LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 1650

Search options

  1. Article ; Online: Use of hyperbaric oxygen therapy in severe earthquake injuries.

    Demir, Levent / Öztürk, Mustafa

    Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES

    2024  Volume 30, Issue 3, Page(s) 185–191

    Abstract: Background: Earthquakes are natural disasters that can often cause severe injuries and traumatic situations. These injuries can include crush injuries, fractures, tissue damage, and blood circulation problems. Hyperbaric oxygen therapy (HBOT) has ... ...

    Title translation Depreme bağlı şiddetli yaralanmalarda Hiperbarik Oksijen Tedavisi'nin kullanımı.
    Abstract Background: Earthquakes are natural disasters that can often cause severe injuries and traumatic situations. These injuries can include crush injuries, fractures, tissue damage, and blood circulation problems. Hyperbaric oxygen therapy (HBOT) has recently become a frequently used treatment modality for individuals suffering from severe injuries. HBOT is a form of treatment that involves administering pure oxygen to the patient under high pressure. This treatment aims to promote tissue healing by increasing cellular oxygenation. It is thought to have a positive effect on factors such as accelerating tissue healing, reducing inflammation, and controlling infection in severe post-earthquake injuries, particularly crush injuries. This study aimed to retrospectively evaluate the clinical effects, contributions to the healing process, and potential advantages of HBOT in 35 patients with severe injuries after the Kahramanmaraş earthquake that occurred on 06.02.2023 and to contribute to the development of emergency intervention strategies.
    Methods: This study was carried out after ethics committee approval. In the study, the data of patients with a MESS Score between 7-14 who were admitted as earthquake victims and treated in the HBOT Unit due to severe earthquake-related injuries were obtained from records and retrospectively analyzed. Demographic information, general distribution of patient data, mean values, number of HBOT sessions, and functional outcomes were recorded.
    Results: The gender distribution of the 35 patients who received HBOT was 31.4% male and 68.6% female. 45.7% of patients were aged 18 years or younger, and 54.3% were aged 19 years or older. The most common injuries in the treated patients were observed in the lower extremities. After HBOT, sensory recovery (54.3%) and functional recovery (51.4%) were achieved in the majority of patients. The minor amputation rate was 20.0% and the major amputation rate was 11.4% after HBOT.
    Conclusion: This study evaluated the possible effects of HBOT on patients with severe earthquake injuries in Türkiye, and the results showed that HBOT may have a beneficial effect on critical factors such as sensory recovery, functional recovery, and amputation rates in this particular group of patients, and that this benefit may be more pronounced in those who started treatment early.
    MeSH term(s) Humans ; Male ; Female ; Hyperbaric Oxygenation/adverse effects ; Hyperbaric Oxygenation/methods ; Earthquakes ; Retrospective Studies ; Wound Healing ; Crush Injuries
    Language English
    Publishing date 2024-03-20
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2253739-9
    ISSN 1307-7945 ; 1306-696X
    ISSN (online) 1307-7945
    ISSN 1306-696X
    DOI 10.14744/tjtes.2024.60979
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Evaluation of the mechanical behaviour of the expandable wedge locked nail fixation in retrograde use: A finite element study.

    Özkaya, Mustafa / Demir, Teyfik

    Computers in biology and medicine

    2024  Volume 174, Page(s) 108419

    Abstract: Introduction: In literature, there have been many studies conducted to research the alternatives of standard interlocking intramedullary nailing. The expandable wedge locked nail fixation, which is thought as a new alternative to the standard ... ...

    Abstract Introduction: In literature, there have been many studies conducted to research the alternatives of standard interlocking intramedullary nailing. The expandable wedge locked nail fixation, which is thought as a new alternative to the standard interlocking nailing, has been presented in previous numerical studies. The antegrade usage of the wedge locked nail fixation has provided promising results. From this point, the aim of the study is to evaluate mechanical behavior of its retrograde usage on femur models. Additionally, another aim of the study is to investigate the effect of fracture level on mechanical properties of the fixation.
    Materials and methods: The mechanical behaviors of the wedge locked nail and standard interlocking nail fixations were compared by finite element methods. Sawbones femurs having osteotomies at five different levels to simulate different fractures were fixed with wedge locked nail or interlocking nail by using retrograde approach. With respect to the fracture level, two different nail lengths were used. Axial compression load was applied to fixations. The mechanical behaviors of the fixations were evaluated with respect to stiffness of the fixations and stresses occurred on both implants and bones.
    Results: Any of the wedge locked nail fixation did not slip at canal. The stress and stiffness results were mostly close with each other for both nail types. The maximum stresses at locking elements or bones contacting these elements increased with decreased distance between the fracture and relevant locking elements.
    Discussion: The wedge locked nail fixation showed comparable results to the standard interlocking nail fixation with respect to the stiffness and stress. Under axial loading, wedge locked nail provided a secured fixation without any slippage and preserved its position inside the medullary canal. It may be thought as a safe alternative to the standard interlocking nail fixation for retrograde usage. Additionally, according to stress results, it is advised to the surgeons to avoid a close locking to the fracture line.
    MeSH term(s) Finite Element Analysis ; Humans ; Bone Nails ; Fracture Fixation, Intramedullary/methods ; Fracture Fixation, Intramedullary/instrumentation ; Femoral Fractures/surgery ; Femoral Fractures/physiopathology ; Biomechanical Phenomena ; Femur/surgery ; Models, Biological
    Language English
    Publishing date 2024-04-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 127557-4
    ISSN 1879-0534 ; 0010-4825
    ISSN (online) 1879-0534
    ISSN 0010-4825
    DOI 10.1016/j.compbiomed.2024.108419
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Diffuse Idiopathic Colonic Varices: Demonstration Using Multiplanar Reconstructions from Triphasic Computed Tomography.

    Demir, Mustafa Kemal / Ecertaştan, Özge

    Balkan medical journal

    2023  Volume 40, Issue 6, Page(s) 447–448

    MeSH term(s) Humans ; Tomography, X-Ray Computed/methods ; Varicose Veins/diagnostic imaging
    Language English
    Publishing date 2023-10-23
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2612982-6
    ISSN 2146-3131 ; 2146-3131
    ISSN (online) 2146-3131
    ISSN 2146-3131
    DOI 10.4274/balkanmedj.galenos.2023.2023-8-99
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Synergic actions of botulinum neurotoxin A and oxaliplatin on colorectal tumour cell death through the upregulation of TRPM2 channel-mediated oxidative stress.

    Demir, Sıdıka / Duman, İpek / Nazıroğlu, Mustafa

    Clinical and experimental pharmacology & physiology

    2024  Volume 51, Issue 4, Page(s) e13844

    Abstract: Botulinum neurotoxin A (BoNT) is being shown to have anticancer action as a potential adjuvant treatment. The transient receptor potential (TRP) melastatin 2 (TRPM2) stimulator action of BoNT was reported in glioblastoma cells, but not in colorectal ... ...

    Abstract Botulinum neurotoxin A (BoNT) is being shown to have anticancer action as a potential adjuvant treatment. The transient receptor potential (TRP) melastatin 2 (TRPM2) stimulator action of BoNT was reported in glioblastoma cells, but not in colorectal cancer (HT29) cells. By activating TRPM2, we evaluated the impacts of BoNT and oxaliplatin (OXA) incubations on oxidant and apoptotic values within the HT29 cells. Control, BoNT (5 IU for 24 h), OXA (50 μM for 24 h) and their combinations were induced. We found that TRPM2 protein is upregulated and mediates enhanced BoNT and OXA-induced Ca
    MeSH term(s) Humans ; Oxaliplatin/pharmacology ; Reactive Oxygen Species/metabolism ; Botulinum Toxins, Type A/metabolism ; Up-Regulation ; TRPM Cation Channels/genetics ; TRPM Cation Channels/metabolism ; Cell Death ; Oxidative Stress/physiology ; Apoptosis/physiology ; Colorectal Neoplasms/drug therapy ; Calcium/metabolism
    Chemical Substances Oxaliplatin (04ZR38536J) ; Reactive Oxygen Species ; Botulinum Toxins, Type A (EC 3.4.24.69) ; TRPM Cation Channels ; Calcium (SY7Q814VUP) ; TRPM2 protein, human
    Language English
    Publishing date 2024-03-22
    Publishing country Australia
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 189277-0
    ISSN 1440-1681 ; 0305-1870 ; 0143-9294
    ISSN (online) 1440-1681
    ISSN 0305-1870 ; 0143-9294
    DOI 10.1111/1440-1681.13844
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Diffuse Idiopathic Colonic Varices

    Mustafa Kemal Demir / Özge Ecertaştan

    Balkan Medical Journal, Vol 40, Iss 6, Pp 447-

    Demonstration Using Multiplanar Reconstructions from Triphasic Computed Tomography

    2023  Volume 448

    Keywords Medicine ; R
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher Galenos Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  6. Article ; Online: Coincidence of Asymptomatic Aorto-left Atrial Fistula and Aneurysmatic Aberrant Right Subclavian Artery

    Mustafa Kemal Demir / Mustafa Güler / Özge Ecertaştan / Okan Akıncı / Vedat Eyiişler

    Balkan Medical Journal, Vol 41, Iss 1, Pp 70-

    The Relevance of Multidetector Computed Tomography Angiography

    2024  Volume 71

    Keywords Medicine ; R
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Galenos Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  7. Article ; Online: Temporal regulation of gene expression and pathways in chemotherapy-induced senescence in HeLa cervical cancer cell line.

    Sucularli, Ceren / Şimay Demir, Yaprak Dilber / Özdemir, Aysun / Ark, Mustafa

    Bio Systems

    2024  Volume 237, Page(s) 105140

    Abstract: Cellular senescence is the state of permanent growth arrest. Chemotherapeutic drugs induce senescence, known as therapy-induced senescence. Although there are studies deciphering processes in senescence, more studies providing detailed information on ... ...

    Abstract Cellular senescence is the state of permanent growth arrest. Chemotherapeutic drugs induce senescence, known as therapy-induced senescence. Although there are studies deciphering processes in senescence, more studies providing detailed information on therapy-induced senescence at the transcriptome level are needed. In order to understand temporal molecular changes of doxorubicin treatment in the course of senescence formation, two data sets from HeLa cells at 16 h and 72 h doxorubicin treatment were analyzed. GO BP enrichment, KEGG pathways and hub genes specific to or shared between 16 h and 72 h doxorubicin treated HeLa cells were identified. Genes functioning in p53 signaling were upregulated only in 16 h, while genes functioning in extracellular matrix organization were upregulated only in 72 h doxorubicin treated HeLa cells. Wound healing genes were gradually upregulated from 16 h to 72 h doxorubicin treatment and metabolic pathways were downregulated at both. ncRNA processing and ribosome biogenesis GO BP terms were enriched in upregulated genes at 16 h, while these terms were enriched in downregulated genes at 72 h senescent HeLa cells. According to our results, genes functioning in p53 signaling may be involved in the induction of senescence, but may not be required to maintain senescence in HeLa cells.
    MeSH term(s) Female ; Humans ; HeLa Cells ; Uterine Cervical Neoplasms/drug therapy ; Uterine Cervical Neoplasms/genetics ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/pharmacology ; Doxorubicin/pharmacology ; Antineoplastic Agents/therapeutic use ; Gene Expression Regulation ; Cellular Senescence/genetics
    Chemical Substances Tumor Suppressor Protein p53 ; Doxorubicin (80168379AG) ; Antineoplastic Agents
    Language English
    Publishing date 2024-02-07
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 186234-0
    ISSN 1872-8324 ; 0303-2647
    ISSN (online) 1872-8324
    ISSN 0303-2647
    DOI 10.1016/j.biosystems.2024.105140
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Coincidence of Asymptomatic Aorto-left Atrial Fistula and Aneurysmatic Aberrant Right Subclavian Artery: The Relevance of Multidetector Computed Tomography Angiography

    Demir, Mustafa Kemal / Güler, Mustafa / Ecertaştan, Özge / Akıncı, Okan / Eyiişler, Vedat

    Balkan medical journal

    2023  Volume 41, Issue 1, Page(s) 70–71

    MeSH term(s) Humans ; Multidetector Computed Tomography ; Subclavian Artery/diagnostic imaging ; Angiography ; Fistula
    Language English
    Publishing date 2023-11-27
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2612982-6
    ISSN 2146-3131 ; 2146-3131
    ISSN (online) 2146-3131
    ISSN 2146-3131
    DOI 10.4274/balkanmedj.galenos.2023.2023-9-69
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Trends in suicide methods by age group.

    Demir, Mustafa

    Asia-Pacific psychiatry : official journal of the Pacific Rim College of Psychiatrists

    2018  Volume 10, Issue 4, Page(s) e12334

    Abstract: Introduction: This study investigates the trends in suicide methods by age group in Turkey.: Method: Secondary data on suicide from 2007 to 2015 were obtained from the Turkish Statistical Institute. The direct standardization method was used to ... ...

    Abstract Introduction: This study investigates the trends in suicide methods by age group in Turkey.
    Method: Secondary data on suicide from 2007 to 2015 were obtained from the Turkish Statistical Institute. The direct standardization method was used to calculate suicide rates. Correlation test was used to show the trends in suicide methods by age.
    Results: Statistically significant changes in suicide methods were seen for persons aged 15 to 24 years and 25 to 44 years, where jumping increased; among persons aged 15 to 24 years, cutting/burning decreased.
    Discussion: The most popular suicide method is jumping.
    MeSH term(s) Adolescent ; Adult ; Age Factors ; Aged ; Cause of Death ; Female ; Humans ; Male ; Middle Aged ; Suicide/statistics & numerical data ; Turkey/epidemiology ; Young Adult
    Language English
    Publishing date 2018-09-03
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2506332-7
    ISSN 1758-5872 ; 1758-5864
    ISSN (online) 1758-5872
    ISSN 1758-5864
    DOI 10.1111/appy.12334
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article: Effect of hyperbaric exposure on pulmonary functions in hyperbaric chamber inside attendants.

    Demir, Levent / Avci, Mustafa

    Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc

    2022  Volume 49, Issue 2, Page(s) 161–169

    Abstract: Objective: The objective of the study was to compare pulmonary function tests results of hyperbaric chamber inside attendants (HCIAs) working in a hyperbaric chamber before and after sessions.: Methods: A total of 68 health care personnel working as ... ...

    Abstract Objective: The objective of the study was to compare pulmonary function tests results of hyperbaric chamber inside attendants (HCIAs) working in a hyperbaric chamber before and after sessions.
    Methods: A total of 68 health care personnel working as HCIAs in the hyperbaric oxygen therapy unit between June 2019 and September 2019 were included in the study. All participants experienced the pressure chamber for the first time. In spirometric evaluation, we measured forced vital capacity (FVC), forced expiratory volume at one second (FEV1), forced expiratory flow at 25%-75% of FVC (FEF25-75) and peak expiratory flow (PEF). In addition, FEV1/FVC ratio (FEV1%) was also calculated.
    Results: The mean FVC was found as 3.56 ± ± 0.66 (min-max: 2.17-5.63) before hyperbaric exposure and 3.44 ± 0.62 (min-max: 2.30-5.28) after the exposure (3.4%) (p≺0.05). The mean FEV1 was found as 3.37 ± 0.63 (2.13-5.39) before the session and 3.24 ± 0.59 (min-max: 2.3-5.28) after the session (3.9%) (p≺0.05). There was no statistically significant difference between the mean FEV1/FVC ratio, PEF and FEF25-75 measured before and after hyperbaric exposure.
    Conclusion: The results of this study indicated that among pulmonary function test parameters, decreases were found in FEV1, FVC, FEF25-75, PEF, but clinical significance has not been established.
    MeSH term(s) Forced Expiratory Volume ; Humans ; Lung ; Respiratory Function Tests ; Spirometry ; Vital Capacity
    Language English
    Publishing date 2022-05-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1154414-4
    ISSN 1066-2936
    ISSN 1066-2936
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top