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Book ; Online: New Insights into Antithrombotic Therapy for Cardio- and Cerebrovascular Disease: From Molecular Mechanisms to Clinical Application

Cimmino, Giovanni / Cirillo, Plinio

2023

Keywords	Medicine ; Clinical & internal medicine ; P2Y12 inhibitor ; monotherapy ; percutaneous coronary intervention ; dual antiplatelet therapy ; high bleeding risk ; high on-treatment platelet reactivity ; randomized controlled trial ; left atrial appendage thrombus ; atrial fibrillation ; stroke ; oral anticoagulant ; cardiovascular diseases ; novel antithrombotic agents ; antiplatelet drugs ; anticoagulants ; hemostasis ; factor XI ; factor XI inhibitor ; thrombosis ; new drugs ; left ventricular thrombus ; anticoagulation ; anterior wall myocardial infarction ; dual therapy ; direct oral anticoagulants ; surface plasmon resonance ; metformin ; matrix metalloproteinase-9 ; plaque instability ; atherosclerosis ; cancer ; acute coronary syndrome (ACS) ; percutaneous coronary intervention (PCI) ; dual antiplatelet therapy (DAPT) ; triple antithrombotic therapy (TAT) ; atrial fibrillation (AF) ; cardiotoxicity ; aspirin ; coronary artery disease ; cerebrovascular disease ; diabetes mellitus ; essential thrombocythemia ; platelet function ; thromboxane ; gastrointestinal bleeding ; enteric-coated aspirin ; cardiovascular prevention ; P2Y12 inhibitors ; acute coronary syndrome ; clopidogrel ; prasugrel ; ticagrelor ; cangrelor ; selatogrel ; zalunfiban ; peripheral artery disease (PAD) ; antithrombotic therapy ; dual pathway inhibition (DPI) ; major adverse cardiovascular events (MACE) ; major adverse limb events (MALE) ; n/a
Language	English
Size	1 electronic resource (188 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Publishing place	Basel
Document type	Book ; Online
Note	English
HBZ-ID	HT030382249
ISBN	9783036581170 ; 3036581170
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: New Insights into Antithrombotic Therapy for Cardio- and Cerebrovascular Disease: From Molecular Mechanisms to Clinical Application.

Cirillo, Plinio / Cimmino, Giovanni

Journal of cardiovascular development and disease

2023 Volume 10, Issue 6

Abstract: Thrombosis has a pivotal role in the pathophysiology of acute cardiovascular events such as myocardial infarction and stroke [ ... ]. ...

Abstract	Thrombosis has a pivotal role in the pathophysiology of acute cardiovascular events such as myocardial infarction and stroke [...].
Language	English
Publishing date	2023-06-14
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2777082-5
ISSN	2308-3425 ; 2308-3425
ISSN (online)	2308-3425
ISSN	2308-3425
DOI	10.3390/jcdd10060258
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Gastrointestinal Angiodysplasia before and after TAVR.

Natale, Francesco / Golino, Paolo / Cimmino, Giovanni

The New England journal of medicine

2024 Volume 390, Issue 1, Page(s) 95

MeSH term(s)	Humans ; Transcatheter Aortic Valve Replacement/adverse effects ; Gastrointestinal Hemorrhage/etiology ; Vascular Diseases ; Angiodysplasia/complications ; Angiodysplasia/diagnosis ; Aortic Valve Stenosis/surgery
Language	English
Publishing date	2024-01-01
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMc2313153
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Angiotensin-converting enzyme inhibitors, statins and the polypill in cardiovascular diseases prevention: ignorance is bliss or not?

Natale, Francesco / Golino, Paolo / Cimmino, Giovanni

Journal of hypertension

2024 Volume 42, Issue 4, Page(s) 746–748

Abstract: The polypill strategy, which combines several medicines that simultaneously control different risk factors/diseases in a single pill, is one of the approaches used in cardiovascular therapy. In different guidelines, this one-pill combination therapy is ... ...

Abstract	The polypill strategy, which combines several medicines that simultaneously control different risk factors/diseases in a single pill, is one of the approaches used in cardiovascular therapy. In different guidelines, this one-pill combination therapy is suggested as first-line step in disease management. Because the cardiovascular diseases (CVD) pandemia, prevention is essential. The approaches that could improve adherence are of great importance to achieve health, social and economical benefits. However, direct or indirect experience of adverse drug reaction is often the reason for discontinuation, with serious fatal and non-fatal consequences especially for a polypill. Angiotensin-converting enzyme inhibitors (ACEi) and statins are the most prescribed medications in CVD prevention. It is well known that both drugs may have adverse effects that induce discontinuation. Often, the personal awareness of these effects is a reason for self-discontinuation. In this study an analysis of the ACEi/statin awareness is reported. Is it potentially harmful for polypill?
MeSH term(s)	Humans ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Cardiovascular Diseases/prevention & control ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Combined Modality Therapy ; Disease Management
Chemical Substances	Angiotensin-Converting Enzyme Inhibitors ; Hydroxymethylglutaryl-CoA Reductase Inhibitors
Language	English
Publishing date	2024-02-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	605532-1
ISSN	1473-5598 ; 0263-6352 ; 0952-1178
ISSN (online)	1473-5598
ISSN	0263-6352 ; 0952-1178
DOI	10.1097/HJH.0000000000003687
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.MO 614: Show issues

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Article: The Color Encoding System used in Color-Doppler Echographic Imaging is Different from the Original Christian Doppler's Principles.

Natale, Francesco / Molinari, Riccardo / Covino, Simona / Golino, Paolo / Cimmino, Giovanni

Journal of cardiovascular echography

2023 Volume 32, Issue 4, Page(s) 229

Language	English
Publishing date	2023-01-23
Publishing country	India
Document type	Journal Article
ZDB-ID	2734045-4
ISSN	2347-193X ; 2211-4122
ISSN (online)	2347-193X
ISSN	2211-4122
DOI	10.4103/jcecho.jcecho_33_22
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Colchicine in Athero-Thrombosis: Molecular Mechanisms and Clinical Evidence.

Cimmino, Giovanni / Loffredo, Francesco S / De Rosa, Gennaro / Cirillo, Plinio

International journal of molecular sciences

2023 Volume 24, Issue 3

Abstract: Several lines of evidence have clearly indicated that inflammation plays a pivotal role in the development of atherosclerosis and of its thrombotic complications such as acute coronary syndromes or ischemic stroke. Thus, it has been postulated that the ... ...

Abstract	Several lines of evidence have clearly indicated that inflammation plays a pivotal role in the development of atherosclerosis and of its thrombotic complications such as acute coronary syndromes or ischemic stroke. Thus, it has been postulated that the use of anti-inflammatory agents might be extremely useful to improve cardiovascular outcome. Recently, increasing attention has been reserved to one of the oldest plant-derived drugs still in use in clinical practice, colchicine that has been used as drug to treat inflammatory diseases such gout or Mediterranean fever. To date, current guidelines of the European Society of Cardiology have included colchicine as first line choice for treatment of acute and recurrent pericarditis. Moreover, several studies have investigated its role in the clinical scenarios of cardiovascular disease including chronic and acute coronary syndromes with promising results. In this review, starting from a description of the mechanism(s) involved behind its anti-inflammatory effects, we give an overview on its potential effects in atherothrombosis and finally present an updated overview of clinical evidence on the role of this drug in cardiovascular disease.
MeSH term(s)	Humans ; Colchicine/therapeutic use ; Acute Coronary Syndrome/drug therapy ; Inflammation/drug therapy ; Pericarditis/drug therapy ; Thrombosis/drug therapy
Chemical Substances	Colchicine (SML2Y3J35T)
Language	English
Publishing date	2023-01-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24032483
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Mitochondrial Dysfunction: The Hidden Player in the Pathogenesis of Atherosclerosis?

Ciccarelli, Giovanni / Conte, Stefano / Cimmino, Giovanni / Maiorano, Patrizia / Morrione, Andrea / Giordano, Antonio

International journal of molecular sciences

2023 Volume 24, Issue 2

Abstract: Atherosclerosis is a multifactorial inflammatory pathology that involves metabolic processes. Improvements in therapy have drastically reduced the prognosis of cardiovascular disease. Nevertheless, a significant residual risk is still relevant, and is ... ...

Abstract	Atherosclerosis is a multifactorial inflammatory pathology that involves metabolic processes. Improvements in therapy have drastically reduced the prognosis of cardiovascular disease. Nevertheless, a significant residual risk is still relevant, and is related to unmet therapeutic targets. Endothelial dysfunction and lipid infiltration are the primary causes of atherosclerotic plaque progression. In this contest, mitochondrial dysfunction can affect arterial wall cells, in particular macrophages, smooth muscle cells, lymphocytes, and endothelial cells, causing an increase in reactive oxygen species (ROS), leading to oxidative stress, chronic inflammation, and intracellular lipid deposition. The detection and characterization of mitochondrial DNA (mtDNA) is crucial for assessing mitochondrial defects and should be considered the goal for new future therapeutic interventions. In this review, we will focus on a new idea, based on the analysis of data from many research groups, namely the link between mitochondrial impairment and endothelial dysfunction and, in particular, its effect on atherosclerosis and aging. Therefore, we discuss known and novel mitochondria-targeting therapies in the contest of atherosclerosis.
MeSH term(s)	Humans ; Endothelial Cells/metabolism ; Atherosclerosis/metabolism ; Plaque, Atherosclerotic/metabolism ; Mitochondria/metabolism ; Oxidative Stress ; Reactive Oxygen Species/metabolism ; DNA, Mitochondrial/genetics ; DNA, Mitochondrial/metabolism ; Lipids
Chemical Substances	Reactive Oxygen Species ; DNA, Mitochondrial ; Lipids
Language	English
Publishing date	2023-01-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24021086
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Pathophysiology and mechanisms of Acute Coronary Syndromes: atherothrombosis, immune-inflammation, and beyond.

Cimmino, Giovanni / Di Serafino, Luigi / Cirillo, Plinio

Expert review of cardiovascular therapy

2022 Volume 20, Issue 5, Page(s) 351–362

Abstract: Introduction: The pathophysiology of atherosclerosis and its acute complications, such as the Acute Coronary Syndromes (ACS), is continuously under investigation. Immunity and inflammation seem to play a pivotal role in promoting formation and grow of ... ...

Abstract	Introduction: The pathophysiology of atherosclerosis and its acute complications, such as the Acute Coronary Syndromes (ACS), is continuously under investigation. Immunity and inflammation seem to play a pivotal role in promoting formation and grow of atherosclerotic plaques. At the same time, plaque rupture followed by both platelets' activation and coagulation cascade induction lead to intracoronary thrombus formation. Although these phenomena might be considered responsible of about 90% of ACS, in up to 5-10% of acute syndromes, a non-obstructive coronary artery disease (MINOCA) might be documented. This paper gives an overview on atherothrombosis and immuno-inflammation processes involved in ACS pathophysiology, also emphasizing the pathological mechanisms potentially involved in MINOCA. Areas covered: The relationship between immuno-inflammation and atherothrombosis is continuously updated by recent findings. At the same time, pathophysiology of MINOCA still remains a partially unexplored field, stimulating the research of potential links between these two aspects of ACS pathophysiology. Expert opinion: Pathophysiology of ACS has been extensively investigated; however, several gray areas still remain. MINOCA represents one of these areas. At the same time, many aspects of immune-inflammation processes are still unknown. Thus, research should be continued to shed a brighter light on both these sides of "ACS" moon.
MeSH term(s)	Acute Coronary Syndrome/etiology ; Atherosclerosis/complications ; Coronary Artery Disease/complications ; Humans ; Inflammation ; Plaque, Atherosclerotic/pathology
Language	English
Publishing date	2022-05-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2192343-7
ISSN	1744-8344 ; 1477-9072
ISSN (online)	1744-8344
ISSN	1477-9072
DOI	10.1080/14779072.2022.2074836
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: An unusual case of retrobulbar haemorrhage following a transoesophageal echocardiogram: a rare but a potential severe complication.

Natale, Francesco / Loffredo, Francesco / Molinari, Riccardo / Golino, Paolo / Cimmino, Giovanni

European heart journal. Cardiovascular Imaging

2022 Volume 23, Issue 12, Page(s) e543

MeSH term(s)	Humans ; Retrobulbar Hemorrhage/complications ; Echocardiography, Transesophageal/adverse effects ; Tomography, X-Ray Computed
Language	English
Publishing date	2022-09-26
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2638345-7
ISSN	2047-2412 ; 2047-2404
ISSN (online)	2047-2412
ISSN	2047-2404
DOI	10.1093/ehjci/jeac185
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Colchicine in Athero-Thrombosis

Giovanni Cimmino / Francesco S. Loffredo / Gennaro De Rosa / Plinio Cirillo

International Journal of Molecular Sciences, Vol 24, Iss 2483, p

Molecular Mechanisms and Clinical Evidence

2023 Volume 2483

Abstract	Several lines of evidence have clearly indicated that inflammation plays a pivotal role in the development of atherosclerosis and of its thrombotic complications such as acute coronary syndromes or ischemic stroke. Thus, it has been postulated that the use of anti-inflammatory agents might be extremely useful to improve cardiovascular outcome. Recently, increasing attention has been reserved to one of the oldest plant-derived drugs still in use in clinical practice, colchicine that has been used as drug to treat inflammatory diseases such gout or Mediterranean fever. To date, current guidelines of the European Society of Cardiology have included colchicine as first line choice for treatment of acute and recurrent pericarditis. Moreover, several studies have investigated its role in the clinical scenarios of cardiovascular disease including chronic and acute coronary syndromes with promising results. In this review, starting from a description of the mechanism(s) involved behind its anti-inflammatory effects, we give an overview on its potential effects in atherothrombosis and finally present an updated overview of clinical evidence on the role of this drug in cardiovascular disease.
Keywords	colchicine ; cardiovascular disease ; inflammation ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	610
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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