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Book ; Online ; E-Book: Essentials of aerosol therapy in critically ill patients

Saeed, Haitham

2021

Author's details	Haitham Saeed [and three others]
Keywords	Aerosol therapy ; Critical care medicine ; Internal medicine ; Aerosolteràpia ; Medicina intensiva
Subject code	615.836
Language	English
Size	1 online resource (245 pages)
Publisher	Springer
Publishing place	Cham, Switzerland
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	3-030-85026-9 ; 3-030-85025-0 ; 978-3-030-85026-5 ; 978-3-030-85025-8
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book: Essentials of Aerosol Therapy in Critically ill Patients

Abdelrahim, Mohamed E. A. / Madney, Yasmin M. / Harb, Hadeer S. / Saeed, Haitham

2021

Author's details	Prof. Mohamed Emam Abdelmobdy Abdelrahim, is a Professor in Department of Clinical Pharmacy, Faculty of Pharmacy, at the Beni-Suef University in Egypt. He received his PhD from Bradford University, Bradford, UK, in 2009. Prof. Abdelrahim has published over 140 papers, more than 80 conference presentations, and 5 book chapters and his main area of expertise is clinical pharmacy and aerosol therapy. Dr Haitham Saeed Abdel Aziz, Ph.D., is a Lecturer in Department of Clinical pharmacy, Faculty of Pharmacy, Beni-suef University, Egypt. His main research interests are clinical pharmacy and aerosols, and he has published over 30 papers, 10 conference papers, and 5 book chapters and his main area of expertise is clinical pharmacy and aerosol therapy. Dr. Hadeer Safwat Hassan Zaki, Ph.D., is a Lecturer in Department of Clinical Pharmacy, Faculty of Pharmacy, Beni-Suef University, Egypt. Her research interest is clinical pharmacy focusing on aerosol therapy and ventilation. She has published
Keywords	Ventilated patient 3. Nasal delivery ; Nasal delivery ; Nebulizers ; MDIs ; Aerosol generator ; oxygen therapy
Language	English
Size	256 p.
Edition	1
Publisher	Springer International Publishing
Document type	Book
Note	PDA Manuell_12
Format	160 x 241 x 19
ISBN	9783030850258 ; 3030850250
Database	PDA

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Article ; Online: Nanoparticles fabricated from the bioactive tilapia scale collagen for wound healing: Experimental approach.

Shalaby, Manal / Hamouda, Dalia / Khedr, Shaimaa M / Mostafa, Haitham M / Saeed, Hesham / Ghareeb, Ahmed Z

PloS one

2023 Volume 18, Issue 10, Page(s) e0282557

Abstract: The creation of innovative wound-healing nanomaterials based on natural compounds emerges as a top research goal. This research aimed to create a gel containing collagen nanoparticles and evaluate its therapeutic potential for skin lesions. Collagen ... ...

Abstract	The creation of innovative wound-healing nanomaterials based on natural compounds emerges as a top research goal. This research aimed to create a gel containing collagen nanoparticles and evaluate its therapeutic potential for skin lesions. Collagen nanoparticles were produced from fish scales using desolvation techniques. Using SDS PAGE electrophoresis, Fourier transform infrared spectroscopy (FTIR) as well as the structure of the isolated collagen and its similarities to collagen type 1 were identified. The surface morphology of the isolated collagen and its reformulation into nanoparticles were examined using transmission and scanning electron microscopy. A Zeta sizer was used to examine the size, zeta potential, and distribution of the synthesized collagen nanoparticles. The cytotoxicity of the nanomaterials was investigated and an experimental model was used to evaluate the wound healing capability. The overall collagen output from Tilapia fish scales was 42%. Electrophoretic patterns revealed that the isolated collagen included a unique protein with chain bands of 126-132 kDa and an elevated beta band of 255 kDa. When compared to the isolated collagen, the collagen nanoparticles' FTIR results revealed a significant drop in the amide II (42% decrease) and amide III (32% decrease) band intensities. According to SEM analysis, the generated collagen nanoparticles ranged in size from 100 to 350 nm, with an average diameter of 182 nm determined by the zeta sizer. The produced collagen nanoparticles were polydispersed in nature and had an equivalent average zeta potential of -17.7 mV. Cytotoxicity study showed that, when treating fibroblast cells with collagen nanoparticle concentrations, very mild morphological alterations were detected after human skin fibroblasts were treated with collagen nanoparticles 32 μg/ml for 24 hours, as higher concentrations of collagen nanoparticles caused cell detachment. Macroscopical and histological investigations proved that the fabricated fish scale collagen nanoparticles promoted the healing process in comparison to the saline group.
MeSH term(s)	Animals ; Humans ; Tilapia/metabolism ; Wound Healing ; Collagen/metabolism ; Nanoparticles ; Amides
Chemical Substances	Collagen (9007-34-5) ; Amides
Language	English
Publishing date	2023-10-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0282557
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Assessment and characteristics of Erenumab therapy on migraine management.

Saeed, Haitham / Tulbah, Alaa S / Gamal, Amr / Kamal, Marwa

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society

2022 Volume 30, Issue 8, Page(s) 1153–1158

Abstract: Background: Migraine is one of the neurological diseases that have a negative impact on subjects' productivity and daily activity of patients. Introducing monoclonal antibodies as a valuable option for resolving the persistent problem of migraine is ... ...

Abstract	Background: Migraine is one of the neurological diseases that have a negative impact on subjects' productivity and daily activity of patients. Introducing monoclonal antibodies as a valuable option for resolving the persistent problem of migraine is still under investigation. The current study aimed to evaluate the efficacy and safety profile related to Erenumab. Methods: A prospective study for clinical data collection and analysis from recruited therapy-refractory migraine subjects were carried through 6 months for each subject. All subjects received Erenumab 70 mg monthly. Each patient provided the clinical data monthly starting from 0 months and for the next 6 months. Migraine disability assessment (MIDAS) questionnaire was used for evaluation of the Erenumab efficacy every 3 months. In addition, data regarding adverse effects, migraine triggers, and the impact of previous COVID-19 on migraine severity were collected and analyzed. Results: Ninety subjects were recruited in the study. Erenumab injections resulted in a significant (p < 0.001) reduction in MIDAS score in the 3rd month compared with baseline, also this significance was continuous in the 6th month. In contrast, there was no significant difference in the 6th month compared with the 3rd. Previously infected COVID-19 subjects showed a higher severity of migraine attacks compared with non-infected subjects. Skin redness and local pain were the most common adverse effects 63.3%, 47.77% respectively associated with Erenumab. Conclusion: Using Erenumab therapy showed a great beneficial impact regarding the reduction of migraine-related disabilities. COVID-19 was related to the increased severity of migraine attacks.
Language	English
Publishing date	2022-06-22
Publishing country	Saudi Arabia
Document type	Journal Article
ZDB-ID	1378024-4
ISSN	1319-0164
ISSN	1319-0164
DOI	10.1016/j.jsps.2022.06.015
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Article ; Online: Impact of different nebulisers' connections on aerosol therapy.

Abdelrahman, Mona A / Abdelrahim, Mohamed E / Saeed, Haitham

International journal of clinical practice

2021 Volume 75, Issue 10, Page(s) e14493

Abstract: Background: Aerosol therapy has the advantage of a higher safety because of the local deposition of inhaled medication to the lung; however, the main drawback is the low and variable amount of delivered drug to patients. Hence, this study aimed to ... ...

Abstract	Background: Aerosol therapy has the advantage of a higher safety because of the local deposition of inhaled medication to the lung; however, the main drawback is the low and variable amount of delivered drug to patients. Hence, this study aimed to investigate the effect of different accessory connections on aerosol delivery from different nebulisers. Method: This study consisted of 3 main models: in vitro, in vivo and ex vivo models. In vitro model, 6 nebulisers (3 Jet (Dolphin (2030 2001), Philips (SideStream) and Tylenol (TL009002)) and 3 vibrating mesh nebulisers (VMNs) (Aerogen Pro, Solo, an Nivo)) were charged with 5 mg/2 mL salbutamol and connected to 2 different connections (T-piece and Circulaire II Hybrid) with an inhalation filter attached to a breathing simulator. Inhaled amounts of drug (inhalation filter) and that remained inside nebuliser were measured. Concerning ex vivo and in vivo models, 24 subjects were involved in the study and they received 5 mg/2 mL salbutamol from 1 Jet nebuliser and 1 VMNs using both connections. Two urine samples were collected post 30 minutes and pooled 24 hours urine collection. For the ex vivo model, inhaled amounts of salbutamol were collected on filters placed between the subjects and the nebuliser. Results: Inhaled amounts of salbutamol expressed by the amount of drug detected on inhalation filters (for both in vitro and ex vivo) were significantly higher from both Jet and VMNs connected to the Circulaire II Hybrid connection than that released from nebulisers connected to T-piece. VMNs delivered a higher amount compared with jet nebulisers. The amount released from jet nebulizers were variables, unlike VMNs. Regarding in vivo results, amounts of drug detected in 30 minutes urine samples were consistent with in vitro and ex vivo models reflecting higher and significant amounts of drug delivered to the patient's lung for Circulaire II Hybrid connection compared with T-piece regarding both nebulisers. Conclusion: Using a valved chamber with jet and VMNs significantly improved the inhaled amount of the emitted aerosol. VMNs were more effective than jet nebulisers with both connections.
Language	English
Publishing date	2021-06-21
Publishing country	England
Document type	Journal Article
ZDB-ID	1386246-7
ISSN	1742-1241 ; 1368-5031
ISSN (online)	1742-1241
ISSN	1368-5031
DOI	10.1111/ijcp.14493
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Article: Enhancing the Bioavailability and Efficacy of Vismodegib for the Control of Skin Cancer: In Vitro and In Vivo Studies.

Salem, Heba F / Gamal, Amr / Saeed, Haitham / Kamal, Marwa / Tulbah, Alaa S

Pharmaceuticals (Basel, Switzerland)

2022 Volume 15, Issue 2

Abstract: Skin cancer is the most frequent cancer throughout the world. Vismodegib (VSD) is a hedgehog blocker approved for the prevention and treatment of skin cancer. VSD, however, is poorly bioavailable and has been linked to side effects. This work focused on ... ...

Abstract	Skin cancer is the most frequent cancer throughout the world. Vismodegib (VSD) is a hedgehog blocker approved for the prevention and treatment of skin cancer. VSD, however, is poorly bioavailable and has been linked to side effects. This work focused on designing a nano-invasome gel as a vehicle for enhancing the permeation, bioavailability, and efficacy of VSD. Additionally, the combined effect of terpenes and ethanol was studied on the permeation of VSD compared with liposomes. The prepared VSD-loaded invasomes (VLI) formulation included cineole (1%
Language	English
Publishing date	2022-01-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2193542-7
ISSN	1424-8247
ISSN	1424-8247
DOI	10.3390/ph15020126
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Article: Aerosol delivery via noninvasive ventilation: role of models and bioanalysis.

Saeed, Haitham / Harb, Hadeer S / Madney, Yasmin M / Abdelrahim, Mohamed E A

Annals of translational medicine

2021 Volume 9, Issue 7, Page(s) 589

Abstract: Non-invasive ventilation (NIV) is external support for respiration to assist breathing in case of respiratory failure (either hypercapnic or hypoxemic) without patient intubation. Nowadays, medicated aerosols are normally delivered to mechanically ... ...

Abstract	Non-invasive ventilation (NIV) is external support for respiration to assist breathing in case of respiratory failure (either hypercapnic or hypoxemic) without patient intubation. Nowadays, medicated aerosols are normally delivered to mechanically ventilated patients by nebulizers and pressurized metered-dose inhaler (pMDI) attached to adapter or spacer that fit into the ventilated circuit. Studies with obstructive lung disease patients have shown that aerosol delivery during mechanical ventilation is possible and of benefit. There are several models for investigating the aerosol delivery and deposition during mechanical ventilation such as
Language	English
Publishing date	2021-04-27
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	2893931-1
ISSN	2305-5847 ; 2305-5839
ISSN (online)	2305-5847
ISSN	2305-5839
DOI	10.21037/atm-20-1261
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Article: The Impact of Improving Dermal Permeation on the Efficacy and Targeting of Liposome Nanoparticles as a Potential Treatment for Breast Cancer.

Salem, Heba F / Gamal, Amr / Saeed, Haitham / Tulbah, Alaa S

Pharmaceutics

2021 Volume 13, Issue 10

Abstract: Breast cancer is the most frequent malignancy in women. This work focuses on developing deformable liposomes as a potential carrier for breast cancer treatment and studying the impact of improving dermal permeation on the efficacy and targeting of ... ...

Abstract	Breast cancer is the most frequent malignancy in women. This work focuses on developing deformable liposomes as a potential carrier for breast cancer treatment and studying the impact of improving dermal permeation on the efficacy and targeting of liposomes. Raloxifene (RXF), an oestrogen antagonist, was used as a model drug. Using Box-Behnken design, different formulations of RXF-loaded deformable liposome (RLDL) were prepared using different propylene glycol, phospholipid and cholesterol concentrations. The percentage of entrapment efficiency (Y
Language	English
Publishing date	2021-10-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics13101633
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Article ; Online: The impact of the clip-tone training device and its smartphone application to pressurized metered-dose inhaler in adult asthmatics.

Mahmoud, Rania A A / Boshra, Marian S / Saeed, Haitham / Abdelrahim, Mohamed E A

The Journal of asthma : official journal of the Association for the Care of Asthma

2022 Volume 60, Issue 2, Page(s) 227–234

Abstract: Background: Despite traditional inhaler technique counseling, many patients make clinically important mistakes when they use their inhalers. This study investigates the value of using a connected inhalation aid when adults with asthma use their metered- ... ...

Abstract	Background: Despite traditional inhaler technique counseling, many patients make clinically important mistakes when they use their inhalers. This study investigates the value of using a connected inhalation aid when adults with asthma use their metered-dose inhaler (pMDI). Methods: Adult asthmatics ( Results: Both groups showed a significant decrease ( Conclusion: The connected Clip-Tone training aid helped patients improve their pMDI inhaler technique and their asthma control compared to traditional methods. These results highlight the potential of connected inhalers in the future management of inhaled therapy.
MeSH term(s)	Adult ; Humans ; Administration, Inhalation ; Asthma/drug therapy ; Bronchodilator Agents ; Metered Dose Inhalers ; Mobile Applications ; Nebulizers and Vaporizers ; Smartphone
Chemical Substances	Bronchodilator Agents
Language	English
Publishing date	2022-02-24
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	603816-5
ISSN	1532-4303 ; 0277-0903
ISSN (online)	1532-4303
ISSN	0277-0903
DOI	10.1080/02770903.2022.2043359
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Article ; Online: Application of different counseling strategies for better adult asthma control.

Mohamed, Basma M E / Laz, Nabila / Saeed, Haitham / Alghamdi, Saleh / AbdElrahman, Mohamed / Abdelrahim, Mohamed E A / Rabea, Hoda

The Journal of asthma : official journal of the Association for the Care of Asthma

2023 , Page(s) 1–8

Abstract: Objective: We aimed to compare the effectiveness of three distinct counseling methods to determine the most effective approach.: Methods: In this prospective cohort study with a two-month follow-up, A group of non-smoking adults, aged 19-60 years, ... ...

Abstract	Objective: We aimed to compare the effectiveness of three distinct counseling methods to determine the most effective approach. Methods: In this prospective cohort study with a two-month follow-up, A group of non-smoking adults, aged 19-60 years, were randomly collected at outpatients clinic with prior asthma diagnosis, based on the forced expiratory volume in one seconds to forced vital capacity ratio (FEV1/FVC) and the guidelines outlined by the Global Initiative for Asthma (GINA), At the baseline assessment, all patients, underwent FEV1/FVC measurements, asthma symptom evaluations using Asthma Control Test (ACT), Asthma Control Questionnaire (ACQ), and GINA symptoms control assessment questionnaire, and assessment of pressurized metered-dose inhaler (pMDI) usage. The patients were divided into three groups, each assigned a distinct counseling strategy: traditional verbal counseling, advanced counseling utilizing the Asthma smartphone-application, and a combination of advanced-verbal counseling. We conducted a two-month monitoring period for all three groups. Results: Significant differences ( Conclusion: The study findings indicate that the combining advanced-verbal counseling by incorporating the Asthma smartphone-application alongside traditional verbal counseling is a more effective approach for improving asthma control in adults.
Language	English
Publishing date	2023-12-28
Publishing country	England
Document type	Journal Article
ZDB-ID	603816-5
ISSN	1532-4303 ; 0277-0903
ISSN (online)	1532-4303
ISSN	0277-0903
DOI	10.1080/02770903.2023.2300709
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