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  1. Article ; Online: Benefit of OTC Formula Against COVID-19 Is Explained by Selection Bias.

    Hemilä, Harri

    Journal of evidence-based integrative medicine

    2021  Volume 26, Page(s) 2515690X211058417

    MeSH term(s) COVID-19 ; Humans ; Nonprescription Drugs ; SARS-CoV-2 ; Selection Bias
    Chemical Substances Nonprescription Drugs
    Language English
    Publishing date 2021-11-11
    Publishing country United States
    Document type Letter ; Comment
    ISSN 2515-690X
    ISSN (online) 2515-690X
    DOI 10.1177/2515690X211058417
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Benefit of OTC Formula Against COVID-19 Is Explained by Selection Bias

    Harri Hemilä

    Journal of Evidence-Based Integrative Medicine, Vol

    2021  Volume 26

    Keywords Other systems of medicine ; RZ201-999 ; Homeopathy ; RX1-681
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher SAGE Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Concerns with the revised Japanese recommendation for administering vitamin C to septic patients.

    Hemilä, Harri / Chalker, Elizabeth

    Journal of intensive care

    2023  Volume 11, Issue 1, Page(s) 52

    Language English
    Publishing date 2023-11-13
    Publishing country England
    Document type Letter
    ZDB-ID 2739853-5
    ISSN 2052-0492
    ISSN 2052-0492
    DOI 10.1186/s40560-023-00702-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Cochrane has not consistently followed the COPE guidelines.

    Hemilä, Harri

    European journal of clinical investigation

    2020  Volume 50, Issue 4, Page(s) e13216

    MeSH term(s) Guidelines as Topic ; Humans ; Scientific Misconduct ; Systematic Reviews as Topic
    Language English
    Publishing date 2020-03-17
    Publishing country England
    Document type Letter
    ZDB-ID 186196-7
    ISSN 1365-2362 ; 0014-2972 ; 0960-135X
    ISSN (online) 1365-2362
    ISSN 0014-2972 ; 0960-135X
    DOI 10.1111/eci.13216
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 677: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article: Response: Commentary: Quantile treatment effect of zinc lozenges on common cold duration: a novel approach to analyze the effect of treatment on illness duration.

    Hemilä, Harri / Chalker, Elizabeth / Tukiainen, Janne

    Frontiers in pharmacology

    2024  Volume 15, Page(s) 1335784

    Language English
    Publishing date 2024-04-09
    Publishing country Switzerland
    Document type Journal Article ; Comment
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2024.1335784
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Vitamin E and Mortality in Male Smokers of the ATBC Study: Implications for Nutritional Recommendations.

    Hemilä, Harri

    Frontiers in nutrition

    2020  Volume 7, Page(s) 36

    Abstract: The Dietary Reference Intakes (DRI)-monograph (USA/Canada) states that the estimated average requirement (EAR) of vitamin E for men and women of any age is 12 mg/day. The EAR value is based ... ...

    Abstract The Dietary Reference Intakes (DRI)-monograph (USA/Canada) states that the estimated average requirement (EAR) of vitamin E for men and women of any age is 12 mg/day. The EAR value is based on
    Language English
    Publishing date 2020-03-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2020.00036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Zinc and Coronavirus Disease 2019.

    Hemilä, Harri / Chalker, Elizabeth

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2023  Volume 76, Issue 10, Page(s) 1865–1866

    MeSH term(s) Humans ; COVID-19 ; Zinc ; SARS-CoV-2
    Chemical Substances Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2023-02-13
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciad078
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1505: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 480: Show issues

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  8. Article ; Online: The effect of β-carotene on the mortality of male smokers is modified by smoking and by vitamins C and E: evidence against a uniform effect of nutrient.

    Hemilä, Harri

    Journal of nutritional science

    2020  Volume 9, Page(s) e11

    Abstract: A previous analysis of the Alpha-Tocopherol Beta-Carotene (ATBC) Study on male smokers found that β-carotene supplementation increased the risk of pneumonia 4-fold in those who started smoking at the age of ≥21 years and smoked ≥21 cigarettes/d (a ... ...

    Abstract A previous analysis of the Alpha-Tocopherol Beta-Carotene (ATBC) Study on male smokers found that β-carotene supplementation increased the risk of pneumonia 4-fold in those who started smoking at the age of ≥21 years and smoked ≥21 cigarettes/d (a subgroup of 7 % of the study population). The present study hypothesised that β-carotene increases mortality in the same subgroup. The ATBC Study (1985-1993) recruited 29 133 Finnish male smokers (≥5 cigarettes/d) aged 50-69 years. Cox regression models were constructed to estimate the effect of β-carotene supplementation in subgroups. β-Carotene increased mortality (risk ratio 1·56; 95 % CI 1·06, 2·3) in those who started to smoke at ≥21 years and smoked ≥21 cigarettes/d. Within this subgroup, there was strong evidence of further heterogeneity. The effect of β-carotene supplementation was further modified by dietary vitamin C intake, fruit and vegetable intake (
    MeSH term(s) Aged ; Antioxidants/pharmacology ; Ascorbic Acid/pharmacology ; Cohort Studies ; Diet ; Dietary Supplements ; Fruit ; Humans ; Male ; Middle Aged ; Nutrients ; Odds Ratio ; Oxidative Stress ; Pneumonia ; Smokers ; Tobacco Smoking/mortality ; Tobacco Smoking/prevention & control ; Vegetables ; Vitamin E/pharmacology ; Young Adult ; alpha-Tocopherol ; beta Carotene/pharmacology
    Chemical Substances Antioxidants ; beta Carotene (01YAE03M7J) ; Vitamin E (1406-18-4) ; alpha-Tocopherol (H4N855PNZ1) ; Ascorbic Acid (PQ6CK8PD0R)
    Language English
    Publishing date 2020-03-11
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 2656288-1
    ISSN 2048-6790 ; 2048-6790
    ISSN (online) 2048-6790
    ISSN 2048-6790
    DOI 10.1017/jns.2020.3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Random-Effects Assumption in Meta-analyses.

    Hemilä, Harri

    JAMA

    2019  Volume 322, Issue 1, Page(s) 81

    MeSH term(s) Computer Simulation ; Models, Statistical
    Language English
    Publishing date 2019-07-02
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2019.5439
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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.88: Show issues Location:
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  10. Article ; Online: Vitamin C reduces the severity of common colds: a meta-analysis.

    Hemilä, Harri / Chalker, Elizabeth

    BMC public health

    2023  Volume 23, Issue 1, Page(s) 2468

    Abstract: Background: Randomized trials have shown that vitamin C shortens the duration of common colds. Some trials reported greater effects on severe cold symptoms compared with mild symptoms. This review systematically compares the effects of vitamin C on ... ...

    Abstract Background: Randomized trials have shown that vitamin C shortens the duration of common colds. Some trials reported greater effects on severe cold symptoms compared with mild symptoms. This review systematically compares the effects of vitamin C on severe and mild common cold symptoms.
    Methods: We included all placebo-controlled trials of orally administered vitamin C in doses of at least 1 g/day for the common cold for people in good health at baseline. The analysis was restricted to trials which reported both the total duration of the common cold, and the severity of the common cold measured using severity scales, the duration of more severe stages of the cold, or proxies for severe colds such as days indoors. Findings were pooled using the inverse variance, fixed effect options of the metacont function of the R package meta to calculate the ratio of means estimate.
    Results: Fifteen comparisons from 10 trials which reported both mild and severe symptoms were identified. All trials were randomized and double-blind. Compared to placebo, vitamin C significantly decreased the severity of the common cold by 15% (95% CI 9-21%). The direct comparison of the effect of vitamin C on mild and severe symptoms was limited to five comparisons which found that vitamin C had a significant benefit on the duration of severe symptoms. In this subset, there was a significant difference in the size of the effect of vitamin C on the overall duration of colds versus the duration of severe colds (P = 0.002), and vitamin C had no significant effect on the duration of mild symptoms.
    Conclusions: The common cold is the leading cause of acute morbidity and a major cause of absenteeism from work and school. However, absenteeism is dependent on the severity of symptoms. The finding that vitamin C may have a greater effect on more severe measures of the common cold is therefore important. Further research on the therapeutic effects of vitamin C on the common cold should measure outcomes of differing levels of severity.
    MeSH term(s) Humans ; Common Cold/drug therapy ; Ascorbic Acid/therapeutic use ; Vitamins/therapeutic use ; Double-Blind Method ; Absenteeism ; Randomized Controlled Trials as Topic
    Chemical Substances Ascorbic Acid (PQ6CK8PD0R) ; Vitamins
    Language English
    Publishing date 2023-12-11
    Publishing country England
    Document type Meta-Analysis ; Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041338-5
    ISSN 1471-2458 ; 1471-2458
    ISSN (online) 1471-2458
    ISSN 1471-2458
    DOI 10.1186/s12889-023-17229-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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