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  1. Book ; Thesis: The Role of the Interferon Regulatory Factor 8 in Retinal Microglia Cells during Retinal Homeostasis and Formation of Choroidal Neovascularization

    Zhang, Pei Pei

    2019  

    Author's details vorgelegt 2018 von Peipei Zhang
    Language English
    Size 116 Blätter, Illustrationen, Diagramme
    Publishing place Freiburg im Breisgau
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Albert-Ludwigs-Universität Freiburg im Breisgau, 2019
    HBZ-ID HT020607917
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2020 E 1295 order for loan Magazin

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  2. Article: [LASSO regression based risk prediction model for postoperative control in chronic sinusitis with nasal polyps].

    Huang, Haiping / Yang, Peipei / Zhang, Dan

    Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery

    2024  Volume 38, Issue 3, Page(s) 200–206

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Humans ; Nasal Polyps/surgery ; Hyperplasia ; Retrospective Studies ; Sinusitis/surgery ; Chronic Disease ; Olfaction Disorders ; Edema ; Carboplatin/analogs & derivatives
    Chemical Substances NK 121 (110172-45-7) ; Carboplatin (BG3F62OND5)
    Language Chinese
    Publishing date 2024-03-04
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 2096-7993
    ISSN 2096-7993
    DOI 10.13201/j.issn.2096-7993.2024.03.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Bacteriophage protein PEIP is a potent Bacillus subtilis enolase inhibitor.

    Zhang, Kaining / Li, Shanshan / Wang, Yawen / Wang, Zhihao / Mulvenna, Nancy / Yang, Hang / Zhang, Peipei / Chen, Huan / Li, Yan / Wang, Hongliang / Gao, Yongxiang / Wigneshweraraj, Sivaramesh / Matthews, Steve / Zhang, Kaiming / Liu, Bing

    Cell reports

    2022  Volume 40, Issue 1, Page(s) 111026

    Abstract: ... of great interest. Here, we report that Gp60, a phage-encoded enolase inhibitor protein (PEIP ... of bacteriophage SPO1 for Bacillus subtilis, is an enolase inhibitor. PEIP-expressing bacteria exhibit growth ... We solve the structure of PEIP-enolase tetramer and show that PEIP disassembles enolase by disrupting ...

    Abstract Enolase is a highly conserved enzyme that presents in all organisms capable of glycolysis or fermentation. Its immediate product phosphoenolpyruvate is essential for other important processes like peptidoglycan synthesis and the phosphotransferase system in bacteria. Therefore, enolase inhibitors are of great interest. Here, we report that Gp60, a phage-encoded enolase inhibitor protein (PEIP) of bacteriophage SPO1 for Bacillus subtilis, is an enolase inhibitor. PEIP-expressing bacteria exhibit growth attenuation, thinner cell walls, and safranin color in Gram staining owing to impaired peptidoglycan synthesis. We solve the structure of PEIP-enolase tetramer and show that PEIP disassembles enolase by disrupting the basic dimer unit. The structure reveals that PEIP does not compete for substrate binding but induces a cascade of conformational changes that limit accessibility to the enolase catalytic site. This phage-inspired disassembly of enolase represents an alternative strategy for the development of anti-microbial drugs.
    MeSH term(s) Bacillus subtilis/metabolism ; Bacteriophages/metabolism ; Catalytic Domain ; Peptidoglycan/metabolism ; Phosphopyruvate Hydratase/metabolism
    Chemical Substances Peptidoglycan ; Phosphopyruvate Hydratase (EC 4.2.1.11)
    Language English
    Publishing date 2022-07-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2022.111026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Identification of testis development-related genes by combining Iso-Seq and RNA-Seq in

    Liu, Peipei / Li, Ziniu / Zhang, Qiuyuan / Qiao, Jiao / Zheng, Chenjun / Zheng, Wenping / Zhang, Hongyu

    Frontiers in cell and developmental biology

    2024  Volume 12, Page(s) 1356151

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2024-03-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2024.1356151
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Oxidative stress, DNA damage, and gene expression in earthworms (Eisenia fetida) exposure to ethiprole.

    Zhou, Min / Zhang, Caixia / Wang, Fuhao / Hao, Peipei / Cheng, Youpu

    Environmental science and pollution research international

    2024  

    Abstract: To evaluate the potential ecotoxicity of ethiprole and early warning to earthworms (Eisenia fetida), different concentrations (0 mg· ... ...

    Abstract To evaluate the potential ecotoxicity of ethiprole and early warning to earthworms (Eisenia fetida), different concentrations (0 mg·kg
    Language English
    Publishing date 2024-03-22
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-024-32964-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 5915: Show issues

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  6. Article ; Online: Bacteriophage protein PEIP is a potent Bacillus subtilis enolase inhibitor

    Kaining Zhang / Shanshan Li / Yawen Wang / Zhihao Wang / Nancy Mulvenna / Hang Yang / Peipei Zhang / Huan Chen / Yan Li / Hongliang Wang / Yongxiang Gao / Sivaramesh Wigneshweraraj / Steve Matthews / Kaiming Zhang / Bing Liu

    Cell Reports, Vol 40, Iss 1, Pp 111026- (2022)

    2022  

    Abstract: ... inhibitors are of great interest. Here, we report that Gp60, a phage-encoded enolase inhibitor protein (PEIP ... of bacteriophage SPO1 for Bacillus subtilis, is an enolase inhibitor. PEIP-expressing bacteria exhibit growth ... We solve the structure of PEIP-enolase tetramer and show that PEIP disassembles enolase by disrupting ...

    Abstract Summary: Enolase is a highly conserved enzyme that presents in all organisms capable of glycolysis or fermentation. Its immediate product phosphoenolpyruvate is essential for other important processes like peptidoglycan synthesis and the phosphotransferase system in bacteria. Therefore, enolase inhibitors are of great interest. Here, we report that Gp60, a phage-encoded enolase inhibitor protein (PEIP) of bacteriophage SPO1 for Bacillus subtilis, is an enolase inhibitor. PEIP-expressing bacteria exhibit growth attenuation, thinner cell walls, and safranin color in Gram staining owing to impaired peptidoglycan synthesis. We solve the structure of PEIP-enolase tetramer and show that PEIP disassembles enolase by disrupting the basic dimer unit. The structure reveals that PEIP does not compete for substrate binding but induces a cascade of conformational changes that limit accessibility to the enolase catalytic site. This phage-inspired disassembly of enolase represents an alternative strategy for the development of anti-microbial drugs.
    Keywords CP: Microbiology ; Biology (General) ; QH301-705.5
    Subject code 500
    Language English
    Publishing date 2022-07-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Article: Driving forces shaping the microbial ecology in meat packing plants.

    Yang, Xianqin / Narvaez-Bravo, Claudia / Zhang, Peipei

    Frontiers in microbiology

    2024  Volume 14, Page(s) 1333696

    Abstract: Meat production is a complex system, continually receiving animals, water, air, and workers, all of which serve as carriers of bacteria. Selective pressures involved in different meat processing stages such as antimicrobial interventions and low ... ...

    Abstract Meat production is a complex system, continually receiving animals, water, air, and workers, all of which serve as carriers of bacteria. Selective pressures involved in different meat processing stages such as antimicrobial interventions and low temperatures, may promote the accumulation of certain residential microbiota in meat cutting facilities. Bacteria including human pathogens from all these sources can contaminate meat surfaces. While significant advancements have been made in enhancing hygienic standards and pathogen control measures in meat plants, resulting in a notable reduction in STEC recalls and clinical cases, STEC still stands as a predominant contributor to foodborne illnesses associated with beef and occasionally with pork. The second-and third-generation sequencing technology has become popular in microbiota related studies and provided a better image of the microbial community in the meat processing environments. In this article, we reviewed the potential factors influencing the microbial ecology in commercial meat processing facilities and conducted a meta-analysis on the microbiota data published in the last 10 years. In addition, the mechanisms by which bacteria persist in meat production environments have been discussed with a focus on the significant human pathogen
    Language English
    Publishing date 2024-01-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1333696
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: A Biomimetic Lignocellulose Aerogel-Based Membrane for Efficient Phenol Extraction from Water.

    Liu, Peipei / Zheng, Chunling / Yao, Zhong / Zhang, Fang

    Gels (Basel, Switzerland)

    2024  Volume 10, Issue 1

    Abstract: Rapid extraction and concentration systems based on green materials such as cellulose or lignin are promising. However, there is still a need to optimize the material properties and production processes. Unlike conventional cellulose or lignin sorbent ... ...

    Abstract Rapid extraction and concentration systems based on green materials such as cellulose or lignin are promising. However, there is still a need to optimize the material properties and production processes. Unlike conventional cellulose or lignin sorbent materials, aquatic reed root cells can concentrate external organic pollutants in the water and accumulate them in the plant. Inspired by this, a new nanocellulose-lignin aerogel (NLAG) was designed, in which nanocellulose was used as a substrate and lignin and polyamide epoxy chloropropane were used to crosslink cellulose in order to enhance the strength of the NLGA, resulting in good mechanical stability and water-oil amphiphilic properties. In practical applications, the organic membrane on the NLAG can transport organic pollutants from water to the NLAG, where they are immobilized. This is evidenced by the fact that the aerogel can remove more than 93% of exogenous phenol within a few minutes, highly enriching it inside. In addition, the aerogel facilitates filtration and shape recovery for reuse. This work establishes a novel biopolymer-aerogel-based extraction system with the advantages of sustainability, high efficiency, stability, and easy detachability, which are hard for the traditional adsorbent materials to attain.
    Language English
    Publishing date 2024-01-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2813982-3
    ISSN 2310-2861 ; 2310-2861
    ISSN (online) 2310-2861
    ISSN 2310-2861
    DOI 10.3390/gels10010059
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Mitochondrial dysfunction in the pathophysiology of renal diseases.

    Guo, Yuxian / Che, Ruochen / Wang, Peipei / Zhang, Aihua

    American journal of physiology. Renal physiology

    2024  

    Abstract: Mitochondria are essential organelles in the human body, serving as the metabolic factory of the whole organism. When mitochondria are dysfunctional, it can affect all organs of the body. The kidney is rich in mitochondria, and its function is closely ... ...

    Abstract Mitochondria are essential organelles in the human body, serving as the metabolic factory of the whole organism. When mitochondria are dysfunctional, it can affect all organs of the body. The kidney is rich in mitochondria, and its function is closely related to the development of kidney diseases. Studying the relationship between mitochondria and kidney disease progression is of great interest. In the past decade, scientists have made inspiring progress in investigating the role of mitochondria in the pathophysiology of renal diseases. This article discusses various mechanisms for maintaining mitochondrial quality, including mitochondrial energetics, mitochondrial biogenesis, mitochondrial dynamics, mitochondrial DNA repair, mitochondrial proteolysis and UPR, mitochondrial autophagy, mitochondria-derived vesicles, and mitocytosis. The article also highlights the crosstalk between mitochondria and other organelles, with a focus on kidney diseases. Finally, the article concludes with an overview of mitochondrial-related clinical research.
    Language English
    Publishing date 2024-03-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00189.2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.89: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Case report: The diagnostic dilemma of indeterminate biliary strictures: report on two cases with a literature review.

    Meng, Chunyan / Wang, Jing / Zhang, Peipei / Wang, Bo

    Frontiers in oncology

    2024  Volume 14, Page(s) 1301937

    Abstract: Background: It is still a challenging problem for clinicians to explore the nature of the indeterminate biliary strictures (IBSs). Approximately 20% of biliary strictures remain undetermined after a thorough preoperative assessment.: Case presentation! ...

    Abstract Background: It is still a challenging problem for clinicians to explore the nature of the indeterminate biliary strictures (IBSs). Approximately 20% of biliary strictures remain undetermined after a thorough preoperative assessment.
    Case presentation: Here, we present two cases of indeterminate biliary strictures patients, whose cross- sectional imaging and endoscopic examination were nondiagnostic. The patients underwent exploratory laparotomy finally and were confirmed as malignancy. We also reviewed the recent reports in literatures regarding the evaluation of IBSs.
    Conclusions: Given the majority of the biliary strictures are malignancy, preoperative differentiation between benign and malignant is critical for choosing the best therapeutic regimen. Thus, close follow-up, multiple multidisciplinary discussion, and prompt surgical exploration are necessary for some difficult diagnostic cases.
    Language English
    Publishing date 2024-03-27
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2024.1301937
    Database MEDical Literature Analysis and Retrieval System OnLINE

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