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  1. Article ; Online: Analysis of cluster randomised trials as if they were individually randomised - Authors' reply.

    Jolliffe, David A / Martineau, Adrian R

    The lancet. Diabetes & endocrinology

    2022  Volume 11, Issue 2, Page(s) 75–76

    Language English
    Publishing date 2022-12-19
    Publishing country England
    Document type Letter ; Comment
    ISSN 2213-8595
    ISSN (online) 2213-8595
    DOI 10.1016/S2213-8587(22)00361-8
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  2. Article ; Online: Consumer perspectives of allied health involvement in a public hospital setting: cross-sectional survey and electronic health record review.

    Jolliffe, Laura / Williams, Cylie M / Bozyk, Natalie / Collyer, Taya A / Caspers, Kirsten / Snowdon, David A

    Australian health review : a publication of the Australian Hospital Association

    2024  Volume 48

    Abstract: Objective Consumer-centred care is fundamental to high-quality health care, with allied health professionals playing a pivotal role in hospital settings. Allied health typically operates within standard weekday working-hours. Consumer preferences for ... ...

    Abstract Objective Consumer-centred care is fundamental to high-quality health care, with allied health professionals playing a pivotal role in hospital settings. Allied health typically operates within standard weekday working-hours. Consumer preferences for receiving allied health services are largely unexplored but could inform whether weekend and/or out-of-hours services are required. This study aims to understand consumer preferences for hospital-based inpatient and outpatient allied health services. Methods Using a cross-sectional survey and convenience sampling approach, consumers of a public health service in Melbourne, Australia were surveyed about preferences for allied health service delivery. Electronic health record reviews compared the accuracy of self-reported service delivery times. Descriptive statistics, concordance and predictive values were calculated. Responses to free-text survey items were analysed using content analysis. Results Of 120 participants (79% response rate), most (69%) received allied health services, however, almost half of inpatient responders (44%) were unsure of the specific allied health professional involved. Audit results found moderate-high concordance overall (range, 77-96%) between self-reported and audit-identified allied health services by profession. Most inpatient responders had no strong day of week preference, equally selecting weekdays and weekend days, with most preferring services between 8 am and 4 pm. Outpatient responders (81%) preferred a weekday appointment between 8 am and 12 pm or before 8 am (29%) to complete scheduled activities early in the day. Conclusion While provision of allied health services during standard working-hours was preferred by most consumers, some inpatient and outpatient consumers are receptive to receiving weekend and out-of-hours services, respectively. Decisions about offering these services should consider operational capacity and research evidence.
    MeSH term(s) Humans ; Cross-Sectional Studies ; Electronic Health Records ; Health Services ; Hospitals, Public ; Australia
    Language English
    Publishing date 2024-02-17
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 639155-2
    ISSN 1449-8944 ; 0159-5709 ; 0156-5788
    ISSN (online) 1449-8944
    ISSN 0159-5709 ; 0156-5788
    DOI 10.1071/AH23225
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  3. Article ; Online: Vitamin D for the management of asthma.

    Williamson, Anne / Martineau, Adrian R / Sheikh, Aziz / Jolliffe, David / Griffiths, Chris J

    The Cochrane database of systematic reviews

    2023  Volume 2, Page(s) CD011511

    Abstract: Background: Since the previous Cochrane Review on this topic in 2016, debate has continued surrounding a potential role for vitamin D in reducing risk of asthma exacerbation and improving asthma control. We therefore conducted an updated meta-analysis ... ...

    Abstract Background: Since the previous Cochrane Review on this topic in 2016, debate has continued surrounding a potential role for vitamin D in reducing risk of asthma exacerbation and improving asthma control. We therefore conducted an updated meta-analysis to include data from new trials completed since this date.
    Objectives: To evaluate the effectiveness and safety of administration of vitamin D or its hydroxylated metabolites in reducing the risk of severe asthma exacerbations (defined as those requiring treatment with systemic corticosteroids) and improving asthma symptom control.
    Search methods: We searched the Cochrane Airways Group Trial Register and reference lists of articles. We contacted the authors of studies in order to identify additional trials. Date of last search: 8 September 2022.
    Selection criteria: We included double-blind, randomised, placebo-controlled trials of vitamin D in children and adults with asthma evaluating exacerbation risk or asthma symptom control, or both.
    Data collection and analysis: Four review authors independently applied study inclusion criteria, extracted the data, and assessed risk of bias. We obtained missing data from the authors where possible. We reported results with 95% confidence intervals (CIs). The primary outcome was the incidence of severe asthma exacerbations requiring treatment with systemic corticosteroids. Secondary outcomes included the incidence of asthma exacerbations precipitating an emergency department visit or requiring hospital admission, or both, end-study childhood Asthma Control Test (cACT) or Asthma Control Test (ACT) scores, and end-study % predicted forced expiratory volume in one second (FEV1). We performed subgroup analyses to determine whether the effect of vitamin D on risk of asthma exacerbation was modified by baseline vitamin D status, vitamin D dose, frequency of dosing regimen, form of vitamin D given, and age of participants.
    Main results: We included 20 studies in this review; 15 trials involving a total of 1155 children and five trials involving a total of 1070 adults contributed data to analyses. Participant ages ranged from 1 to 84 years, with two trials providing data specific to participants under five years (n = 69) and eight trials providing data specific to participants aged 5 to 16 (n = 766). Across the trials, 1245 participants were male and 1229 were female, with two studies not reporting sex distribution. Fifteen trials contributed to the primary outcome analysis of exacerbations requiring systemic corticosteroids. The duration of trials ranged from three to 40 months; all but two investigated effects of administering cholecalciferol (vitamin D3). As in the previous Cochrane Review, the majority of participants had mild to moderate asthma, and profound vitamin D deficiency (25-hydroxyvitamin D (25(OH)D) < 25 nmol/L) at baseline was rare. Administration of vitamin D or its hydroxylated metabolites did not reduce or increase the proportion of participants experiencing one or more asthma exacerbations treated with systemic corticosteroids (odds ratio (OR) 1.04, 95% CI 0.81 to 1.34; I
    Authors' conclusions: In contrast to findings of our previous Cochrane Review on this topic, this updated review does not find evidence to support a role for vitamin D supplementation or its hydroxylated metabolites to reduce risk of asthma exacerbations or improve asthma control. Participants with severe asthma and those with baseline 25(OH)D concentrations < 25 nmol/L were poorly represented, so further research is warranted here. A single study investigating effects of calcidiol yielded positive results, so further studies investigating effects of this metabolite are needed.
    MeSH term(s) Adult ; Child ; Humans ; Male ; Female ; Infant ; Child, Preschool ; Adolescent ; Young Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Calcifediol ; Hypercalciuria ; Disease Progression ; Asthma/drug therapy ; Vitamins/adverse effects ; Adrenal Cortex Hormones/adverse effects ; Vitamin D/adverse effects ; Cholecalciferol ; Anti-Asthmatic Agents/adverse effects ; Randomized Controlled Trials as Topic
    Chemical Substances Calcifediol (P6YZ13C99Q) ; Vitamins ; Adrenal Cortex Hormones ; Vitamin D (1406-16-2) ; Cholecalciferol (1C6V77QF41) ; Anti-Asthmatic Agents
    Language English
    Publishing date 2023-02-06
    Publishing country England
    Document type Meta-Analysis ; Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Systematic Review
    ISSN 1469-493X
    ISSN (online) 1469-493X
    DOI 10.1002/14651858.CD011511.pub3
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  4. Article ; Online: Development of an implementation strategy for routine collection of generic patient reported outcome measures: a qualitative study in multidisciplinary community rehabilitation.

    Jolliffe, Laura / Andrew, Nadine E / Srikanth, Velandai / Beare, Richard / Noeske, Kate E / Snowdon, David A

    Disability and rehabilitation

    2023  , Page(s) 1–10

    Abstract: Purpose: To explore staff perceptions of barriers and enablers towards implementing the EQ-5D-5L in community rehabilitation, and develop a theory-informed implementation approach for routine administration of generic patient-reported outcome measures ( ... ...

    Abstract Purpose: To explore staff perceptions of barriers and enablers towards implementing the EQ-5D-5L in community rehabilitation, and develop a theory-informed implementation approach for routine administration of generic patient-reported outcome measures (PROMs) using implementation science frameworks.
    Materials and methods: A qualitative study was conducted at three sites. Multidisciplinary rehabilitation staff completed individual semi-structured interviews, which were transcribed and coded against the Theoretical Domains Framework (TDF). We identified and selected potentially effective behaviour change techniques using the Behavior Change Wheel. Hypothetical strategies were operationalised.
    Results: Twenty-one interviews were conducted, and four themes emerged: (1) The Impact of PROMs on patient centered-care; (2) Considerations for validity of PROMs; (3) Service-level impact of embedding PROMs; (4) Practical issues of embedding PROMs within the service. Barriers and enablers were mapped to seven of the TDF domains; relating most to clinicians' "belief about consequences", "reinforcement", and "environmental context and resources". Five hypothetical strategies were developed to overcome identified barriers and strengthen enablers. Key behaviour change techniques underpinning the strategies include: restructuring the physical environment, incentivisation, persuasion and education, enablement, and, social support.
    Conclusions: Our implementation approach highlights the importance of automating processes, engaging site champions, routinely reporting, and using PROM data to inform service provision.
    Language English
    Publishing date 2023-09-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 1104775-6
    ISSN 1464-5165 ; 0963-8288
    ISSN (online) 1464-5165
    ISSN 0963-8288
    DOI 10.1080/09638288.2023.2258334
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Staying Active with Multimorbidity In Acute hospital settings (StAMInA) trial: protocol for a feasibility randomised controlled trial of allied health assistant mobility rehabilitation for patients with multimorbidity.

    Snowdon, David A / Wang, Yi Tian / Callisaya, Michele L / Collyer, Taya A / Jolliffe, Laura / Johns, Nathan / Vincent, Peggy / Pragash, Nandhinee / Taylor, Nicholas F

    BMJ open

    2024  Volume 14, Issue 1, Page(s) e078843

    Abstract: Introduction: Key to improving outcomes for patients with multimorbidity is increasing mobility through prescription of a physical activity programme, but this can be difficult to achieve in acute hospital settings. One approach that would assist ... ...

    Abstract Introduction: Key to improving outcomes for patients with multimorbidity is increasing mobility through prescription of a physical activity programme, but this can be difficult to achieve in acute hospital settings. One approach that would assist physiotherapists to increase levels of physical activity is delegation of rehabilitation to allied health assistants. We aim to conduct a randomised controlled trial to determine the feasibility of an allied health assistant providing daily inpatient mobility rehabilitation for patients with multimorbidity.
    Methods and analysis: Using a parallel group randomised controlled design, participants will be allocated to allied health assistant mobility rehabilitation or physiotherapist mobility rehabilitation. Adult inpatients (n=60) in an acute hospital with a diagnosis of multimorbidity who walked independently preadmission will be included. The experimental group will receive routine mobility rehabilitation, including daily mobilisation, from an allied health assistant under the supervision of a physiotherapist. The comparison group will receive routine rehabilitation from a physiotherapist. Feasibility will be determined using the following areas of focus in Bowen's feasibility framework: Acceptability (patient satisfaction); demand (proportion of patients who participate); implementation (time allied health assistant/physiotherapist spends with participant, occasions of service); and practicality (cost, adverse events). Staff involved in the implementation of allied health assistant rehabilitation will be interviewed to explore their perspectives on feasibility. Secondary outcomes include: Physical activity (daily time spent walking); daily mobilisation (Y/N); discharge destination; hospital readmission; falls; functional activity (Modified Iowa Level of Assistance Scale); and length of stay. Descriptive statistics will be used to describe feasibility. Secondary outcomes will be compared between groups using Poisson or negative binomial regression, Cox proportional hazards regression, survival analysis, linear regression or logistic regression.
    Ethics and dissemination: Ethics approval was obtained from Peninsula Health (HREC/97 431/PH-2023). Findings will be disseminated in peer-reviewed journals and conference presentations.
    Trial registration number: Australian and New Zealand Clinical Trial Registry ACTRN12623000584639p.
    MeSH term(s) Adult ; Humans ; Feasibility Studies ; Multimorbidity ; Australia ; Physical Therapy Modalities ; Hospitals ; Randomized Controlled Trials as Topic
    Language English
    Publishing date 2024-01-12
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2023-078843
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  6. Article ; Online: Senotherapeutic drug treatment ameliorates chemotherapy-induced cachexia.

    Englund, Davis A / Jolliffe, Alyssa M / Hanson, Gabriel J / Aversa, Zaira / Zhang, Xu / Jiang, Xinyi / White, Thomas A / Zhang, Lei / Monroe, David G / Robbins, Paul D / Niedernhofer, Laura J / Kamenecka, Theodore M / Khosla, Sundeep / LeBrasseur, Nathan K

    JCI insight

    2024  Volume 9, Issue 2

    Abstract: Cachexia is a debilitating skeletal muscle wasting condition for which we currently lack effective treatments. In the context of cancer, certain chemotherapeutics cause DNA damage and cellular senescence. Senescent cells exhibit chronic activation of the ...

    Abstract Cachexia is a debilitating skeletal muscle wasting condition for which we currently lack effective treatments. In the context of cancer, certain chemotherapeutics cause DNA damage and cellular senescence. Senescent cells exhibit chronic activation of the transcription factor NF-κB, a known mediator of the proinflammatory senescence-associated secretory phenotype (SASP) and skeletal muscle atrophy. Thus, targeting NF-κB represents a logical therapeutic strategy to alleviate unintended consequences of genotoxic drugs. Herein, we show that treatment with the IKK/NF-κB inhibitor SR12343 during a course of chemotherapy reduces markers of cellular senescence and the SASP in liver, skeletal muscle, and circulation and, correspondingly, attenuates features of skeletal muscle pathology. Lastly, we demonstrate that SR12343 mitigates chemotherapy-induced reductions in body weight, lean mass, fat mass, and muscle strength. These findings support senescent cells as a promising druggable target to counteract the SASP and skeletal muscle wasting in the context of chemotherapy.
    MeSH term(s) Humans ; NF-kappa B/metabolism ; Signal Transduction ; Cachexia/chemically induced ; Cachexia/drug therapy ; Senotherapeutics ; Muscular Atrophy/chemically induced ; Muscular Atrophy/drug therapy ; Antineoplastic Agents/adverse effects
    Chemical Substances NF-kappa B ; Senotherapeutics ; Antineoplastic Agents
    Language English
    Publishing date 2024-01-23
    Publishing country United States
    Document type Journal Article
    ISSN 2379-3708
    ISSN (online) 2379-3708
    DOI 10.1172/jci.insight.169512
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  7. Article ; Online: Influence of vitamin D supplementation on growth, body composition, pubertal development and spirometry in South African schoolchildren: a randomised controlled trial (ViDiKids).

    Middelkoop, Keren / Micklesfield, Lisa / Stewart, Justine / Walker, Neil / Jolliffe, David A / Mendham, Amy E / Coussens, Anna K / Nuttall, James / Tang, Jonathan / Fraser, William D / Momand, Waheedullah / Cooper, Cyrus / Harvey, Nicholas C / Wilkinson, Robert J / Bekker, Linda-Gail / Martineau, Adrian R

    BMJ paediatrics open

    2024  Volume 8, Issue 1

    Abstract: Objective: To determine whether weekly oral vitamin D supplementation influences growth, body composition, pubertal development or spirometric outcomes in South African schoolchildren.: Design: Phase 3 double-blind randomised placebo-controlled trial. ...

    Abstract Objective: To determine whether weekly oral vitamin D supplementation influences growth, body composition, pubertal development or spirometric outcomes in South African schoolchildren.
    Design: Phase 3 double-blind randomised placebo-controlled trial.
    Setting: Socioeconomically disadvantaged peri-urban district of Cape Town, South Africa.
    Participants: 1682 children of black African ancestry attending government primary schools and aged 6-11 years at baseline.
    Interventions: Oral vitamin D
    Main outcome measures: Height-for-age and body mass index-for-age, measured in all participants; Tanner scores for pubertal development, spirometric lung volumes and body composition, measured in a subset of 450 children who additionally took part in a nested substudy.
    Results: Mean serum 25-hydroxyvitamin D
    Conclusions: Weekly oral administration of 10 000 IU vitamin D
    Trial registration numbers: ClinicalTrials.gov NCT02880982, South African National Clinical Trials Register DOH-27-0916-5527.
    MeSH term(s) Child ; Humans ; Body Composition ; Cholecalciferol/therapeutic use ; Cholestanes/therapeutic use ; Dietary Supplements ; South Africa/epidemiology ; Spirometry ; Vitamin D/therapeutic use ; Vitamin D Deficiency/drug therapy ; Vitamins/therapeutic use ; Double-Blind Method
    Chemical Substances Cholecalciferol (1C6V77QF41) ; Cholestanes ; Vitamin D (1406-16-2) ; Vitamins
    Language English
    Publishing date 2024-04-10
    Publishing country England
    Document type Clinical Trial, Phase III ; Journal Article ; Randomized Controlled Trial
    ISSN 2399-9772
    ISSN (online) 2399-9772
    DOI 10.1136/bmjpo-2024-002495
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  8. Article: Influence of vitamin D supplementation on muscle strength and exercise capacity in Mongolian schoolchildren: a randomised controlled trial.

    Ganmaa, Davaasambuu / Hemmings, Stephanie / Jolliffe, David A / Buyanjargal, Uyanga / Garmaa, Gantsetseg / Adiya, Unaganshagai / Tumurbaatar, Tumenulzii / Dorjnamjil, Khulan / Tserenkhuu, Enkhtsetseg / Erdenenbaatar, Sumiya / Tsendjav, Enkhjargal / Enkhamgalan, Nomin / Achtai, Chuluun-Erdene / Talhaasuren, Yagaantsetseg / Byambasuren, Tuya / Ganbaatar, Erdenetuya / Purevdorj, Erkhembulgan / Martineau, Adrian R

    medRxiv : the preprint server for health sciences

    2024  

    Abstract: Objective: To determine whether weekly oral vitamin D supplementation influences grip strength, explosive leg power, cardiorespiratory fitness or spirometric lung volumes in Mongolian schoolchildren.: Methods: Multicentre, randomised, double-blind, ... ...

    Abstract Objective: To determine whether weekly oral vitamin D supplementation influences grip strength, explosive leg power, cardiorespiratory fitness or spirometric lung volumes in Mongolian schoolchildren.
    Methods: Multicentre, randomised, double-blind, placebo-controlled clinical trial conducted in children aged 6-13 years at baseline attending 18 schools in Ulaanbaatar. The intervention was weekly oral doses of 14,000 IU vitamin D
    Results: 99.8% of participants had serum 25(OH)D concentrations <75 nmol/L at baseline, and mean end-study 25(OH)D concentrations in children randomised to vitamin D vs. placebo were 77.4 vs. 26.7 nmol/L (mean difference 50.7 nmol/L, 95% CI, 49.7 to 51.4). However, vitamin D supplementation did not influence mean grip strength, standing long jump distance, VO
    Conclusion: A 3-year course of weekly oral supplementation with 14,000 IU vitamin D
    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.27.24304943
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  9. Article ; Online: Staying Active with Multimorbidity In Acute hospital settings (StAMInA) trial

    Nicholas F Taylor / Laura Jolliffe / Michele L Callisaya / David A Snowdon / Taya A Collyer / Peggy Vincent / Yi Tian Wang / Nathan Johns / Nandhinee Pragash

    BMJ Open, Vol 14, Iss

    protocol for a feasibility randomised controlled trial of allied health assistant mobility rehabilitation for patients with multimorbidity

    2024  Volume 1

    Abstract: Introduction Key to improving outcomes for patients with multimorbidity is increasing mobility through prescription of a physical activity programme, but this can be difficult to achieve in acute hospital settings. One approach that would assist ... ...

    Abstract Introduction Key to improving outcomes for patients with multimorbidity is increasing mobility through prescription of a physical activity programme, but this can be difficult to achieve in acute hospital settings. One approach that would assist physiotherapists to increase levels of physical activity is delegation of rehabilitation to allied health assistants. We aim to conduct a randomised controlled trial to determine the feasibility of an allied health assistant providing daily inpatient mobility rehabilitation for patients with multimorbidity.Methods and analysis Using a parallel group randomised controlled design, participants will be allocated to allied health assistant mobility rehabilitation or physiotherapist mobility rehabilitation. Adult inpatients (n=60) in an acute hospital with a diagnosis of multimorbidity who walked independently preadmission will be included. The experimental group will receive routine mobility rehabilitation, including daily mobilisation, from an allied health assistant under the supervision of a physiotherapist. The comparison group will receive routine rehabilitation from a physiotherapist. Feasibility will be determined using the following areas of focus in Bowen’s feasibility framework: Acceptability (patient satisfaction); demand (proportion of patients who participate); implementation (time allied health assistant/physiotherapist spends with participant, occasions of service); and practicality (cost, adverse events). Staff involved in the implementation of allied health assistant rehabilitation will be interviewed to explore their perspectives on feasibility. Secondary outcomes include: Physical activity (daily time spent walking); daily mobilisation (Y/N); discharge destination; hospital readmission; falls; functional activity (Modified Iowa Level of Assistance Scale); and length of stay. Descriptive statistics will be used to describe feasibility. Secondary outcomes will be compared between groups using Poisson or negative binomial regression, Cox proportional hazards ...
    Keywords Medicine ; R
    Subject code 300
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Incidence determinants and serological correlates of reactive symptoms following SARS-CoV-2 vaccination.

    Holt, Hayley / Jolliffe, David A / Talaei, Mohammad / Faustini, Sian / Vivaldi, Giulia / Greenig, Matthew / Richter, Alex G / Lyons, Ronan A / Griffiths, Christopher J / Kee, Frank / Sheikh, Aziz / Davies, Gwyneth A / Shaheen, Seif O / Martineau, Adrian R

    NPJ vaccines

    2023  Volume 8, Issue 1, Page(s) 26

    Abstract: Prospective population-based studies investigating associations between reactive symptoms following SARS-CoV-2 vaccination and serologic responses to vaccination are lacking. We therefore conducted a study in 9003 adults from the UK general population ... ...

    Abstract Prospective population-based studies investigating associations between reactive symptoms following SARS-CoV-2 vaccination and serologic responses to vaccination are lacking. We therefore conducted a study in 9003 adults from the UK general population receiving SARS-CoV-2 vaccines as part of the national vaccination programme. Titres of combined IgG/IgA/IgM responses to SARS-CoV-2 spike (S) glycoprotein were determined in eluates of dried blood spots collected from all participants before and after vaccination. 4262 (47.3%) participants experienced systemic reactive symptoms after a first vaccine dose. Factors associating with lower risk of such symptoms included older age (aOR per additional 10 years of age 0.85, 95% CI: 0.81-0.90), male vs. female sex (0.59, 0.53-0.65) and receipt of an mRNA vaccine vs. ChAdOx1 nCoV-19 (0.29, 0.26-0.32 for BNT162b2; 0.06, 0.01-0.26 for mRNA-1273). Higher risk of such symptoms was associated with SARS-CoV-2 seropositivity and COVID-19 symptoms prior to vaccination (2.23, 1.78-2.81), but not with SARS-CoV-2 seropositivity in the absence of COVID-19 symptoms (0.94, 0.81-1.09). Presence vs. absence of self-reported anxiety or depression at enrolment associated with higher risk of such symptoms (1.24, 1.12-1.39). Post-vaccination anti-S titres were higher among participants who experienced reactive symptoms after vaccination vs. those who did not (P < 0.001). We conclude that factors influencing risk of systemic symptoms after SARS-CoV-2 vaccination include demographic characteristics, pre-vaccination SARS-CoV-2 serostatus and vaccine type. Participants experiencing reactive symptoms following SARS-CoV-2 vaccination had higher post-vaccination titres of IgG/A/M anti-S antibodies. Improved public understanding of the frequency of reactogenic symptoms and their positive association with vaccine immunogenicity could potentially increase vaccine uptake.
    Language English
    Publishing date 2023-02-25
    Publishing country England
    Document type Journal Article
    ISSN 2059-0105
    ISSN (online) 2059-0105
    DOI 10.1038/s41541-023-00614-0
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