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  1. Article ; Online: Letter to the Editor: Severe Rebound-Associated Vertebral Fractures After Denosumab Discontinuation: Nine Clinical Cases Report.

    Trovas, George

    The Journal of clinical endocrinology and metabolism

    2017  Volume 102, Issue 3, Page(s) 1086

    Language English
    Publishing date 2017-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/jc.2016-3781
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  2. Article ; Online: Vitamin D and COVID-19.

    Trovas, George / Tournis, Symeon

    Hormones (Athens, Greece)

    2020  Volume 20, Issue 1, Page(s) 207–208

    Abstract: Epidemiological data report that several countries with a high prevalence of hypovitaminosis D may have increased susceptibility to complications and mortality due to COVID-19 infection. These reports, however, have limitations given that they derive ... ...

    Abstract Epidemiological data report that several countries with a high prevalence of hypovitaminosis D may have increased susceptibility to complications and mortality due to COVID-19 infection. These reports, however, have limitations given that they derive from observational studies. Nevertheless, while awaiting more robust data, clinicians should treat patients with vitamin D deficiency irrespective of whether or not it has a link with respiratory infections.
    MeSH term(s) COVID-19/complications ; COVID-19/prevention & control ; Humans ; SARS-CoV-2 ; Vitamin D/administration & dosage ; Vitamin D/therapeutic use ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/drug therapy
    Chemical Substances Vitamin D (1406-16-2)
    Keywords covid19
    Language English
    Publishing date 2020-07-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2075912-5
    ISSN 2520-8721 ; 1109-3099
    ISSN (online) 2520-8721
    ISSN 1109-3099
    DOI 10.1007/s42000-020-00231-9
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  3. Article ; Online: Vitamin D and COVID-19

    Trovas, George / Tournis, Symeon

    Hormones ; ISSN 1109-3099 2520-8721

    2020  

    Keywords Endocrinology, Diabetes and Metabolism ; General Medicine ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    DOI 10.1007/s42000-020-00231-9
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  4. Article: Vitamin D and COVID-19

    Trovas, George / Tournis, Symeon

    Hormones (Athens)

    Abstract: Epidemiological data report that several countries with a high prevalence of hypovitaminosis D may have increased susceptibility to complications and mortality due to COVID-19 infection. These reports, however, have limitations given that they derive ... ...

    Abstract Epidemiological data report that several countries with a high prevalence of hypovitaminosis D may have increased susceptibility to complications and mortality due to COVID-19 infection. These reports, however, have limitations given that they derive from observational studies. Nevertheless, while awaiting more robust data, clinicians should treat patients with vitamin D deficiency irrespective of whether or not it has a link with respiratory infections.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #648413
    Database COVID19

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  5. Article ; Online: Cardiovascular Risk in Patients with Primary Hyperparathyroidism.

    Tournis, Symeon / Makris, Konstantinos / Cavalier, Etienne / Trovas, George

    Current pharmaceutical design

    2020  Volume 26, Issue 43, Page(s) 5628–5636

    Abstract: Primary hyperparathyroidism (PHPT) is one of the most common endocrine disorders characterized by parathyroid hormone (PTH)-dependent hypercalcemia. Cardinal features include low trauma fractures, nephrolithiasis, and chronic kidney disease. Several ... ...

    Abstract Primary hyperparathyroidism (PHPT) is one of the most common endocrine disorders characterized by parathyroid hormone (PTH)-dependent hypercalcemia. Cardinal features include low trauma fractures, nephrolithiasis, and chronic kidney disease. Several experimental studies established that parathyroid hormone exerts actions on the cardiovascular (CV) system, including vasodilatation and positive inotropic and chronotropic effects. Observational studies, especially in severe cases, report a higher prevalence of hypertension, diabetes mellitus, lipid abnormalities, endothelial dysfunction, arrhythmias, and left ventricular hypertrophy in patients with PHPT, while the risk of CV events seems to be increased in severe cases. However, the effect of surgery is inconsistent on CV abnormalities and, more importantly, on CV disease (CVD) events, especially in mild cases. In the current review, we describe the available evidence linking PHPT and CVD, as well as the effect of surgical management and pharmacological treatment on CVD manifestations in patients with PHPT. Based on the current evidence, CVD is not considered an indication for surgery.
    MeSH term(s) Calcium ; Cardiovascular Diseases/etiology ; Heart Disease Risk Factors ; Humans ; Hyperparathyroidism, Primary/complications ; Hyperparathyroidism, Primary/epidemiology ; Hyperparathyroidism, Primary/surgery ; Parathyroid Hormone ; Parathyroidectomy ; Risk Factors
    Chemical Substances Parathyroid Hormone ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2020-11-06
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 1304236-1
    ISSN 1873-4286 ; 1381-6128
    ISSN (online) 1873-4286
    ISSN 1381-6128
    DOI 10.2174/1381612824999201105165642
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    Zs.A 4714: Show issues Location:
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  6. Article ; Online: Long non-coding RNAs regulate Aedes aegypti vector competence for Zika virus and reproduction.

    Belavilas-Trovas, Alexandros / Tastsoglou, Spyros / Dong, Shengzhang / Kefi, Mary / Tavadia, Mihra / Mathiopoulos, Kostas D / Dimopoulos, George

    PLoS pathogens

    2023  Volume 19, Issue 6, Page(s) e1011440

    Abstract: Long non-coding RNAs (lncRNAs) play critical regulatory roles in various cellular and metabolic processes in mosquitoes and all other organisms studied thus far. In particular, their involvement in essential processes such as reproduction makes them ... ...

    Abstract Long non-coding RNAs (lncRNAs) play critical regulatory roles in various cellular and metabolic processes in mosquitoes and all other organisms studied thus far. In particular, their involvement in essential processes such as reproduction makes them potential targets for the development of novel pest control approaches. However, their function in mosquito biology remains largely unexplored. To elucidate the role of lncRNAs in mosquitoes' reproduction and vector competence for arboviruses, we have implemented a computational and experimental pipeline to mine, screen, and characterize lncRNAs related to these two biological processes. Through analysis of publicly available Zika virus (ZIKV) infection-regulated Aedes aegypti transcriptomes, at least six lncRNAs were identified as being significantly upregulated in response to infection in various mosquito tissues. The roles of these ZIKV-regulated lncRNAs (designated Zinc1, Zinc2, Zinc3, Zinc9, Zinc10 and Zinc22), were further investigated by dsRNA-mediated silencing studies. Our results show that silencing of Zinc1, Zinc2, and Zinc22 renders mosquitoes significantly less permissive to ZIKV infection, while silencing of Zinc22 also reduces fecundity, indicating a potential role for Zinc22 in trade-offs between vector competence and reproduction. We also found that silencing of Zinc9 significantly increases fecundity but has no effect on ZIKV infection, suggesting that Zinc9 may be a negative regulator of oviposition. Our work demonstrates that some lncRNAs play host factor roles by facilitating viral infection in mosquitoes. We also show that lncRNAs can influence both mosquito reproduction and permissiveness to virus infection, two biological systems with important roles in mosquito vectorial capacity.
    MeSH term(s) Animals ; Female ; Zika Virus/physiology ; Zika Virus Infection ; Aedes/genetics ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Mosquito Vectors/genetics ; Reproduction
    Chemical Substances RNA, Long Noncoding
    Language English
    Publishing date 2023-06-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7374
    ISSN (online) 1553-7374
    ISSN 1553-7374
    DOI 10.1371/journal.ppat.1011440
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  7. Article ; Online: Long non-coding RNAs regulate Aedes aegypti vector competence for Zika virus and reproduction.

    Alexandros Belavilas-Trovas / Spyros Tastsoglou / Shengzhang Dong / Mary Kefi / Mihra Tavadia / Kostas D Mathiopoulos / George Dimopoulos

    PLoS Pathogens, Vol 19, Iss 6, p e

    2023  Volume 1011440

    Abstract: Long non-coding RNAs (lncRNAs) play critical regulatory roles in various cellular and metabolic processes in mosquitoes and all other organisms studied thus far. In particular, their involvement in essential processes such as reproduction makes them ... ...

    Abstract Long non-coding RNAs (lncRNAs) play critical regulatory roles in various cellular and metabolic processes in mosquitoes and all other organisms studied thus far. In particular, their involvement in essential processes such as reproduction makes them potential targets for the development of novel pest control approaches. However, their function in mosquito biology remains largely unexplored. To elucidate the role of lncRNAs in mosquitoes' reproduction and vector competence for arboviruses, we have implemented a computational and experimental pipeline to mine, screen, and characterize lncRNAs related to these two biological processes. Through analysis of publicly available Zika virus (ZIKV) infection-regulated Aedes aegypti transcriptomes, at least six lncRNAs were identified as being significantly upregulated in response to infection in various mosquito tissues. The roles of these ZIKV-regulated lncRNAs (designated Zinc1, Zinc2, Zinc3, Zinc9, Zinc10 and Zinc22), were further investigated by dsRNA-mediated silencing studies. Our results show that silencing of Zinc1, Zinc2, and Zinc22 renders mosquitoes significantly less permissive to ZIKV infection, while silencing of Zinc22 also reduces fecundity, indicating a potential role for Zinc22 in trade-offs between vector competence and reproduction. We also found that silencing of Zinc9 significantly increases fecundity but has no effect on ZIKV infection, suggesting that Zinc9 may be a negative regulator of oviposition. Our work demonstrates that some lncRNAs play host factor roles by facilitating viral infection in mosquitoes. We also show that lncRNAs can influence both mosquito reproduction and permissiveness to virus infection, two biological systems with important roles in mosquito vectorial capacity.
    Keywords Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
    Subject code 570
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
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  8. Article: Robust Bioinformatics Approaches Result in the First Polygenic Risk Score for BMI in Greek Adults.

    Kafyra, Maria / Kalafati, Ioanna Panagiota / Dimitriou, Maria / Grigoriou, Effimia / Kokkinos, Alexandros / Rallidis, Loukianos / Kolovou, Genovefa / Trovas, Georgios / Marouli, Eirini / Deloukas, Panos / Moulos, Panagiotis / Dedoussis, George V

    Journal of personalized medicine

    2023  Volume 13, Issue 2

    Abstract: Quantifying the role of genetics via construction of polygenic risk scores (PRSs) is deemed a resourceful tool to enable and promote effective obesity prevention strategies. The present paper proposes a novel methodology for PRS extraction and presents ... ...

    Abstract Quantifying the role of genetics via construction of polygenic risk scores (PRSs) is deemed a resourceful tool to enable and promote effective obesity prevention strategies. The present paper proposes a novel methodology for PRS extraction and presents the first PRS for body mass index (BMI) in a Greek population. A novel pipeline for PRS derivation was used to analyze genetic data from a unified database of three cohorts of Greek adults. The pipeline spans various steps of the process, from iterative dataset splitting to training and test partitions, calculation of summary statistics and PRS extraction, up to PRS aggregation and stabilization, achieving higher evaluation metrics. Using data from 2185 participants, implementation of the pipeline enabled consecutive repetitions in splitting training and testing samples and resulted in a 343-single nucleotide polymorphism PRS yielding an R
    Language English
    Publishing date 2023-02-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm13020327
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  9. Article ; Online: Letter to the Editor: "Evaluation of Bone Mineral Density Using DXA and cQCT in Postmenopausal Patients Under Thyrotropin Suppressive Therapy".

    Tournis, Symeon / Trovas, George / Triantafyllopoulos, Ioannis K / Balanika, Alexia P

    The Journal of clinical endocrinology and metabolism

    2018  Volume 104, Issue 4, Page(s) 1345–1346

    MeSH term(s) Absorptiometry, Photon ; Bone Density ; Humans ; Postmenopause ; Thyrotropin ; Thyroxine
    Chemical Substances Thyrotropin (9002-71-5) ; Thyroxine (Q51BO43MG4)
    Language English
    Publishing date 2018-09-26
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/jc.2018-01638
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  10. Article: Does Vitamin D affects changes in volumetric bone mineral density and architecture in postmenopausal women after conservatively treated distal radius fractures?

    Raptis, Konstantinos / Makris, Konstantinos / Trovas, George / Galanos, Antonios / Koutserimpas, Christos / Papaioannou, Nikolaos / Vlamis, Ioannis / Vlasis, Konstantinos / Tournis, Symeon

    Journal of musculoskeletal & neuronal interactions

    2021  Volume 21, Issue 1, Page(s) 93–103

    Abstract: Objective: We examined the role of vitamin D on volumetric bone mineral density (vBMD) and architecture during the first week's post-fracture in postmenopausal women (PMW) with distal radial fractures (DRF) treated conservatively using peripheral ... ...

    Abstract Objective: We examined the role of vitamin D on volumetric bone mineral density (vBMD) and architecture during the first week's post-fracture in postmenopausal women (PMW) with distal radial fractures (DRF) treated conservatively using peripheral Quantitative Computed Tomography (pQCT).
    Methods: Patients were classified into 2 groups according to initial median 25(OH)D level; Group A (25(OH)D ≥15 ng/ml) and group B (25(OH)D <15 ng/ml). All patients were followed for 12 weeks at three visits: baseline, 6 weeks and 12 weeks post fracture. pQCT was performed at baseline in fractured and contralateral non-fractured radius and at 6
    Results: 39 patients completed the protocol. Mean 25(OH)D levels were 15.60±7.35 ng/ml (3.5-41.7). Trabecular (trab) bone mineral content (BMC) and trabvBMD increased at 6 wk. vs. baseline (p<0.001). Cortical BMC, cortvBMD and cross- sectional area (CSA) progressively decreased (p<0.001) during the 12 weeks. There was no interaction between baseline 25(OH)D levels and changes in trabecular and cortical BMC, vBMD and CSA. Advanced age and higher CTX and P1NP were associated with higher cortical bone loss.
    Conclusion: Vitamin D deficiency does not affect the early architectural changes after a DRF. Advanced age and higher bone remodeling were associated with higher cortical bone loss, probably related to immobilization and independent of vitamin D levels.
    MeSH term(s) Aged ; Bone Density/physiology ; Bone Remodeling/physiology ; Conservative Treatment/methods ; Female ; Humans ; Middle Aged ; Postmenopause/blood ; Prospective Studies ; Radius Fractures/blood ; Radius Fractures/diagnostic imaging ; Tomography, X-Ray Computed/methods ; Vitamin D/blood ; Vitamin D Deficiency/blood ; Vitamin D Deficiency/diagnostic imaging
    Chemical Substances Vitamin D (1406-16-2)
    Language English
    Publishing date 2021-02-03
    Publishing country Greece
    Document type Journal Article ; Observational Study
    ZDB-ID 2041366-X
    ISSN 1108-7161
    ISSN 1108-7161
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