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  1. Book ; Online ; E-Book: Feldman and Pike's Vitamin D / Volume 1

    Feldman, David / Hewison, Martin

    2024  

    Title variant Vitamin D
    Author's details edited by Martin Hewison [und 5 weiteren]
    Collection Feldman and Pike's Vitamin D
    Dates of publication 2024-2024
    Size 1 Online-Ressource (lii, 1179 Seiten)
    Edition Fifth edition
    Publisher Elsevier Academic Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT030688120
    ISBN 978-0-323-91390-4 ; 9780323913867 ; 0-323-91390-3 ; 0323913865
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: Feldman and Pike's vitamin D / Volume 2

    Feldman, David / Hewison, Martin

    2024  

    Author's details edited by Martin Hewison [und 5 weiteren]
    Collection Feldman and Pike's Vitamin D
    Dates of publication 2024-2024
    Size 1 Online-Ressource (li, 1327 Seiten), Illustrationen, Diagramme
    Edition Fifth edition
    Publisher Elsevier Academic Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT030687028
    ISBN 978-0-323-91339-3 ; 9780323913386 ; 0-323-91339-3 ; 0323913385
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online: Feldman and Pike's Vitamin D

    Feldman, David / Hewison, Martin

    2024  

    Author's details edited by Martin Hewison [und 5 weiteren]
    Size 1 Online-Ressource
    Publisher Elsevier Academic Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online
    HBZ-ID HT030687021
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: There is more to life than serum vitamin D: a lesson from the past.

    Hewison, Martin

    Clinical science (London, England : 1979)

    2022  Volume 136, Issue 8, Page(s) 639–642

    Abstract: This commentary revisits a paper from Clinical Science in 1972 entitled "The distribution and storage of vitamin D and its metabolites in human tissues" by Barbara Mawer, Bill Stanbury and colleagues. The paper continues to be well cited 50 years later, ... ...

    Abstract This commentary revisits a paper from Clinical Science in 1972 entitled "The distribution and storage of vitamin D and its metabolites in human tissues" by Barbara Mawer, Bill Stanbury and colleagues. The paper continues to be well cited 50 years later, in part because the study it describes - which includes the use of human autopsy tissue - would be difficult to replicate today. However, the paper also has resonance today because the focus of the study - what is the fate of vitamin D in the body? - is still not clear. This commentary discusses why the Mawer et al. study was a major advance when published and why there is still much to be learned from this paper half a century later.
    MeSH term(s) Humans ; Vitamin D/metabolism
    Chemical Substances Vitamin D (1406-16-2)
    Language English
    Publishing date 2022-04-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 206835-7
    ISSN 1470-8736 ; 0301-0538 ; 0009-0360 ; 0143-5221
    ISSN (online) 1470-8736
    ISSN 0301-0538 ; 0009-0360 ; 0143-5221
    DOI 10.1042/CS20211176
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.220: Show issues Location:
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  5. Article ; Online: The earlier the better: preconception vitamin D and protection against pregnancy loss.

    Hewison, Martin

    The lancet. Diabetes & endocrinology

    2018  Volume 6, Issue 9, Page(s) 680–681

    MeSH term(s) Abortion, Spontaneous ; Female ; Humans ; Pregnancy ; Pregnancy Outcome ; Prospective Studies ; Vitamin D/analogs & derivatives
    Chemical Substances Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
    Language English
    Publishing date 2018-06-05
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2213-8595
    ISSN (online) 2213-8595
    DOI 10.1016/S2213-8587(18)30178-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The impact of vitamin D on cancer: A mini review.

    Seraphin, Gerbenn / Rieger, Sandra / Hewison, Martin / Capobianco, Enrico / Lisse, Thomas S

    The Journal of steroid biochemistry and molecular biology

    2023  Volume 231, Page(s) 106308

    Abstract: In this review, we summarize the most recent advances in vitamin D cancer research to provide molecular clarity, as well as its translational trajectory across the cancer landscape. Vitamin D is well known for its role in regulating mineral homeostasis; ... ...

    Abstract In this review, we summarize the most recent advances in vitamin D cancer research to provide molecular clarity, as well as its translational trajectory across the cancer landscape. Vitamin D is well known for its role in regulating mineral homeostasis; however, vitamin D deficiency has also been linked to the development and progression of a number of cancer types. Recent epigenomic, transcriptomic, and proteomic studies have revealed novel vitamin D-mediated biological mechanisms that regulate cancer cell self-renewal, differentiation, proliferation, transformation, and death. Tumor microenvironmental studies have also revealed dynamic relationships between the immune system and vitamin D's anti-neoplastic properties. These findings help to explain the large number of population-based studies that show clinicopathological correlations between circulating vitamin D levels and risk of cancer development and death. The majority of evidence suggests that low circulating vitamin D levels are associated with an increased risk of cancers, whereas supplementation alone or in combination with other chemo/immunotherapeutic drugs may improve clinical outcomes even further. These promising results still necessitate further research and development into novel approaches that target vitamin D signaling and metabolic systems to improve cancer outcomes.
    MeSH term(s) Humans ; Vitamin D/metabolism ; Proteomics ; Vitamins/therapeutic use ; Neoplasms/drug therapy ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/drug therapy ; Antineoplastic Agents ; Receptors, Calcitriol/metabolism
    Chemical Substances Vitamin D (1406-16-2) ; Vitamins ; Antineoplastic Agents ; Receptors, Calcitriol
    Language English
    Publishing date 2023-04-11
    Publishing country England
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1049188-0
    ISSN 1879-1220 ; 0960-0760
    ISSN (online) 1879-1220
    ISSN 0960-0760
    DOI 10.1016/j.jsbmb.2023.106308
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 708: Show issues Location:
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  7. Article ; Online: The impact of genetic variation within the vitamin D pathway upon skeletal muscle function: A systematic review.

    Bollen, Shelby E / Bass, Joseph J / Wilkinson, Daniel J / Hewison, Martin / Atherton, Philip J

    The Journal of steroid biochemistry and molecular biology

    2023  Volume 229, Page(s) 106266

    Abstract: Studies in vitro have demonstrated a key molecular role for 1,25-dihydroxyvitamin D (1,25D) in skeletal muscle function, with vitamin D-deficiency (low serum 25-hydroxyvitamin D, 25D) being associated with muscle pain and weakness. Despite this, an ... ...

    Abstract Studies in vitro have demonstrated a key molecular role for 1,25-dihydroxyvitamin D (1,25D) in skeletal muscle function, with vitamin D-deficiency (low serum 25-hydroxyvitamin D, 25D) being associated with muscle pain and weakness. Despite this, an understanding of the overall role of vitamin D in muscle health (particularly the impact of vitamin D-related genetic variants) has yet to be fully resolved, relative to more well-studied targets such as the skeleton. Thus, we aimed to review existing studies that have investigated relationships between skeletal muscle function and single nucleotide polymorphisms (SNPs) within vitamin D-related genes. A systematic review of papers published between January 2000 and June 2022 on PubMed, EMBASE and Web of Science pertaining to association between functionally relevant vitamin D receptor genetic variants and variants within genes of the vitamin D pathway and skeletal muscle function/outcomes was performed. 21 articles were included in the review for final analysis, of which 20 only studied genetic variation of the VDR gene. Of the included articles, 81 % solely included participants aged ≥ 50 years and of the 9 studies that did not only include White individuals, only 2 included Black participants. Within the vitamin D system, the VDR gene is the primary gene of which associations between polymorphisms and muscle function have been investigated. VDR polymorphisms have been significantly associated with muscle phenotypes in two or more studies. Of note A1012G was significantly associated with higher handgrip strength, but the results for other SNPs were notably variable between studies. While the lack of definitive evidence and study heterogeneity makes it difficult to draw conclusions, the findings of this review highlight a need for improvements with regards to the use of more diverse study populations, i.e., inclusion of Black individuals and other people of colour, and expanding research scope beyond the VDR gene.
    MeSH term(s) Receptors, Calcitriol/genetics ; Receptors, Calcitriol/metabolism ; Hand Strength ; Vitamin D ; Muscle, Skeletal/metabolism ; Vitamins/metabolism ; Polymorphism, Single Nucleotide
    Chemical Substances Receptors, Calcitriol ; Vitamin D (1406-16-2) ; Vitamins
    Language English
    Publishing date 2023-02-21
    Publishing country England
    Document type Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1049188-0
    ISSN 1879-1220 ; 0960-0760
    ISSN (online) 1879-1220
    ISSN 0960-0760
    DOI 10.1016/j.jsbmb.2023.106266
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    Zs.A 708: Show issues Location:
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  8. Article ; Online: Vitamin D binding protein/GC-globulin: a novel regulator of alpha cell function and glucagon secretion.

    Viloria, Katrina / Hewison, Martin / Hodson, David J

    The Journal of physiology

    2021  Volume 600, Issue 5, Page(s) 1119–1133

    Abstract: The contribution of glucagon to type 1 and type 2 diabetes has long been known, but the underlying defects in alpha cell function are not well-described. During both disease states, alpha cells respond inappropriately to stimuli, leading to dysregulated ... ...

    Abstract The contribution of glucagon to type 1 and type 2 diabetes has long been known, but the underlying defects in alpha cell function are not well-described. During both disease states, alpha cells respond inappropriately to stimuli, leading to dysregulated glucagon secretion, impaired glucose tolerance and hypoglycaemia. The mechanisms involved in this dysfunction are complex, but possibly include changes in alpha cell glucose-sensing, alpha cell de-differentiation, paracrine feedback, as well as alpha cell mass. However, the molecular underpinnings of alpha cell failure are still poorly understood. Recent transcriptomic analyses have identified vitamin D binding protein (DBP), encoded by GC/Gc, as an alpha cell signature gene. DBP is highly localized to the liver and alpha cells and is virtually absent from other tissues and cell types under non-pathological conditions. While the vitamin D transportation role of DBP is well characterized in the liver and circulation, its function in alpha cells remains more enigmatic. Recent work reveals that loss of DBP leads to smaller and hyperplastic alpha cells, which secrete less glucagon in response to low glucose concentration, despite vitamin D sufficiency. Alpha cells lacking DBP display impaired Ca
    MeSH term(s) Actins/metabolism ; Diabetes Mellitus, Type 2 ; Globulins/metabolism ; Glucagon ; Glucose ; Humans ; Vitamin D/metabolism ; Vitamin D-Binding Protein/genetics ; Vitamin D-Binding Protein/metabolism
    Chemical Substances Actins ; Globulins ; Vitamin D-Binding Protein ; Vitamin D (1406-16-2) ; Glucagon (9007-92-5) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2021-05-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP280890
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.65: Show issues Location:
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  9. Article ; Online: Vitamin D and the immune system: new perspectives on an old theme.

    Hewison, Martin

    Rheumatic diseases clinics of North America

    2012  Volume 38, Issue 1, Page(s) 125–139

    Abstract: It is almost 30 years since an interaction between vitamin D and the immune system was first documented. Although this was initially proposed as a nonclassic effect of vitamin D associated with granulomatous diseases, our current view is now changed ... ...

    Abstract It is almost 30 years since an interaction between vitamin D and the immune system was first documented. Although this was initially proposed as a nonclassic effect of vitamin D associated with granulomatous diseases, our current view is now changed considerably. Recent studies have shown a potential physiologic role for vitamin D in regulating normal innate and adaptive immunity. Future studies now need to focus on the clinical implications of vitamin D–mediated immunity and, in particular, the possible beneficial effects of supplementary vitamin D with respect to infectious and autoimmune diseases.
    Language English
    Publishing date 2012-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 92118-x
    ISSN 1558-3163 ; 0889-857X
    ISSN (online) 1558-3163
    ISSN 0889-857X
    DOI 10.1016/j.rdc.2012.03.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Vitamin D and immune function: autocrine, paracrine or endocrine?

    Hewison, Martin

    Scandinavian journal of clinical and laboratory investigation. Supplementum

    2012  Volume 243, Page(s) 92–102

    Abstract: Prominent amongst the non-classical effects of vitamin D is its interaction with the immune system. Although this has been recognized for many years, it is only through recent studies that we have been able to fully understand the impact of vitamin D on ... ...

    Abstract Prominent amongst the non-classical effects of vitamin D is its interaction with the immune system. Although this has been recognized for many years, it is only through recent studies that we have been able to fully understand the impact of vitamin D on normal innate and adaptive immune function. In particular these studies have illustrated how impaired vitamin D status has important ramifications for dysregulated immune responses to infection and aberrant inflammatory responses associated with autoimmune disease. Indeed it seems likely that the effects of vitamin D will extend beyond these established immune diseases to include additional novel effects, such as interaction with the enteric gut microbiota. Central to this new perspective on vitamin D and immunity has been the elucidation of pivotal mechanisms that underpin the interface between vitamin D and target immune cells. In particular, it is now clear that effects of vitamin D on monocytes, macrophages, dendritic cells, and lymphocytes are not constrained by the metabolic pathways associated with classical endocrine actions of vitamin D. Instead, it is now important to also consider intracrine and paracrine pathways that are subject to a distinct set of modulatory signals, and which may also be influenced by disease-specific dysregulation. The current review will discuss this by comparing the intracrine, paracrine and endocrine metabolic systems that influence the interaction between vitamin D and the immune system.
    MeSH term(s) Adaptive Immunity ; Animals ; Antigen Presentation ; Humans ; Immune System/physiology ; Immunity, Innate ; Inflammation/etiology ; Neutrophils/physiology ; T-Lymphocytes/immunology ; Toll-Like Receptors/physiology ; Vitamin D/physiology
    Chemical Substances Toll-Like Receptors ; Vitamin D (1406-16-2)
    Language English
    Publishing date 2012
    Publishing country Norway
    Document type Journal Article ; Review
    ISSN 2166-1030
    ISSN (online) 2166-1030
    DOI 10.3109/00365513.2012.682862
    Database MEDical Literature Analysis and Retrieval System OnLINE

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