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  1. Article ; Online: Draft genome sequence including the capsule operon of a

    Okutani, Akiko / Okugawa, Shu / Fujimoto, Fumie / Ikeda, Mahoko / Tsutsumi, Takeya / Moriya, Kyoji / Maeda, Ken

    Microbiology resource announcements

    2024  Volume 13, Issue 2, Page(s) e0076623

    Abstract: ... Bacillus ... ...

    Abstract Bacillus cereus
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/MRA.00766-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Comparison of phylogenetic and virulence factors between

    Ikeda, Mahoko / Kobayashi, Tatsuya / Okugawa, Shu / Fujimoto, Fumie / Okada, Yuta / Tatsuno, Keita / Higurashi, Yoshimi / Tsutsumi, Takeya / Moriya, Kyoji

    Heliyon

    2023  Volume 9, Issue 11, Page(s) e21748

    Abstract: Escherichia ... ...

    Abstract Escherichia coli
    Language English
    Publishing date 2023-10-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e21748
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: [Bone metabolism and aging].

    Ikeda, Kyoji

    Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics

    2013  Volume 50, Issue 2, Page(s) 211–212

    MeSH term(s) Aging/physiology ; Animals ; Bone Remodeling/physiology ; Bone and Bones/metabolism ; Humans ; Mice ; Rats
    Language Japanese
    Publishing date 2013-05-01
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 604107-3
    ISSN 0300-9173
    ISSN 0300-9173
    DOI 10.3143/geriatrics.50.211
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: [Renin-aldosterone and bone metabolism].

    Ikeda, Kyoji

    Clinical calcium

    2014  Volume 24, Issue 6, Page(s) 885–891

    Abstract: Among the components of the renin-angiotensin-aldosterone (RAAS) system, which controls blood pressure as well as fluid and electrolyte balance, renin, angiotensin II and its receptors AT1/2, and aldosterone and the mineralocorticoid receptor have been ... ...

    Abstract Among the components of the renin-angiotensin-aldosterone (RAAS) system, which controls blood pressure as well as fluid and electrolyte balance, renin, angiotensin II and its receptors AT1/2, and aldosterone and the mineralocorticoid receptor have been exploited as targets of drug development. Accumulating evidence suggests that the RAAS is linked, through a systemic/endocrine as well as a local loop, to inflammation, oxidative stress, cardiovascular and renal injury, and calcium and bone metabolism.
    MeSH term(s) Acute Kidney Injury/genetics ; Aldosterone/physiology ; Angiotensin II/physiology ; Animals ; Bone and Bones/metabolism ; Calcium/metabolism ; Cardiovascular Diseases/genetics ; Drug Discovery ; Humans ; Hypertension/drug therapy ; Hypertension/genetics ; Inflammation/genetics ; Molecular Targeted Therapy ; Osteoporosis/drug therapy ; Osteoporosis/genetics ; Oxidative Stress/genetics ; Receptor, Angiotensin, Type 1/physiology ; Receptor, Angiotensin, Type 2/physiology ; Receptors, Mineralocorticoid/physiology ; Renin/physiology ; Renin-Angiotensin System/physiology
    Chemical Substances Receptor, Angiotensin, Type 1 ; Receptor, Angiotensin, Type 2 ; Receptors, Mineralocorticoid ; Angiotensin II (11128-99-7) ; Aldosterone (4964P6T9RB) ; Renin (EC 3.4.23.15) ; Calcium (SY7Q814VUP)
    Language Japanese
    Publishing date 2014-06
    Publishing country Japan
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 2386417-5
    ISSN 0917-5857
    ISSN 0917-5857
    DOI CliCa1406885891
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: [Skeletal aging].

    Ikeda, Kyoji

    Clinical calcium

    2013  Volume 23, Issue 1, Page(s) 11–14

    Abstract: Skeletal aging means aging of calcified bone matrix. Although calcification is an essential part of bone formation and its strength, in case of calcium deficiency, calcium is mobilized from bone at the expense of skeletal integrity. The quality as well ... ...

    Abstract Skeletal aging means aging of calcified bone matrix. Although calcification is an essential part of bone formation and its strength, in case of calcium deficiency, calcium is mobilized from bone at the expense of skeletal integrity. The quality as well as quantity of bone matrix is maintained through remodeling activity collaboratively performed by osteoclasts, osteoblasts and osteocytes, and remodeling disorder results in compromised bone strength. Energy homeostasis and vascular system are also closely linked with bone metabolism.
    MeSH term(s) Aging ; Animals ; Bone Matrix/metabolism ; Bone Remodeling/physiology ; Bone and Bones/cytology ; Bone and Bones/metabolism ; Calcification, Physiologic/physiology ; Calcium/metabolism ; Humans
    Chemical Substances Calcium (SY7Q814VUP)
    Language Japanese
    Publishing date 2013-01
    Publishing country Japan
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 2386417-5
    ISSN 0917-5857
    ISSN 0917-5857
    DOI CliCa13011114
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: [Characteristics and limitations of animal models for bone and joint diseases].

    Ikeda, Kyoji

    Clinical calcium

    2011  Volume 21, Issue 2, Page(s) 163

    MeSH term(s) Animals ; Bone Diseases ; Disease Models, Animal ; Humans ; Joint Diseases ; Mice ; Rats
    Language Japanese
    Publishing date 2011-02
    Publishing country Japan
    Document type Introductory Journal Article
    ZDB-ID 2386417-5
    ISSN 0917-5857
    ISSN 0917-5857
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: [Mitochondrial function in bone resorption and formation].

    Ikeda, Kyoji

    Nihon rinsho. Japanese journal of clinical medicine

    2011  Volume 69, Issue 7, Page(s) 1203–1208

    Abstract: Mitochondria are involved in diverse biological processes through energy production, ROS generation and apoptosis, and mitochondrial dysfunction causes metabolic disorders, neurodegenerative disease, cancer and aging. Recent evidence links mitochondrial ... ...

    Abstract Mitochondria are involved in diverse biological processes through energy production, ROS generation and apoptosis, and mitochondrial dysfunction causes metabolic disorders, neurodegenerative disease, cancer and aging. Recent evidence links mitochondrial function to bone cell activity, especially bone-resorbing ostroclasts. Mitochondria of bone cells may provide a clue to the understanding of the pathogenesis of bone disease and also for development of new treatment options.
    MeSH term(s) Animals ; Bone Resorption/physiopathology ; Humans ; Mice ; Mitochondria/physiology ; Osteoclasts/physiology ; Osteogenesis/physiology
    Language Japanese
    Publishing date 2011-07
    Publishing country Japan
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 390903-7
    ISSN 0047-1852
    ISSN 0047-1852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: [Animal models for bone and joint disease. Rodent models of natural aging].

    Ikeda, Kyoji

    Clinical calcium

    2011  Volume 21, Issue 2, Page(s) 217–223

    Abstract: This review summarizes changes in bone mass and metabolism during natural aging of C57BL/6J mice and F344/N rats, as models of senile osteoporosis. The effects of caloric restriction, an evolutionally conserved remedy known to slow aging process and ... ...

    Abstract This review summarizes changes in bone mass and metabolism during natural aging of C57BL/6J mice and F344/N rats, as models of senile osteoporosis. The effects of caloric restriction, an evolutionally conserved remedy known to slow aging process and counter age-related disorders, on bone metabolism are also discussed.
    MeSH term(s) Aging/metabolism ; Animals ; Bone Density ; Bone and Bones/metabolism ; Caloric Restriction ; Disease Models, Animal ; Humans ; Mice ; Mice, Inbred C57BL ; Osteoporosis/etiology ; Osteoporosis/metabolism ; Rats ; Rats, Inbred F344
    Language Japanese
    Publishing date 2011-02
    Publishing country Japan
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 2386417-5
    ISSN 0917-5857
    ISSN 0917-5857
    DOI CliCa1102217223
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Pre-Transplant Seroprevalence, Associated Factors, and Post-Transplant Incidence of Toxoplasma gondii Infection Among Heart Transplant Recipients in Japan.

    Kanno, Yoshiaki / Okamoto, Koh / Shinohara, Takayuki / Kinoshita, Osamu / Hatano, Masaru / Ikeda, Mahoko / Harada, Sohei / Okugawa, Shu / Moriya, Kyoji / Ono, Minoru / Tsutsumi, Takeya

    Transplantation proceedings

    2024  Volume 56, Issue 1, Page(s) 148–152

    Abstract: Background: Among solid organ transplant (SOT) recipients, heart transplant (HT) recipients are at a higher risk of Toxoplasma gondii infection. As Toxoplasma seroprevalence varies by geographic location, updated local epidemiology is essential to guide ...

    Abstract Background: Among solid organ transplant (SOT) recipients, heart transplant (HT) recipients are at a higher risk of Toxoplasma gondii infection. As Toxoplasma seroprevalence varies by geographic location, updated local epidemiology is essential to guide preventive and therapeutic strategies. However, the Toxoplasma seroprevalence and incidence of post-transplant toxoplasmosis among SOT recipients in Japan are unknown.
    Methods: We performed a single-center retrospective observational study at an HT center in Tokyo, Japan. All HT recipients aged ≥18 years between 2006 and April 2019 were included. We reviewed patient charts and conducted a questionnaire survey to investigate the risk factors for infection.
    Results: Among 105 recipients included in the study, 11 (10.5%) were seropositive before transplant. Ninety-five recipients (90.5%), including all pre-transplant seropositive recipients, answered the questionnaire. The recipients who had lived in Okinawa (odds ratio [OR] 7.5 [95% CI 1.42-39.61]; P = .032) and who reported raw-meat eating habits (OR 4.64 [95% CI 1.04-23.3]; P = .021) were more likely to be seropositive. None of the patients developed symptoms of toxoplasmosis. The post-transplant incidence of other major adverse outcomes was not significantly different according to the pre-transplant serostatus.
    Conclusions: About 10% of HT recipients at an HT center in Tokyo were seropositive for Toxoplasma pre-transplant, and none developed symptomatic toxoplasmosis post-transplant on trimethoprim-sulfamethoxazole. The history of raw meat consumption was associated with seropositivity; therefore, avoiding it might be recommended for HT recipient candidates.
    MeSH term(s) Adolescent ; Adult ; Humans ; Heart Transplantation/adverse effects ; Incidence ; Japan/epidemiology ; Risk Factors ; Seroepidemiologic Studies ; Toxoplasma ; Toxoplasmosis/diagnosis ; Toxoplasmosis/epidemiology ; Toxoplasmosis/etiology ; Transplant Recipients ; Retrospective Studies
    Language English
    Publishing date 2024-01-04
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 82046-5
    ISSN 1873-2623 ; 0041-1345
    ISSN (online) 1873-2623
    ISSN 0041-1345
    DOI 10.1016/j.transproceed.2023.11.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Nafamostat mesylate treatment in combination with favipiravir for patients critically ill with Covid-19: a case series.

    Doi, Kent / Ikeda, Mahoko / Hayase, Naoki / Moriya, Kyoji / Morimura, Naoto

    Critical care (London, England)

    2020  Volume 24, Issue 1, Page(s) 392

    MeSH term(s) Aged ; Amides/therapeutic use ; Benzamidines ; Coronavirus Infections/drug therapy ; Critical Illness ; Drug Therapy, Combination ; Female ; Guanidines/therapeutic use ; Humans ; Male ; Middle Aged ; Pyrazines/therapeutic use ; Treatment Outcome ; COVID-19 Drug Treatment
    Chemical Substances Amides ; Benzamidines ; Guanidines ; Pyrazines ; favipiravir (EW5GL2X7E0) ; nafamostat (Y25LQ0H97D)
    Keywords covid19
    Language English
    Publishing date 2020-07-03
    Publishing country England
    Document type Letter
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-020-03078-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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