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  1. Article ; Online: Discrepancies between current guidance from NICE on the treatment of vitamin D deficiency and the recommended daily amounts [RDAs] for its prevention in the UK.

    Boucher, Barbara J

    Expert review of endocrinology & metabolism

    2022  Volume 17, Issue 3, Page(s) 201–203

    MeSH term(s) Humans ; United Kingdom ; Vitamin D/therapeutic use ; Vitamin D Deficiency/drug therapy ; Vitamin D Deficiency/prevention & control
    Chemical Substances Vitamin D (1406-16-2)
    Language English
    Publishing date 2022-04-22
    Publishing country England
    Document type Editorial
    ISSN 1744-8417
    ISSN (online) 1744-8417
    DOI 10.1080/17446651.2022.2067143
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Vitamin D deficiency in British South Asians, a persistent but avoidable problem associated with many health risks (including rickets, T2DM, CVD, COVID-19 and pregnancy complications): the case for correcting this deficiency.

    Boucher, Barbara J

    Endocrine connections

    2022  Volume 11, Issue 12

    Abstract: High vitamin D deficiency rates, with rickets and osteomalacia, have been common in South Asians (SAs) arriving in Britain since the 1950s with preventable infant deaths from hypocalcaemic status-epilepticus and cardiomyopathy. Vitamin D deficiency ... ...

    Abstract High vitamin D deficiency rates, with rickets and osteomalacia, have been common in South Asians (SAs) arriving in Britain since the 1950s with preventable infant deaths from hypocalcaemic status-epilepticus and cardiomyopathy. Vitamin D deficiency increases common SA disorders (type 2 diabetes and cardiovascular disease), recent trials and non-linear Mendelian randomisation studies having shown deficiency to be causal for both disorders. Ethnic minority, obesity, diabetes and social deprivation are recognised COVID-19 risk factors, but vitamin D deficiency is not, despite convincing mechanistic evidence of it. Adjusting analyses for obesity/ethnicity abolishes vitamin D deficiency in COVID-19 risk prediction, but both factors lower serum 25(OH)D specifically. Social deprivation inadequately explains increased ethnic minority COVID-19 risks. SA vitamin D deficiency remains uncorrected after 70 years, official bodies using 'education', 'assimilation' and 'diet' as 'proxies' for ethnic differences and increasing pressures to assimilate. Meanwhile, English rickets was abolished from ~1940 by free 'welfare foods' (meat, milk, eggs, cod liver oil), for all pregnant/nursing mothers and young children (<5 years old). Cod liver oil was withdrawn from antenatal clinics in 1994 (for excessive vitamin A teratogenicity), without alternative provision. The take-up of the 2006 'Healthy-Start' scheme of food-vouchers for low-income families with young children (<3 years old) has been poor, being inaccessible and poorly publicised. COVID-19 pandemic advice for UK adults in 'lockdown' was '400 IU vitamin D/day', inadequate for correcting the deficiency seen winter/summer at 17.5%/5.9% in White, 38.5%/30% in Black and 57.2%/50.8% in SA people in representative UK Biobank subjects when recruited ~14 years ago and remaining similar in 2018. Vitamin D inadequacy worsens many non-skeletal health risks. Not providing vitamin D for preventing SA rickets and osteomalacia continues to be unacceptable, as deficiency-related health risks increase ethnic health disparities, while abolishing vitamin D deficiency would be easier and more cost-effective than correcting any other factor worsening ethnic minority health in Britain.
    Language English
    Publishing date 2022-10-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2668428-7
    ISSN 2049-3614
    ISSN 2049-3614
    DOI 10.1530/EC-22-0234
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: No evidence that vitamin D is able to prevent or affect the severity of COVID-19 in individuals with European ancestry: a Mendelian randomisation study of open data, by Amin

    Boucher, Barbara J

    BMJ nutrition, prevention & health

    2021  Volume 4, Issue 1, Page(s) 352–353

    Language English
    Publishing date 2021-03-16
    Publishing country England
    Document type Journal Article
    ISSN 2516-5542
    ISSN (online) 2516-5542
    DOI 10.1136/bmjnph-2021-000263
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  4. Article ; Online: About adverse effects of high-dose vitamin D supplementation on volumetric bone density.

    Boucher, Barbara J

    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

    2021  Volume 36, Issue 7, Page(s) 1416

    MeSH term(s) Bone Density ; Dietary Supplements ; Humans ; Vitamin D/adverse effects ; Vitamin D Deficiency ; Vitamins
    Chemical Substances Vitamins ; Vitamin D (1406-16-2)
    Language English
    Publishing date 2021-02-10
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 632783-7
    ISSN 1523-4681 ; 0884-0431
    ISSN (online) 1523-4681
    ISSN 0884-0431
    DOI 10.1002/jbmr.4252
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    Zs.A 2142: Show issues Location:
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  5. Article ; Online: Regarding: Low vitamin D is a marker for poor health and increased risk for disease: But causality is still unclear in most cases.

    Grant, William B / Boucher, Barbara J

    Journal of internal medicine

    2023  Volume 293, Issue 6, Page(s) 791–792

    MeSH term(s) Humans ; Causality ; Vitamin D ; Vitamin D Deficiency/complications
    Chemical Substances Vitamin D (1406-16-2)
    Language English
    Publishing date 2023-02-22
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 96274-0
    ISSN 1365-2796 ; 0954-6820
    ISSN (online) 1365-2796
    ISSN 0954-6820
    DOI 10.1111/joim.13621
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  6. Article ; Online: Vitamin D status as a predictor of Covid-19 risk in Black, Asian and other ethnic minority groups in the UK.

    Boucher, Barbara J

    Diabetes/metabolism research and reviews

    2020  Volume 36, Issue 8, Page(s) e3375

    MeSH term(s) Asians ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Dietary Supplements ; Ethnicity ; Humans ; Influenza, Human ; Minority Groups ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; United Kingdom/epidemiology ; Vitamin D
    Chemical Substances Vitamin D (1406-16-2)
    Keywords covid19
    Language English
    Publishing date 2020-07-31
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1470192-3
    ISSN 1520-7560 ; 1520-7552
    ISSN (online) 1520-7560
    ISSN 1520-7552
    DOI 10.1002/dmrr.3375
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    Zs.A 2119: Show issues Location:
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  7. Article: Why do so many trials of vitamin D supplementation fail?

    Boucher, Barbara J

    Endocrine connections

    2020  Volume 9, Issue 9, Page(s) R195–R206

    Abstract: Our knowledge of vitamin D has come a long way since the 100 years it took for doctors to accept, between 1860 and 1890, that both sunlight and cod liver oil (a well-known folk remedy) cured and prevented rickets. Vitamins D2/D3 were discovered exactly a ...

    Abstract Our knowledge of vitamin D has come a long way since the 100 years it took for doctors to accept, between 1860 and 1890, that both sunlight and cod liver oil (a well-known folk remedy) cured and prevented rickets. Vitamins D2/D3 were discovered exactly a hundred years ago, and over the last 50 years vitamin D has been found to have many effects on virtually all human tissues and not just on bone health, while mechanisms affecting the actions of vitamin D at the cellular level are increasingly understood, but deficiency persists globally. Observational studies in humans have shown that better provision of vitamin D is strongly associated, dose-wise, with reductions in current and future health risks in line with the known actions of vitamin D. Randomised controlled trials, commonly accepted as providing a 'gold standard' for assessing the efficacy of new forms of treatment, have frequently failed to provide supportive evidence for the expected health benefits of supplementation. Such RCTs, however, have used designs evolved for testing drugs while vitamin D is a nutrient; the appreciation of this difference is critical to identifying health benefits from existing RCT data and for improving future RCT design. This report aims, therefore, to provide a brief overview of the evidence for a range of non-bony health benefits of vitamin D repletion; to discuss specific aspects of vitamin D biology that can confound RCT design and how to allow for them.
    Keywords covid19
    Language English
    Publishing date 2020-09-24
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2668428-7
    ISSN 2049-3614
    ISSN 2049-3614
    DOI 10.1530/EC-20-0274
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Comment on: Association between vitamin D and cardiovascular health: Myth or fact? A narrative review of the evidence.

    Grant, William B / Al Anouti, Fatme / Boucher, Barbara J

    Women's health (London, England)

    2023  Volume 19, Page(s) 17455057231175310

    MeSH term(s) Humans ; Vitamin D ; Dietary Supplements ; Vitamin D Deficiency/complications
    Chemical Substances Vitamin D (1406-16-2)
    Language English
    Publishing date 2023-05-25
    Publishing country United States
    Document type Review ; Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2274503-8
    ISSN 1745-5065 ; 1745-5057
    ISSN (online) 1745-5065
    ISSN 1745-5057
    DOI 10.1177/17455057231175310
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6629: Show issues Location:
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  9. Article ; Online: R Scragg's and JD Slutyer's "Is There Proof of Extraskeletal Benefits From Vitamin D Supplementation From Recent Mega Trials of Vitamin D?"

    Boucher, Barbara J / Grant, William B

    JBMR plus

    2021  Volume 5, Issue 7, Page(s) e10491

    Language English
    Publishing date 2021-03-30
    Publishing country England
    Document type Journal Article
    ISSN 2473-4039
    ISSN (online) 2473-4039
    DOI 10.1002/jbm4.10491
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  10. Article ; Online: Comment on Di Marco, N., Kaufman, J., Rodda, C.P. Shedding Light on Vitamin D Status and Its Complexities during Pregnancy, Infancy and Childhood: An Australian Perspective.

    Boucher, Barbara J

    International journal of environmental research and public health

    2019  Volume 16, Issue 8

    Abstract: In their report on the roles of vitamin D status during early life development in Australia, Di Marco et al [ ... ]. ...

    Abstract In their report on the roles of vitamin D status during early life development in Australia, Di Marco et al [...].
    MeSH term(s) Australia ; Child ; Continental Population Groups ; Female ; Humans ; Infant ; Pregnancy ; Public Health ; Vitamin D ; Vitamins
    Chemical Substances Vitamins ; Vitamin D (1406-16-2)
    Language English
    Publishing date 2019-04-16
    Publishing country Switzerland
    Document type Journal Article ; Comment
    ISSN 1660-4601
    ISSN (online) 1660-4601
    DOI 10.3390/ijerph16081373
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