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  1. Article ; Online: The Integral Role of Magnesium in Muscle Integrity and Aging: A Comprehensive Review.

    Souza, Ana Carolina Remondi / Vasconcelos, Andrea Rodrigues / Dias, Denise Deo / Komoni, Geovana / Name, José João

    Nutrients

    2023  Volume 15, Issue 24

    Abstract: Aging is characterized by significant physiological changes, with the degree of decline varying significantly among individuals. The preservation of intrinsic capacity over the course of an individual's lifespan is fundamental for healthy aging. ... ...

    Abstract Aging is characterized by significant physiological changes, with the degree of decline varying significantly among individuals. The preservation of intrinsic capacity over the course of an individual's lifespan is fundamental for healthy aging. Locomotion, which entails the capacity for independent movement, is intricately connected with various dimensions of human life, including cognition, vitality, sensory perception, and psychological well-being. Notably, skeletal muscle functions as a pivotal nexus within this intricate framework. Any perturbation in its functionality can manifest as compromised physical performance and an elevated susceptibility to frailty. Magnesium is an essential mineral that plays a central role in approximately 800 biochemical reactions within the human body. Its distinctive physical and chemical attributes render it an indispensable stabilizing factor in the orchestration of diverse cellular reactions and organelle functions, thereby rendering it irreplaceable in processes directly impacting muscle health. This narrative review offers a comprehensive exploration of the pivotal role played by magnesium in maintaining skeletal muscle integrity, emphasizing the critical importance of maintaining optimal magnesium levels for promoting healthy aging.
    MeSH term(s) Humans ; Magnesium ; Sarcopenia ; Aging/physiology ; Muscle, Skeletal/physiology ; Minerals
    Chemical Substances Magnesium (I38ZP9992A) ; Minerals
    Language English
    Publishing date 2023-12-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15245127
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Vitamin D, zinc and glutamine: Synergistic action with OncoTherad immunomodulator in interferon signaling and COVID‑19 (Review).

    Name, José João / Vasconcelos, Andrea Rodrigues / Souza, Ana Carolina Remondi / Fávaro, Wagner José

    International journal of molecular medicine

    2021  Volume 47, Issue 3

    Abstract: Coronavirus disease 2019 (COVID‑19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2), was identified in December, 2019 in Wuhan, China. Since then, it has continued to spread rapidly in numerous countries, while the search for ... ...

    Abstract Coronavirus disease 2019 (COVID‑19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2), was identified in December, 2019 in Wuhan, China. Since then, it has continued to spread rapidly in numerous countries, while the search for effective therapeutic options persists. Coronaviruses, including SARS‑CoV‑2, are known to suppress and evade the antiviral responses of the host organism mediated by interferon (IFN), a family of cytokines that plays an important role in antiviral defenses associated with innate immunity, and has been used therapeutically for chronic viral diseases and cancer. On the other hand, OncoTherad, a safe and effective immunotherapeutic agent in the treatment of non‑muscle invasive bladder cancer (NMIBC), increases IFN signaling and has been shown to be a promising therapeutic approach for COVID‑19 in a case report that described the rapid recovery of a 78‑year‑old patient with NMIBC with comorbidities. The present review discusses the possible synergistic action of OncoTherad with vitamin D, zinc and glutamine, nutrients that have been shown to facilitate immune responses mediated by IFN signaling, as well as the potential of this combination as a therapeutic option for COVID‑19.
    MeSH term(s) Aged ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; COVID-19/metabolism ; Comorbidity ; Drug Synergism ; Glutamine/pharmacology ; Glycoproteins/pharmacology ; Glycoproteins/therapeutic use ; Humans ; Immunity, Innate/drug effects ; Immunologic Factors/pharmacology ; Immunologic Factors/therapeutic use ; Interferons/metabolism ; Male ; Phosphates/pharmacology ; Phosphates/therapeutic use ; Urinary Bladder Calculi/drug therapy ; Urinary Bladder Calculi/epidemiology ; Vitamin D/pharmacology ; Zinc/pharmacology
    Chemical Substances Antiviral Agents ; Glycoproteins ; Immunologic Factors ; MRB-CFI-1 ; Phosphates ; Glutamine (0RH81L854J) ; Vitamin D (1406-16-2) ; Interferons (9008-11-1) ; Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2021-01-15
    Publishing country Greece
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 1444428-8
    ISSN 1791-244X ; 1107-3756
    ISSN (online) 1791-244X
    ISSN 1107-3756
    DOI 10.3892/ijmm.2021.4844
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4942: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Zinc, Vitamin D and Vitamin C: Perspectives for COVID-19 With a Focus on Physical Tissue Barrier Integrity.

    Name, José João / Souza, Ana Carolina Remondi / Vasconcelos, Andrea Rodrigues / Prado, Pietra Sacramento / Pereira, Carolina Parga Martins

    Frontiers in nutrition

    2020  Volume 7, Page(s) 606398

    Abstract: Some nutrients play key roles in maintaining the integrity and function of the immune system, presenting synergistic actions in steps determinant for the immune response. Among these elements, zinc and vitamins C and D stand out for having ... ...

    Abstract Some nutrients play key roles in maintaining the integrity and function of the immune system, presenting synergistic actions in steps determinant for the immune response. Among these elements, zinc and vitamins C and D stand out for having immunomodulatory functions and for playing roles in preserving physical tissue barriers. Considering the COVID-19 pandemic, nutrients that can optimize the immune system to prevent or lower the risk of severe progression and prognosis of this viral infection become relevant. Thus, the present review aims to provide a comprehensive overview of the roles of zinc and vitamins C and D in the immune response to viral infections, focusing on the synergistic action of these nutrients in the maintenance of physical tissue barriers, such as the skin and mucous membranes. The evidence found in the literature shows that deficiency of one or more of these three elements compromises the immune response, making an individual more vulnerable to viral infections and to a worse disease prognosis. Thus, during the COVID-19 pandemic, the adequate intake of zinc and vitamins C and D may represent a promising pharmacological tool due to the high demand for these nutrients in the case of contact with the virus and onset of the inflammatory process. Ongoing clinical trials will help to clarify the role of these nutrients for COVID-19 management.
    Language English
    Publishing date 2020-12-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2020.606398
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Antioxidant and anti‑inflammatory mechanisms of action of astaxanthin in cardiovascular diseases (Review).

    Pereira, Carolina Parga Martins / Souza, Ana Carolina Remondi / Vasconcelos, Andrea Rodrigues / Prado, Pietra Sacramento / Name, José João

    International journal of molecular medicine

    2020  Volume 47, Issue 1, Page(s) 37–48

    Abstract: Cardiovascular diseases are the most common cause of mortality worldwide. Oxidative stress and inflammation are pathophysiological processes involved in the development of cardiovascular diseases; thus, anti‑inflammatory and antioxidant agents that ... ...

    Abstract Cardiovascular diseases are the most common cause of mortality worldwide. Oxidative stress and inflammation are pathophysiological processes involved in the development of cardiovascular diseases; thus, anti‑inflammatory and antioxidant agents that modulate redox balance have become research targets so as to evaluate their molecular mechanisms of action and therapeutic properties. Astaxanthin, a carotenoid of the xanthophyll group, has potent antioxidant properties due to its molecular structure and its arrangement in the plasma membrane, factors that favor the neutralization of reactive oxygen and nitrogen species. This carotenoid also has prominent anti‑inflammatory activity, possibly interrelated with its antioxidant effect, and is also involved in the modulation of lipid and glucose metabolism. Considering the potential beneficial effects of astaxanthin on cardiovascular health evidenced by preclinical and clinical studies, the aim of the present review was to describe the molecular and cellular mechanisms associated with the antioxidant and anti‑inflammatory properties of this carotenoid in cardiovascular diseases, particularly atherosclerosis. The beneficial properties and safety profile of astaxanthin indicate that this compound may be used for preventing progression or as an adjuvant in the treatment of cardiovascular diseases.
    MeSH term(s) Antioxidants/therapeutic use ; Cardiovascular Diseases/metabolism ; Cardiovascular Diseases/prevention & control ; Glucose/metabolism ; Humans ; Lipid Metabolism/drug effects ; Xanthophylls/therapeutic use
    Chemical Substances Antioxidants ; Xanthophylls ; astaxanthine (8XPW32PR7I) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2020-11-04
    Publishing country Greece
    Document type Journal Article ; Review
    ZDB-ID 1444428-8
    ISSN 1791-244X ; 1107-3756
    ISSN (online) 1791-244X
    ISSN 1107-3756
    DOI 10.3892/ijmm.2020.4783
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4942: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Iron Bisglycinate Chelate and Polymaltose Iron for the Treatment of Iron Deficiency Anemia: A Pilot Randomized Trial.

    Name, José João / Vasconcelos, Añdrea Rodrigues / Valzachi Rocha Maluf, Maria Cristina

    Current pediatric reviews

    2018  Volume 14, Issue 4, Page(s) 261–268

    Abstract: Background: Iron Deficiency Anemia (IDA) is a major public health problem worldwide. Iron Bisglycinate Chelate (FeBC) and polymaltose iron (FeP) are used for the treatment of IDA and exhibit good tolerability with a low incidence of adverse effects. ... ...

    Abstract Background: Iron Deficiency Anemia (IDA) is a major public health problem worldwide. Iron Bisglycinate Chelate (FeBC) and polymaltose iron (FeP) are used for the treatment of IDA and exhibit good tolerability with a low incidence of adverse effects. However, these compounds have important differences in their structures and bioavailability.
    Objective: To compare the efficacy of oral supplementation with FeBC and FeP in anemic children.
    Methods: In this double-blind study, children aged 1 to 13 years who were diagnosed with IDA were randomly divided into two groups: i) FeBC, supplemented with iron bisglycinate chelate, and ii) FeP, supplemented with polymaltose iron (3.0 mg iron/kg body weight/day for 45 days for both groups).
    Results: Both treatments resulted in significant increases in hemoglobin levels, Mean Corpuscular Volume (MCV) and Cell Distribution Width (RDW) and in a reduction of transferrin levels, relative to initial values. However, only FeBC treatment significantly increased ferritin and Mean Corpuscular Hemoglobin (MCH) levels. A significant negative correlation was observed between the increase in ferritin and initial hemoglobin levels in the FeBC group, indicating that the absorption of FeBC is regulated by the body iron demand.
    Conclusion: These results provide preliminary evidence to suggest a greater efficacy of FeBC than FeP in increasing iron stores.
    MeSH term(s) Adolescent ; Anemia, Iron-Deficiency/drug therapy ; Child ; Child, Preschool ; Dietary Supplements/adverse effects ; Double-Blind Method ; Erythrocyte Indices/drug effects ; Ferric Compounds/therapeutic use ; Ferritins/blood ; Hematinics/therapeutic use ; Hemoglobins/analysis ; Humans ; Infant ; Iron/therapeutic use ; Pilot Projects ; Transferrin/analysis ; Treatment Outcome
    Chemical Substances Ferric Compounds ; Hematinics ; Hemoglobins ; Transferrin ; Ferritins (9007-73-2) ; Iron (E1UOL152H7) ; teferrol (UM5219H89V)
    Language English
    Publishing date 2018-10-02
    Publishing country United Arab Emirates
    Document type Clinical Trial ; Randomized Controlled Trial
    ISSN 1875-6336
    ISSN (online) 1875-6336
    DOI 10.2174/1573396314666181002170040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Vitamin D, Zinc and Glutamine

    Name, José João / Rodrigues Vasconcelos, Andrea / Remondi Souza, Ana Carolina / Favaro, Wagner

    SSRN Electronic Journal ; ISSN 1556-5068

    Synergistic Action with OncoTherad Immunomodulator in Interferon Signaling and COVID-19

    2020  

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.2139/ssrn.3650249
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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