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  1. Article ; Online: Vitamin D axis status and the severity of COVID-19.

    Celikbilek, Asuman

    Journal of medical virology

    2021  Volume 93, Issue 7, Page(s) 4085

    MeSH term(s) COVID-19 ; Humans ; SARS-CoV-2 ; Vitamin D ; Vitamin D Deficiency ; Vitamins
    Chemical Substances Vitamins ; Vitamin D (1406-16-2)
    Language English
    Publishing date 2021-03-14
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.26920
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  2. Article ; Online: The Role of Vasomotor and Autonomic Changes in Migraine.

    Celikbilek, Asuman

    Pain medicine (Malden, Mass.)

    2020  Volume 22, Issue 4, Page(s) 1009–1010

    MeSH term(s) Autonomic Nervous System ; Humans ; Migraine Disorders
    Language English
    Publishing date 2020-06-25
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2015903-1
    ISSN 1526-4637 ; 1526-2375
    ISSN (online) 1526-4637
    ISSN 1526-2375
    DOI 10.1093/pm/pnaa194
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  3. Article: Possible Associations of Vitamin D, Vitamin D-Binding Protein, and Vitamin D Receptor with Diabetic Neuropathic Pain and Balance [Letter].

    Celikbilek, Asuman

    Journal of pain research

    2020  Volume 13, Page(s) 465–466

    Language English
    Publishing date 2020-02-28
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2495284-9
    ISSN 1178-7090
    ISSN 1178-7090
    DOI 10.2147/JPR.S249871
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  4. Article ; Online: Inflammatory Milieu May Trigger Metabolic Changes in Migraine Attacks.

    Celikbilek, Asuman

    Headache

    2020  Volume 60, Issue 5, Page(s) 990–991

    MeSH term(s) Blood Glucose ; Epilepsy ; Humans ; Migraine Disorders/etiology ; Precipitating Factors
    Chemical Substances Blood Glucose
    Language English
    Publishing date 2020-04-15
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 410130-3
    ISSN 1526-4610 ; 0017-8748
    ISSN (online) 1526-4610
    ISSN 0017-8748
    DOI 10.1111/head.13799
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  5. Article ; Online: Role of vitamin D in the association between pre-stroke sleep quality and poststroke depression and anxiety.

    Asuman, Celikbilek / Aydan, Koysuren / Meric, Konar Naime

    Sleep & breathing = Schlaf & Atmung

    2023  

    Abstract: Purpose: Poor sleep quality, mood disorders, and vitamin D deficiency are common in stroke. We investigated the association between serum vitamin D levels and pre-stroke sleep quality and the occurrence of poststroke depression (PSD) and poststroke ... ...

    Abstract Purpose: Poor sleep quality, mood disorders, and vitamin D deficiency are common in stroke. We investigated the association between serum vitamin D levels and pre-stroke sleep quality and the occurrence of poststroke depression (PSD) and poststroke anxiety (PSA) in acute ischemic stroke (AIS).
    Methods: This prospective cross-sectional study included hospitalized patients with AIS and age- and sex-matched controls. Vitamin D levels were measured within 24 h of admission. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) at admission. The severity of depression and anxiety symptoms was evaluated according to Beck Depression Inventory and Beck Anxiety Inventory scores, respectively, within 72 h after admission.
    Results: Comparing 214 AIS patients with 103 controls, patients had significantly higher scores of Beck Depression Inventory, Beck Anxiety Inventory, and PSQI and lower vitamin D levels (p < 0.001). Among AIS patients, Beck Depression Inventory (p = 0.004) and Beck Anxiety Inventory (p = 0.018) scores were significantly higher in bad sleepers (PSQI score ≥ 6) than in good sleepers (PSQI score ≤ 5). Correlation analysis revealed negative correlations between serum vitamin D levels and Beck Depression Inventory (r =  - 0.234; p < 0.001), Beck Anxiety Inventory (r =  - 0.135; p = 0.016), and PSQI (r =  - 0.218; p < 0.001) scores.
    Conclusion: Decreased serum vitamin D levels at admission are associated with a high risk for PSD and PSA in patients with poor pre-stroke sleep quality during the early stages of AIS.
    Language English
    Publishing date 2023-08-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1500381-4
    ISSN 1522-1709 ; 1520-9512
    ISSN (online) 1522-1709
    ISSN 1520-9512
    DOI 10.1007/s11325-023-02894-1
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  6. Article ; Online: A Rare Case of Epilepsia Partialis Continua Caused by a Transient Thalamic Pulvinar Lesion

    Yusuf KOÇAK / Asuman ÇELİKBİLEK

    Ahi Evran Medical Journal, Vol 5, Iss 3, Pp 258-

    2021  Volume 261

    Abstract: Epilepsia partialis continua (EPC) is a subclass of focal motor status epilepticus. Despite the evidence for a cortical origin, subcortical pathologies-especially those involving the thalamus-have been proposed. Here, we report a case of EPC with focal ... ...

    Abstract Epilepsia partialis continua (EPC) is a subclass of focal motor status epilepticus. Despite the evidence for a cortical origin, subcortical pathologies-especially those involving the thalamus-have been proposed. Here, we report a case of EPC with focal faciobrachial seizures, with a reversible pulvinar thalamic lesion detected on magnetic resonance imaging (MRI), such as has not previously been reported. An 89-year-old man presented to our emergency department with a three-hour history of right-sided continuous faciobrachial seizure activity. Diffusion-weighted images showed hyperintensity in the left thalamus in the pulvinar region. Follow-up MRI revealed complete resolution of the abnormal signal in the same region. Our case was interesting because of the EPC caused by a transient thalamic pulvinar lesion in an unusual localization in an elderly patient with no previous brain lesions.
    Keywords epilepsia partialis continua ; faciobracial seizure ; magnetic resonance imaging ; thalamus ; pulvinar ; Medicine ; R
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher Kirsehir Ahi Evran University
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Homocysteine Levels in Patients with Hemorrhagic Stroke

    Aysu YETİŞ / Asuman ÇELİKBİLEK / Aysel KAYA TEKEŞİN / Orhan YAĞIZ

    Ahi Evran Medical Journal, Vol 7, Iss 1, Pp 101-

    2023  Volume 105

    Abstract: Purpose: Accumulating data demonstrated that raised homocysteine is a risk factor for ischemic stroke. However, it remains unclear whether high homocysteine level is also a risk factor for hemorrhagic stroke, which accounts for about one-fifth of stroke ... ...

    Abstract Purpose: Accumulating data demonstrated that raised homocysteine is a risk factor for ischemic stroke. However, it remains unclear whether high homocysteine level is also a risk factor for hemorrhagic stroke, which accounts for about one-fifth of stroke patients. Our aim was to measure the plasma homocysteine levels in patients with hemorrhagic stroke to explore a possible link. Materıals and Methods: We included thirty patients with ischemic stroke, thirty patients with hemorrhagic stroke, and thirty healthy volunteers. All participants were examined for traditional risk factors and levels of folic acid, homocysteine, and vitamin B12. Results: Hypertension was higher in both ischemic stroke and hemorrhagic stroke patients than in healthy participants (p=0.029). Homocysteine levels were significantly higher in both ischemic stroke and hemorrhagic stroke groups than in the control group (p=0.001), with no statistically difference between each other (p>0.05). Vitamin B12 levels were significantly lower in both ischemic stroke and hemorrhagic stroke patients than in the controls (p=0.001), with no statistically difference between each other (p>0.05). Folic acid levels did not significantly differ between the groups (p>0.05). We did not find correlation between homocysteine, vitamin B12 and folic acid levels (p>0.05). Conclusion: Our study indicated that the homocysteine levels were high in patients with hemorrhagic stroke. Larger cohorts are needed to clarify the role of homocysteine in hemorrhagic stroke.
    Keywords hemorragic stroke ; homocysteine ; vitamin b12 ; folic acid ; Medicine ; R
    Subject code 616
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Kirsehir Ahi Evran University
    Document type Article ; Online
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  8. Article ; Online: Cognitive impairment in patients with nonalcoholic fatty liver disease with liver fibrosis.

    Celikbilek, Asuman / Celikbilek, Mehmet

    Liver international : official journal of the International Association for the Study of the Liver

    2019  Volume 40, Issue 5, Page(s) 1239

    MeSH term(s) Adult ; Cognition ; Cognitive Dysfunction ; Humans ; Liver ; Liver Cirrhosis ; Middle Aged ; Non-alcoholic Fatty Liver Disease
    Language English
    Publishing date 2019-11-13
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2102783-3
    ISSN 1478-3231 ; 1478-3223
    ISSN (online) 1478-3231
    ISSN 1478-3223
    DOI 10.1111/liv.14288
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    Zs.A 1632: Show issues Location:
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  9. Article: Associations of the neutrophil/lymphocyte ratio, monocyte/ lymphocyte ratio, and platelet/lymphocyte ratio with COVID-19 disease severity in patients with neurological symptoms: A cross-sectional monocentric study.

    Sahin, Burc Esra / Celikbilek, Asuman / Kocak, Yusuf / Koysuren, Aydan / Hizmali, Lokman

    Journal of neurosciences in rural practice

    2022  Volume 14, Issue 2, Page(s) 224–229

    Abstract: Objectives: Data are limited regarding the relationship of neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR), and platelet/ lymphocyte ratio (PLR) with neurological symptoms (NS) in COVID-19 patients. This study is the first to assess ... ...

    Abstract Objectives: Data are limited regarding the relationship of neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR), and platelet/ lymphocyte ratio (PLR) with neurological symptoms (NS) in COVID-19 patients. This study is the first to assess the utility of the NLR, MLR, and PLR for predicting COVID-19 severity in infected patients with NS.
    Materials and methods: Consecutive 192 PCR-positive COVID-19 patients with NS were included in this cross-sectional and prospective study. The patients were classified into the non-severe and severe groups. We analyzed routinely complete blood count in these groups in terms of COVID-19 disease severity.
    Results: Advanced age, a higher body mass index, and comorbidities were significantly more common in the severe group (
    Conclusion: We found positive associations of COVID-19 severity with the NLR and PLR in infected patients with NS. Further research is required to shed more light on the role of neurological involvement in disease prognosis and outcomes.
    Language English
    Publishing date 2022-10-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2601242-X
    ISSN 0976-3155 ; 0976-3147
    ISSN (online) 0976-3155
    ISSN 0976-3147
    DOI 10.25259/JNRP_6_2022
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  10. Article ; Online: Cognitive assessment of patients with nonalcoholic fatty liver disease.

    Celikbilek, Asuman / Celikbilek, Mehmet / Bozkurt, Gurbet

    European journal of gastroenterology & hepatology

    2018  Volume 30, Issue 8, Page(s) 944–950

    Abstract: Objective: The aim of this study was to investigate cognitive performance for the first time in participants with nonalcoholic fatty liver disease (NAFLD) using the Montreal Cognitive Assessment (MoCA).: Participants and methods: In total, 70 ... ...

    Abstract Objective: The aim of this study was to investigate cognitive performance for the first time in participants with nonalcoholic fatty liver disease (NAFLD) using the Montreal Cognitive Assessment (MoCA).
    Participants and methods: In total, 70 participants with NAFLD and 73 age-matched and sex-matched healthy participants were enrolled in this prospective cross-sectional study. The diagnosis of NAFLD was made on the basis of abdominal ultrasonography findings. Anthropometric indices were calculated, and routine laboratory analyses were carried out for each participant. All participants provided sociodemographic data and completed the Beck Depression Inventory-II. Cognitive functions were evaluated using the Turkish version of the MoCA, with a cut-off score for mild cognitive impairment of less than 21 points.
    Results: The MoCA scores were significantly lower in participants with NAFLD than in the healthy group (P<0.05). In addition, more NAFLD participants than healthy participants presented with deficits in the visuospatial (P<0.05) and executive function domains (P<0.05). In the multivariate model, education level [2.79 (1.12-6.96); P<0.05] and area of residence [5.68 (2.24-14.38); P<0.001] were associated independently with cognitive dysfunction in both the NAFLD and the healthy groups. The MoCA scores were correlated negatively with fibrosis 4 scores in NAFLD participants (r=-0.359; P<0.05). However, hepatosteatosis grade and the presence of metabolic syndrome were not correlated with MoCA scores in the NAFLD group (P>0.05).
    Conclusion: Our results show that NAFLD patients may have early or subtle cognitive dysfunction, including in the visuospatial and executive function domains, as indexed by scores on the MoCA test. Further targeted psychometric testing will be required to confirm the presence of cognitive impairment in this population.
    MeSH term(s) Adult ; Case-Control Studies ; Chi-Square Distribution ; Cognition ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/etiology ; Cognitive Dysfunction/psychology ; Cross-Sectional Studies ; Executive Function ; Female ; Humans ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Neuropsychological Tests ; Non-alcoholic Fatty Liver Disease/complications ; Non-alcoholic Fatty Liver Disease/diagnostic imaging ; Non-alcoholic Fatty Liver Disease/psychology ; Odds Ratio ; Prognosis ; Prospective Studies ; Risk Factors ; Space Perception ; Visual Perception
    Language English
    Publishing date 2018-03-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 1034239-4
    ISSN 1473-5687 ; 0954-691X
    ISSN (online) 1473-5687
    ISSN 0954-691X
    DOI 10.1097/MEG.0000000000001131
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