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Article ; Online: Acne in adult women and the markers of peripheral 3 alpha-diol G activity.

Cunha, Marisa G / Martins, Carolina P / M Filho, Carlos D'Aparecida / Alves, Beatriz C A / Adami, Fernando / Azzalis, Ligia A / Fonseca, Fernando L A

Journal of cosmetic dermatology

2016 Volume 15, Issue 4, Page(s) 330–334

Abstract: ... To establish the relation between 3 alpha-diol G levels and acne in female patients with normal androgenic ... over. According to age, 12 studied patients showed serum 3 alpha-diol G levels within normal range and ... show an increase in 3 alpha-diol G. Therefore, a pharmacological approach with anti-androgenic drugs ...

Abstract	Background: Acne in adult women is a frequent hard-to-manage disease with many relapse cases. It mostly interferes with the quality of life of patients, bringing them major metabolic and social losses. As androgenic hormones play a very important role in the acne pathogenesis, the early diagnosis of hyperandrogenic states is very useful for the proper evaluation of each patient and for a better choice of therapeutic management. Defining a pattern for laboratory profile analysis is important for the control of relapses of acne breakouts in adult women, which lately has been the aim of many published studies. Aim: To establish the relation between 3 alpha-diol G levels and acne in female patients with normal androgenic status without menstrual dysfunctions. Patients/methods: The evaluation of serum 3 alpha-androstanediol glucuronide levels through an enzymatic immunoassay method (Androstanediol Glucuronide ELISA Kit) for a direct quantitative measurement in 26 patients with grade II and III acne, ages ranging from 13 to 50. Results: Among the analyzed patients, 83% had grade II acne, and among this total, 60% were aged 14 or over. According to age, 12 studied patients showed serum 3 alpha-diol G levels within normal range and 11 patients had increased levels. Conclusions: A total of 60% of adult women with acne present increased levels of androgens and among those with normal levels and without menstrual dysfunctions, 50% show an increase in 3 alpha-diol G. Therefore, a pharmacological approach with anti-androgenic drugs for acne therapy in most of these patients is advisable.
MeSH term(s)	Acne Vulgaris/blood ; Acne Vulgaris/complications ; Acne Vulgaris/enzymology ; Adolescent ; Adult ; Age Factors ; Androstane-3,17-diol/analogs & derivatives ; Androstane-3,17-diol/blood ; Biomarkers/blood ; Cholestenone 5 alpha-Reductase/metabolism ; Hirsutism/blood ; Hirsutism/complications ; Humans ; Prospective Studies ; Puberty/blood ; Severity of Illness Index ; Young Adult
Chemical Substances	Biomarkers ; Androstane-3,17-diol (25126-76-5) ; androstane-3,17-diol glucuronide (27195-25-1) ; Cholestenone 5 alpha-Reductase (EC 1.3.1.22)
Language	English
Publishing date	2016-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2280551-5
ISSN	1473-2165 ; 1473-2130
ISSN (online)	1473-2165
ISSN	1473-2130
DOI	10.1111/jocd.12232
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Article: Spontaneous splenic rupture following stem cell mobilization with G-CSF and plerixafor in AL amyloidosis.

Lessi, Federica / Marson, Piero / Colpo, Anna / Marino, Filippo / Branca, Antonio / Tison, Tiziana / Adami, Fausto

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis

2015 Volume 54, Issue 2, Page(s) 256–258

Abstract: ... splenic rupture following administration of G-CSF and plerixafor in a patient with AL amyloidosis who previously ... the first report of spontaneous splenic rupture following stem cell mobilization with G-CSF and plerixafor ...

Abstract	Background: AL amyloidosis is a rare plasma cell dyscrasia with multiorgan involvement. Good risk patients are candidate to high dose chemotherapy and autologous stem cell transplantation. However both transplantation and stem cell collection entail significant risk in such patients. Plerixafor is a novel mobilizing agent approved for use in "poor mobilizer" patients with lymphoma and multiple myeloma; experience in systemic amyloidosis patients is limited. Case report: We describe a case of spontaneous splenic rupture following administration of G-CSF and plerixafor in a patient with AL amyloidosis who previously underwent heart transplantation due to amyloid heart involvement. Results and conclusion: This is the first report of spontaneous splenic rupture following stem cell mobilization with G-CSF and plerixafor in AL amyloidosis. The role of plerixafor has to be established. AL amyloidosis patients undergoing stem cell mobilization need careful monitoring of signs and symptoms of spontaneous splenic rupture.
MeSH term(s)	Adult ; Amyloidosis/pathology ; Amyloidosis/therapy ; Female ; Granulocyte Colony-Stimulating Factor/administration & dosage ; Granulocyte Colony-Stimulating Factor/adverse effects ; Hematopoietic Stem Cell Mobilization/adverse effects ; Heterocyclic Compounds/administration & dosage ; Heterocyclic Compounds/adverse effects ; Humans ; Rupture, Spontaneous ; Splenic Rupture/etiology ; Splenic Rupture/pathology
Chemical Substances	Heterocyclic Compounds ; Granulocyte Colony-Stimulating Factor (143011-72-7) ; plerixafor (S915P5499N)
Language	English
Publishing date	2015-09-28
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2046795-3
ISSN	1878-1683 ; 1473-0502
ISSN (online)	1878-1683
ISSN	1473-0502
DOI	10.1016/j.transci.2015.09.001
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Article: Comparative Pathology: Reports of Cases.

Adami, J G

The Journal of comparative medicine and veterinary archives

2022 Volume 15, Issue 7, Page(s) 444–447

Language	English
Publishing date	2022-10-24
Publishing country	United States
Document type	Journal Article
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Article ; Online: Regulation of bone mass in inflammatory diseases.

Adami, Giovanni

Best practice & research. Clinical endocrinology & metabolism

2021 Volume 36, Issue 2, Page(s) 101611

Abstract: Inflammation is among the major determinants of bone loss in chronic disease and aging. Bone metabolism is radically affected by inflammation with consequent bone loss and increased fracture risk. Various cytokines and mediators are involved in the ... ...

Abstract	Inflammation is among the major determinants of bone loss in chronic disease and aging. Bone metabolism is radically affected by inflammation with consequent bone loss and increased fracture risk. Various cytokines and mediators are involved in the pathogenesis of bone loss in inflammatory conditions. The present review has the aim of discussing the main pathways involved in the pathogenesis of bone loss in inflammatory diseases, focusing in particular on the Wnt system and its regulators. Literature review of studies published between inception to 2021 on osteoporosis and inflammation was conducted. I will discuss the epidemiology of osteoporosis and fractures in common inflammatory diseases. The molecular basis of bone loss related to inflammation will be discussed as well. Finally, the effects of various anti-inflammatory medications on bone metabolism will be reviewed.
MeSH term(s)	Bone Density ; Cytokines/pharmacology ; Fractures, Bone/etiology ; Humans ; Inflammation/complications ; Osteoporosis/epidemiology
Chemical Substances	Cytokines
Language	English
Publishing date	2021-12-28
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2052339-7
ISSN	1878-1594 ; 1532-1908 ; 1521-690X
ISSN (online)	1878-1594 ; 1532-1908
ISSN	1521-690X
DOI	10.1016/j.beem.2021.101611
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Article ; Online: Emergence of functional information from multivariate correlations.

Adami, Christoph / C G, Nitash

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences

2022 Volume 380, Issue 2227, Page(s) 20210250

Abstract: The information content of symbolic sequences (such as nucleic or amino acid sequences, but also neuronal firings or strings of letters) can be calculated from an ensemble of such sequences, but because information cannot be assigned to single sequences, ...

Abstract	The information content of symbolic sequences (such as nucleic or amino acid sequences, but also neuronal firings or strings of letters) can be calculated from an ensemble of such sequences, but because information cannot be assigned to single sequences, we cannot correlate information to other observables attached to the sequence. Here we show that an information
MeSH term(s)	Amino Acid Sequence
Language	English
Publishing date	2022-05-23
Publishing country	England
Document type	Journal Article
ZDB-ID	208381-4
ISSN	1471-2962 ; 0080-4614 ; 0264-3820 ; 0264-3952 ; 1364-503X
ISSN (online)	1471-2962
ISSN	0080-4614 ; 0264-3820 ; 0264-3952 ; 1364-503X
DOI	10.1098/rsta.2021.0250
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Article ; Online: Short-term incidence of protein-energy malnutrition is insufficient to evaluate long-term outcomes of hyposorptive bariatric surgery.

Papadia, Francesco Saverio / Adami, Gian Franco / Camerini, Giovanni

Surgical endoscopy

2024 Volume 38, Issue 3, Page(s) 1117–1118

MeSH term(s)	Humans ; Protein-Energy Malnutrition/etiology ; Protein-Energy Malnutrition/complications ; Incidence ; Bariatric Surgery/adverse effects ; Obesity, Morbid/complications ; Obesity, Morbid/surgery ; Malnutrition/etiology ; Malnutrition/prevention & control
Language	English
Publishing date	2024-01-29
Publishing country	Germany
Document type	Journal Article
ZDB-ID	639039-0
ISSN	1432-2218 ; 0930-2794
ISSN (online)	1432-2218
ISSN	0930-2794
DOI	10.1007/s00464-024-10694-1
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Article ; Online: Information-theoretic characterization of the complete genotype-phenotype map of a complex pre-biotic world: Comment on "From genotypes to organisms: State-of-the-art and perspectives of a cornerstone in evolutionary dynamics" by Susanna Manrubia et al.

C G, Nitash / Adami, Christoph

Physics of life reviews

2021 Volume 38, Page(s) 111–114

Abstract: How information is encoded in bio-molecular sequences is difficult to quantify since such an analysis usually requires sampling an exponentially large genetic space. Here we show how information theory reveals both robust and compressed encodings in the ... ...

Abstract	How information is encoded in bio-molecular sequences is difficult to quantify since such an analysis usually requires sampling an exponentially large genetic space. Here we show how information theory reveals both robust and compressed encodings in the largest complete genotype-phenotype map (over 5 trillion sequences) obtained to date.
MeSH term(s)	Biological Evolution ; Genotype ; Phenotype
Language	English
Publishing date	2021-06-29
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	2148883-6
ISSN	1873-1457 ; 1571-0645
ISSN (online)	1873-1457
ISSN	1571-0645
DOI	10.1016/j.plrev.2021.06.001
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Article: Bi-weekly chemotherapy with cisplatin, epirubicin, folinic acid and 5-fluororacil continuous infusion plus g-csf in advanced gastric cancer: a multicentric phase II study.

Felici, Alessandra / Carlini, Paolo / Ruggeri, Enzo Maria / Gamucci, Teresa / Pollera, Camillo Franco / De Marco, Salvatore / Fariello, Anna Maria / Moscetti, Luca / Gelibter, Alain / Adami, Ennio / Sperduti, Isabella / Cognetti, Francesco

Cancer chemotherapy and pharmacology

2006 Volume 57, Issue 1, Page(s) 59–64

Abstract: ... G-CSF (5 microg/kg) was administered on day 6, 8, 10, and 12. Cycles were repeated every 2 weeks ...

Abstract	Background: It has been demonstrated that the 3-weekly PELF regimen is superior to FAM and FAMTX in advanced gastric cancer. The aim of this multicentric phase II study was to evaluate the efficacy and tolerability of a PELF regimen, given every 2 weeks as a first-line therapy in patients with unresectable or metastatic gastric carcinoma. Methods: Fifty-nine patients were treated with the following schedule: cisplatin (40 mg/m2, day 1), epirubicin (30 mg/m2, day 1), 5-fluorouracil (400 mg/m2 bolus, followed by 600 mg/m2, 22 h continuous infusion, day 1 and 2) and folinic acid (100 mg/m2, 2-h infusion, day 1 and 2). G-CSF (5 microg/kg) was administered on day 6, 8, 10, and 12. Cycles were repeated every 2 weeks for a maximum of twelve courses. Results: Of the 52 evaluable patients, three (5.8%) complete responses, and 15 (28.8%) partial responses were observed, for an overall response rate of 34.6%. The median duration of response was 8 months. Nineteen patients had stable disease and 15 progressed on therapy. At a median follow-up of 12 months, the median time to progression was 8 months and the median survival duration was 13 months, with a 1-year survival rate of 53.5%. Grade 3 or 4 observed toxicities were: neutropenia in 26 patients (44%), thrombocytopenia in four patients (6.7%), and mucositis in seven patients (11.9%). Conclusions: The bi-weekly PELF regimen seems to be feasible with an acceptable toxicity profile and an activity comparable to the 3-weekly schedule.
MeSH term(s)	Adenocarcinoma/drug therapy ; Adenocarcinoma/mortality ; Adenocarcinoma/pathology ; Adult ; Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Cisplatin/administration & dosage ; Cisplatin/adverse effects ; Cisplatin/therapeutic use ; Disease-Free Survival ; Drug Administration Schedule ; Epirubicin/administration & dosage ; Epirubicin/adverse effects ; Epirubicin/therapeutic use ; Female ; Fluorouracil/administration & dosage ; Fluorouracil/adverse effects ; Fluorouracil/therapeutic use ; Granulocyte Colony-Stimulating Factor/administration & dosage ; Granulocyte Colony-Stimulating Factor/adverse effects ; Granulocyte Colony-Stimulating Factor/therapeutic use ; Humans ; Infusions, Intravenous ; Leucovorin/administration & dosage ; Leucovorin/adverse effects ; Leucovorin/therapeutic use ; Male ; Middle Aged ; Neoplasm Metastasis ; Recombinant Proteins ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/mortality ; Stomach Neoplasms/pathology ; Time Factors
Chemical Substances	Recombinant Proteins ; Granulocyte Colony-Stimulating Factor (143011-72-7) ; Epirubicin (3Z8479ZZ5X) ; Cisplatin (Q20Q21Q62J) ; Leucovorin (Q573I9DVLP) ; Fluorouracil (U3P01618RT)
Language	English
Publishing date	2006-01
Publishing country	Germany
Document type	Clinical Trial, Phase II ; Journal Article ; Multicenter Study
ZDB-ID	6820-2
ISSN	1432-0843 ; 0344-5704 ; 0943-9404
ISSN (online)	1432-0843
ISSN	0344-5704 ; 0943-9404
DOI	10.1007/s00280-005-0032-5
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Article ; Online: New point-of-care calcaneal ultrasound densitometer (Osteosys BeeTLE) compared to standard dual-energy X-ray absorptiometry (DXA).

Adami, Giovanni / Rossini, Maurizio / Gatti, Davide / Serpi, Paolo / Fabrizio, Christian / Lovato, Roberto

Scientific reports

2024 Volume 14, Issue 1, Page(s) 6898

Abstract: ... compared to standard DXA. BMD (g/cm ...

Abstract	Dual-energy X-ray absorptiometry (DXA) represents the gold standard for measuring bone mineral density (BMD). However, its size and bulkiness limit its use in mass screening. Portable and easily accessible instruments are more suitable for this purpose. We conducted a study to assess the repeatability, sensitivity, accuracy, and validation of a new ultrasound densitometer for the calcaneus (OsteoSys BeeTLe) compared to standard DXA. BMD (g/cm
MeSH term(s)	Female ; Humans ; Middle Aged ; Aged ; Male ; Absorptiometry, Photon ; Calcaneus/diagnostic imaging ; Point-of-Care Systems ; Sensitivity and Specificity ; Bone Density ; Ultrasonography ; Osteoporotic Fractures
Language	English
Publishing date	2024-03-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-56787-8
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Article ; Online: Assessing the impact of urban landfills as feeding sites on physiological parameters of a generalist seabird species.

Adami, Miguel A / Bertellotti, Marcelo / Agüero, María Laura / Frixione, Martin G / D'Amico, Verónica L

Marine pollution bulletin

2024 Volume 202, Page(s) 116327

Abstract: The increasing human population and associated urban waste pose a significant threat to wildlife. Our study focused on the Kelp gull (Larus dominicanus), known for opportunistic feeding in anthropogenic areas, particularly urban landfills. We assessed ... ...

Abstract	The increasing human population and associated urban waste pose a significant threat to wildlife. Our study focused on the Kelp gull (Larus dominicanus), known for opportunistic feeding in anthropogenic areas, particularly urban landfills. We assessed the physiological status of Kelp gulls at a landfill and compared it with gulls from a protected natural site. Results indicate that gulls from the anthropogenic site exhibited lower levels of key physiological parameters linked to diet, including triglycerides, total proteins, uric acid, plasmatic enzyme activity, body condition index, and leukocyte count, in comparison to their counterparts from the natural site. These findings suggest that Kelp gulls experience inferior physical and nutritional conditions when utilizing anthropogenic sites like landfills governmentally managed.
Language	English
Publishing date	2024-04-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2001296-2
ISSN	1879-3363 ; 0025-326X
ISSN (online)	1879-3363
ISSN	0025-326X
DOI	10.1016/j.marpolbul.2024.116327
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