogene, Eduardo / Ferrario, Alessandra / Fürst, Jurij / Garuoliene, Kristina / Gomes, Miguel / Harris, Katharine /

Haycox, Alan / Herholz, Harald / Hviding, Krystyna / Jan, Saira / Kalaba, Marija / Kvalheim, Christina / Laius, Ott / Lööv, Sven-Ake / Malinowska, Kamila / Martin, Andrew / McCullagh, Laura / Nilsson, Fredrik / Paterson, Ken / Schwabe, Ulrich / Selke, Gisbert / Sermet, Catherine / Simoens, Steven / Tomek, Dominik / Vlahovic-Palcevski, Vera / Voncina, Luka / Wladysiuk, Magdalena / van Woerkom, Menno / Wong-Rieger, Durhane / Zara, Corrine / Ali, Raghib / Gustafsson, Lars L

BMC medicine

2013 Volume 11, Page(s) 179

Abstract: Considerable variety in how patients respond to treatments, driven by differences in their geno- and/ or phenotypes, calls for a more tailored approach. This is already happening, and will accelerate with developments in personalized medicine. However, ... ...

Abstract	Considerable variety in how patients respond to treatments, driven by differences in their geno- and/ or phenotypes, calls for a more tailored approach. This is already happening, and will accelerate with developments in personalized medicine. However, its promise has not always translated into improvements in patient care due to the complexities involved. There are also concerns that advice for tests has been reversed, current tests can be costly, there is fragmentation of funding of care, and companies may seek high prices for new targeted drugs. There is a need to integrate current knowledge from a payer's perspective to provide future guidance. Multiple findings including general considerations; influence of pharmacogenomics on response and toxicity of drug therapies; value of biomarker tests; limitations and costs of tests; and potentially high acquisition costs of new targeted therapies help to give guidance on potential ways forward for all stakeholder groups. Overall, personalized medicine has the potential to revolutionize care. However, current challenges and concerns need to be addressed to enhance its uptake and funding to benefit patients.
MeSH term(s)	Delivery of Health Care/methods ; Delivery of Health Care/trends ; Feasibility Studies ; Forecasting ; Humans ; Patient Care/methods ; Patient Care/trends ; Pharmacogenetics/methods ; Pharmacogenetics/trends ; Precision Medicine/methods ; Precision Medicine/trends
Language	English
Publishing date	2013-08-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2131669-7
ISSN	1741-7015 ; 1741-7015
ISSN (online)	1741-7015
ISSN	1741-7015
DOI	10.1186/1741-7015-11-179
Database	MEDical Literature Analysis and Retrieval System OnLINE

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