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Article ; Online: Zinc Oxide Nanoparticles and Cancer Chemotherapy: Helpful Tools for Enhancing Chemo-sensitivity and Reducing Side Effects?

Vaghari-Tabari, Mostafa / Jafari-Gharabaghlou, Davoud / Mohammadi, Mozafar / Hashemzadeh, Mohammad Sadegh

2023 Volume 202, Issue 5, Page(s) 1878–1900

Abstract: Cancer chemotherapy is still a serious challenge. Chemo-resistance and destructive side effects of chemotherapy drugs are the most critical limitations of chemotherapy. Chemo-resistance is the leading cause of chemotherapy failure. Chemo-resistance, ... ...

Abstract	Cancer chemotherapy is still a serious challenge. Chemo-resistance and destructive side effects of chemotherapy drugs are the most critical limitations of chemotherapy. Chemo-resistance is the leading cause of chemotherapy failure. Chemo-resistance, which refers to the resistance of cancer cells to the anticancer effects of chemotherapy drugs, is caused by various reasons. Among the most important of these reasons is the increase in the efflux of chemotherapy drugs due to the rise in the expression and activity of ABC transporters, the weakening of apoptosis, and the strengthening of stemness. In the last decade, a significant number of studies focused on the application of nanotechnology in cancer treatment. Considering the anti-cancer properties of zinc, zinc oxide nanoparticles have received much attention in recent years. Some studies have indicated that zinc oxide nanoparticles can target the critical mechanisms of cancer chemo-resistance and enhance the effectiveness of chemotherapy drugs. These studies have shown that zinc oxide nanoparticles can reduce the activity of ABC transporters, increase DNA damage and apoptosis, and attenuate stemness in cancer cells, leading to enhanced chemo-sensitivity. Some other studies have also shown that zinc oxide nanoparticles in low doses can be helpful in minimizing the harmful side effects of chemotherapy drugs. In this article, after a brief overview of the mechanisms of chemo-resistance and anticancer effects of zinc, we will review all these studies in detail.
MeSH term(s)	Humans ; Antineoplastic Agents/adverse effects ; Zinc Oxide/therapeutic use ; Zinc Oxide/pharmacology ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Nanoparticles ; Zinc/metabolism ; ATP-Binding Cassette Transporters/therapeutic use
Chemical Substances	Antineoplastic Agents ; Zinc Oxide (SOI2LOH54Z) ; Zinc (J41CSQ7QDS) ; ATP-Binding Cassette Transporters
Language	English
Publishing date	2023-08-28
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	445336-0
ISSN	1559-0720 ; 0163-4984
ISSN (online)	1559-0720
ISSN	0163-4984
DOI	10.1007/s12011-023-03803-z
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Article ; Online: Melatonin and inflammatory bowel disease: From basic mechanisms to clinical application

Vaghari-Tabari, Mostafa / Moein, Soheila / Alipourian, Ali / Qujeq, Durdi / Malakoti, Faezeh / Alemi, Forough / Yousefi, Bahman / Khazaie, Sepideh

Biochimie. 2023 June, v. 209 p.20-36

2023

Abstract: Inflammatory bowel disease is a chronic inflammatory disease and has periods of recurrence and remission. Improper immune responses to gut flora bacteria, along with genetic susceptibility, appear to be involved in causing this complex disease. It seems ... ...

Abstract	Inflammatory bowel disease is a chronic inflammatory disease and has periods of recurrence and remission. Improper immune responses to gut flora bacteria, along with genetic susceptibility, appear to be involved in causing this complex disease. It seems dysbiosis and oxidative stress may also be involved in IBD pathogenesis. A significant number of clinical studies have shown an interesting association between sleep disturbances and IBD. Studies in animal models have also shown that sleep deprivation has a significant effect on the pathogenesis of IBD and can aggravate inflammation. These interesting findings have drawn attention to melatonin, a sleep-related hormone. Melatonin is mainly produced by the pineal gland, but many tissues in the body, including the intestines, can produce it. Melatonin can have an interesting effect on the pathogenesis of IBD. Melatonin can enhance the intestinal mucosal barrier, alter the composition of intestinal bacteria in favor of bacteria with anti-inflammatory properties, regulate the immune response, alleviate inflammation and attenuate oxidative stress. It seems that, melatonin supplementation is effective in relieving inflammation and healing intestinal ulcers in IBD animal models. Some clinical studies have also shown that melatonin supplementation as an adjuvant therapy may be helpful in reducing disease activity in IBD patients. In this review article, in addition to reviewing the effects of sleep disturbances and melatonin on key mechanisms involved in the pathogenesis of IBD, we will review the findings of clinical studies regarding the effects of melatonin supplementation on IBD treatment.
Keywords	adjuvants ; animals ; dysbiosis ; immune response ; inflammation ; inflammatory bowel disease ; intestinal microorganisms ; intestines ; melatonin ; oxidative stress ; pathogenesis ; pineal body ; remission ; sleep deprivation ; therapeutics ; IBD ; Sleep disturbances ; Intestinal bacteria ; IBD treatment
Language	English
Dates of publication	2023-06
Size	p. 20-36.
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	120345-9
ISSN	0300-9084
ISSN	0300-9084
DOI	10.1016/j.biochi.2022.12.007
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Article ; Online: MicroRNAs and osteosarcoma: Potential targets for inhibiting metastasis and increasing chemosensitivity.

Soghli, Negin / Ferns, Gordon A / Sadeghsoltani, Fatemeh / Qujeq, Durdi / Yousefi, Tooba / Vaghari-Tabari, Mostafa

Biochemical pharmacology

2022 Volume 201, Page(s) 115094

Abstract: Osteosarcoma (OS) is the third most common cancer in young adults after lymphoma and brain cancer. Metastasis, like other cellular events, is dependent on signaling pathways; a series of changes in some proteins and signaling pathways pave the way for OS ...

Abstract	Osteosarcoma (OS) is the third most common cancer in young adults after lymphoma and brain cancer. Metastasis, like other cellular events, is dependent on signaling pathways; a series of changes in some proteins and signaling pathways pave the way for OS cells to invade and migrate. Ezrin, TGF-β, Notch, RUNX2, matrix metalloproteinases (MMPs), Wnt/β-catenin, and phosphoinositide 3-kinase (PI3K)/AKT are among the most important of these proteins and signaling pathways. Despite the improvements in treating OS, the overall survival of patients suffering from the metastatic disease has not experienced any significant change after surgical treatments and chemotherapy and 5-years overall survival in patients with metastatic OS is about 20%. Studies have shown that overexpression or inhibition of some microRNAs (miRNAs) has significant effects in limiting the invasion and migration of OS cells. The results of these studies highlight the potential of the clinical application of some miRNA mimics and miRNA inhibitors (antagomiRs) to inhibit OS metastasis in the future. In addition, some studies have shown that miRNAs are associated with the most important drug resistance mechanisms in OS, and some miRNAs are highly effective targets to increase chemosensitivity. The results of these studies suggest that miRNA mimics and antagomiRs may be helpful to increase the efficacy of conventional chemotherapy drugs in the treatment of metastatic OS. In this article, we discussed the role of various signaling pathways and the involved miRNAs in the metastasis of OS, attempting to provide a comprehensive review of the literature on OS metastasis and chemosensitivity.
MeSH term(s)	Antagomirs/metabolism ; Bone Neoplasms/drug therapy ; Bone Neoplasms/genetics ; Bone Neoplasms/pathology ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Humans ; MicroRNAs/metabolism ; Osteosarcoma/drug therapy ; Osteosarcoma/genetics ; Osteosarcoma/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Young Adult
Chemical Substances	Antagomirs ; MicroRNAs
Language	English
Publishing date	2022-05-16
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	208787-x
ISSN	1873-2968 ; 0006-2952
ISSN (online)	1873-2968
ISSN	0006-2952
DOI	10.1016/j.bcp.2022.115094
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Article ; Online: Vitamin D in respiratory viral infections: a key immune modulator?

Vaghari-Tabari, Mostafa / Mohammadzadeh, Iraj / Qujeq, Durdi / Majidinia, Maryam / Alemi, Forough / Younesi, Simin / Mahmoodpoor, Ata / Maleki, Masomeh / Yousefi, Bahman / Asemi, Zatollah

Critical Reviews in Food Science and Nutrition. 2023 May 30, v. 63, no. 14 p.2231-2246

2023

Abstract: Respiratory viral infections are common respiratory diseases. Influenza viruses, RSV and SARS-COV2 have the potential to cause severe respiratory infections. Numerous studies have shown that unregulated immune response to these viruses can cause ... ...

Abstract	Respiratory viral infections are common respiratory diseases. Influenza viruses, RSV and SARS-COV2 have the potential to cause severe respiratory infections. Numerous studies have shown that unregulated immune response to these viruses can cause excessive inflammation and tissue damage. Therefore, regulating the antiviral immune response in the respiratory tract is of importance. In this regard, recent years studies have emphasized the importance of vitamin D in respiratory viral infections. Although, the most well-known role of vitamin D is to regulate the metabolism of phosphorus and calcium, it has been shown that this vitamin has other important functions. One of these functions is immune regulation. Vitamin D can regulate the antiviral immune response in the respiratory tract in order to provide an effective defense against respiratory viral infections and prevention from excessive inflammatory response and tissue damage. In addition, this vitamin has preventive effects against respiratory viral infections. Some studies during the COVID-19 pandemic have shown that vitamin D deficiency may be associated with a higher risk of mortality and sever disease in patients with COVID-19. Since, more attention has recently been focused on vitamin D. In this article, after a brief overview of the antiviral immune response in the respiratory system, we will review the role of vitamin D in regulating the antiviral immune response comprehensively. Then we will discuss the importance of this vitamin in influenza, RSV, and COVID-19.
Keywords	COVID-19 infection ; calcium ; food science ; immune response ; immunomodulators ; inflammation ; influenza ; metabolism ; mortality ; phosphorus ; respiratory system ; risk ; vitamin D ; COVID-19 ; respiratory viral infections ; RSV
Language	English
Dates of publication	2023-0530
Size	p. 2231-2246.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	1037504-1
ISSN	1549-7852 ; 1040-8398
ISSN (online)	1549-7852
ISSN	1040-8398
DOI	10.1080/10408398.2021.1972407
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Article ; Online: Signaling, metabolism, and cancer: An important relationship for therapeutic intervention.

Vaghari-Tabari, Mostafa / Ferns, Gordon A / Qujeq, Durdi / Andevari, Ali Nosrati / Sabahi, Zahra / Moein, Soheila

Journal of cellular physiology

2021 Volume 236, Issue 8, Page(s) 5512–5532

Abstract: In cancerous cells, significant changes occur in the activity of signaling pathways affecting a wide range of cellular activities ranging from growth and proliferation to apoptosis, invasiveness, and metastasis. Extensive changes also happen with respect ...

Abstract	In cancerous cells, significant changes occur in the activity of signaling pathways affecting a wide range of cellular activities ranging from growth and proliferation to apoptosis, invasiveness, and metastasis. Extensive changes also happen with respect to the metabolism of a cancerous cell encompassing a wide range of functions that include: nutrient acquisition, biosynthesis of macromolecules, and energy generation. These changes are important and some therapeutic approaches for treating cancers have focused on targeting the metabolism of cancerous cells. Oncogenes and tumor suppressor genes have a significant effect on the metabolism of cells. There appears to be a close interaction between metabolism and the signaling pathways in a cancerous cell, in which the interaction provides the metabolic needs of a cancerous cell for uncontrolled proliferation, resistance to apoptosis, and metastasis. In this review, we have reviewed the latest findings in this regard and briefly review the most recent research findings regarding targeting the metabolism of cancer cells as a therapeutic approach for treatment of cancer.
MeSH term(s)	Apoptosis/drug effects ; Apoptosis/physiology ; Cell Proliferation/drug effects ; Cell Proliferation/physiology ; Energy Metabolism/drug effects ; Energy Metabolism/physiology ; Humans ; Neoplasm Metastasis/pathology ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Neoplasms/pathology ; Signal Transduction/drug effects ; Signal Transduction/physiology
Language	English
Publishing date	2021-02-12
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	3116-1
ISSN	1097-4652 ; 0021-9541
ISSN (online)	1097-4652
ISSN	0021-9541
DOI	10.1002/jcp.30276
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Article: From inflammatory bowel disease to colorectal cancer: what's the role of miRNAs?

Vaghari-Tabari, Mostafa / Targhazeh, Niloufar / Moein, Soheila / Qujeq, Durdi / Alemi, Forough / Majidina, Maryam / Younesi, Simin / Asemi, Zatollah / Yousefi, Bahman

Cancer cell international

2022 Volume 22, Issue 1, Page(s) 146

Abstract: Inflammatory Bowel Disease (IBD) is a chronic inflammatory disease with relapse and remission periods. Ulcerative colitis and Crohn's disease are two major forms of the disease. IBD imposes a lot of sufferings on the patient and has many consequences; ... ...

Abstract	Inflammatory Bowel Disease (IBD) is a chronic inflammatory disease with relapse and remission periods. Ulcerative colitis and Crohn's disease are two major forms of the disease. IBD imposes a lot of sufferings on the patient and has many consequences; however, the most important is the increased risk of colorectal cancer, especially in patients with Ulcerative colitis. This risk is increased with increasing the duration of disease, thus preventing the progression of IBD to cancer is very important. Therefore, it is necessary to know the details of events contributed to the progression of IBD to cancer. In recent years, the importance of miRNAs as small molecules with 20-22 nucleotides has been recognized in pathophysiology of many diseases, in which IBD and colorectal cancer have not been excluded. As a result, the effectiveness of these small molecules as therapeutic target is hopefully confirmed. This paper has reviewed the related studies and findings about the role of miRNAs in the course of events that promote the progression of IBD to colorectal carcinoma, as well as a review about the effectiveness of some of these miRNAs as therapeutic targets.
Language	English
Publishing date	2022-04-11
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2091573-1
ISSN	1475-2867
ISSN	1475-2867
DOI	10.1186/s12935-022-02557-3
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Article ; Online: Polyphenols and inflammatory bowel disease: Natural products with therapeutic effects?

Vaghari-Tabari, Mostafa / Alemi, Forough / Zokaei, Maryam / Moein, Soheila / Qujeq, Durdi / Yousefi, Bahman / Farzami, Payam / Hosseininasab, Seyed Soheil

Critical reviews in food science and nutrition

2022 , Page(s) 1–24

Abstract: Inflammatory bowel disease (IBD) is a long-life disease with periods of recurrence and relief. Oxidative stress plays an important role in the pathogenesis of this disease. Recent years' studies in the field of IBD treatment mostly have focused on ... ...

Abstract	Inflammatory bowel disease (IBD) is a long-life disease with periods of recurrence and relief. Oxidative stress plays an important role in the pathogenesis of this disease. Recent years' studies in the field of IBD treatment mostly have focused on targeting cytokines and immune cell trafficking using antibodies and inhibitors, altering the composition of intestinal bacteria in the line of attenuation of inflammation using probiotics and prebiotics, and attenuating oxidative stress through antioxidant supplementation. Studies in animal models of IBD have shown that some polyphenolic compounds including curcumin, quercetin, resveratrol, naringenin, and epigallocatechin-3-gallate can affect almost all of the above aspects and are useful compounds in the treatment of IBD. Clinical studies performed on IBD patients have also confirmed the findings of animal model studies and have shown that supplementation with some of the above-mentioned polyphenolic compounds has positive effects in reducing disease clinical and endoscopic activity, inducing and maintaining remission, and improving quality of life. In this review article, in addition to a detailed reviewing the effects of the above-mentioned polyphenolic compounds on the events involved in the pathogenesis of IBD, the results of these clinical studies will also be reviewed.
Language	English
Publishing date	2022-11-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	1037504-1
ISSN	1549-7852 ; 1040-8398
ISSN (online)	1549-7852
ISSN	1040-8398
DOI	10.1080/10408398.2022.2139222
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Article ; Online: Quercetin: an effective polyphenol in alleviating diabetes and diabetic complications.

Yan, Lei / Vaghari-Tabari, Mostafa / Malakoti, Faezeh / Moein, Soheila / Qujeq, Durdi / Yousefi, Bahman / Asemi, Zatollah

Critical reviews in food science and nutrition

2022 Volume 63, Issue 28, Page(s) 9163–9186

Abstract: Various studies, especially in recent years, have shown that quercetin has beneficial therapeutic effects in various human diseases, including diabetes. Quercetin has significant anti-diabetic effects and may be helpful in lowering blood sugar and ... ...

Abstract	Various studies, especially in recent years, have shown that quercetin has beneficial therapeutic effects in various human diseases, including diabetes. Quercetin has significant anti-diabetic effects and may be helpful in lowering blood sugar and increasing insulin sensitivity. Quercetin appears to affect many factors and signaling pathways involved in insulin resistance and the pathogenesis of type 2 of diabetes. TNFα, NFKB, AMPK, AKT, and NRF2 are among the factors that are affected by quercetin. In addition, quercetin can be effective in preventing and ameliorating the diabetic complications, including diabetic nephropathy, cardiovascular complications, neuropathy, delayed wound healing, and retinopathy, and affects the key mechanisms involved in the pathogenesis of these complications. These positive effects of quercetin may be related to its anti-inflammatory and anti-oxidant properties. In this article, after a brief review of the pathogenesis of insulin resistance and type 2 diabetes, we will review the latest findings on the anti-diabetic effects of quercetin with a molecular perspective. Then we will review the effects of quercetin on the key mechanisms of pathogenesis of diabetes complications including nephropathy, cardiovascular complications, neuropathy, delayed wound healing, and retinopathy. Finally, clinical trials investigating the effect of quercetin on diabetes and diabetes complications will be reviewed.
MeSH term(s)	Humans ; Quercetin/pharmacology ; Quercetin/therapeutic use ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Insulin Resistance ; Polyphenols/pharmacology ; Polyphenols/therapeutic use ; Diabetes Complications/drug therapy ; Diabetes Complications/prevention & control ; Diabetes Complications/metabolism ; Retinal Diseases/drug therapy
Chemical Substances	Quercetin (9IKM0I5T1E) ; Polyphenols
Language	English
Publishing date	2022-04-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	1037504-1
ISSN	1549-7852 ; 1040-8398
ISSN (online)	1549-7852
ISSN	1040-8398
DOI	10.1080/10408398.2022.2067825
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Article ; Online: CRISPR/Cas9 gene editing: a new approach for overcoming drug resistance in cancer.

Vaghari-Tabari, Mostafa / Hassanpour, Parisa / Sadeghsoltani, Fatemeh / Malakoti, Faezeh / Alemi, Forough / Qujeq, Durdi / Asemi, Zatollah / Yousefi, Bahman

Cellular & molecular biology letters

2022 Volume 27, Issue 1, Page(s) 49

Abstract: The CRISPR/Cas9 system is an RNA-based adaptive immune system in bacteria and archaea. Various studies have shown that it is possible to target a wide range of human genes and treat some human diseases, including cancers, by the CRISPR/Cas9 system. In ... ...

Abstract	The CRISPR/Cas9 system is an RNA-based adaptive immune system in bacteria and archaea. Various studies have shown that it is possible to target a wide range of human genes and treat some human diseases, including cancers, by the CRISPR/Cas9 system. In fact, CRISPR/Cas9 gene editing is one of the most efficient genome manipulation techniques. Studies have shown that CRISPR/Cas9 technology, in addition to having the potential to be used as a new therapeutic approach in the treatment of cancers, can also be used to enhance the effectiveness of existing treatments. Undoubtedly, the issue of drug resistance is one of the main obstacles in the treatment of cancers. Cancer cells resist anticancer drugs by a variety of mechanisms, such as enhancing anticancer drugs efflux, enhancing DNA repair, enhancing stemness, and attenuating apoptosis. Mutations in some proteins of different cellular signaling pathways are associated with these events and drug resistance. Recent studies have shown that the CRISPR/Cas9 technique can be used to target important genes involved in these mechanisms, thereby increasing the effectiveness of anticancer drugs. In this review article, studies related to the applications of this technique in overcoming drug resistance in cancer cells will be reviewed. In addition, we will give a brief overview of the limitations of the CRISP/Cas9 gene-editing technique.
MeSH term(s)	CRISPR-Cas Systems/genetics ; Drug Resistance ; Gene Editing/methods ; Humans ; Neoplasms/drug therapy ; Neoplasms/genetics ; RNA
Chemical Substances	RNA (63231-63-0)
Language	English
Publishing date	2022-06-17
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2108724-6
ISSN	1689-1392 ; 1689-1392
ISSN (online)	1689-1392
ISSN	1689-1392
DOI	10.1186/s11658-022-00348-2
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Article ; Online: Melatonin and inflammatory bowel disease: From basic mechanisms to clinical application.

Vaghari-Tabari, Mostafa / Moein, Soheila / Alipourian, Ali / Qujeq, Durdi / Malakoti, Faezeh / Alemi, Forough / Yousefi, Bahman / Khazaie, Sepideh

Biochimie

2022 Volume 209, Page(s) 20–36

Abstract	Inflammatory bowel disease is a chronic inflammatory disease and has periods of recurrence and remission. Improper immune responses to gut flora bacteria, along with genetic susceptibility, appear to be involved in causing this complex disease. It seems dysbiosis and oxidative stress may also be involved in IBD pathogenesis. A significant number of clinical studies have shown an interesting association between sleep disturbances and IBD. Studies in animal models have also shown that sleep deprivation has a significant effect on the pathogenesis of IBD and can aggravate inflammation. These interesting findings have drawn attention to melatonin, a sleep-related hormone. Melatonin is mainly produced by the pineal gland, but many tissues in the body, including the intestines, can produce it. Melatonin can have an interesting effect on the pathogenesis of IBD. Melatonin can enhance the intestinal mucosal barrier, alter the composition of intestinal bacteria in favor of bacteria with anti-inflammatory properties, regulate the immune response, alleviate inflammation and attenuate oxidative stress. It seems that, melatonin supplementation is effective in relieving inflammation and healing intestinal ulcers in IBD animal models. Some clinical studies have also shown that melatonin supplementation as an adjuvant therapy may be helpful in reducing disease activity in IBD patients. In this review article, in addition to reviewing the effects of sleep disturbances and melatonin on key mechanisms involved in the pathogenesis of IBD, we will review the findings of clinical studies regarding the effects of melatonin supplementation on IBD treatment.
MeSH term(s)	Animals ; Melatonin/therapeutic use ; Inflammatory Bowel Diseases/drug therapy ; Inflammatory Bowel Diseases/pathology ; Intestines ; Intestinal Mucosa/pathology ; Inflammation/drug therapy ; Bacteria
Chemical Substances	Melatonin (JL5DK93RCL)
Language	English
Publishing date	2022-12-17
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	120345-9
ISSN	1638-6183 ; 0300-9084
ISSN (online)	1638-6183
ISSN	0300-9084
DOI	10.1016/j.biochi.2022.12.007
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