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  1. Article ; Online: Vitamin D Supplementation: A Potential Approach for Coronavirus/COVID-19 Therapeutics?

    Arboleda, John F / Urcuqui-Inchima, Silvio

    Frontiers in immunology

    2020  Volume 11, Page(s) 1523

    MeSH term(s) Betacoronavirus ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Coronavirus Infections/virology ; Dietary Supplements ; Host-Pathogen Interactions/drug effects ; Humans ; Pandemics ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/virology ; Protective Agents/administration & dosage ; Protective Agents/pharmacology ; Protective Agents/therapeutic use ; Renin-Angiotensin System/drug effects ; Signal Transduction/drug effects ; Spike Glycoprotein, Coronavirus/metabolism ; Vitamin D/administration & dosage ; Vitamin D/pharmacology ; Vitamin D/therapeutic use ; Vitamins/administration & dosage ; Vitamins/pharmacology ; Vitamins/therapeutic use
    Chemical Substances Protective Agents ; Spike Glycoprotein, Coronavirus ; Vitamins ; spike protein, SARS-CoV-2 ; Vitamin D (1406-16-2) ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; angiotensin converting enzyme 2 (EC 3.4.17.-)
    Keywords covid19
    Language English
    Publishing date 2020-06-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.01523
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Vitamin D Supplementation

    John F. Arboleda / Silvio Urcuqui-Inchima

    Frontiers in Immunology, Vol

    A Potential Approach for Coronavirus/COVID-19 Therapeutics?

    2020  Volume 11

    Keywords SARS-Cov-2 ; COVID-19 ; vitamin D ; antiviral ; anti-inflammatory ; Immunologic diseases. Allergy ; RC581-607 ; covid19
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Vitamin D-mediated attenuation of miR-155 in human macrophages infected with dengue virus: Implications for the cytokine response.

    Arboleda, John F / Fernandez, Geysson J / Urcuqui-Inchima, Silvio

    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases

    2019  Volume 69, Page(s) 12–21

    Abstract: Clinical manifestations of dengue disease rely on complex interactions between dengue virus (DENV) and host factors that drive altered immune responses, including excessive inflammation. We have recently established that vitamin D can modulate DENV- ... ...

    Abstract Clinical manifestations of dengue disease rely on complex interactions between dengue virus (DENV) and host factors that drive altered immune responses, including excessive inflammation. We have recently established that vitamin D can modulate DENV-induced cytokine responses and restrict infection in human macrophages. Cytokine responses are finely regulated by several homeostatic mechanisms, including microRNAs (miRNAs) that can rapidly target specific genes involved in the control of immune signaling pathways. However, the modulation of miRNAs by vitamin D during DENV infection is still unknown. Here, using a qPCR miRNA array we profiled immune-related miRNAs induced by DENV infection in human monocyte-derived macrophages (MDM) differentiated in absence or presence of vitamin D (D
    MeSH term(s) Adult ; Biomarkers ; Cytokines/metabolism ; Dengue/genetics ; Dengue/metabolism ; Dengue/virology ; Dengue Virus/physiology ; Female ; Gene Expression Profiling ; Gene Expression Regulation/drug effects ; Host-Pathogen Interactions/genetics ; Humans ; Macrophages/immunology ; Macrophages/metabolism ; Macrophages/virology ; Male ; MicroRNAs/genetics ; Signal Transduction ; Vitamin D/metabolism ; Vitamin D/pharmacology ; Young Adult
    Chemical Substances Biomarkers ; Cytokines ; MIRN155 microRNA, human ; MicroRNAs ; Vitamin D (1406-16-2)
    Language English
    Publishing date 2019-01-09
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2037068-4
    ISSN 1567-7257 ; 1567-1348
    ISSN (online) 1567-7257
    ISSN 1567-1348
    DOI 10.1016/j.meegid.2018.12.033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5645: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  4. Article ; Online: Vitamin D Supplementation

    Arboleda, John F. / Urcuqui-Inchima, Silvio

    Frontiers in Immunology

    A Potential Approach for Coronavirus/COVID-19 Therapeutics?

    2020  Volume 11

    Keywords covid19
    Publisher Frontiers Media SA
    Publishing country ch
    Document type Article ; Online
    ZDB-ID 2606827-8
    ISSN 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.01523
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Vitamin D-Regulated MicroRNAs: Are They Protective Factors against Dengue Virus Infection?

    Arboleda, John F / Urcuqui-Inchima, Silvio

    Advances in virology

    2016  Volume 2016, Page(s) 1016840

    Abstract: Over the last few years, an increasing body of evidence has highlighted the critical participation of vitamin D in the regulation of proinflammatory responses and protection against many infectious pathogens, including viruses. The activity of vitamin D ... ...

    Abstract Over the last few years, an increasing body of evidence has highlighted the critical participation of vitamin D in the regulation of proinflammatory responses and protection against many infectious pathogens, including viruses. The activity of vitamin D is associated with microRNAs, which are fine tuners of immune activation pathways and provide novel mechanisms to avoid the damage that arises from excessive inflammatory responses. Severe symptoms of an ongoing dengue virus infection and disease are strongly related to highly altered production of proinflammatory mediators, suggesting impairment in homeostatic mechanisms that control the host's immune response. Here, we discuss the possible implications of emerging studies anticipating the biological effects of vitamin D and microRNAs during the inflammatory response, and we attempt to extrapolate these findings to dengue virus infection and to their potential use for disease management strategies.
    Language English
    Publishing date 2016-05-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2625776-2
    ISSN 1687-8647 ; 1687-8639
    ISSN (online) 1687-8647
    ISSN 1687-8639
    DOI 10.1155/2016/1016840
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Disseminated Lyme disease and dilated cardiomyopathy: A systematic review.

    Motamed, Mehras / Liblik, Kiera / Miranda-Arboleda, Andres F / Wamboldt, Rachel / Wang, Chang Nancy / Cingolani, Oscar / Rebman, Alison W / Novak, Cheryl B / Aucott, John N / Farina, Juan M / Baranchuk, Adrian

    Trends in cardiovascular medicine

    2022  Volume 33, Issue 8, Page(s) 531–536

    Abstract: Lyme carditis is a well-established manifestation of early disseminated Lyme infection, yet the relationship between late disseminated Lyme disease and the development of dilated cardiomyopathy (DCM) remains unclear. The present systematic review aims to ...

    Abstract Lyme carditis is a well-established manifestation of early disseminated Lyme infection, yet the relationship between late disseminated Lyme disease and the development of dilated cardiomyopathy (DCM) remains unclear. The present systematic review aims to summarize existing literature on the association between late disseminated Lyme disease and DCM. A systematic review was conducted in PubMed, Embase, CENTRAL, and MEDLINE databases, after which a total of 11 observational studies (n = 771) were ultimately included for final data extraction. Although most studies (7/11) identified evidence associating Borrelia-infection with DCM, further research is required to isolate late disseminated Borrelia infection as a causative agent of DCM.
    MeSH term(s) Humans ; Cardiomyopathy, Dilated/diagnosis ; Cardiomyopathy, Dilated/etiology ; Lyme Disease/diagnosis ; Lyme Disease/epidemiology
    Language English
    Publishing date 2022-06-03
    Publishing country United States
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 1097434-9
    ISSN 1873-2615 ; 1050-1738
    ISSN (online) 1873-2615
    ISSN 1050-1738
    DOI 10.1016/j.tcm.2022.05.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3419: Show issues Location:
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  8. Article ; Online: Assessment of the Effect of Remediation Strategies on the Environmental Quality of Aquaculture Ponds in Marilao and Meycauayan, Bulacan, Philippines.

    Pleto, John Vincent R / Arboleda, Mark Dondi M / Simbahan, Jessica F / Migo, Veronica P

    Journal of health & pollution

    2018  Volume 8, Issue 20, Page(s) 181205

    Abstract: Background: Water quality in the Marilao-Meycauayan-Obando river system (MMORS) of Bulacan, the Philippines, is of great concern due to the pollution load from local industries. The river system is currently used as a source of water for the aquaculture ...

    Abstract Background: Water quality in the Marilao-Meycauayan-Obando river system (MMORS) of Bulacan, the Philippines, is of great concern due to the pollution load from local industries. The river system is currently used as a source of water for the aquaculture industry in Bulacan.
    Objectives: In order to address organic and heavy metal pollution, several remediation strategies were tested in aquaculture ponds along the river system. Strategies such as phytoremediation (vetiver grass pontoons), application of probiotics and zeolite (with filtration as pre-treatment) were utilized in ponds to decrease or remove toxic pollutants in water and sediments.
    Methods: Two sites were chosen as the pilot remediation sites - ponds in Barangay Nagbalon, Marilao and Barangay Liputan, Meycauayan, Bulacan. Pond bottom preparation was done to improve the condition of the pond bottom sediments before stocking by adding zeolite. Physicochemical parameters of water such as dissolved oxygen (DO), temperature, pH, salinity, ammonia, phosphate, biochemical oxygen demand (BOD) and chemical oxygen demand (COD) were monitored throughout the culture period. Heavy metals in sediments and fish were monitored. Fish parameters such as average body weight and feed conversion ratio were determined.
    Results: The DO levels were below recommended levels in the morning and reached a supersaturated level in the afternoon. Ammonia and COD levels were above recommended limits. A decreasing trend was observed for ammonia levels in treatment ponds. In terms of the growth of milkfish, the pond with probiotics showed the highest growth and better feed conversion ratio in Nagbalon and in the phytoremediation pond in Liputan. Percentage survival of milkfish was much higher at Liputan. Copper, chromium, lead and manganese were detected in pond sediments. After application of zeolite, there was a decrease in lead levels throughout the culture period.
    Conclusions: The different remediation studies were compared in terms of cost, effectivity and application and phytoremediation (vetiver grass pontoons) was determined to be the most cost-effective remediation strategy.
    Competing interests: The authors declare no competing financial interests.
    Language English
    Publishing date 2018-12-03
    Publishing country United States
    Document type Journal Article
    ISSN 2156-9614
    ISSN (online) 2156-9614
    DOI 10.5696/2156-9614-8.20.181205
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Papel de las células dendríticas tolerogénicas ILT3+/ILT4+ en la respuesta inmunitaria a trasplante de órganos y tejidos.

    Arboleda, John F / García, Luis F / Alvarez, Cristiam M

    Biomedica : revista del Instituto Nacional de Salud

    2011  Volume 31, Issue 2, Page(s) 281–295

    Abstract: Dendritic cells, the most powerful antigen-presenting cells, are important for triggering of the immune responses to allo-antigens. However, they also play a fundamental role in the peripheral tolerance maintenance. Tolerance is enhanced by the presence ... ...

    Title translation ILT3+/ILT4+ tolerogenic dendritic cells and their influence on allograft survival.
    Abstract Dendritic cells, the most powerful antigen-presenting cells, are important for triggering of the immune responses to allo-antigens. However, they also play a fundamental role in the peripheral tolerance maintenance. Tolerance is enhanced by the presence on the dendritic cell surface of the inhibitor receptors ILT3 and ILT4. They recruit protein tyrosine-phosphatases to their ITIM domains and inhibit antigen-presenting cell activation, leading T cell hypo-responsivensess. Moreover, these receptors favor a bidirectional interaction with T-suppressor and T-regulator cells, generating an antigen-specific immunoregulator cascade, in which the dendritic cell behaves as a tolerogenic cell. In the current review, analysis is centered on the biology and behavior of the tolerogenic dendritic cells that express high levels of ILT3 and ILT4. Some molecular and genetics aspects of these receptors are discussed as well as their importance in the modulation of the allo-specific antigen immune response to transplants.
    MeSH term(s) Dendritic Cells/immunology ; Graft Survival/immunology ; Immune Tolerance/immunology ; Membrane Glycoproteins/immunology ; Receptors, Cell Surface/immunology ; Receptors, Immunologic/immunology ; T-Lymphocytes, Regulatory/immunology ; Transplantation, Homologous/immunology
    Chemical Substances LILRB2 protein, human ; LILRB4 protein, human ; Membrane Glycoproteins ; Receptors, Cell Surface ; Receptors, Immunologic
    Language Spanish
    Publishing date 2011-06
    Publishing country Colombia
    Document type English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 0120-4157
    ISSN 0120-4157
    DOI 10.1590/S0120-41572011000200017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: TNF-α signaling regulates RUNX1 function in endothelial cells.

    Whitmore, Hannah A B / Amarnani, Dhanesh / O'Hare, Michael / Delgado-Tirado, Santiago / Gonzalez-Buendia, Lucia / An, Miranda / Pedron, Julien / Bushweller, John H / Arboleda-Velasquez, Joseph F / Kim, Leo A

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    2020  Volume 35, Issue 2, Page(s) e21155

    Abstract: Runt-related transcription factor 1 (RUNX1) acts as a mediator of aberrant retinal angiogenesis and has been implicated in the progression of proliferative diabetic retinopathy (PDR). Patients with PDR, retinopathy of prematurity (ROP), and wet age- ... ...

    Abstract Runt-related transcription factor 1 (RUNX1) acts as a mediator of aberrant retinal angiogenesis and has been implicated in the progression of proliferative diabetic retinopathy (PDR). Patients with PDR, retinopathy of prematurity (ROP), and wet age-related macular degeneration (wet AMD) have been found to have elevated levels of Tumor Necrosis Factor-alpha (TNF-α) in the eye. In fibrovascular membranes (FVMs) taken from patients with PDR RUNX1 expression was increased in the vasculature, while in human retinal microvascular endothelial cells (HRMECs), TNF-α stimulation causes increased RUNX1 expression, which can be modulated by RUNX1 inhibitors. Using TNF-α pathway inhibitors, we determined that in HRMECs, TNF-α-induced RUNX1 expression occurs via JNK activation, while NF-κB and p38/MAPK inhibition did not affect RUNX1 expression. JNK inhibitors were also effective at stopping high D-glucose-stimulated RUNX1 expression. We further linked JNK to RUNX1 through Activator Protein 1 (AP-1) and investigated the JNK-AP-1-RUNX1 regulatory feedback loop, which can be modulated by VEGF. Additionally, stimulation with TNF-α and D-glucose had an additive effect on RUNX1 expression, which was downregulated by VEGF modulation. These data suggest that the downregulation of RUNX1 in conjunction with anti-VEGF agents may be important in future treatments for the management of diseases of pathologic ocular angiogenesis.
    MeSH term(s) Animals ; Cells, Cultured ; Choroidal Neovascularization/metabolism ; Core Binding Factor Alpha 2 Subunit/antagonists & inhibitors ; Core Binding Factor Alpha 2 Subunit/metabolism ; Diabetic Retinopathy/metabolism ; Disease Models, Animal ; Endothelial Cells/drug effects ; Endothelial Cells/metabolism ; Glucose/pharmacology ; Humans ; MAP Kinase Signaling System/drug effects ; Mice ; Mice, Inbred C57BL ; Retina/cytology ; Retina/metabolism ; Retinopathy of Prematurity/metabolism ; Tumor Necrosis Factor-alpha/antagonists & inhibitors ; Tumor Necrosis Factor-alpha/metabolism ; Tumor Necrosis Factor-alpha/pharmacology ; Up-Regulation/drug effects ; Vascular Endothelial Growth Factor A/antagonists & inhibitors ; Vascular Endothelial Growth Factor A/metabolism ; Wet Macular Degeneration/metabolism
    Chemical Substances Core Binding Factor Alpha 2 Subunit ; RUNX1 protein, human ; Runx1 protein, mouse ; TNF protein, human ; Tumor Necrosis Factor-alpha ; VEGFA protein, human ; Vascular Endothelial Growth Factor A ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2020-11-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 639186-2
    ISSN 1530-6860 ; 0892-6638
    ISSN (online) 1530-6860
    ISSN 0892-6638
    DOI 10.1096/fj.202001668R
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2266: Show issues Location:
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    Zs.MO 296: Show issues

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